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Protein

Argininosuccinate lyase 2

Gene

argH2

Organism
Bacillus clausii (strain KSM-K16)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine.UniRule annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Ornithine carbamoyltransferase (argF)
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase 2 (argH2), Argininosuccinate lyase 1 (argH1)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processAmino-acid biosynthesis, Arginine biosynthesis

Enzyme and pathway databases

BioCyciBCLA66692:G1G25-2892-MONOMER
UniPathwayi
UPA00068;UER00114

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate lyase 2UniRule annotation (EC:4.3.2.1UniRule annotation)
Short name:
ASAL 2UniRule annotation
Alternative name(s):
Arginosuccinase 2UniRule annotation
Gene namesi
Name:argH2UniRule annotation
Ordered Locus Names:ABC2736
OrganismiBacillus clausii (strain KSM-K16)
Taxonomic identifieri66692 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001168 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002407131 – 462Argininosuccinate lyase 2Add BLAST462

Interactioni

Protein-protein interaction databases

STRINGi66692.ABC2736

Structurei

3D structure databases

ProteinModelPortaliQ5WED9
SMRiQ5WED9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CH7 Bacteria
COG0165 LUCA
HOGENOMiHOG000242744
KOiK01755
OMAiSIMPHKK
OrthoDBiPOG091H026A

Family and domain databases

CDDicd01359 Argininosuccinate_lyase, 1 hit
Gene3Di1.10.275.10, 2 hits
HAMAPiMF_00006 Arg_succ_lyase, 1 hit
InterProiView protein in InterPro
IPR029419 Arg_succ_lyase_C
IPR009049 Argininosuccinate_lyase
IPR024083 Fumarase/histidase_N
IPR020557 Fumarate_lyase_CS
IPR000362 Fumarate_lyase_fam
IPR022761 Fumarate_lyase_N
IPR008948 L-Aspartase-like
PANTHERiPTHR43814 PTHR43814, 1 hit
PfamiView protein in Pfam
PF14698 ASL_C2, 1 hit
PF00206 Lyase_1, 1 hit
PRINTSiPR00149 FUMRATELYASE
SUPFAMiSSF48557 SSF48557, 1 hit
TIGRFAMsiTIGR00838 argH, 1 hit
PROSITEiView protein in PROSITE
PS00163 FUMARATE_LYASES, 1 hit

Sequencei

Sequence statusi: Complete.

Q5WED9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSKLWGGRFT KTAEQWVDEF GASIGFDQQL VEEDITGSIA HVTMLAKQHI
60 70 80 90 100
LSEEEAAQIK NGLKTLQKKA AAGELVFSAA QEDIHLNLEK LLIDEIGPVG
110 120 130 140 150
GKLHTGRSRN DQVATDMHLY LRTQTEEIME AIRTLQAALV KQAEGHVETL
160 170 180 190 200
IPGYTHLQRA QPVSFAHHLL AYFWMLERDY GRLQDSLKRV NISPLGAGAL
210 220 230 240 250
AGTTFPIDRA YTAELLHFEG IYENSLDAVS DRDFIVEFLA ASATLMMHLS
260 270 280 290 300
RLCEELILWS AQEFQFIEID DAFATGSSIM PQKKNPDMAE LIRGKTGRVY
310 320 330 340 350
GSLFSLLTTL KGLPLAYNKD MQEDKEGMFD TVKTVKGSLR IFAGMIETIT
360 370 380 390 400
VNTDAMAKAV TSDFSNATEL ADYLATKGMP FREAHEVVGK LVLTAIEKGV
410 420 430 440 450
YLLDLPIEVY KEASSLFADD IYEVLQPKTV VGRRNSAGGT GFEQVKLALG
460
KANDLLSQSI KG
Length:462
Mass (Da):51,026
Last modified:November 23, 2004 - v1
Checksum:i477E236E219BC471
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006627 Genomic DNA Translation: BAD65271.1
RefSeqiWP_011247579.1, NC_006582.1

Genome annotation databases

EnsemblBacteriaiBAD65271; BAD65271; ABC2736
GeneIDi34045402
KEGGibcl:ABC2736

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006627 Genomic DNA Translation: BAD65271.1
RefSeqiWP_011247579.1, NC_006582.1

3D structure databases

ProteinModelPortaliQ5WED9
SMRiQ5WED9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi66692.ABC2736

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD65271; BAD65271; ABC2736
GeneIDi34045402
KEGGibcl:ABC2736

Phylogenomic databases

eggNOGiENOG4105CH7 Bacteria
COG0165 LUCA
HOGENOMiHOG000242744
KOiK01755
OMAiSIMPHKK
OrthoDBiPOG091H026A

Enzyme and pathway databases

UniPathwayi
UPA00068;UER00114

BioCyciBCLA66692:G1G25-2892-MONOMER

Family and domain databases

CDDicd01359 Argininosuccinate_lyase, 1 hit
Gene3Di1.10.275.10, 2 hits
HAMAPiMF_00006 Arg_succ_lyase, 1 hit
InterProiView protein in InterPro
IPR029419 Arg_succ_lyase_C
IPR009049 Argininosuccinate_lyase
IPR024083 Fumarase/histidase_N
IPR020557 Fumarate_lyase_CS
IPR000362 Fumarate_lyase_fam
IPR022761 Fumarate_lyase_N
IPR008948 L-Aspartase-like
PANTHERiPTHR43814 PTHR43814, 1 hit
PfamiView protein in Pfam
PF14698 ASL_C2, 1 hit
PF00206 Lyase_1, 1 hit
PRINTSiPR00149 FUMRATELYASE
SUPFAMiSSF48557 SSF48557, 1 hit
TIGRFAMsiTIGR00838 argH, 1 hit
PROSITEiView protein in PROSITE
PS00163 FUMARATE_LYASES, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiARLY2_BACSK
AccessioniPrimary (citable) accession number: Q5WED9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: November 23, 2004
Last modified: October 10, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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