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UniProtKB - Q5W5X9 (TTC23_HUMAN)

Entry version 133 (07 Apr 2021)
Sequence version 1 (07 Dec 2004)
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Protein

Tetratricopeptide repeat protein 23

Gene

TTC23

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Participates positively in the ciliary Hedgehog (Hh) signaling.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q5W5X9

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tetratricopeptide repeat protein 23
Short name:
TPR repeat protein 23
Alternative name(s):
Cervical cancer proto-oncogene 8 protein
Short name:
HCC-8
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TTC23
ORF Names:HCC8
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:25730, TTC23

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q5W5X9

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000103852.12

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell projection

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		64927

Open Targets

More...OpenTargetsi		ENSG00000103852

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA142670675

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q5W5X9, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TTC23

Domain mapping of disease mutations (DMDM)

More...DMDMi		74708246

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002895481 – 447Tetratricopeptide repeat protein 23Add BLAST447

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q5W5X9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q5W5X9

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q5W5X9

PeptideAtlas

More...PeptideAtlasi		Q5W5X9

PRoteomics IDEntifications database

More...PRIDEi		Q5W5X9

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		65810 [Q5W5X9-1]
65811 [Q5W5X9-2]
65812 [Q5W5X9-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q5W5X9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q5W5X9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000103852, Expressed in lower esophagus and 159 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q5W5X9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q5W5X9, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000103852, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Found Associated with the EvC complex composed of EFCAB7, IQCE, EVC2 and EVC.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q5W5X9
With#Exp.IntAct
ALAS1 [P13196]3EBI-6447954,EBI-3905054
BHLHE40 [O14503]3EBI-6447954,EBI-711810
CCNDBP1 [O95273]3EBI-6447954,EBI-748961
CNTROB [Q8N137]3EBI-6447954,EBI-947360
CREBZF [Q9NS37]3EBI-6447954,EBI-632965
GOLGA2 [Q08379]3EBI-6447954,EBI-618309
KRT31 [Q15323]3EBI-6447954,EBI-948001
KRT40 [Q6A162]3EBI-6447954,EBI-10171697
LDOC1 [O95751]4EBI-6447954,EBI-740738
LZTS2 [Q9BRK4]3EBI-6447954,EBI-741037
MAGED1 [Q9Y5V3]3EBI-6447954,EBI-716006
MDFI [Q99750]3EBI-6447954,EBI-724076
PNMA5 [Q96PV4]3EBI-6447954,EBI-10171633
SPAG5 [Q96R06]3EBI-6447954,EBI-413317
SSX2IP [Q9Y2D8]3EBI-6447954,EBI-2212028
TADA2A [O75478]3EBI-6447954,EBI-742268
TRIM10 [Q9UDY6]4EBI-6447954,EBI-6427325
TRIM54 [Q9BYV2]3EBI-6447954,EBI-2130429
Isoform 3 [Q5W5X9-3]
With#Exp.IntAct
ABI1 - isoform 5 [Q8IZP0-5]3EBI-9090990,EBI-11743294
ADCY4 [Q8NFM4]3EBI-9090990,EBI-2838710
BANP - isoform 2 [Q8N9N5-2]3EBI-9090990,EBI-11524452
BLZF1 [Q9H2G9]5EBI-9090990,EBI-2548012
C1orf109 [Q9NX04]3EBI-9090990,EBI-8643161
CBX8 [Q9HC52]3EBI-9090990,EBI-712912
CCDC102B [Q68D86]3EBI-9090990,EBI-10171570
CCDC24 [Q8N4L8]3EBI-9090990,EBI-1104933
CDK18 [Q07002]3EBI-9090990,EBI-746238
CDR2 [Q01850]3EBI-9090990,EBI-1181367
CREBZF [Q9NS37]3EBI-9090990,EBI-632965
CTNNA3 - isoform 2 [Q9UI47-2]3EBI-9090990,EBI-11962928
CYSRT1 [A8MQ03]3EBI-9090990,EBI-3867333
DISC1 - isoform 2 [Q9NRI5-2]3EBI-9090990,EBI-11988027
DNM2 - isoform 2 [P50570-2]3EBI-9090990,EBI-10968534
EFCAB3 - isoform 2 [Q8N7B9-2]3EBI-9090990,EBI-11958551
ENKD1 [Q9H0I2]3EBI-9090990,EBI-744099
FAM161B [Q96MY7]3EBI-9090990,EBI-7225287
FANCL [Q9NW38]3EBI-9090990,EBI-2339898
FSD2 [A1L4K1]3EBI-9090990,EBI-5661036
GOLGA2 [Q08379]3EBI-9090990,EBI-618309
GOLGA6L9 [A6NEM1]3EBI-9090990,EBI-5916454
GPANK1 [O95872]3EBI-9090990,EBI-751540
GPRASP2 [Q96D09]3EBI-9090990,EBI-473189
GRIPAP1 [Q4V328]3EBI-9090990,EBI-717919
GRN [P28799]3EBI-9090990,EBI-747754
HOOK2 - isoform 2 [Q96ED9-2]3EBI-9090990,EBI-10961706
HSF2BP [O75031]3EBI-9090990,EBI-7116203
HTT [P42858]18EBI-9090990,EBI-466029
INSC [Q1MX18]3EBI-9090990,EBI-12081118
IQCE [Q6IPM2]3EBI-9090990,EBI-3893098
KASH5 [Q8N6L0]3EBI-9090990,EBI-749265
KDM1A [O60341]3EBI-9090990,EBI-710124
KIAA1328 [Q86T90]3EBI-9090990,EBI-3437878
KLHL42 [Q9P2K6]3EBI-9090990,EBI-739890
KRT15 [P19012]3EBI-9090990,EBI-739566
KRT16 [P08779]3EBI-9090990,EBI-356410
KRT27 [Q7Z3Y8]3EBI-9090990,EBI-3044087
KRT31 [Q15323]3EBI-9090990,EBI-948001
KRT34 [O76011]3EBI-9090990,EBI-1047093
KRT36 - isoform 2 [O76013-2]3EBI-9090990,EBI-11958506
KRTAP10-8 [P60410]3EBI-9090990,EBI-10171774
LCN2 [P80188]3EBI-9090990,EBI-11911016
LDOC1 [O95751]3EBI-9090990,EBI-740738
LZTS2 [Q9BRK4]3EBI-9090990,EBI-741037
MAGED1 [Q9Y5V3]3EBI-9090990,EBI-716006
MBD3 - isoform 2 [O95983-2]3EBI-9090990,EBI-11978579
MDFI [Q99750]3EBI-9090990,EBI-724076
MED12L [Q86YW9]3EBI-9090990,EBI-3957138
MESD [Q14696]3EBI-9090990,EBI-6165891
MFAP1 [P55081]3EBI-9090990,EBI-1048159
MID2 - isoform 2 [Q9UJV3-2]3EBI-9090990,EBI-10172526
MIPOL1 [Q8TD10]3EBI-9090990,EBI-2548751
MKRN3 [Q13064]3EBI-9090990,EBI-2340269
MNS1 [Q8NEH6]3EBI-9090990,EBI-743811
MTUS2 - isoform 2 [Q5JR59-3]4EBI-9090990,EBI-11522433
NEFL [P07196]3EBI-9090990,EBI-475646
NOTO [A8MTQ0]3EBI-9090990,EBI-17490746
NSMF - isoform 2 [Q6X4W1-2]3EBI-9090990,EBI-12028784
PICK1 [Q9NRD5]3EBI-9090990,EBI-79165
PIH1D2 [Q8WWB5]3EBI-9090990,EBI-10232538
PLEKHG4 [Q58EX7]3EBI-9090990,EBI-949255
PNMA1 [Q8ND90]3EBI-9090990,EBI-302345
POLR2J3 [Q9H1A7]3EBI-9090990,EBI-12818681
POU6F2 [P78424]3EBI-9090990,EBI-12029004
PPP1R16A [Q96I34]3EBI-9090990,EBI-710402
PRDM6 [Q9NQX0]3EBI-9090990,EBI-11320284
PRKAB2 [O43741]3EBI-9090990,EBI-1053424
PRPF18 [Q99633]3EBI-9090990,EBI-2798416
PRPH [P41219]3EBI-9090990,EBI-752074
PRPS1 [P60891]3EBI-9090990,EBI-749195
PSORS1C2 [Q9UIG4]3EBI-9090990,EBI-11974061
RAD51D [O75771]3EBI-9090990,EBI-1055693
RBCK1 [Q9BYM8]3EBI-9090990,EBI-2340624
SPAG11B - isoform EP2D [Q08648-4]3EBI-9090990,EBI-14835966
SPAG8 - isoform 2 [Q99932-2]3EBI-9090990,EBI-11959123
SPDEF [O95238]3EBI-9090990,EBI-12811275
TEX13A [Q9BXU3]3EBI-9090990,EBI-10301068
TLE5 - isoform 2 [Q08117-2]3EBI-9090990,EBI-11741437
TRAF2 [Q12933]3EBI-9090990,EBI-355744
TRAPPC6A - isoform 2 [O75865-2]3EBI-9090990,EBI-8451480
TRIB3 [Q96RU7]3EBI-9090990,EBI-492476
TRIM32 [Q13049]3EBI-9090990,EBI-742790
TRIM54 [Q9BYV2]3EBI-9090990,EBI-2130429
TRIM74 - isoform 2 [Q86UV6-2]3EBI-9090990,EBI-10259086
TRIP6 [Q15654]3EBI-9090990,EBI-742327
TSGA10IP [Q3SY00]3EBI-9090990,EBI-10241197
UBXN11 - isoform 6 [Q5T124-6]3EBI-9090990,EBI-11524408
USHBP1 [Q8N6Y0]3EBI-9090990,EBI-739895
WFS1 [O76024]3EBI-9090990,EBI-720609
XIAP [P98170]3EBI-9090990,EBI-517127
XRN2 [Q9H0D6]3EBI-9090990,EBI-372110
ZBED1 [O96006]3EBI-9090990,EBI-740037
ZBTB16 [Q05516]3EBI-9090990,EBI-711925
ZBTB42 [B2RXF5]3EBI-9090990,EBI-12287587
ZFHX3 - isoform B [Q15911-2]3EBI-9090990,EBI-10237226
ZFYVE26 - isoform 5 [Q68DK2-5]3EBI-9090990,EBI-8656416
ZIM2 [Q9NZV7]3EBI-9090990,EBI-11962760
ZNF410 - isoform 3 [Q86VK4-3]3EBI-9090990,EBI-11741890
ZNF417 [Q8TAU3]3EBI-9090990,EBI-740727

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		122349, 100 interactors

Protein interaction database and analysis system

More...IntActi		Q5W5X9, 112 interactors

Molecular INTeraction database

More...MINTi		Q5W5X9

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000377690

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q5W5X9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q5W5X9

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati45 – 78TPR 1Add BLAST34
Repeati137 – 170TPR 2Add BLAST34
Repeati186 – 219TPR 3Add BLAST34
Repeati356 – 389TPR 4Add BLAST34

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502RQY0, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00530000063847

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_030458_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q5W5X9

Identification of Orthologs from Complete Genome Data

More...OMAi		VPPYNDN

Database of Orthologous Groups

More...OrthoDBi		1014824at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q5W5X9

TreeFam database of animal gene trees

More...TreeFami		TF332604

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011990, TPR-like_helical_dom_sf
IPR019734, TPR_repeat
IPR042621, TTC23/TTC23L

The PANTHER Classification System

More...PANTHERi		PTHR14485, PTHR14485, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00028, TPR, 4 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48452, SSF48452, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5W5X9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQESQETHIS NHLDEVVAAV SITHRKKFQN KLLQTALFQP PREKLHLCEE 
        60         70         80         90        100
KAKSYSNSHE YKQAVHELVR CVALTRICYG DSHWKLAEAH VNLAQGYLQL 
       110        120        130        140        150
KGLSLQAKQH AEKARQILAN SIVPPYSENT DVFKFSIELF HTMGRALLSL 
       160        170        180        190        200
QKFKEAAENL TKAERLSKEL LQCGRIIKEE WIEIEARIRL SFAQVYQGQK 
       210        220        230        240        250
KSKEALSHYQ AALEYVEISK GETSRECVPI LRELAGVEQA LGLHDVSINH 
       260        270        280        290        300
FLQAHLIILS RSPSQVEAAD SAHIVAHAAV ASGRHEHHDV AEQYFQESMA 
       310        320        330        340        350
HLKDSEGMGR TKFLSIQDEF CHFLQMTGQK ERATSILRES LEAKVEAFGD 
       360        370        380        390        400
FSPEVAETYR LLGGADLAQG NHSGARKKLK KCLQIQTLLY GPQDKRTLAT 
       410        420        430        440 
QQAMGMLSTA PKVASKPRQA SKAKVAFCTS IPQDTLLGKA RPGTTAD
Length:447
Mass (Da):50,009
Last modified:December 7, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7548138692B33E57
GO
Isoform 2 (identifier: Q5W5X9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     382-447: CLQIQTLLYG...GKARPGTTAD → VKLEPVLTRD

Show »
Length:391
Mass (Da):44,174
Checksum:i4D38FFBA005B3041
GO
Isoform 3 (identifier: Q5W5X9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     382-447: CLQIQTLLYG...GKARPGTTAD → GDLSFLLSATLP

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:393
Mass (Da):44,238
Checksum:iA7C4AAC73EAA15A5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7BZG4H7BZG4_HUMAN
Tetratricopeptide repeat protein 23
TTC23
263Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YET0H0YET0_HUMAN
Tetratricopeptide repeat protein 23
TTC23
73Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YNV8H0YNV8_HUMAN
Tetratricopeptide repeat protein 23
TTC23
157Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YM10H0YM10_HUMAN
Tetratricopeptide repeat protein 23
TTC23
115Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YNH7H0YNH7_HUMAN
Tetratricopeptide repeat protein 23
TTC23
151Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YN45H0YN45_HUMAN
Tetratricopeptide repeat protein 23
TTC23
83Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YKN9H0YKN9_HUMAN
Tetratricopeptide repeat protein 23
TTC23
53Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YMN1H0YMN1_HUMAN
Tetratricopeptide repeat protein 23
TTC23
56Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB14144 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti374G → E in BAD96300 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_026017382 – 447CLQIQ…GTTAD → VKLEPVLTRD in isoform 2. 1 PublicationAdd BLAST66
Alternative sequenceiVSP_026018382 – 447CLQIQ…GTTAD → GDLSFLLSATLP in isoform 3. 1 PublicationAdd BLAST66

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF411456 mRNA Translation: AAQ03215.1
AK022634 mRNA Translation: BAB14144.1 Different initiation.
AK023230 mRNA Translation: BAB14480.1
AK222580 mRNA Translation: BAD96300.1
AK291690 mRNA Translation: BAF84379.1
BC015728 mRNA Translation: AAH15728.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS10379.2 [Q5W5X9-1]

NCBI Reference Sequences

More...RefSeqi		NP_001275544.1, NM_001288615.1 [Q5W5X9-1]
NP_001275545.1, NM_001288616.1 [Q5W5X9-1]
XP_016878001.1, XM_017022512.1 [Q5W5X9-1]
XP_016878002.1, XM_017022513.1 [Q5W5X9-1]
XP_016878003.1, XM_017022514.1 [Q5W5X9-1]
XP_016878004.1, XM_017022515.1 [Q5W5X9-1]
XP_016878005.1, XM_017022516.1 [Q5W5X9-1]
XP_016878006.1, XM_017022517.1
XP_016878007.1, XM_017022518.1 [Q5W5X9-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000262074; ENSP00000262074; ENSG00000103852 [Q5W5X9-3]
ENST00000394129; ENSP00000457901; ENSG00000103852 [Q5W5X9-2]
ENST00000394132; ENSP00000377690; ENSG00000103852 [Q5W5X9-1]
ENST00000394135; ENSP00000377692; ENSG00000103852 [Q5W5X9-1]
ENST00000459771; ENSP00000433162; ENSG00000103852 [Q5W5X9-3]
ENST00000558663; ENSP00000452923; ENSG00000103852 [Q5W5X9-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		64927

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:64927

UCSC genome browser

More...UCSCi		uc002buy.5, human [Q5W5X9-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF411456 mRNA Translation: AAQ03215.1
AK022634 mRNA Translation: BAB14144.1 Different initiation.
AK023230 mRNA Translation: BAB14480.1
AK222580 mRNA Translation: BAD96300.1
AK291690 mRNA Translation: BAF84379.1
BC015728 mRNA Translation: AAH15728.1
CCDSiCCDS10379.2 [Q5W5X9-1]
RefSeqiNP_001275544.1, NM_001288615.1 [Q5W5X9-1]
NP_001275545.1, NM_001288616.1 [Q5W5X9-1]
XP_016878001.1, XM_017022512.1 [Q5W5X9-1]
XP_016878002.1, XM_017022513.1 [Q5W5X9-1]
XP_016878003.1, XM_017022514.1 [Q5W5X9-1]
XP_016878004.1, XM_017022515.1 [Q5W5X9-1]
XP_016878005.1, XM_017022516.1 [Q5W5X9-1]
XP_016878006.1, XM_017022517.1
XP_016878007.1, XM_017022518.1 [Q5W5X9-1]

3D structure databases

SMRiQ5W5X9
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi122349, 100 interactors
IntActiQ5W5X9, 112 interactors
MINTiQ5W5X9
STRINGi9606.ENSP00000377690

PTM databases

iPTMnetiQ5W5X9
PhosphoSitePlusiQ5W5X9

Genetic variation databases

BioMutaiTTC23
DMDMi74708246

Proteomic databases

EPDiQ5W5X9
MassIVEiQ5W5X9
PaxDbiQ5W5X9
PeptideAtlasiQ5W5X9
PRIDEiQ5W5X9
ProteomicsDBi65810 [Q5W5X9-1]
65811 [Q5W5X9-2]
65812 [Q5W5X9-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		29144, 177 antibodies

The DNASU plasmid repository

More...DNASUi		64927

Genome annotation databases

EnsembliENST00000262074; ENSP00000262074; ENSG00000103852 [Q5W5X9-3]
ENST00000394129; ENSP00000457901; ENSG00000103852 [Q5W5X9-2]
ENST00000394132; ENSP00000377690; ENSG00000103852 [Q5W5X9-1]
ENST00000394135; ENSP00000377692; ENSG00000103852 [Q5W5X9-1]
ENST00000459771; ENSP00000433162; ENSG00000103852 [Q5W5X9-3]
ENST00000558663; ENSP00000452923; ENSG00000103852 [Q5W5X9-1]
GeneIDi64927
KEGGihsa:64927
UCSCiuc002buy.5, human [Q5W5X9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		64927
DisGeNETi64927

GeneCards: human genes, protein and diseases

More...GeneCardsi		TTC23
HGNCiHGNC:25730, TTC23
HPAiENSG00000103852, Low tissue specificity
neXtProtiNX_Q5W5X9
OpenTargetsiENSG00000103852
PharmGKBiPA142670675
VEuPathDBiHostDB:ENSG00000103852.12

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502RQY0, Eukaryota
GeneTreeiENSGT00530000063847
HOGENOMiCLU_030458_0_0_1
InParanoidiQ5W5X9
OMAiVPPYNDN
OrthoDBi1014824at2759
PhylomeDBiQ5W5X9
TreeFamiTF332604

Enzyme and pathway databases

PathwayCommonsiQ5W5X9

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		64927, 2 hits in 997 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TTC23, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		64927
PharosiQ5W5X9, Tdark

Protein Ontology

More...PROi		PR:Q5W5X9
RNActiQ5W5X9, protein

Gene expression databases

BgeeiENSG00000103852, Expressed in lower esophagus and 159 other tissues
ExpressionAtlasiQ5W5X9, baseline and differential
GenevisibleiQ5W5X9, HS

Family and domain databases

Gene3Di1.25.40.10, 2 hits
InterProiView protein in InterPro
IPR011990, TPR-like_helical_dom_sf
IPR019734, TPR_repeat
IPR042621, TTC23/TTC23L
PANTHERiPTHR14485, PTHR14485, 1 hit
SMARTiView protein in SMART
SM00028, TPR, 4 hits
SUPFAMiSSF48452, SSF48452, 3 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTTC23_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5W5X9
Secondary accession number(s): A8K6M5
, Q53HK0, Q96BC9, Q9H8W9, Q9H9S7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: December 7, 2004
Last modified: April 7, 2021
This is version 133 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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