UniProtKB - Q5W5X9 (TTC23_HUMAN)
Protein
Tetratricopeptide repeat protein 23
Gene
TTC23
Organism
Homo sapiens (Human)
Status
Functioni
Participates positively in the ciliary Hedgehog (Hh) signaling.By similarity
GO - Biological processi
- positive regulation of smoothened signaling pathway Source: UniProtKB
Enzyme and pathway databases
PathwayCommonsi | Q5W5X9 |
Names & Taxonomyi
Protein namesi | Recommended name: Tetratricopeptide repeat protein 23Short name: TPR repeat protein 23 Alternative name(s): Cervical cancer proto-oncogene 8 protein Short name: HCC-8 |
Gene namesi | Name:TTC23 ORF Names:HCC8 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000103852.12 |
HGNCi | HGNC:25730, TTC23 |
neXtProti | NX_Q5W5X9 |
Subcellular locationi
Keywords - Cellular componenti
Cell projectionPathology & Biotechi
Organism-specific databases
DisGeNETi | 64927 |
OpenTargetsi | ENSG00000103852 |
PharmGKBi | PA142670675 |
Miscellaneous databases
Pharosi | Q5W5X9, Tdark |
Polymorphism and mutation databases
BioMutai | TTC23 |
DMDMi | 74708246 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000289548 | 1 – 447 | Tetratricopeptide repeat protein 23Add BLAST | 447 |
Proteomic databases
EPDi | Q5W5X9 |
MassIVEi | Q5W5X9 |
PaxDbi | Q5W5X9 |
PeptideAtlasi | Q5W5X9 |
PRIDEi | Q5W5X9 |
ProteomicsDBi | 65810 [Q5W5X9-1] 65811 [Q5W5X9-2] 65812 [Q5W5X9-3] |
PTM databases
iPTMneti | Q5W5X9 |
PhosphoSitePlusi | Q5W5X9 |
Expressioni
Gene expression databases
Bgeei | ENSG00000103852, Expressed in lower esophagus and 159 other tissues |
ExpressionAtlasi | Q5W5X9, baseline and differential |
Genevisiblei | Q5W5X9, HS |
Organism-specific databases
HPAi | ENSG00000103852, Low tissue specificity |
Interactioni
Subunit structurei
Found Associated with the EvC complex composed of EFCAB7, IQCE, EVC2 and EVC.
By similarityBinary interactionsi
Q5W5X9
Isoform 3 [Q5W5X9-3]
Protein-protein interaction databases
BioGRIDi | 122349, 100 interactors |
IntActi | Q5W5X9, 107 interactors |
MINTi | Q5W5X9 |
STRINGi | 9606.ENSP00000377690 |
Miscellaneous databases
RNActi | Q5W5X9, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 45 – 78 | TPR 1Add BLAST | 34 | |
Repeati | 137 – 170 | TPR 2Add BLAST | 34 | |
Repeati | 186 – 219 | TPR 3Add BLAST | 34 | |
Repeati | 356 – 389 | TPR 4Add BLAST | 34 |
Keywords - Domaini
Repeat, TPR repeatPhylogenomic databases
eggNOGi | ENOG502RQY0, Eukaryota |
GeneTreei | ENSGT00530000063847 |
HOGENOMi | CLU_030458_0_0_1 |
InParanoidi | Q5W5X9 |
OMAi | VPPYNDN |
OrthoDBi | 1014824at2759 |
PhylomeDBi | Q5W5X9 |
TreeFami | TF332604 |
Family and domain databases
Gene3Di | 1.25.40.10, 2 hits |
InterProi | View protein in InterPro IPR011990, TPR-like_helical_dom_sf IPR019734, TPR_repeat IPR042621, TTC23/TTC23L |
PANTHERi | PTHR14485, PTHR14485, 1 hit |
SMARTi | View protein in SMART SM00028, TPR, 4 hits |
SUPFAMi | SSF48452, SSF48452, 3 hits |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q5W5X9-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MQESQETHIS NHLDEVVAAV SITHRKKFQN KLLQTALFQP PREKLHLCEE
60 70 80 90 100
KAKSYSNSHE YKQAVHELVR CVALTRICYG DSHWKLAEAH VNLAQGYLQL
110 120 130 140 150
KGLSLQAKQH AEKARQILAN SIVPPYSENT DVFKFSIELF HTMGRALLSL
160 170 180 190 200
QKFKEAAENL TKAERLSKEL LQCGRIIKEE WIEIEARIRL SFAQVYQGQK
210 220 230 240 250
KSKEALSHYQ AALEYVEISK GETSRECVPI LRELAGVEQA LGLHDVSINH
260 270 280 290 300
FLQAHLIILS RSPSQVEAAD SAHIVAHAAV ASGRHEHHDV AEQYFQESMA
310 320 330 340 350
HLKDSEGMGR TKFLSIQDEF CHFLQMTGQK ERATSILRES LEAKVEAFGD
360 370 380 390 400
FSPEVAETYR LLGGADLAQG NHSGARKKLK KCLQIQTLLY GPQDKRTLAT
410 420 430 440
QQAMGMLSTA PKVASKPRQA SKAKVAFCTS IPQDTLLGKA RPGTTAD
Isoform 3 (identifier: Q5W5X9-3) [UniParc]FASTAAdd to basket
The sequence of this isoform differs from the canonical sequence as follows:
382-447: CLQIQTLLYG...GKARPGTTAD → GDLSFLLSATLP
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH7BZG4 | H7BZG4_HUMAN | Tetratricopeptide repeat protein 23 | TTC23 | 263 | Annotation score: | ||
H0YET0 | H0YET0_HUMAN | Tetratricopeptide repeat protein 23 | TTC23 | 73 | Annotation score: | ||
H0YNV8 | H0YNV8_HUMAN | Tetratricopeptide repeat protein 23 | TTC23 | 157 | Annotation score: | ||
H0YM10 | H0YM10_HUMAN | Tetratricopeptide repeat protein 23 | TTC23 | 115 | Annotation score: | ||
H0YNH7 | H0YNH7_HUMAN | Tetratricopeptide repeat protein 23 | TTC23 | 151 | Annotation score: | ||
H0YN45 | H0YN45_HUMAN | Tetratricopeptide repeat protein 23 | TTC23 | 83 | Annotation score: | ||
H0YKN9 | H0YKN9_HUMAN | Tetratricopeptide repeat protein 23 | TTC23 | 53 | Annotation score: | ||
H0YMN1 | H0YMN1_HUMAN | Tetratricopeptide repeat protein 23 | TTC23 | 56 | Annotation score: |
Sequence cautioni
The sequence BAB14144 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 374 | G → E in BAD96300 (PubMed:14702039).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_026017 | 382 – 447 | CLQIQ…GTTAD → VKLEPVLTRD in isoform 2. 1 PublicationAdd BLAST | 66 | |
Alternative sequenceiVSP_026018 | 382 – 447 | CLQIQ…GTTAD → GDLSFLLSATLP in isoform 3. 1 PublicationAdd BLAST | 66 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF411456 mRNA Translation: AAQ03215.1 AK022634 mRNA Translation: BAB14144.1 Different initiation. AK023230 mRNA Translation: BAB14480.1 AK222580 mRNA Translation: BAD96300.1 AK291690 mRNA Translation: BAF84379.1 BC015728 mRNA Translation: AAH15728.1 |
CCDSi | CCDS10379.2 [Q5W5X9-1] |
RefSeqi | NP_001275544.1, NM_001288615.1 [Q5W5X9-1] NP_001275545.1, NM_001288616.1 [Q5W5X9-1] XP_016878001.1, XM_017022512.1 [Q5W5X9-1] XP_016878002.1, XM_017022513.1 [Q5W5X9-1] XP_016878003.1, XM_017022514.1 [Q5W5X9-1] XP_016878004.1, XM_017022515.1 [Q5W5X9-1] XP_016878005.1, XM_017022516.1 [Q5W5X9-1] XP_016878006.1, XM_017022517.1 XP_016878007.1, XM_017022518.1 [Q5W5X9-1] |
Genome annotation databases
Ensembli | ENST00000262074; ENSP00000262074; ENSG00000103852 [Q5W5X9-3] ENST00000394129; ENSP00000457901; ENSG00000103852 [Q5W5X9-2] ENST00000394132; ENSP00000377690; ENSG00000103852 [Q5W5X9-1] ENST00000394135; ENSP00000377692; ENSG00000103852 [Q5W5X9-1] ENST00000459771; ENSP00000433162; ENSG00000103852 [Q5W5X9-3] ENST00000558663; ENSP00000452923; ENSG00000103852 [Q5W5X9-1] |
GeneIDi | 64927 |
KEGGi | hsa:64927 |
UCSCi | uc002buy.5, human [Q5W5X9-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF411456 mRNA Translation: AAQ03215.1 AK022634 mRNA Translation: BAB14144.1 Different initiation. AK023230 mRNA Translation: BAB14480.1 AK222580 mRNA Translation: BAD96300.1 AK291690 mRNA Translation: BAF84379.1 BC015728 mRNA Translation: AAH15728.1 |
CCDSi | CCDS10379.2 [Q5W5X9-1] |
RefSeqi | NP_001275544.1, NM_001288615.1 [Q5W5X9-1] NP_001275545.1, NM_001288616.1 [Q5W5X9-1] XP_016878001.1, XM_017022512.1 [Q5W5X9-1] XP_016878002.1, XM_017022513.1 [Q5W5X9-1] XP_016878003.1, XM_017022514.1 [Q5W5X9-1] XP_016878004.1, XM_017022515.1 [Q5W5X9-1] XP_016878005.1, XM_017022516.1 [Q5W5X9-1] XP_016878006.1, XM_017022517.1 XP_016878007.1, XM_017022518.1 [Q5W5X9-1] |
3D structure databases
SMRi | Q5W5X9 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 122349, 100 interactors |
IntActi | Q5W5X9, 107 interactors |
MINTi | Q5W5X9 |
STRINGi | 9606.ENSP00000377690 |
PTM databases
iPTMneti | Q5W5X9 |
PhosphoSitePlusi | Q5W5X9 |
Polymorphism and mutation databases
BioMutai | TTC23 |
DMDMi | 74708246 |
Proteomic databases
EPDi | Q5W5X9 |
MassIVEi | Q5W5X9 |
PaxDbi | Q5W5X9 |
PeptideAtlasi | Q5W5X9 |
PRIDEi | Q5W5X9 |
ProteomicsDBi | 65810 [Q5W5X9-1] 65811 [Q5W5X9-2] 65812 [Q5W5X9-3] |
Protocols and materials databases
Antibodypediai | 29144, 170 antibodies |
DNASUi | 64927 |
Genome annotation databases
Ensembli | ENST00000262074; ENSP00000262074; ENSG00000103852 [Q5W5X9-3] ENST00000394129; ENSP00000457901; ENSG00000103852 [Q5W5X9-2] ENST00000394132; ENSP00000377690; ENSG00000103852 [Q5W5X9-1] ENST00000394135; ENSP00000377692; ENSG00000103852 [Q5W5X9-1] ENST00000459771; ENSP00000433162; ENSG00000103852 [Q5W5X9-3] ENST00000558663; ENSP00000452923; ENSG00000103852 [Q5W5X9-1] |
GeneIDi | 64927 |
KEGGi | hsa:64927 |
UCSCi | uc002buy.5, human [Q5W5X9-1] |
Organism-specific databases
CTDi | 64927 |
DisGeNETi | 64927 |
EuPathDBi | HostDB:ENSG00000103852.12 |
GeneCardsi | TTC23 |
HGNCi | HGNC:25730, TTC23 |
HPAi | ENSG00000103852, Low tissue specificity |
neXtProti | NX_Q5W5X9 |
OpenTargetsi | ENSG00000103852 |
PharmGKBi | PA142670675 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RQY0, Eukaryota |
GeneTreei | ENSGT00530000063847 |
HOGENOMi | CLU_030458_0_0_1 |
InParanoidi | Q5W5X9 |
OMAi | VPPYNDN |
OrthoDBi | 1014824at2759 |
PhylomeDBi | Q5W5X9 |
TreeFami | TF332604 |
Enzyme and pathway databases
PathwayCommonsi | Q5W5X9 |
Miscellaneous databases
BioGRID-ORCSi | 64927, 2 hits in 845 CRISPR screens |
ChiTaRSi | TTC23, human |
GenomeRNAii | 64927 |
Pharosi | Q5W5X9, Tdark |
PROi | PR:Q5W5X9 |
RNActi | Q5W5X9, protein |
Gene expression databases
Bgeei | ENSG00000103852, Expressed in lower esophagus and 159 other tissues |
ExpressionAtlasi | Q5W5X9, baseline and differential |
Genevisiblei | Q5W5X9, HS |
Family and domain databases
Gene3Di | 1.25.40.10, 2 hits |
InterProi | View protein in InterPro IPR011990, TPR-like_helical_dom_sf IPR019734, TPR_repeat IPR042621, TTC23/TTC23L |
PANTHERi | PTHR14485, PTHR14485, 1 hit |
SMARTi | View protein in SMART SM00028, TPR, 4 hits |
SUPFAMi | SSF48452, SSF48452, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TTC23_HUMAN | |
Accessioni | Q5W5X9Primary (citable) accession number: Q5W5X9 Secondary accession number(s): A8K6M5 Q9H9S7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 29, 2007 |
Last sequence update: | December 7, 2004 | |
Last modified: | December 2, 2020 | |
This is version 131 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM