Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 65 (16 Oct 2019)
Sequence version 1 (07 Dec 2004)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Pleiotropic drug resistance protein 3

Gene

PDR3

Organism
Nicotiana tabacum (Common tobacco)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be a general defense protein.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi205 – 212ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi892 – 899ATP 2PROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pleiotropic drug resistance protein 3
Alternative name(s):
NtPDR3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PDR3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiNicotiana tabacum (Common tobacco)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri4097 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeNicotianoideaeNicotianeaeNicotiana
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000084051 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei541 – 561HelicalSequence analysisAdd BLAST21
Transmembranei575 – 595HelicalSequence analysisAdd BLAST21
Transmembranei628 – 648HelicalSequence analysisAdd BLAST21
Transmembranei659 – 679HelicalSequence analysisAdd BLAST21
Transmembranei685 – 705HelicalSequence analysisAdd BLAST21
Transmembranei712 – 732HelicalSequence analysisAdd BLAST21
Transmembranei769 – 789HelicalSequence analysisAdd BLAST21
Transmembranei1191 – 1211HelicalSequence analysisAdd BLAST21
Transmembranei1222 – 1242HelicalSequence analysisAdd BLAST21
Transmembranei1272 – 1292HelicalSequence analysisAdd BLAST21
Transmembranei1306 – 1326HelicalSequence analysisAdd BLAST21
Transmembranei1336 – 1356HelicalSequence analysisAdd BLAST21
Transmembranei1364 – 1384HelicalSequence analysisAdd BLAST21
Transmembranei1419 – 1439HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002346561 – 1447Pleiotropic drug resistance protein 3Add BLAST1447

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q5W274

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By iron deficiency, methyl jasmonate (MeJA), salicylic acid (SA), 1-naphthalene acetic acid (1-NAA), ethanol, and cembrene, a macrocyclic diterpene.

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini173 – 445ABC transporter 1PROSITE-ProRule annotationAdd BLAST273
Domaini523 – 735ABC transmembrane type-2 1Add BLAST213
Domaini847 – 1099ABC transporter 2PROSITE-ProRule annotationAdd BLAST253
Domaini1172 – 1386ABC transmembrane type-2 2Add BLAST215

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
324553at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd03233 ABCG_PDR_domain1, 1 hit
cd03232 ABCG_PDR_domain2, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR013525 ABC_2_trans
IPR029481 ABC_trans_N
IPR003439 ABC_transporter-like
IPR034001 ABCG_PDR_1
IPR034003 ABCG_PDR_2
IPR027417 P-loop_NTPase
IPR013581 PDR_assoc

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01061 ABC2_membrane, 2 hits
PF00005 ABC_tran, 2 hits
PF14510 ABC_trans_N, 1 hit
PF08370 PDR_assoc, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50893 ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5W274-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQLVGSDEI ESFRMDLAEI GRSLRSSFRG QSSSFRSNSA LSASQKDDAV
60 70 80 90 100
DEENMLAWAA IERLPTFDRL RSSLFEEING NDANVKRKRV TDVTKLGALE
110 120 130 140 150
RHVFIEKMIK HIEHDNLQLL HKIRKRIDKV GVELPTVEVR YKNLTIEAEC
160 170 180 190 200
ELVHGKPLPT LWNSLKSITM NLARLPGLQS ELAKIKILND VSGVIKPGRM
210 220 230 240 250
TLLLGPPGCG KTSLLKALSG NLDKSLKVSG EISYNGYKLE EFVPQKTSAY
260 270 280 290 300
VSQNDLHIPE MTVRETLDYS SRFQGVGSRA EIMTDLSRRE KEAGVVPDPD
310 320 330 340 350
IDTYMKAISI EGQKKNLQTD YILKILGLDI CADTLVGDAM RRGISGGQKK
360 370 380 390 400
RLTTGELIVG PIKALFMDEI SNGLDSSTTY QIVACLQQLA HITDATILVS
410 420 430 440 450
LLQPAPETFD LFDDIILMAE GKILYHGPRN SALEFFESCG FKCPERKGVA
460 470 480 490 500
DFLQEVTSKK DQAQYWHGTK ETYKFVSVDM LSRKFKESPY RKKLNEELSV
510 520 530 540 550
PYDNSRSHRN SITFRDYSLP KWELFRACMS REFLLMKRNS FIYIFKTVQL
560 570 580 590 600
AIIASITMTV FLRTRMDTDL VHANYYLGAL FYALIILLVD GFPELSMTIT
610 620 630 640 650
RLAVFYKQSE LCFYPAWAYT IPATILKIPL SLLESVIWAS MTYYVIGFSP
660 670 680 690 700
EAGRFFRQLL LLFAVHMTSI SMFRFLASVC RTIVASTAAG GLSILFVLCF
710 720 730 740 750
SGFIIPRPSM PIWLKWGFWI SPLTYGEIGL AVNEFLAPRW QKTLPTNTSI
760 770 780 790 800
GNEVLESRGL NFDGYFYWIS VCALFGFTIL FNIGFTLALT FLKAPGSRAI
810 820 830 840 850
ISTDKYSQIE GSSDSIDKAD AAENSKATMD SHERAGRMVL PFEPLSLVFQ
860 870 880 890 900
DVQYYVDTPA AMTELGFTQK RLQLLSDITG ALRPGILTAL MGVSGAGKTT
910 920 930 940 950
LLDVLAGRKT TGYVEGEIKV GGYPKVQETF ARVSGYCEQT DIHSPQITVE
960 970 980 990 1000
ESVIFSAWLR LHPQIDSKTK YEFVKEVIET IELDGIKGML VGMPGVSGLS
1010 1020 1030 1040 1050
TEQRKRLTIA VELVANPSII FMDEPTTGLD ARSAAIVMRA VKNVADTGRT
1060 1070 1080 1090 1100
IVCTIHQPSI DIFEAFDELI LLKTGGRMIY WGHLGRNSCK MIEYFEGISC
1110 1120 1130 1140 1150
VPKIKNNHNP ATWMLEVTST SSEADISIDF AEVYKNSALH KNNEELVKKL
1160 1170 1180 1190 1200
SFPPAGSKDL HFPTRFSQNG WGQFKTCFWK QYWSYWRSPS YNLMRSLHML
1210 1220 1230 1240 1250
FASLVSGLLF WDKGKKLDNQ QSVFSVFGAM FTAVIFCGIN NSSSVLPYVT
1260 1270 1280 1290 1300
TERSVLYRER FAGMYASWAY ALAQVAIEIP YLLAQALAFT VITYPMIGYY
1310 1320 1330 1340 1350
WSAYKVFWYF YSMFCTLLYF TYLGMMLVSM TPSFPVAAIL QSSFYTMFNL
1360 1370 1380 1390 1400
FAGFLMPKAQ IPKWWIWFYY LTPTSWTLNG MLTSQYGDIE KEITVFQEKK
1410 1420 1430 1440
TVAAFLGDYF GFHHNQLPIV AFVLIAYPLV FASLFAFFIG KLNFQRR
Length:1,447
Mass (Da):163,331
Last modified:December 7, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4B3939CBF57A024C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ831379 mRNA Translation: CAH39853.1
AM050393 Genomic DNA Translation: CAJ19055.1

NCBI Reference Sequences

More...
RefSeqi
XP_016438065.1, XM_016582579.1
XP_016492566.1, XM_016637080.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
107764055
107812050

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
nta:107764055
nta:107812050

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ831379 mRNA Translation: CAH39853.1
AM050393 Genomic DNA Translation: CAJ19055.1
RefSeqiXP_016438065.1, XM_016582579.1
XP_016492566.1, XM_016637080.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PRIDEiQ5W274

Genome annotation databases

GeneIDi107764055
107812050
KEGGinta:107764055
nta:107812050

Phylogenomic databases

OrthoDBi324553at2759

Family and domain databases

CDDicd03233 ABCG_PDR_domain1, 1 hit
cd03232 ABCG_PDR_domain2, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR013525 ABC_2_trans
IPR029481 ABC_trans_N
IPR003439 ABC_transporter-like
IPR034001 ABCG_PDR_1
IPR034003 ABCG_PDR_2
IPR027417 P-loop_NTPase
IPR013581 PDR_assoc
PfamiView protein in Pfam
PF01061 ABC2_membrane, 2 hits
PF00005 ABC_tran, 2 hits
PF14510 ABC_trans_N, 1 hit
PF08370 PDR_assoc, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS50893 ABC_TRANSPORTER_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPDR3_TOBAC
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5W274
Secondary accession number(s): Q3BKZ2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: December 7, 2004
Last modified: October 16, 2019
This is version 65 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again