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Protein

SPRY domain-containing protein 7

Gene

SPRYD7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
SPRY domain-containing protein 7
Alternative name(s):
Chronic lymphocytic leukemia deletion region gene 6 protein
Short name:
CLL deletion region gene 6 protein
Gene namesi
Name:SPRYD7
Synonyms:C13orf1, CLLD6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000123178.14
HGNCiHGNC:14297 SPRYD7
MIMi607866 gene
neXtProtiNX_Q5W111

Pathology & Biotechi

Organism-specific databases

DisGeNETi57213
OpenTargetsiENSG00000123178
PharmGKBiPA25511

Polymorphism and mutation databases

BioMutaiSPRYD7
DMDMi109821809

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002439252 – 196SPRY domain-containing protein 7Add BLAST195

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ5W111
MaxQBiQ5W111
PaxDbiQ5W111
PeptideAtlasiQ5W111
PRIDEiQ5W111
ProteomicsDBi65791
65792 [Q5W111-2]

PTM databases

iPTMnetiQ5W111
PhosphoSitePlusiQ5W111
SwissPalmiQ5W111

Expressioni

Gene expression databases

BgeeiENSG00000123178 Expressed in 184 organ(s), highest expression level in anterior cingulate cortex
CleanExiHS_C13orf1
ExpressionAtlasiQ5W111 baseline and differential
GenevisibleiQ5W111 HS

Organism-specific databases

HPAiHPA043934

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi121451, 17 interactors
IntActiQ5W111, 11 interactors
STRINGi9606.ENSP00000354774

Structurei

3D structure databases

ProteinModelPortaliQ5W111
SMRiQ5W111
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 184B30.2/SPRYPROSITE-ProRule annotationAdd BLAST183

Phylogenomic databases

eggNOGiKOG4030 Eukaryota
ENOG410XNNE LUCA
GeneTreeiENSGT00390000011048
HOVERGENiHBG056533
InParanoidiQ5W111
OMAiDRESWCL
OrthoDBiEOG091G0KM6
PhylomeDBiQ5W111
TreeFamiTF314996

Family and domain databases

CDDicd12880 SPRYD7, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR013320 ConA-like_dom_sf
IPR003877 SPRY_dom
IPR035766 SPRYD7
PANTHERiPTHR20951 PTHR20951, 1 hit
PfamiView protein in Pfam
PF00622 SPRY, 1 hit
SMARTiView protein in SMART
SM00449 SPRY, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q5W111-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATSVLCCLR CCRDGGTGHI PLKEMPAVQL DTQHMGTDVV IVKNGRRICG
60 70 80 90 100
TGGCLASAPL HQNKSYFEFK IQSTGIWGIG VATQKVNLNQ IPLGRDMHSL
110 120 130 140 150
VMRNDGALYH NNEEKNRLPA NSLPQEGDVV GITYDHVELN VYLNGKNMHC
160 170 180 190
PASGIRGTVY PVVYVDDSAI LDCQFSEFYH TPPPGFEKIL FEQQIF
Length:196
Mass (Da):21,666
Last modified:June 27, 2006 - v2
Checksum:i3E6633F59C636174
GO
Isoform 2 (identifier: Q5W111-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     37-75: Missing.

Show »
Length:157
Mass (Da):17,487
Checksum:i0F3242D696565E41
GO

Sequence cautioni

The sequence AAC09363 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti165V → D in AAH22519 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01949837 – 75Missing in isoform 2. 2 PublicationsAdd BLAST39

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF334405 mRNA Translation: AAK38371.1
AF055016 mRNA Translation: AAC09363.1 Different initiation.
AK290576 mRNA Translation: BAF83265.1
AL136123 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08843.1
BC022519 mRNA Translation: AAH22519.1
CCDSiCCDS45046.1 [Q5W111-2]
CCDS9422.1 [Q5W111-1]
RefSeqiNP_001120954.1, NM_001127482.2 [Q5W111-2]
NP_065189.1, NM_020456.3 [Q5W111-1]
UniGeneiHs.44235

Genome annotation databases

EnsembliENST00000361840; ENSP00000354774; ENSG00000123178 [Q5W111-1]
ENST00000378195; ENSP00000367437; ENSG00000123178 [Q5W111-2]
ENST00000613924; ENSP00000484495; ENSG00000123178 [Q5W111-2]
GeneIDi57213
KEGGihsa:57213
UCSCiuc001vdl.3 human [Q5W111-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF334405 mRNA Translation: AAK38371.1
AF055016 mRNA Translation: AAC09363.1 Different initiation.
AK290576 mRNA Translation: BAF83265.1
AL136123 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08843.1
BC022519 mRNA Translation: AAH22519.1
CCDSiCCDS45046.1 [Q5W111-2]
CCDS9422.1 [Q5W111-1]
RefSeqiNP_001120954.1, NM_001127482.2 [Q5W111-2]
NP_065189.1, NM_020456.3 [Q5W111-1]
UniGeneiHs.44235

3D structure databases

ProteinModelPortaliQ5W111
SMRiQ5W111
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121451, 17 interactors
IntActiQ5W111, 11 interactors
STRINGi9606.ENSP00000354774

PTM databases

iPTMnetiQ5W111
PhosphoSitePlusiQ5W111
SwissPalmiQ5W111

Polymorphism and mutation databases

BioMutaiSPRYD7
DMDMi109821809

Proteomic databases

EPDiQ5W111
MaxQBiQ5W111
PaxDbiQ5W111
PeptideAtlasiQ5W111
PRIDEiQ5W111
ProteomicsDBi65791
65792 [Q5W111-2]

Protocols and materials databases

DNASUi57213
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361840; ENSP00000354774; ENSG00000123178 [Q5W111-1]
ENST00000378195; ENSP00000367437; ENSG00000123178 [Q5W111-2]
ENST00000613924; ENSP00000484495; ENSG00000123178 [Q5W111-2]
GeneIDi57213
KEGGihsa:57213
UCSCiuc001vdl.3 human [Q5W111-1]

Organism-specific databases

CTDi57213
DisGeNETi57213
EuPathDBiHostDB:ENSG00000123178.14
GeneCardsiSPRYD7
HGNCiHGNC:14297 SPRYD7
HPAiHPA043934
MIMi607866 gene
neXtProtiNX_Q5W111
OpenTargetsiENSG00000123178
PharmGKBiPA25511
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4030 Eukaryota
ENOG410XNNE LUCA
GeneTreeiENSGT00390000011048
HOVERGENiHBG056533
InParanoidiQ5W111
OMAiDRESWCL
OrthoDBiEOG091G0KM6
PhylomeDBiQ5W111
TreeFamiTF314996

Miscellaneous databases

GeneWikiiC13orf1
GenomeRNAii57213
PROiPR:Q5W111
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000123178 Expressed in 184 organ(s), highest expression level in anterior cingulate cortex
CleanExiHS_C13orf1
ExpressionAtlasiQ5W111 baseline and differential
GenevisibleiQ5W111 HS

Family and domain databases

CDDicd12880 SPRYD7, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR013320 ConA-like_dom_sf
IPR003877 SPRY_dom
IPR035766 SPRYD7
PANTHERiPTHR20951 PTHR20951, 1 hit
PfamiView protein in Pfam
PF00622 SPRY, 1 hit
SMARTiView protein in SMART
SM00449 SPRY, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSPRY7_HUMAN
AccessioniPrimary (citable) accession number: Q5W111
Secondary accession number(s): A8K3G1
, O60648, Q8TBG8, Q96T69
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: September 12, 2018
This is version 112 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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