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Entry version 113 (08 May 2019)
Sequence version 1 (07 Dec 2004)
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Protein

SUMO-specific isopeptidase USPL1

Gene

USPL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

SUMO-specific isopeptidase involved in protein desumoylation. Specifically binds SUMO proteins with a higher affinity for SUMO2 and SUMO3 which it cleaves more efficiently. Also able to process full-length SUMO proteins to their mature forms (PubMed:22878415). Plays a key role in RNA polymerase-II-mediated snRNA transcription in the Cajal bodies (PubMed:24413172). Is a component of complexes that can bind to U snRNA genes (PubMed:24413172).2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei236Nucleophile1
Active sitei456Proton acceptorBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Thiol protease

Protein family/group databases

MEROPS protease database

More...
MEROPSi
C98.001

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SUMO-specific isopeptidase USPL1 (EC:3.4.22.-)
Alternative name(s):
Ubiquitin-specific peptidase-like protein 1
Short name:
USP-like 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:USPL1
Synonyms:C13orf22, D13S106
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20294 USPL1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617470 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5W0Q7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi229W → L: Altered SUMO-binding and SUMO-specific isopeptidase activity. 1 Publication1
Mutagenesisi236C → S: Abolishes the SUMO-specific isopeptidase activity. 1 Publication1
Mutagenesisi237W → F: Altered SUMO-binding and SUMO-specific isopeptidase activity. 1 Publication1
Mutagenesisi340 – 341LL → AA: Altered SUMO-binding and SUMO-specific isopeptidase activity. 1 Publication2
Mutagenesisi421H → A: Altered SUMO-binding and SUMO-specific isopeptidase activity. 1 Publication1
Mutagenesisi494 – 495IV → AA: Loss of SUMO-binding and catalytic activity. 1 Publication2

Organism-specific databases

DisGeNET

More...
DisGeNETi
10208

Open Targets

More...
OpenTargetsi
ENSG00000132952

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134872379

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
USPL1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74747969

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002795261 – 1092SUMO-specific isopeptidase USPL1Add BLAST1092

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei909PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5W0Q7

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5W0Q7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q5W0Q7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5W0Q7

PeptideAtlas

More...
PeptideAtlasi
Q5W0Q7

PRoteomics IDEntifications database

More...
PRIDEi
Q5W0Q7

ProteomicsDB human proteome resource

More...
ProteomicsDBi
65772
65773 [Q5W0Q7-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5W0Q7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5W0Q7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000132952 Expressed in 214 organ(s), highest expression level in sperm

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q5W0Q7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA039342
HPA040172

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ELL.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115503, 25 interactors

Database of interacting proteins

More...
DIPi
DIP-47278N

Protein interaction database and analysis system

More...
IntActi
Q5W0Q7, 18 interactors

Molecular INTeraction database

More...
MINTi
Q5W0Q7

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000255304

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5W0Q7

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini227 – 500USPAdd BLAST274

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni236 – 495SUMO-bindingAdd BLAST260

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase C19 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IJ9P Eukaryota
ENOG410YB7R LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000002316

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000154801

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q5W0Q7

KEGG Orthology (KO)

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KOi
K23008

Identification of Orthologs from Complete Genome Data

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OMAi
CLNEVRD

Database of Orthologous Groups

More...
OrthoDBi
204698at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5W0Q7

TreeFam database of animal gene trees

More...
TreeFami
TF350670

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029388 DUF4650
IPR038765 Papain-like_cys_pep_sf
IPR028890 Peptidase_C98
IPR028889 USP_dom
IPR033505 USPL1

The PANTHER Classification System

More...
PANTHERi
PTHR15294 PTHR15294, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15509 DUF4650, 1 hit
PF15499 Peptidase_C98, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54001 SSF54001, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50235 USP_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q5W0Q7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMDSPKIGNG LPVIGPGTDI GISSLHMVGY LGKNFDSAKV PSDEYCPACR
60 70 80 90 100
EKGKLKALKT YRISFQESIF LCEDLQCIYP LGSKSLNNLI SPDLEECHTP
110 120 130 140 150
HKPQKRKSLE SSYKDSLLLA NSKKTRNYIA IDGGKVLNSK HNGEVYDETS
160 170 180 190 200
SNLPDSSGQQ NPIRTADSLE RNEILEADTV DMATTKDPAT VDVSGTGRPS
210 220 230 240 250
PQNEGCTSKL EMPLESKCTS FPQALCVQWK NAYALCWLDC ILSALVHSEE
260 270 280 290 300
LKNTVTGLCS KEESIFWRLL TKYNQANTLL YTSQLSGVKD GDCKKLTSEI
310 320 330 340 350
FAEIETCLNE VRDEIFISLQ PQLRCTLGDM ESPVFAFPLL LKLETHIEKL
360 370 380 390 400
FLYSFSWDFE CSQCGHQYQN RHMKSLVTFT NVIPEWHPLN AAHFGPCNNC
410 420 430 440 450
NSKSQIRKMV LEKVSPIFML HFVEGLPQND LQHYAFHFEG CLYQITSVIQ
460 470 480 490 500
YRANNHFITW ILDADGSWLE CDDLKGPCSE RHKKFEVPAS EIHIVIWERK
510 520 530 540 550
ISQVTDKEAA CLPLKKTNDQ HALSNEKPVS LTSCSVGDAA SAETASVTHP
560 570 580 590 600
KDISVAPRTL SQDTAVTHGD HLLSGPKGLV DNILPLTLEE TIQKTASVSQ
610 620 630 640 650
LNSEAFLLEN KPVAENTGIL KTNTLLSQES LMASSVSAPC NEKLIQDQFV
660 670 680 690 700
DISFPSQVVN TNMQSVQLNT EDTVNTKSVN NTDATGLIQG VKSVEIEKDA
710 720 730 740 750
QLKQFLTPKT EQLKPERVTS QVSNLKKKET TADSQTTTSK SLQNQSLKEN
760 770 780 790 800
QKKPFVGSWV KGLISRGASF MPLCVSAHNR NTITDLQPSV KGVNNFGGFK
810 820 830 840 850
TKGINQKASH VSKKARKSAS KPPPISKPPA GPPSSNGTAA HPHAHAASEV
860 870 880 890 900
LEKSGSTSCG AQLNHSSYGN GISSANHEDL VEGQIHKLRL KLRKKLKAEK
910 920 930 940 950
KKLAALMSSP QSRTVRSENL EQVPQDGSPN DCESIEDLLN ELPYPIDIAS
960 970 980 990 1000
ESACTTVPGV SLYSSQTHEE ILAELLSPTP VSTELSENGE GDFRYLGMGD
1010 1020 1030 1040 1050
SHIPPPVPSE FNDVSQNTHL RQDHNYCSPT KKNPCEVQPD SLTNNACVRT
1060 1070 1080 1090
LNLESPMKTD IFDEFFSSSA LNALANDTLD LPHFDEYLFE NY
Length:1,092
Mass (Da):120,440
Last modified:December 7, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFBE4626FC311E706
GO
Isoform 2 (identifier: Q5W0Q7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-329: Missing.

Note: No experimental confirmation available.
Show »
Length:763
Mass (Da):84,094
Checksum:i3E1D7BDC10690EDA
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_030916173E → G1 PublicationCorresponds to variant dbSNP:rs17853512Ensembl.1
Natural variantiVAR_030917384P → S. Corresponds to variant dbSNP:rs3742303Ensembl.1
Natural variantiVAR_030918522A → P. Corresponds to variant dbSNP:rs17609459Ensembl.1
Natural variantiVAR_030919531L → S1 PublicationCorresponds to variant dbSNP:rs7984952Ensembl.1
Natural variantiVAR_051542583I → V. Corresponds to variant dbSNP:rs41412648Ensembl.1
Natural variantiVAR_030920739S → C. Corresponds to variant dbSNP:rs9578190Ensembl.1
Natural variantiVAR_051543786L → I. Corresponds to variant dbSNP:rs35371042Ensembl.1
Natural variantiVAR_030921950S → N1 PublicationCorresponds to variant dbSNP:rs3742302Ensembl.1
Natural variantiVAR_0309221043T → S1 PublicationCorresponds to variant dbSNP:rs17857086Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0234791 – 329Missing in isoform 2. 1 PublicationAdd BLAST329

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X59131 mRNA Translation: CAA41848.1
CR627370 mRNA Translation: CAH10469.1
AL138681 Genomic DNA No translation available.
BC036027 mRNA Translation: AAH36027.1
BC038103 mRNA Translation: AAH38103.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS81760.1 [Q5W0Q7-2]
CCDS9336.1 [Q5W0Q7-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
I37273

NCBI Reference Sequences

More...
RefSeqi
NP_001308461.1, NM_001321532.1
NP_001308462.1, NM_001321533.1 [Q5W0Q7-2]
NP_001308463.1, NM_001321534.1 [Q5W0Q7-2]
NP_005791.3, NM_005800.4 [Q5W0Q7-1]
XP_005266270.1, XM_005266213.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000255304; ENSP00000255304; ENSG00000132952 [Q5W0Q7-1]
ENST00000614860; ENSP00000480656; ENSG00000132952 [Q5W0Q7-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
10208

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10208

UCSC genome browser

More...
UCSCi
uc001utc.3 human [Q5W0Q7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59131 mRNA Translation: CAA41848.1
CR627370 mRNA Translation: CAH10469.1
AL138681 Genomic DNA No translation available.
BC036027 mRNA Translation: AAH36027.1
BC038103 mRNA Translation: AAH38103.1
CCDSiCCDS81760.1 [Q5W0Q7-2]
CCDS9336.1 [Q5W0Q7-1]
PIRiI37273
RefSeqiNP_001308461.1, NM_001321532.1
NP_001308462.1, NM_001321533.1 [Q5W0Q7-2]
NP_001308463.1, NM_001321534.1 [Q5W0Q7-2]
NP_005791.3, NM_005800.4 [Q5W0Q7-1]
XP_005266270.1, XM_005266213.3

3D structure databases

SMRiQ5W0Q7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115503, 25 interactors
DIPiDIP-47278N
IntActiQ5W0Q7, 18 interactors
MINTiQ5W0Q7
STRINGi9606.ENSP00000255304

Protein family/group databases

MEROPSiC98.001

PTM databases

iPTMnetiQ5W0Q7
PhosphoSitePlusiQ5W0Q7

Polymorphism and mutation databases

BioMutaiUSPL1
DMDMi74747969

Proteomic databases

EPDiQ5W0Q7
jPOSTiQ5W0Q7
MaxQBiQ5W0Q7
PaxDbiQ5W0Q7
PeptideAtlasiQ5W0Q7
PRIDEiQ5W0Q7
ProteomicsDBi65772
65773 [Q5W0Q7-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000255304; ENSP00000255304; ENSG00000132952 [Q5W0Q7-1]
ENST00000614860; ENSP00000480656; ENSG00000132952 [Q5W0Q7-2]
GeneIDi10208
KEGGihsa:10208
UCSCiuc001utc.3 human [Q5W0Q7-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
10208
DisGeNETi10208

GeneCards: human genes, protein and diseases

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GeneCardsi
USPL1

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0023052
HGNCiHGNC:20294 USPL1
HPAiHPA039342
HPA040172
MIMi617470 gene
neXtProtiNX_Q5W0Q7
OpenTargetsiENSG00000132952
PharmGKBiPA134872379

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IJ9P Eukaryota
ENOG410YB7R LUCA
GeneTreeiENSGT00390000002316
HOGENOMiHOG000154801
InParanoidiQ5W0Q7
KOiK23008
OMAiCLNEVRD
OrthoDBi204698at2759
PhylomeDBiQ5W0Q7
TreeFamiTF350670

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
USPL1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
10208

Protein Ontology

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PROi
PR:Q5W0Q7

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000132952 Expressed in 214 organ(s), highest expression level in sperm
GenevisibleiQ5W0Q7 HS

Family and domain databases

InterProiView protein in InterPro
IPR029388 DUF4650
IPR038765 Papain-like_cys_pep_sf
IPR028890 Peptidase_C98
IPR028889 USP_dom
IPR033505 USPL1
PANTHERiPTHR15294 PTHR15294, 1 hit
PfamiView protein in Pfam
PF15509 DUF4650, 1 hit
PF15499 Peptidase_C98, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS50235 USP_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUSPL1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5W0Q7
Secondary accession number(s): Q14109
, Q6AI45, Q8IY30, Q8IYE8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: December 7, 2004
Last modified: May 8, 2019
This is version 113 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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