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Protein

SUMO-specific isopeptidase USPL1

Gene

USPL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

SUMO-specific isopeptidase involved in protein desumoylation. Specifically binds SUMO proteins with a higher affinity for SUMO2 and SUMO3 which it cleaves more efficiently. Also able to process full-length SUMO proteins to their mature forms (PubMed:22878415). Plays a key role in RNA polymerase-II-mediated snRNA transcription in the Cajal bodies (PubMed:24413172). Is a component of complexes that can bind to U snRNA genes (PubMed:24413172).2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei236Nucleophile1
Active sitei456Proton acceptorBy similarity1

GO - Molecular functioni

  • SUMO binding Source: UniProtKB
  • SUMO-specific isopeptidase activity Source: UniProtKB

GO - Biological processi

  • Cajal body organization Source: UniProtKB
  • cell proliferation Source: UniProtKB
  • protein desumoylation Source: UniProtKB
  • snRNA transcription Source: UniProtKB

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease

Protein family/group databases

MEROPSiC98.001

Names & Taxonomyi

Protein namesi
Recommended name:
SUMO-specific isopeptidase USPL1 (EC:3.4.22.-)
Alternative name(s):
Ubiquitin-specific peptidase-like protein 1
Short name:
USP-like 1
Gene namesi
Name:USPL1
Synonyms:C13orf22, D13S106
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000132952.11
HGNCiHGNC:20294 USPL1
MIMi617470 gene
neXtProtiNX_Q5W0Q7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi229W → L: Altered SUMO-binding and SUMO-specific isopeptidase activity. 1 Publication1
Mutagenesisi236C → S: Abolishes the SUMO-specific isopeptidase activity. 1 Publication1
Mutagenesisi237W → F: Altered SUMO-binding and SUMO-specific isopeptidase activity. 1 Publication1
Mutagenesisi340 – 341LL → AA: Altered SUMO-binding and SUMO-specific isopeptidase activity. 1 Publication2
Mutagenesisi421H → A: Altered SUMO-binding and SUMO-specific isopeptidase activity. 1 Publication1
Mutagenesisi494 – 495IV → AA: Loss of SUMO-binding and catalytic activity. 1 Publication2

Organism-specific databases

DisGeNETi10208
OpenTargetsiENSG00000132952
PharmGKBiPA134872379

Polymorphism and mutation databases

BioMutaiUSPL1
DMDMi74747969

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002795261 – 1092SUMO-specific isopeptidase USPL1Add BLAST1092

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei909PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ5W0Q7
MaxQBiQ5W0Q7
PaxDbiQ5W0Q7
PeptideAtlasiQ5W0Q7
PRIDEiQ5W0Q7
ProteomicsDBi65772
65773 [Q5W0Q7-2]

PTM databases

iPTMnetiQ5W0Q7
PhosphoSitePlusiQ5W0Q7

Expressioni

Gene expression databases

BgeeiENSG00000132952 Expressed in 214 organ(s), highest expression level in sperm
CleanExiHS_USPL1
GenevisibleiQ5W0Q7 HS

Organism-specific databases

HPAiHPA039342
HPA040172

Interactioni

Subunit structurei

Interacts with ELL.1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115503, 25 interactors
DIPiDIP-47278N
IntActiQ5W0Q7, 17 interactors
MINTiQ5W0Q7
STRINGi9606.ENSP00000255304

Structurei

3D structure databases

ProteinModelPortaliQ5W0Q7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini227 – 500USPAdd BLAST274

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni236 – 495SUMO-bindingAdd BLAST260

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated

Phylogenomic databases

eggNOGiENOG410IJ9P Eukaryota
ENOG410YB7R LUCA
GeneTreeiENSGT00390000002316
HOGENOMiHOG000154801
HOVERGENiHBG094141
InParanoidiQ5W0Q7
OMAiKDGDCKK
OrthoDBiEOG091G18IX
PhylomeDBiQ5W0Q7
TreeFamiTF350670

Family and domain databases

InterProiView protein in InterPro
IPR029388 DUF4650
IPR038765 Papain_like_cys_pep_sf
IPR028890 Peptidase_C98
IPR028889 USP_dom
IPR033505 USPL1
PANTHERiPTHR15294 PTHR15294, 1 hit
PfamiView protein in Pfam
PF15509 DUF4650, 1 hit
PF15499 Peptidase_C98, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS50235 USP_3, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q5W0Q7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMDSPKIGNG LPVIGPGTDI GISSLHMVGY LGKNFDSAKV PSDEYCPACR
60 70 80 90 100
EKGKLKALKT YRISFQESIF LCEDLQCIYP LGSKSLNNLI SPDLEECHTP
110 120 130 140 150
HKPQKRKSLE SSYKDSLLLA NSKKTRNYIA IDGGKVLNSK HNGEVYDETS
160 170 180 190 200
SNLPDSSGQQ NPIRTADSLE RNEILEADTV DMATTKDPAT VDVSGTGRPS
210 220 230 240 250
PQNEGCTSKL EMPLESKCTS FPQALCVQWK NAYALCWLDC ILSALVHSEE
260 270 280 290 300
LKNTVTGLCS KEESIFWRLL TKYNQANTLL YTSQLSGVKD GDCKKLTSEI
310 320 330 340 350
FAEIETCLNE VRDEIFISLQ PQLRCTLGDM ESPVFAFPLL LKLETHIEKL
360 370 380 390 400
FLYSFSWDFE CSQCGHQYQN RHMKSLVTFT NVIPEWHPLN AAHFGPCNNC
410 420 430 440 450
NSKSQIRKMV LEKVSPIFML HFVEGLPQND LQHYAFHFEG CLYQITSVIQ
460 470 480 490 500
YRANNHFITW ILDADGSWLE CDDLKGPCSE RHKKFEVPAS EIHIVIWERK
510 520 530 540 550
ISQVTDKEAA CLPLKKTNDQ HALSNEKPVS LTSCSVGDAA SAETASVTHP
560 570 580 590 600
KDISVAPRTL SQDTAVTHGD HLLSGPKGLV DNILPLTLEE TIQKTASVSQ
610 620 630 640 650
LNSEAFLLEN KPVAENTGIL KTNTLLSQES LMASSVSAPC NEKLIQDQFV
660 670 680 690 700
DISFPSQVVN TNMQSVQLNT EDTVNTKSVN NTDATGLIQG VKSVEIEKDA
710 720 730 740 750
QLKQFLTPKT EQLKPERVTS QVSNLKKKET TADSQTTTSK SLQNQSLKEN
760 770 780 790 800
QKKPFVGSWV KGLISRGASF MPLCVSAHNR NTITDLQPSV KGVNNFGGFK
810 820 830 840 850
TKGINQKASH VSKKARKSAS KPPPISKPPA GPPSSNGTAA HPHAHAASEV
860 870 880 890 900
LEKSGSTSCG AQLNHSSYGN GISSANHEDL VEGQIHKLRL KLRKKLKAEK
910 920 930 940 950
KKLAALMSSP QSRTVRSENL EQVPQDGSPN DCESIEDLLN ELPYPIDIAS
960 970 980 990 1000
ESACTTVPGV SLYSSQTHEE ILAELLSPTP VSTELSENGE GDFRYLGMGD
1010 1020 1030 1040 1050
SHIPPPVPSE FNDVSQNTHL RQDHNYCSPT KKNPCEVQPD SLTNNACVRT
1060 1070 1080 1090
LNLESPMKTD IFDEFFSSSA LNALANDTLD LPHFDEYLFE NY
Length:1,092
Mass (Da):120,440
Last modified:December 7, 2004 - v1
Checksum:iFBE4626FC311E706
GO
Isoform 2 (identifier: Q5W0Q7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-329: Missing.

Note: No experimental confirmation available.
Show »
Length:763
Mass (Da):84,094
Checksum:i3E1D7BDC10690EDA
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_030916173E → G1 PublicationCorresponds to variant dbSNP:rs17853512Ensembl.1
Natural variantiVAR_030917384P → S. Corresponds to variant dbSNP:rs3742303Ensembl.1
Natural variantiVAR_030918522A → P. Corresponds to variant dbSNP:rs17609459Ensembl.1
Natural variantiVAR_030919531L → S1 PublicationCorresponds to variant dbSNP:rs7984952Ensembl.1
Natural variantiVAR_051542583I → V. Corresponds to variant dbSNP:rs41412648Ensembl.1
Natural variantiVAR_030920739S → C. Corresponds to variant dbSNP:rs9578190Ensembl.1
Natural variantiVAR_051543786L → I. Corresponds to variant dbSNP:rs35371042Ensembl.1
Natural variantiVAR_030921950S → N1 PublicationCorresponds to variant dbSNP:rs3742302Ensembl.1
Natural variantiVAR_0309221043T → S1 PublicationCorresponds to variant dbSNP:rs17857086Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0234791 – 329Missing in isoform 2. 1 PublicationAdd BLAST329

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59131 mRNA Translation: CAA41848.1
CR627370 mRNA Translation: CAH10469.1
AL138681 Genomic DNA No translation available.
BC036027 mRNA Translation: AAH36027.1
BC038103 mRNA Translation: AAH38103.1
CCDSiCCDS81760.1 [Q5W0Q7-2]
CCDS9336.1 [Q5W0Q7-1]
PIRiI37273
RefSeqiNP_001308461.1, NM_001321532.1
NP_001308462.1, NM_001321533.1 [Q5W0Q7-2]
NP_001308463.1, NM_001321534.1 [Q5W0Q7-2]
NP_005791.3, NM_005800.4 [Q5W0Q7-1]
XP_005266270.1, XM_005266213.3
UniGeneiHs.533831

Genome annotation databases

EnsembliENST00000255304; ENSP00000255304; ENSG00000132952 [Q5W0Q7-1]
ENST00000614860; ENSP00000480656; ENSG00000132952 [Q5W0Q7-2]
GeneIDi10208
KEGGihsa:10208
UCSCiuc001utc.3 human [Q5W0Q7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59131 mRNA Translation: CAA41848.1
CR627370 mRNA Translation: CAH10469.1
AL138681 Genomic DNA No translation available.
BC036027 mRNA Translation: AAH36027.1
BC038103 mRNA Translation: AAH38103.1
CCDSiCCDS81760.1 [Q5W0Q7-2]
CCDS9336.1 [Q5W0Q7-1]
PIRiI37273
RefSeqiNP_001308461.1, NM_001321532.1
NP_001308462.1, NM_001321533.1 [Q5W0Q7-2]
NP_001308463.1, NM_001321534.1 [Q5W0Q7-2]
NP_005791.3, NM_005800.4 [Q5W0Q7-1]
XP_005266270.1, XM_005266213.3
UniGeneiHs.533831

3D structure databases

ProteinModelPortaliQ5W0Q7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115503, 25 interactors
DIPiDIP-47278N
IntActiQ5W0Q7, 17 interactors
MINTiQ5W0Q7
STRINGi9606.ENSP00000255304

Protein family/group databases

MEROPSiC98.001

PTM databases

iPTMnetiQ5W0Q7
PhosphoSitePlusiQ5W0Q7

Polymorphism and mutation databases

BioMutaiUSPL1
DMDMi74747969

Proteomic databases

EPDiQ5W0Q7
MaxQBiQ5W0Q7
PaxDbiQ5W0Q7
PeptideAtlasiQ5W0Q7
PRIDEiQ5W0Q7
ProteomicsDBi65772
65773 [Q5W0Q7-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000255304; ENSP00000255304; ENSG00000132952 [Q5W0Q7-1]
ENST00000614860; ENSP00000480656; ENSG00000132952 [Q5W0Q7-2]
GeneIDi10208
KEGGihsa:10208
UCSCiuc001utc.3 human [Q5W0Q7-1]

Organism-specific databases

CTDi10208
DisGeNETi10208
EuPathDBiHostDB:ENSG00000132952.11
GeneCardsiUSPL1
H-InvDBiHIX0023052
HGNCiHGNC:20294 USPL1
HPAiHPA039342
HPA040172
MIMi617470 gene
neXtProtiNX_Q5W0Q7
OpenTargetsiENSG00000132952
PharmGKBiPA134872379
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJ9P Eukaryota
ENOG410YB7R LUCA
GeneTreeiENSGT00390000002316
HOGENOMiHOG000154801
HOVERGENiHBG094141
InParanoidiQ5W0Q7
OMAiKDGDCKK
OrthoDBiEOG091G18IX
PhylomeDBiQ5W0Q7
TreeFamiTF350670

Miscellaneous databases

ChiTaRSiUSPL1 human
GenomeRNAii10208
PROiPR:Q5W0Q7
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000132952 Expressed in 214 organ(s), highest expression level in sperm
CleanExiHS_USPL1
GenevisibleiQ5W0Q7 HS

Family and domain databases

InterProiView protein in InterPro
IPR029388 DUF4650
IPR038765 Papain_like_cys_pep_sf
IPR028890 Peptidase_C98
IPR028889 USP_dom
IPR033505 USPL1
PANTHERiPTHR15294 PTHR15294, 1 hit
PfamiView protein in Pfam
PF15509 DUF4650, 1 hit
PF15499 Peptidase_C98, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS50235 USP_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUSPL1_HUMAN
AccessioniPrimary (citable) accession number: Q5W0Q7
Secondary accession number(s): Q14109
, Q6AI45, Q8IY30, Q8IYE8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: December 7, 2004
Last modified: November 7, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Peptidase families
    Classification of peptidase families and list of entries
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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