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Protein

Transmembrane protein 236

Gene

TMEM236

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 236
Gene namesi
Name:TMEM236
Synonyms:FAM23A, FAM23B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000148483.8
HGNCiHGNC:23473 TMEM236
neXtProtiNX_Q5W0B7

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei7 – 27HelicalSequence analysisAdd BLAST21
Transmembranei49 – 69HelicalSequence analysisAdd BLAST21
Transmembranei88 – 108HelicalSequence analysisAdd BLAST21
Transmembranei121 – 141HelicalSequence analysisAdd BLAST21
Transmembranei264 – 284HelicalSequence analysisAdd BLAST21
Transmembranei301 – 321HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000148483
PharmGKBiPA134931867

Polymorphism and mutation databases

DMDMi73620896

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001867161 – 351Transmembrane protein 236Add BLAST351

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi193N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ5W0B7
PeptideAtlasiQ5W0B7
PRIDEiQ5W0B7
ProteomicsDBi65759

PTM databases

iPTMnetiQ5W0B7
PhosphoSitePlusiQ5W0B7

Expressioni

Gene expression databases

BgeeiENSG00000148483

Organism-specific databases

HPAiHPA045096

Interactioni

Protein-protein interaction databases

BioGridi575888, 1 interactor
IntActiQ5W0B7, 1 interactor
STRINGi9606.ENSP00000414144

Structurei

3D structure databases

ProteinModelPortaliQ5W0B7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM236 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGEQ Eukaryota
ENOG410YD0S LUCA
GeneTreeiENSGT00390000015525
HOVERGENiHBG080454
InParanoidiQ5W0B7
OMAiWLYPVYI
OrthoDBiEOG091G0DFD
PhylomeDBiQ5W0B7
TreeFamiTF328759

Family and domain databases

InterProiView protein in InterPro
IPR020394 Uncharacterised_FAM23-like_TM
PANTHERiPTHR31453 PTHR31453, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD098445 Uncharacterised_FAM23-like_TM, 1 hit

Sequencei

Sequence statusi: Complete.

Q5W0B7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASGRLIKFV VFELLEFAAF SIPTLVITEQ FATAYQGTRA RSDNTHYWLI
60 70 80 90 100
ISCSIAYVAL VTLLIWVPVK VILHKKRYIY RKIKGWRPVL MMCVVLTTLP
110 120 130 140 150
CLTFSIAVTE VQKSINGSAD VLPDMLPDLP VSLVLLSLIM VDIIEKLRIY
160 170 180 190 200
PLRGSQKSSE NGHIHSTSLQ HIKTVTEQVR QSPENAASPQ ATNSTQVSQP
210 220 230 240 250
SGAMTRSQES VFMGPQEPSC DSGILRMMSR RDVRAELFLW SFLLWSDTIE
260 270 280 290 300
MVRVAGHPNV YKSSWLYPVY IFSFISLLRI TFTPQNPLLN SLSVLLQDLP
310 320 330 340 350
FVFVRLGLII ALGTITPVLG LCKNILVTLS YIYFNYLTRI RIFSAFEMSP

F
Length:351
Mass (Da):39,663
Last modified:December 7, 2004 - v1
Checksum:i9DE0E117BE24D76C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL139238 Genomic DNA No translation available.
BC157856 mRNA Translation: AAI57857.1
CCDSiCCDS41492.1
RefSeqiNP_001092314.1, NM_001098844.2
UniGeneiHs.564139
Hs.733272

Genome annotation databases

EnsembliENST00000377495; ENSP00000366715; ENSG00000148483
GeneIDi653567
KEGGihsa:653567
UCSCiuc009xjx.5 human

Similar proteinsi

Entry informationi

Entry nameiTM236_HUMAN
AccessioniPrimary (citable) accession number: Q5W0B7
Secondary accession number(s): B2RXH7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: December 7, 2004
Last modified: June 20, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

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