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Entry version 113 (11 Dec 2019)
Sequence version 1 (07 Dec 2004)
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Protein

Transmembrane protein 236

Gene

TMEM236

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transmembrane protein 236
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TMEM236
Synonyms:FAM23A, FAM23B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000148483.8

Human Gene Nomenclature Database

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HGNCi
HGNC:23473 TMEM236

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5W0B7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei7 – 27HelicalSequence analysisAdd BLAST21
Transmembranei49 – 69HelicalSequence analysisAdd BLAST21
Transmembranei88 – 108HelicalSequence analysisAdd BLAST21
Transmembranei121 – 141HelicalSequence analysisAdd BLAST21
Transmembranei264 – 284HelicalSequence analysisAdd BLAST21
Transmembranei301 – 321HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000148483

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134931867

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q5W0B7 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TMEM236

Domain mapping of disease mutations (DMDM)

More...
DMDMi
73620896

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001867161 – 351Transmembrane protein 236Add BLAST351

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi193N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5W0B7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q5W0B7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5W0B7

PeptideAtlas

More...
PeptideAtlasi
Q5W0B7

PRoteomics IDEntifications database

More...
PRIDEi
Q5W0B7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
65759

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5W0B7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5W0B7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000148483 Expressed in 60 organ(s), highest expression level in mucosa of transverse colon

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA045096

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
575888, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q5W0B7, 6 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000366715

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q5W0B7 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TMEM236 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IGEQ Eukaryota
ENOG410YD0S LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000015525

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5W0B7

Identification of Orthologs from Complete Genome Data

More...
OMAi
VIMEQFA

Database of Orthologous Groups

More...
OrthoDBi
667499at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5W0B7

TreeFam database of animal gene trees

More...
TreeFami
TF328759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR020394 Uncharacterised_FAM23-like_TM

The PANTHER Classification System

More...
PANTHERi
PTHR31453 PTHR31453, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5W0B7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASGRLIKFV VFELLEFAAF SIPTLVITEQ FATAYQGTRA RSDNTHYWLI
60 70 80 90 100
ISCSIAYVAL VTLLIWVPVK VILHKKRYIY RKIKGWRPVL MMCVVLTTLP
110 120 130 140 150
CLTFSIAVTE VQKSINGSAD VLPDMLPDLP VSLVLLSLIM VDIIEKLRIY
160 170 180 190 200
PLRGSQKSSE NGHIHSTSLQ HIKTVTEQVR QSPENAASPQ ATNSTQVSQP
210 220 230 240 250
SGAMTRSQES VFMGPQEPSC DSGILRMMSR RDVRAELFLW SFLLWSDTIE
260 270 280 290 300
MVRVAGHPNV YKSSWLYPVY IFSFISLLRI TFTPQNPLLN SLSVLLQDLP
310 320 330 340 350
FVFVRLGLII ALGTITPVLG LCKNILVTLS YIYFNYLTRI RIFSAFEMSP

F
Length:351
Mass (Da):39,663
Last modified:December 7, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9DE0E117BE24D76C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL139238 Genomic DNA No translation available.
BC157856 mRNA Translation: AAI57857.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS41492.1

NCBI Reference Sequences

More...
RefSeqi
NP_001092314.1, NM_001098844.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000377495; ENSP00000366715; ENSG00000148483

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
653567

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:653567

UCSC genome browser

More...
UCSCi
uc009xjx.5 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL139238 Genomic DNA No translation available.
BC157856 mRNA Translation: AAI57857.1
CCDSiCCDS41492.1
RefSeqiNP_001092314.1, NM_001098844.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi575888, 1 interactor
IntActiQ5W0B7, 6 interactors
STRINGi9606.ENSP00000366715

PTM databases

iPTMnetiQ5W0B7
PhosphoSitePlusiQ5W0B7

Polymorphism and mutation databases

BioMutaiTMEM236
DMDMi73620896

Proteomic databases

jPOSTiQ5W0B7
MassIVEiQ5W0B7
PaxDbiQ5W0B7
PeptideAtlasiQ5W0B7
PRIDEiQ5W0B7
ProteomicsDBi65759

Genome annotation databases

EnsembliENST00000377495; ENSP00000366715; ENSG00000148483
GeneIDi653567
KEGGihsa:653567
UCSCiuc009xjx.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
653567
EuPathDBiHostDB:ENSG00000148483.8

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TMEM236
HGNCiHGNC:23473 TMEM236
HPAiHPA045096
neXtProtiNX_Q5W0B7
OpenTargetsiENSG00000148483
PharmGKBiPA134931867

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IGEQ Eukaryota
ENOG410YD0S LUCA
GeneTreeiENSGT00390000015525
InParanoidiQ5W0B7
OMAiVIMEQFA
OrthoDBi667499at2759
PhylomeDBiQ5W0B7
TreeFamiTF328759

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TMEM236 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
653567
PharosiQ5W0B7 Tdark

Protein Ontology

More...
PROi
PR:Q5W0B7
RNActiQ5W0B7 protein

Gene expression databases

BgeeiENSG00000148483 Expressed in 60 organ(s), highest expression level in mucosa of transverse colon

Family and domain databases

InterProiView protein in InterPro
IPR020394 Uncharacterised_FAM23-like_TM
PANTHERiPTHR31453 PTHR31453, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTM236_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5W0B7
Secondary accession number(s): B2RXH7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: December 7, 2004
Last modified: December 11, 2019
This is version 113 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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