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Entry version 154 (12 Aug 2020)
Sequence version 1 (07 Dec 2004)
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Protein

ORC ubiquitin ligase 1

Gene

OBI1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

E3 ubiquitin ligase essential for DNA replication origin activation during S phase (PubMed:31160578). Acts as a replication origin selector which selects the origins to be fired and catalyzes the multi-mono-ubiquitination of a subset of chromatin-bound ORC3 and ORC5 during S-phase (PubMed:31160578).1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri18 – 56RING-type; degeneratePROSITE-ProRule annotationAdd BLAST39

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q5W0B1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ORC ubiquitin ligase 1Curated (EC:2.3.2.271 Publication)
Short name:
OBI11 Publication
Alternative name(s):
RING finger protein 219
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:OBI1Imported
Synonyms:C13orf7, RNF219
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000152193.7

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20308, OBI1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
615906, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5W0B1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Chromosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi38C → S: Loss of E3 ubiquitin transferase activity. No effect on association with ORC complex. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
79596

Open Targets

More...
OpenTargetsi
ENSG00000152193

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162401869

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q5W0B1, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RNF219

Domain mapping of disease mutations (DMDM)

More...
DMDMi
73917812

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000558761 – 726ORC ubiquitin ligase 1Add BLAST726

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei210PhosphoserineCombined sources1
Modified residuei526PhosphoserineCombined sources1
Modified residuei553PhosphoserineBy similarity1
Modified residuei561PhosphoserineCombined sources1
Modified residuei568PhosphoserineBy similarity1
Modified residuei570PhosphoserineBy similarity1
Modified residuei719PhosphoserineCombined sources1
Modified residuei721PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Auto-ubiquitinated.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5W0B1

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5W0B1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q5W0B1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q5W0B1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5W0B1

PeptideAtlas

More...
PeptideAtlasi
Q5W0B1

PRoteomics IDEntifications database

More...
PRIDEi
Q5W0B1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
65758

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5W0B1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5W0B1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000152193, Expressed in forebrain and 224 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5W0B1, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000152193, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Associates with ORC complex (PubMed:31160578). Binds to chromatin; association is cell cycle-regulated, absent from mitotic chromosomes, is associated with chromatin from G1 and partially released from chromatin from mid S-phase (PubMed:31160578).

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
122736, 55 interactors

Protein interaction database and analysis system

More...
IntActi
Q5W0B1, 38 interactors

Molecular INTeraction database

More...
MINTi
Q5W0B1

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000282003

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q5W0B1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5W0B1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili87 – 129Sequence analysisAdd BLAST43
Coiled coili155 – 270Sequence analysisAdd BLAST116

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi304 – 310Poly-Ser7
Compositional biasi434 – 721Ser-richAdd BLAST288

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri18 – 56RING-type; degeneratePROSITE-ProRule annotationAdd BLAST39

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QTFT, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000013512

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_023039_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5W0B1

KEGG Orthology (KO)

More...
KOi
K24091

Identification of Orthologs from Complete Genome Data

More...
OMAi
NHVFCSV

Database of Orthologous Groups

More...
OrthoDBi
487392at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5W0B1

TreeFam database of animal gene trees

More...
TreeFami
TF329331

Family and domain databases

Conserved Domains Database

More...
CDDi
cd16562, RING-HC_RNF219, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039209, OBI1
IPR035691, RNF219_RING-HC
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD

The PANTHER Classification System

More...
PANTHERi
PTHR14609, PTHR14609, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50089, ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5W0B1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQTVQNVTL SLTLPITCHI CLGKVRQPVI CINNHVFCSI CIDLWLKNNS
60 70 80 90 100
QCPACRVPIT PENPCKEIIG GTSESEPMLS HTVRKHLRKT RLELLHKEYE
110 120 130 140 150
DEIDCLQKEV EELKSKNLSL ESQIKTILDP LTLVQGNQNE DKHLVTDNPS
160 170 180 190 200
KINPETVAEW KKKLRTANEI YEKVKDDVDK LKEANKKLKL ENGGLVRENL
210 220 230 240 250
RLKAEVDNRS PQKFGRFAVA ALQSKVEQYE RETNRLKKAL ERSDKYIEEL
260 270 280 290 300
ESQVAQLKNS SEEKEAMNSI CQTALSADGK GSKGSEEDVV SKNQGDSARK
310 320 330 340 350
QPGSSTSSSS HLAKPSSSRL CDTSSARQES TSKADLNCSK NKDLYQEQVE
360 370 380 390 400
VMLDVTDTSM DTYLEREWGN KPSDCVPYKD EELYDLPAPC TPLSLSCLQL
410 420 430 440 450
STPENRESSV VQAGGSKKHS NHLRKLVFDD FCDSSNVSNK DSSEDDISRS
460 470 480 490 500
ENEKKSECFS SPKTGFWDCC STSYAQNLDF ESSEGNTIAN SVGEISSKLS
510 520 530 540 550
EKSGLCLSKR LNSIRSFEMN RTRTSSEASM DAAYLDKISE LDSMMSESDN
560 570 580 590 600
SKSPCNNGFK SLDLDGLSKS SQGSEFLEEP DKLEEKTELN LSKGSLTNDQ
610 620 630 640 650
LENGSEWKPT SFFLLSPSDQ EMNEDFSLHS SSCPVTNEIK PPSCLFQTEF
660 670 680 690 700
SQGILLSSSH RLFEDQRFGS SLFKMSSEMH SLHNHLQSPW STSFVPEKRN
710 720
KNVNQSTKRK IQSSLSSASP SKATKS
Length:726
Mass (Da):81,116
Last modified:December 7, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2ADD8EAE5282A1CF
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB14594 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BC028586 differs from that shown. Reason: Frameshift.Curated
The sequence CAB66586 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti126T → A in CAB66586 (PubMed:11230166).Curated1
Sequence conflicti386L → F in CAB66586 (PubMed:11230166).Curated1
Sequence conflicti462P → T in CAB66586 (PubMed:11230166).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL136651 mRNA Translation: CAB66586.3 Sequence problems.
AL139319 Genomic DNA No translation available.
AL445209 Genomic DNA No translation available.
BC028586 mRNA No translation available.
CH471093 Genomic DNA Translation: EAW80586.1
BC136764 mRNA Translation: AAI36765.1
BC136765 mRNA Translation: AAI36766.1
AK023511 mRNA Translation: BAB14594.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS31997.1

NCBI Reference Sequences

More...
RefSeqi
NP_078822.3, NM_024546.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000282003; ENSP00000282003; ENSG00000152193

Database of genes from NCBI RefSeq genomes

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GeneIDi
79596

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:79596

UCSC genome browser

More...
UCSCi
uc001vkw.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136651 mRNA Translation: CAB66586.3 Sequence problems.
AL139319 Genomic DNA No translation available.
AL445209 Genomic DNA No translation available.
BC028586 mRNA No translation available.
CH471093 Genomic DNA Translation: EAW80586.1
BC136764 mRNA Translation: AAI36765.1
BC136765 mRNA Translation: AAI36766.1
AK023511 mRNA Translation: BAB14594.1 Different initiation.
CCDSiCCDS31997.1
RefSeqiNP_078822.3, NM_024546.3

3D structure databases

SMRiQ5W0B1
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi122736, 55 interactors
IntActiQ5W0B1, 38 interactors
MINTiQ5W0B1
STRINGi9606.ENSP00000282003

PTM databases

iPTMnetiQ5W0B1
PhosphoSitePlusiQ5W0B1

Polymorphism and mutation databases

BioMutaiRNF219
DMDMi73917812

Proteomic databases

EPDiQ5W0B1
jPOSTiQ5W0B1
MassIVEiQ5W0B1
MaxQBiQ5W0B1
PaxDbiQ5W0B1
PeptideAtlasiQ5W0B1
PRIDEiQ5W0B1
ProteomicsDBi65758

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
24695, 149 antibodies

Genome annotation databases

EnsembliENST00000282003; ENSP00000282003; ENSG00000152193
GeneIDi79596
KEGGihsa:79596
UCSCiuc001vkw.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
79596
DisGeNETi79596
EuPathDBiHostDB:ENSG00000152193.7

GeneCards: human genes, protein and diseases

More...
GeneCardsi
OBI1
HGNCiHGNC:20308, OBI1
HPAiENSG00000152193, Low tissue specificity
MIMi615906, gene
neXtProtiNX_Q5W0B1
OpenTargetsiENSG00000152193
PharmGKBiPA162401869

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502QTFT, Eukaryota
GeneTreeiENSGT00390000013512
HOGENOMiCLU_023039_0_0_1
InParanoidiQ5W0B1
KOiK24091
OMAiNHVFCSV
OrthoDBi487392at2759
PhylomeDBiQ5W0B1
TreeFamiTF329331

Enzyme and pathway databases

PathwayCommonsiQ5W0B1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
79596, 8 hits in 867 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
RNF219, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
79596
PharosiQ5W0B1, Tdark

Protein Ontology

More...
PROi
PR:Q5W0B1
RNActiQ5W0B1, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000152193, Expressed in forebrain and 224 other tissues
GenevisibleiQ5W0B1, HS

Family and domain databases

CDDicd16562, RING-HC_RNF219, 1 hit
Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR039209, OBI1
IPR035691, RNF219_RING-HC
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD
PANTHERiPTHR14609, PTHR14609, 1 hit
PROSITEiView protein in PROSITE
PS50089, ZF_RING_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiOBI1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5W0B1
Secondary accession number(s): B2RN99
, Q8TBY2, Q9H0T2, Q9H8M0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: December 7, 2004
Last modified: August 12, 2020
This is version 154 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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