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Entry version 99 (16 Oct 2019)
Sequence version 1 (07 Dec 2004)
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Protein

Glutamate-rich protein 6B

Gene

ERICH6B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glutamate-rich protein 6B
Alternative name(s):
Protein FAM194B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ERICH6B
Synonyms:FAM194B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26523 ERICH6B

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5W0A0

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA165505094

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q5W0A0

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ERICH6B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74747903

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003260501 – 696Glutamate-rich protein 6BAdd BLAST696

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5W0A0

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5W0A0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5W0A0

PeptideAtlas

More...
PeptideAtlasi
Q5W0A0

PRoteomics IDEntifications database

More...
PRIDEi
Q5W0A0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
65755 [Q5W0A0-1]
65756 [Q5W0A0-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5W0A0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5W0A0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000165837 Expressed in 87 organ(s), highest expression level in right hemisphere of cerebellum

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA043559

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
128626, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q5W0A0, 2 interactors

Molecular INTeraction database

More...
MINTi
Q5W0A0

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000298738

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5W0A0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi30 – 198Glu-richAdd BLAST169

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ERICH6 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IJPV Eukaryota
ENOG4111TGA LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153655

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000155621

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5W0A0

Identification of Orthologs from Complete Genome Data

More...
OMAi
MSAENNQ

Database of Orthologous Groups

More...
OrthoDBi
866189at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5W0A0

TreeFam database of animal gene trees

More...
TreeFami
TF350393

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029281 FAM194_C

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14977 FAM194, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q5W0A0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSAENNQLSG ASPPHPPTTP QYSTQNLPSE KEDTEVELDE ESLQDESPFS
60 70 80 90 100
PEGESLEDKE YLEEEEDLEE EEYLGKEEYL KEEEYLGKEE HLEEEEYLEK
110 120 130 140 150
AGYLEEEEYI EEEEYLGKEG YLEEEEYLGK EEHLEEEEYL GKEGYLEKED
160 170 180 190 200
YIEEVDYLGK KAYLEEEEYL GKKSYLEEEK ALEKEENLEE EEALEKEENL
210 220 230 240 250
DGKENLYKKY LKEPKASYSS QTMLLRDARS PDAGPSQVTT FLTVPLTFAT
260 270 280 290 300
PSPVSESATE SSELLLTLYR RSQASQTDWC YDRTAVKSLK SKSETEQETT
310 320 330 340 350
TKLAPEEHVN TKVQQKKEEN VLEFASKENF WDGITDESID KLEVEDLDEN
360 370 380 390 400
FLNSSYQTVF KTIIKEMAAH NELEEDFDIP LTKLLESENR WKLVIMLKKN
410 420 430 440 450
YEKFKETILR IKRRREAQKL TEMTSFTFHL MSKPTPEKPE TEEIQKPQRV
460 470 480 490 500
VHHRKKLERD KEWIQKKTVV HQGDGKLILY PNKNVYQILF PDGTGQIHYP
510 520 530 540 550
SGNLAMLILY AKMKKFTYII LEDSLEGRIR ALINNSGNAT FYDENSDIWL
560 570 580 590 600
NLSSNLGYYF PKDKRQKAWN WWNLNIHVHA PPVQPISLKI NEYIQVQIRS
610 620 630 640 650
QDKIIFCFTY EQKQICLNLG TRYKFVIPEV LSEMKKKTIL EAEPGPTAQK
660 670 680 690
IRVLLGKMNR LLNYATTPDL ENFIEAVSIS LMDNKYLKKM LSKLWF
Length:696
Mass (Da):81,686
Last modified:December 7, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE82E8019FB58C9A9
GO
Isoform 2 (identifier: Q5W0A0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     134-139: Missing.

Note: No experimental confirmation available.
Show »
Length:690
Mass (Da):80,893
Checksum:i3BB417340E8E5E72
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti101A → V in BAB71393 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03996963E → D. Corresponds to variant dbSNP:rs12020217Ensembl.1
Natural variantiVAR_03997099E → G. Corresponds to variant dbSNP:rs12020731Ensembl.1
Natural variantiVAR_039971174S → T. Corresponds to variant dbSNP:rs17066954Ensembl.1
Natural variantiVAR_039972178E → K1 PublicationCorresponds to variant dbSNP:rs3014939Ensembl.1
Natural variantiVAR_039973303L → P. Corresponds to variant dbSNP:rs11618506Ensembl.1
Natural variantiVAR_039974427T → I. Corresponds to variant dbSNP:rs749071Ensembl.1
Natural variantiVAR_039975439P → R. Corresponds to variant dbSNP:rs12429125Ensembl.1
Natural variantiVAR_039976453H → R. Corresponds to variant dbSNP:rs17066902Ensembl.1
Natural variantiVAR_039977565R → C. Corresponds to variant dbSNP:rs7327901Ensembl.1
Natural variantiVAR_039978653V → F. Corresponds to variant dbSNP:rs1536207Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_032523134 – 139Missing in isoform 2. 1 Publication6

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK057244 mRNA Translation: BAB71393.1
AL139326 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS45045.1 [Q5W0A0-1]

NCBI Reference Sequences

More...
RefSeqi
NP_872348.2, NM_182542.2 [Q5W0A0-1]
XP_016875907.1, XM_017020418.1 [Q5W0A0-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000298738; ENSP00000298738; ENSG00000165837 [Q5W0A0-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
220081

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:220081

UCSC genome browser

More...
UCSCi
uc001val.2 human [Q5W0A0-1]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057244 mRNA Translation: BAB71393.1
AL139326 Genomic DNA No translation available.
CCDSiCCDS45045.1 [Q5W0A0-1]
RefSeqiNP_872348.2, NM_182542.2 [Q5W0A0-1]
XP_016875907.1, XM_017020418.1 [Q5W0A0-1]

3D structure databases

SMRiQ5W0A0
ModBaseiSearch...

Protein-protein interaction databases

BioGridi128626, 1 interactor
IntActiQ5W0A0, 2 interactors
MINTiQ5W0A0
STRINGi9606.ENSP00000298738

PTM databases

iPTMnetiQ5W0A0
PhosphoSitePlusiQ5W0A0

Polymorphism and mutation databases

BioMutaiERICH6B
DMDMi74747903

Proteomic databases

EPDiQ5W0A0
jPOSTiQ5W0A0
PaxDbiQ5W0A0
PeptideAtlasiQ5W0A0
PRIDEiQ5W0A0
ProteomicsDBi65755 [Q5W0A0-1]
65756 [Q5W0A0-2]

Genome annotation databases

EnsembliENST00000298738; ENSP00000298738; ENSG00000165837 [Q5W0A0-1]
GeneIDi220081
KEGGihsa:220081
UCSCiuc001val.2 human [Q5W0A0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
220081

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ERICH6B
HGNCiHGNC:26523 ERICH6B
HPAiHPA043559
neXtProtiNX_Q5W0A0
PharmGKBiPA165505094

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IJPV Eukaryota
ENOG4111TGA LUCA
GeneTreeiENSGT00940000153655
HOGENOMiHOG000155621
InParanoidiQ5W0A0
OMAiMSAENNQ
OrthoDBi866189at2759
PhylomeDBiQ5W0A0
TreeFamiTF350393

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ERICH6B human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
220081
PharosiQ5W0A0

Protein Ontology

More...
PROi
PR:Q5W0A0

Gene expression databases

BgeeiENSG00000165837 Expressed in 87 organ(s), highest expression level in right hemisphere of cerebellum

Family and domain databases

InterProiView protein in InterPro
IPR029281 FAM194_C
PfamiView protein in Pfam
PF14977 FAM194, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiERI6B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5W0A0
Secondary accession number(s): Q96MB5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: December 7, 2004
Last modified: October 16, 2019
This is version 99 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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