Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Lipase member J

Gene

LIPJ

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei141NucleophileBy similarity1
Active sitei312Charge relay systemPROSITE-ProRule annotation1
Active sitei341Charge relay systemPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processLipid degradation, Lipid metabolism

Enzyme and pathway databases

ReactomeiR-HSA-6809371 Formation of the cornified envelope

Protein family/group databases

ESTHERihuman-LIPJ Acidic_Lipase
MEROPSiS33.020

Names & Taxonomyi

Protein namesi
Recommended name:
Lipase member J (EC:3.1.1.-)
Alternative name(s):
Lipase-like abhydrolase domain-containing protein 1
Gene namesi
Name:LIPJ
Synonyms:LIPL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000204022.9
HGNCiHGNC:21773 LIPJ
MIMi613921 gene
neXtProtiNX_Q5W064

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000204022
PharmGKBiPA162394099

Polymorphism and mutation databases

BioMutaiLIPJ
DMDMi317373431

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002889701 – 366Lipase member JAdd BLAST366

Proteomic databases

PaxDbiQ5W064
PeptideAtlasiQ5W064
PRIDEiQ5W064
ProteomicsDBi65753

PTM databases

iPTMnetiQ5W064
PhosphoSitePlusiQ5W064

Expressioni

Gene expression databases

BgeeiENSG00000204022
CleanExiHS_LIPJ
ExpressionAtlasiQ5W064 baseline and differential
GenevisibleiQ5W064 HS

Organism-specific databases

HPAiHPA048594

Interactioni

Protein-protein interaction databases

IntActiQ5W064, 1 interactor
STRINGi9606.ENSP00000361007

Structurei

3D structure databases

ProteinModelPortaliQ5W064
SMRiQ5W064
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. Lipase family.Curated

Phylogenomic databases

eggNOGiKOG2624 Eukaryota
COG0596 LUCA
GeneTreeiENSGT00550000074328
HOGENOMiHOG000240694
HOVERGENiHBG006265
InParanoidiQ5W064
OMAiEIFYVGH
OrthoDBiEOG091G09AX
PhylomeDBiQ5W064
TreeFamiTF315485

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR006693 AB_hydrolase_lipase
IPR025483 Lipase_euk
PfamiView protein in Pfam
PF04083 Abhydro_lipase, 1 hit
PIRSFiPIRSF000862 Steryl_ester_lip, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00120 LIPASE_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Q5W064-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNISQIISYW GYPDEEYDIV TEDGYILGLY RIPYWRTDNN KNLAQRVVVY
60 70 80 90 100
LQHGLLTSAS SWISNLPNNS LGFILADAGY DVWMGNSRGN TWSRKHLYLE
110 120 130 140 150
TSSKEFWAFS FDEMAKYDLP ASIDFTVKQT RQEEIFYVGH SQGTTIGFIT
160 170 180 190 200
FSTISKIAER IKIFFALAPV FSTKYLKSPL IRMTYKWKSI VMAFSGNKDF
210 220 230 240 250
LPKTSFKKFI GSKLCPLQIF DKICLNILFM MFGYDPKNLN MSRLDVYFSH
260 270 280 290 300
NPAGTSVQNM LHWSQLLNST HLKAYDWGSP DLNLVHYNQT TSPLYNMTNM
310 320 330 340 350
NVATAIWNGK SDLLADPEDV NILHSEITNH IYYKTISYYN HIDSLFGLDV
360
YDQVYHEIID IIQDNL
Length:366
Mass (Da):42,388
Last modified:January 11, 2011 - v3
Checksum:i0019AE513B75DD7A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032543210I → V1 PublicationCorresponds to variant dbSNP:rs1409136Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL139406 Genomic DNA No translation available.
BC031219 mRNA Translation: AAH31219.1
CCDSiCCDS31240.1
RefSeqiNP_001010939.2, NM_001010939.2
XP_006717698.1, XM_006717635.2
XP_011537616.1, XM_011539314.2
XP_011537617.1, XM_011539315.2
UniGeneiHs.440959
Hs.601660

Genome annotation databases

EnsembliENST00000371939; ENSP00000361007; ENSG00000204022
GeneIDi142910
KEGGihsa:142910
UCSCiuc001kff.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiLIPJ_HUMAN
AccessioniPrimary (citable) accession number: Q5W064
Secondary accession number(s): A8MT98, Q0P671
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: January 11, 2011
Last modified: June 20, 2018
This is version 101 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health