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UniProtKB - Q5W026 (Q5W026_HUMAN)

Entry version 125 (07 Oct 2020)
Sequence version 2 (11 Dec 2019)
Previous versions | rss
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Protein
Submitted name:

Ankyrin repeat domain-containing protein 30A

Gene

ANKRD30A

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Ankyrin repeat domain-containing protein 30AImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ANKRD30AImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000148513.17

Human Gene Nomenclature Database

More...HGNCi		HGNC:17234, ANKRD30A

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000148513

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q5W026

PRoteomics IDEntifications database

More...PRIDEi		Q5W026

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		65746

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000148513, Expressed in epithelium of mammary gland and 54 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q5W026, baseline and differential

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini37 – 259ANK_REP_REGIONInterPro annotationAdd BLAST223
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati72 – 104ANKPROSITE-ProRule annotationAdd BLAST33
Repeati105 – 137ANKPROSITE-ProRule annotationAdd BLAST33
Repeati138 – 170ANKPROSITE-ProRule annotationAdd BLAST33
Repeati171 – 203ANKPROSITE-ProRule annotationAdd BLAST33

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni267 – 376DisorderedSequence analysisAdd BLAST110
Regioni453 – 482DisorderedSequence analysisAdd BLAST30
Regioni782 – 807DisorderedSequence analysisAdd BLAST26
Regioni901 – 926DisorderedSequence analysisAdd BLAST26
Regioni1021 – 1050DisorderedSequence analysisAdd BLAST30

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili54 – 74Sequence analysisAdd BLAST21
Coiled coili1118 – 1142Sequence analysisAdd BLAST25
Coiled coili1150 – 1205Sequence analysisAdd BLAST56
Coiled coili1230 – 1250Sequence analysisAdd BLAST21
Coiled coili1255 – 1275Sequence analysisAdd BLAST21
Coiled coili1287 – 1307Sequence analysisAdd BLAST21
Coiled coili1407 – 1441Sequence analysisAdd BLAST35
Coiled coili1496 – 1516Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi294 – 308PolyampholyteSequence analysisAdd BLAST15
Compositional biasi349 – 376PolyampholyteSequence analysisAdd BLAST28
Compositional biasi453 – 468PolarSequence analysisAdd BLAST16
Compositional biasi782 – 804PolyampholyteSequence analysisAdd BLAST23
Compositional biasi901 – 923PolyampholyteSequence analysisAdd BLAST23
Compositional biasi1029 – 1050PolyampholyteSequence analysisAdd BLAST22

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

ANK repeatPROSITE-ProRule annotationARBA annotation, Coiled coilSequence analysis, RepeatARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00940000165686

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q5W026

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.40.20, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR039497, CC144C-like_CC_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00023, Ank, 2 hits
PF12796, Ank_2, 1 hit
PF14915, CCDC144C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00248, ANK, 6 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48403, SSF48403, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q5W026-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEEISAAAVK VVPGPERPSP FSQLVYTSND SYIVHSGDLR KIHKAASRGQ 
        60         70         80         90        100
VRKLEKMTKR KKTINLNIQD AQKRTALHWA CVNGHEEVVT FLVDRKCQLD 
       110        120        130        140        150
VLDGEHRTPL MKALQCHQEA CANILIDSGA DINLVDVYGN TALHYAVYSE 
       160        170        180        190        200
ILSVVAKLLS HGAVIEVHNK ASLTPLLLSI TKRSEQIVEF LLIKNANANA 
       210        220        230        240        250
VNKYKCTALM LAVCHGSSEI VGMLLQQNVD VFAADICGVT AEHYAVTCGF 
       260        270        280        290        300
HHIHEQIMEY IRKLSKNHQN TNPEGTSAGT PDEAAPLAER TPDTAESLVE 
       310        320        330        340        350
KTPDEAAPLV ERTPDTAESL VEKTPDEAAS LVEGTSDKIQ CLEKATSGKF 
       360        370        380        390        400
EQSAEETPRE ITSPAKETSE KFTWPAKGRP RKIAWEKKED TPREIMSPAK 
       410        420        430        440        450
ETSEKFTWAA KGRPRKIAWE KKETPVKTGC VARVTSNKTK VLEKGRSKMI 
       460        470        480        490        500
ACPTKESSTK ASANDQRFPS ESKQEEDEEY SCDSRSLFES SAKIQVCIPE 
       510        520        530        540        550
SIYQKVMEIN REVEEPPKKP SAFKPAIEMQ NSVPNKAFEL KNEQTLRADP 
       560        570        580        590        600
MFPPESKQKD YEENSWDSES LCETVSQKDV CLPKATHQKE IDKINGKLEE 
       610        620        630        640        650
SPNKDGLLKA TCGMKVSIPT KALELKDMQT FKAEPPGKPS AFEPATEMQK 
       660        670        680        690        700
SVPNKALELK NEQTLRADEI LPSESKQKDY EENSWDTESL CETVSQKDVC 
       710        720        730        740        750
LPKAAHQKEI DKINGKLEGS PVKDGLLKAN CGMKVSIPTK ALELMDMQTF 
       760        770        780        790        800
KAEPPEKPSA FEPAIEMQKS VPNKALELKN EQTLRADEIL PSESKQKDYE 
       810        820        830        840        850
ESSWDSESLC ETVSQKDVCL PKAAHQKEID KINGKLEGSP VKDGLLKANC 
       860        870        880        890        900
GMKVSIPTKA LELMDMQTFK AEPPEKPSAF EPAIEMQKSV PNKALELKNE 
       910        920        930        940        950
QTLRADEILP SESKQKDYEE SSWDSESLCE TVSQKDVCLP KATHQKEIDK 
       960        970        980        990       1000
INGKLEESPD NDGFLKAPCR MKVSIPTKAL ELMDMQTFKA EPPEKPSAFE 
      1010       1020       1030       1040       1050
PAIEMQKSVP NKALELKNEQ TLRADQMFPS ESKQKKVEEN SWDSESLRET 
      1060       1070       1080       1090       1100
VSQKDVCVPK ATHQKEMDKI SGKLEDSTSL SKILDTVHSC ERARELQKDH 
      1110       1120       1130       1140       1150
CEQRTGKMEQ MKKKFCVLKK KLSEAKEIKS QLENQKVKWE QELCSVRLTL 
      1160       1170       1180       1190       1200
NQEEEKRRNA DILNEKIREE LGRIEEQHRK ELEVKQQLEQ ALRIQDIELK 
      1210       1220       1230       1240       1250
SVESNLNQVS HTHENENYLL HENCMLKKEI AMLKLEIATL KHQYQEKENK 
      1260       1270       1280       1290       1300
YFEDIKILKE KNAELQMTLK LKEESLTKRA SQYSGQLKVL IAENTMLTSK 
      1310       1320       1330       1340       1350
LKEKQDKEIL EAEIESHHPR LASAVQDHDQ IVTSRKSQEP AFHIAGDACL 
      1360       1370       1380       1390       1400
QRKMNVDVSS TIYNNEVLHQ PLSEAQRKSK SLKINLNYAG DALRENTLVS 
      1410       1420       1430       1440       1450
EHAQRDQRET QCQMKEAEHM YQNEQDNVNK HTEQQESLDQ KLFQLQSKNM 
      1460       1470       1480       1490       1500
WLQQQLVHAH KKADNKSKIT IDIHFLERKM QHHLLKEKNE EIFNYNNHLK 
      1510 
NRIYQYEKEK AETENS
Length:1,516
Mass (Da):172,035
Last modified:December 11, 2019 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAF25C3AC8E577B94
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9BXX3AN30A_HUMAN
Ankyrin repeat domain-containing pr...
ANKRD30A
1,397Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
R4GNA2R4GNA2_HUMAN
Ankyrin repeat domain-containing pr...
ANKRD30A
1,341Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC067744 Genomic DNA No translation available.
AL157387 Genomic DNA No translation available.
AL357148 Genomic DNA No translation available.
AL391686 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000374660; ENSP00000363792; ENSG00000148513

UCSC genome browser

More...UCSCi		uc057sub.1, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC067744 Genomic DNA No translation available.
AL157387 Genomic DNA No translation available.
AL357148 Genomic DNA No translation available.
AL391686 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Proteomic databases

MaxQBiQ5W026
PRIDEiQ5W026
ProteomicsDBi65746

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1797, 57 antibodies

Genome annotation databases

EnsembliENST00000374660; ENSP00000363792; ENSG00000148513
UCSCiuc057sub.1, human

Organism-specific databases

EuPathDBiHostDB:ENSG00000148513.17
HGNCiHGNC:17234, ANKRD30A
OpenTargetsiENSG00000148513

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

GeneTreeiENSGT00940000165686
PhylomeDBiQ5W026

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ANKRD30A, human

Gene expression databases

BgeeiENSG00000148513, Expressed in epithelium of mammary gland and 54 other tissues
ExpressionAtlasiQ5W026, baseline and differential

Family and domain databases

Gene3Di1.25.40.20, 2 hits
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR039497, CC144C-like_CC_dom
PfamiView protein in Pfam
PF00023, Ank, 2 hits
PF12796, Ank_2, 1 hit
PF14915, CCDC144C, 1 hit
SMARTiView protein in SMART
SM00248, ANK, 6 hits
SUPFAMiSSF48403, SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ5W026_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5W026
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 7, 2004
Last sequence update: December 11, 2019
Last modified: October 7, 2020
This is version 125 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health

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