Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein-lysine methyltransferase METTL21C

Gene

METTL21C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protein-lysine methyltransferase.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei92S-adenosyl-L-methionine; via amide nitrogen1 Publication1
Binding sitei141S-adenosyl-L-methionine1 Publication1
Binding sitei172S-adenosyl-L-methionine; via amide nitrogen1 Publication1
Binding sitei193S-adenosyl-L-methionine; via carbonyl oxygen1 Publication1

GO - Molecular functioni

  • heat shock protein binding Source: UniProtKB
  • protein-lysine N-methyltransferase activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

SIGNORiQ5VZV1

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-lysine methyltransferase METTL21C (EC:2.1.1.-)
Alternative name(s):
Methyltransferase-like protein 21C
Gene namesi
Name:METTL21C
Synonyms:C13orf39
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000139780.7
HGNCiHGNC:33717 METTL21C
MIMi615259 gene
neXtProtiNX_Q5VZV1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi141D → A: Abolishes methyltransferase activity. 1 Publication1

Organism-specific databases

DisGeNETi196541
OpenTargetsiENSG00000139780
PharmGKBiPA162378126

Polymorphism and mutation databases

DMDMi74757117

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003195901 – 264Protein-lysine methyltransferase METTL21CAdd BLAST264

Proteomic databases

EPDiQ5VZV1
MaxQBiQ5VZV1
PaxDbiQ5VZV1
PRIDEiQ5VZV1
ProteomicsDBi65729

PTM databases

iPTMnetiQ5VZV1
PhosphoSitePlusiQ5VZV1

Expressioni

Gene expression databases

BgeeiENSG00000139780 Expressed in 52 organ(s), highest expression level in deltoid
CleanExiHS_C13orf39
GenevisibleiQ5VZV1 HS

Interactioni

Subunit structurei

Interacts with members of the heat shock protein 70 families; these proteins may possibly be methylation substrates for the enzyme.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ELOCQ153695EBI-10236049,EBI-301231

GO - Molecular functioni

Protein-protein interaction databases

BioGridi128220, 17 interactors
IntActiQ5VZV1, 1 interactor
STRINGi9606.ENSP00000267273

Structurei

Secondary structure

1264
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ5VZV1
SMRiQ5VZV1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni120 – 122S-adenosyl-L-methionine binding1 Publication3

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2793 Eukaryota
COG0500 LUCA
GeneTreeiENSGT00550000074572
HOVERGENiHBG107723
InParanoidiQ5VZV1
KOiK21805
OMAiVWPGAMA
OrthoDBiEOG091G0NXA
PhylomeDBiQ5VZV1
TreeFamiTF354267

Family and domain databases

InterProiView protein in InterPro
IPR019410 Methyltransf_16
IPR029063 SAM-dependent_MTases
PfamiView protein in Pfam
PF10294 Methyltransf_16, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit

Sequencei

Sequence statusi: Complete.

Q5VZV1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDVCLSSAQQ PGRRGEGLSS PGGWLEAEKK GAPQKDSTGG VLEESNKIEP
60 70 80 90 100
SLHSLQKFVP TDYASYTQEH YRFAGKEIVI QESIESYGAV VWPGAMALCQ
110 120 130 140 150
YLEEHAEELN FQDAKILEIG AGPGLVSIVA SILGAQVTAT DLPDVLGNLQ
160 170 180 190 200
YNLLKNTLQC TAHLPEVKEL VWGEDLDKNF PKSAFYYDYV LASDVVYHHY
210 220 230 240 250
FLDKLLTTMV YLSQPGTVLL WANKFRFSTD YEFLDKFKQV FDTTLLAEYP
260
ESSVKLFKGI LKWD
Length:264
Mass (Da):29,565
Last modified:December 7, 2004 - v1
Checksum:i239B4B24D62DC1D0
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06222915G → R. Corresponds to variant dbSNP:rs2390760Ensembl.1
Natural variantiVAR_03901346N → S. Corresponds to variant dbSNP:rs16960383Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL158063 Genomic DNA No translation available.
BC132748 mRNA Translation: AAI32749.1
BC132750 mRNA Translation: AAI32751.1
CCDSiCCDS32003.1
RefSeqiNP_001010977.1, NM_001010977.2
XP_016875896.1, XM_017020407.1
XP_016875897.1, XM_017020408.1
UniGeneiHs.508623

Genome annotation databases

EnsembliENST00000267273; ENSP00000267273; ENSG00000139780
GeneIDi196541
KEGGihsa:196541
UCSCiuc001vpj.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL158063 Genomic DNA No translation available.
BC132748 mRNA Translation: AAI32749.1
BC132750 mRNA Translation: AAI32751.1
CCDSiCCDS32003.1
RefSeqiNP_001010977.1, NM_001010977.2
XP_016875896.1, XM_017020407.1
XP_016875897.1, XM_017020408.1
UniGeneiHs.508623

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4MTLX-ray1.65A/B22-264[»]
ProteinModelPortaliQ5VZV1
SMRiQ5VZV1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128220, 17 interactors
IntActiQ5VZV1, 1 interactor
STRINGi9606.ENSP00000267273

PTM databases

iPTMnetiQ5VZV1
PhosphoSitePlusiQ5VZV1

Polymorphism and mutation databases

DMDMi74757117

Proteomic databases

EPDiQ5VZV1
MaxQBiQ5VZV1
PaxDbiQ5VZV1
PRIDEiQ5VZV1
ProteomicsDBi65729

Protocols and materials databases

DNASUi196541
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000267273; ENSP00000267273; ENSG00000139780
GeneIDi196541
KEGGihsa:196541
UCSCiuc001vpj.5 human

Organism-specific databases

CTDi196541
DisGeNETi196541
EuPathDBiHostDB:ENSG00000139780.7
GeneCardsiMETTL21C
HGNCiHGNC:33717 METTL21C
MIMi615259 gene
neXtProtiNX_Q5VZV1
OpenTargetsiENSG00000139780
PharmGKBiPA162378126
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2793 Eukaryota
COG0500 LUCA
GeneTreeiENSGT00550000074572
HOVERGENiHBG107723
InParanoidiQ5VZV1
KOiK21805
OMAiVWPGAMA
OrthoDBiEOG091G0NXA
PhylomeDBiQ5VZV1
TreeFamiTF354267

Enzyme and pathway databases

SIGNORiQ5VZV1

Miscellaneous databases

GenomeRNAii196541
PROiPR:Q5VZV1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000139780 Expressed in 52 organ(s), highest expression level in deltoid
CleanExiHS_C13orf39
GenevisibleiQ5VZV1 HS

Family and domain databases

InterProiView protein in InterPro
IPR019410 Methyltransf_16
IPR029063 SAM-dependent_MTases
PfamiView protein in Pfam
PF10294 Methyltransf_16, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMT21C_HUMAN
AccessioniPrimary (citable) accession number: Q5VZV1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: December 7, 2004
Last modified: November 7, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again