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Entry version 100 (11 Dec 2019)
Sequence version 2 (10 Jun 2008)
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Protein

NUT family member 2G

Gene

NUTM2G

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
NUT family member 2G
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NUTM2G
Synonyms:FAM22G
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000188152.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23449 NUTM2G

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5VZR2

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000188152

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134899635

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q5VZR2 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NUTM2G

Domain mapping of disease mutations (DMDM)

More...
DMDMi
190358885

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002660341 – 741NUT family member 2GAdd BLAST741

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q5VZR2

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q5VZR2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5VZR2

PeptideAtlas

More...
PeptideAtlasi
Q5VZR2

PRoteomics IDEntifications database

More...
PRIDEi
Q5VZR2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
65718 [Q5VZR2-1]
65719 [Q5VZR2-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5VZR2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5VZR2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000188152 Expressed in 77 organ(s), highest expression level in lower esophagus mucosa

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5VZR2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA064635

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
137488, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000361397

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q5VZR2 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi156 – 162Poly-Pro7
Compositional biasi302 – 377Pro-richAdd BLAST76

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NUT family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410J94Q Eukaryota
ENOG4111C0H LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00410000025793

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000112470

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5VZR2

Identification of Orthologs from Complete Genome Data

More...
OMAi
PTARINH

Database of Orthologous Groups

More...
OrthoDBi
425279at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5VZR2

TreeFam database of animal gene trees

More...
TreeFami
TF337728

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024310 NUT
IPR024309 NUT_N

The PANTHER Classification System

More...
PANTHERi
PTHR22879 PTHR22879, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12881 NUT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q5VZR2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASNGAYPVL GPGVTVNPGT SLSVFTALPF ATPSPGPTHR PPLVTAVVPP
60 70 80 90 100
AGPLVLSAFP STPLVAGQDG RGPSGAGASN VFVQMRTEVG PVKPPQAQTL
110 120 130 140 150
ILTQAPLVWQ APGTLCGGVM CPPPLLLAAA PGVPVTSAQV VGGTQACEGG
160 170 180 190 200
WSHGLPLPPP PPAAQVAPIV SPGNAGPWPQ GAHGEGSLAP SQAKARPDDS
210 220 230 240 250
CKPKSVYENF RLWQHYKPLA RRHLPQSPDT EALSCFLIPV LRSLARRKPT
260 270 280 290 300
MTLEEGLWRA MREWQHTSNF DRMIFYEMAA KFLEFEAEEE MQIQKSQWMK
310 320 330 340 350
GPQSLPPPAP PRLEPRGPPA PEVVKQPVYL PSKDGPKAPT ACLPPPRPQR
360 370 380 390 400
PAETKAHLPP PRPPRPAETK VPEEIPPEVV QEYVDIMEEL LGSHPGDTGE
410 420 430 440 450
PEGQREKGKV EQPQEEDGMT SDPGLLSYID KLCSQEDFVT KVEAVIHPRF
460 470 480 490 500
LEELLSPDPQ MDFLALSQEL EQEEGLTLAQ LVEKRLLSLK EKGCGRAAPR
510 520 530 540 550
HGTARLDSSP SEFAAGQEAA REVPDPQQRV SVETSPPQTA AQDPQGQGRV
560 570 580 590 600
RTGMARSEDP AVLLGCQDSP RLKAVRPTSP PQDHRPTCPG LGTKDALGLP
610 620 630 640 650
GESPVKESHG LAKGSSEETE LPGMVYVVGS HHRLRPWRLS QSPVPSSGLL
660 670 680 690 700
SPGGRGPQGA LQSPSAQKRG LSPSPSPASK SKKRPLFGSP SPAEKTPHPG
710 720 730 740
PGLRVSGEQS LAWGLGGPSQ SQKRKGDPLA SRRKKKRHCS Q
Length:741
Mass (Da):79,011
Last modified:June 10, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i58DEDDE717F390AE
GO
Isoform 2 (identifier: Q5VZR2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     481-492: LVEKRLLSLKEK → GAPSDALGTDRC
     493-741: Missing.

Show »
Length:492
Mass (Da):52,702
Checksum:i41DF00FCF2C5A60A
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_034023481 – 492LVEKR…SLKEK → GAPSDALGTDRC in isoform 2. CuratedAdd BLAST12
Alternative sequenceiVSP_034024493 – 741Missing in isoform 2. CuratedAdd BLAST249

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AL158827 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS43854.1 [Q5VZR2-2]
CCDS55329.1 [Q5VZR2-1]

NCBI Reference Sequences

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RefSeqi
NP_001038942.1, NM_001045477.2 [Q5VZR2-2]
NP_001164212.1, NM_001170741.1 [Q5VZR2-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000354649; ENSP00000346670; ENSG00000188152 [Q5VZR2-2]
ENST00000372322; ENSP00000361397; ENSG00000188152 [Q5VZR2-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
441457

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:441457

UCSC genome browser

More...
UCSCi
uc004awq.3 human [Q5VZR2-1]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL158827 Genomic DNA No translation available.
CCDSiCCDS43854.1 [Q5VZR2-2]
CCDS55329.1 [Q5VZR2-1]
RefSeqiNP_001038942.1, NM_001045477.2 [Q5VZR2-2]
NP_001164212.1, NM_001170741.1 [Q5VZR2-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi137488, 1 interactor
STRINGi9606.ENSP00000361397

PTM databases

iPTMnetiQ5VZR2
PhosphoSitePlusiQ5VZR2

Polymorphism and mutation databases

BioMutaiNUTM2G
DMDMi190358885

Proteomic databases

jPOSTiQ5VZR2
MassIVEiQ5VZR2
PaxDbiQ5VZR2
PeptideAtlasiQ5VZR2
PRIDEiQ5VZR2
ProteomicsDBi65718 [Q5VZR2-1]
65719 [Q5VZR2-2]

Genome annotation databases

EnsembliENST00000354649; ENSP00000346670; ENSG00000188152 [Q5VZR2-2]
ENST00000372322; ENSP00000361397; ENSG00000188152 [Q5VZR2-1]
GeneIDi441457
KEGGihsa:441457
UCSCiuc004awq.3 human [Q5VZR2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
441457
EuPathDBiHostDB:ENSG00000188152.12

GeneCards: human genes, protein and diseases

More...
GeneCardsi
NUTM2G
HGNCiHGNC:23449 NUTM2G
HPAiHPA064635
neXtProtiNX_Q5VZR2
OpenTargetsiENSG00000188152
PharmGKBiPA134899635

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410J94Q Eukaryota
ENOG4111C0H LUCA
GeneTreeiENSGT00410000025793
HOGENOMiHOG000112470
InParanoidiQ5VZR2
OMAiPTARINH
OrthoDBi425279at2759
PhylomeDBiQ5VZR2
TreeFamiTF337728

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
441457
PharosiQ5VZR2 Tdark

Protein Ontology

More...
PROi
PR:Q5VZR2
RNActiQ5VZR2 protein

Gene expression databases

BgeeiENSG00000188152 Expressed in 77 organ(s), highest expression level in lower esophagus mucosa
GenevisibleiQ5VZR2 HS

Family and domain databases

InterProiView protein in InterPro
IPR024310 NUT
IPR024309 NUT_N
PANTHERiPTHR22879 PTHR22879, 1 hit
PfamiView protein in Pfam
PF12881 NUT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNTM2G_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5VZR2
Secondary accession number(s): A6NNI5, Q5VZR3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: June 10, 2008
Last modified: December 11, 2019
This is version 100 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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