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Protein

Inactive dual specificity phosphatase 27

Gene

DUSP27

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be required for myofiber maturation.By similarity

Caution

Ser-225 is present instead of the conserved Cys which is expected to be an active site residue suggesting that this protein has lost its phosphatase activity.Curated

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Inactive dual specificity phosphatase 27Curated
Gene namesi
Name:DUSP27Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000198842.9
HGNCiHGNC:25034 DUSP27
neXtProtiNX_Q5VZP5

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi92235
OpenTargetsiENSG00000198842
PharmGKBiPA142671922

Polymorphism and mutation databases

BioMutaiDUSP27
DMDMi74747829

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003028381 – 1158Inactive dual specificity phosphatase 27Add BLAST1158

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei377PhosphoserineBy similarity1
Modified residuei433PhosphothreonineBy similarity1
Modified residuei509PhosphoserineBy similarity1
Modified residuei985PhosphoserineBy similarity1
Modified residuei1036PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ5VZP5
PaxDbiQ5VZP5
PeptideAtlasiQ5VZP5
PRIDEiQ5VZP5
ProteomicsDBi65715

PTM databases

iPTMnetiQ5VZP5
PhosphoSitePlusiQ5VZP5

Expressioni

Gene expression databases

BgeeiENSG00000198842 Expressed in 83 organ(s), highest expression level in quadriceps femoris
CleanExiHS_DUSP27
GenevisibleiQ5VZP5 HS

Organism-specific databases

HPAiHPA012608
HPA012912

Interactioni

Protein-protein interaction databases

BioGridi124920, 1 interactor
IntActiQ5VZP5, 1 interactor
STRINGi9606.ENSP00000271385

Structurei

3D structure databases

ProteinModelPortaliQ5VZP5
SMRiQ5VZP5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini201 – 259Tyrosine-protein phosphataseAdd BLAST59

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi891 – 1036Ser-richAdd BLAST146

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1716 Eukaryota
COG2453 LUCA
GeneTreeiENSGT00760000118853
HOGENOMiHOG000112296
HOVERGENiHBG099426
InParanoidiQ5VZP5
KOiK14165
OMAiRGKYTRS
OrthoDBiEOG091G0249
PhylomeDBiQ5VZP5
TreeFamiTF351505

Family and domain databases

CDDicd00127 DSPc, 1 hit
Gene3Di3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR020417 Atypical_DUSP
IPR020405 Atypical_DUSP_famA
IPR000340 Dual-sp_phosphatase_cat-dom
IPR024950 DUSP
IPR029021 Prot-tyrosine_phosphatase-like
IPR000387 TYR_PHOSPHATASE_dom
IPR020422 TYR_PHOSPHATASE_DUAL_dom
PANTHERiPTHR10159 PTHR10159, 1 hit
PfamiView protein in Pfam
PF00782 DSPc, 1 hit
PRINTSiPR01908 ADSPHPHTASE
PR01909 ADSPHPHTASEA
SMARTiView protein in SMART
SM00195 DSPc, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50054 TYR_PHOSPHATASE_DUAL, 1 hit

Sequencei

Sequence statusi: Complete.

Q5VZP5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATRKDTEEE QVVPSEEDEA NVRAVQAHYL RSPSPSQYSM VSDAETESIF
60 70 80 90 100
MEPIHLSSAI AAKQIINEEL KPPGVRADAE CPGMLESAEQ LLVEDLYNRV
110 120 130 140 150
REKMDDTSLY NTPCVLDLQR ALVQDRQEAP WNEVDEVWPN VFIAEKSVAV
160 170 180 190 200
NKGRLKRLGI THILNAAHGT GVYTGPEFYT GLEIQYLGVE VDDFPEVDIS
210 220 230 240 250
QHFRKASEFL DEALLTYRGK VLVSSEMGIS RSAVLVVAYL MIFHNMAILE
260 270 280 290 300
ALMTVRKKRA IYPNEGFLKQ LRELNEKLME EREEDYGREG GSAEAEEGEG
310 320 330 340 350
TGSMLGARVH ALTVEEEDDS ASHLSGSSLG KATQASKPLT LIDEEEEEKL
360 370 380 390 400
YEQWKKGQGL LSDKVPQDGG GWRSASSGQG GEELEDEDVE RIIQEWQSRN
410 420 430 440 450
ERYQAEGYRR WGREEEKEEE SDAGSSVGRR RRTLSESSAW ESVSSHDIWV
460 470 480 490 500
LKQQLELNRP DHGRRRRADS MSSESTWDAW NERLLEIEKE ASRRYHAKSK
510 520 530 540 550
REEAADRSSE AGSRVREDDE DSVGSEASSF YNFCSRNKDK LTALERWKIK
560 570 580 590 600
RIQFGFHKKD LGAGDSSGEP GAEEAVGEKN PSDVSLTAYQ AWKLKHQKKV
610 620 630 640 650
GSENKEEVVE LSKGEDSALA KKRQRRLELL ERSRQTLEES QSMASWEADS
660 670 680 690 700
STASGSIPLS AFWSADPSVS ADGDTTSVLS TQSHRSHLSQ AASNIAGCST
710 720 730 740 750
SNPTTPLPNL PVGPGDTISI ASIQNWIANV VSETLAQKQN EMLLLSRSPS
760 770 780 790 800
VASMKAVPAA SCLGDDQVSM LSGHSSSSLG GCLLPQSQAR PSSDMQSVLS
810 820 830 840 850
CNTTLSSPAE SCRSKVRGTS KPIFSLFADN VDLKELGRKE KEMQMELREK
860 870 880 890 900
MSEYKMEKLA SDNKRSSLFK KKKVKEDEDD GVGDGDEDTD SAIGSFRYSS
910 920 930 940 950
RSNSQKPETD TCSSLAVCDH YASGSRVGKE MDSSINKWLS GLRTEEKPPF
960 970 980 990 1000
QSDWSGSSRG KYTRSSLLRE TESKSSSYKF SKSQSEEQDT SSYHEANGNS
1010 1020 1030 1040 1050
VRSTSRFSSS STREGREMHK FSRSTYNETS SSREESPEPY FFRRTPESSE
1060 1070 1080 1090 1100
REESPEPQRP NWARSRDWED VEESSKSDFS EFGAKRKFTQ SFMRSEEEGE
1110 1120 1130 1140 1150
KERTENREEG RFASGRRSQY RRSTDREEEE EMDDEAIIAA WRRRQEETRT

KLQKRRED
Length:1,158
Mass (Da):130,176
Last modified:December 7, 2004 - v1
Checksum:i6843A7062D80CBB2
GO

Sequence cautioni

The sequence AAK02011 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034964265E → D1 PublicationCorresponds to variant dbSNP:rs267745Ensembl.1
Natural variantiVAR_034965466R → H. Corresponds to variant dbSNP:rs6668826Ensembl.1
Natural variantiVAR_034966505A → T. Corresponds to variant dbSNP:rs3795605Ensembl.1
Natural variantiVAR_034967855K → Q1 PublicationCorresponds to variant dbSNP:rs267746Ensembl.1
Natural variantiVAR_0349681124T → N. Corresponds to variant dbSNP:rs2281959Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL158837 Genomic DNA No translation available.
BC115387 mRNA Translation: AAI15388.1
AF119045 mRNA Translation: AAK02011.1 Different initiation.
CCDSiCCDS30932.1
RefSeqiNP_001073895.1, NM_001080426.2
UniGeneiHs.632462

Genome annotation databases

EnsembliENST00000271385; ENSP00000271385; ENSG00000198842
ENST00000361200; ENSP00000354483; ENSG00000198842
ENST00000443333; ENSP00000404874; ENSG00000198842
GeneIDi92235
KEGGihsa:92235
UCSCiuc001geb.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiDUS27_HUMAN
AccessioniPrimary (citable) accession number: Q5VZP5
Secondary accession number(s): A0AUM4, Q9C074
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: December 7, 2004
Last modified: September 12, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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