Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger MYM-type protein 4

Gene

ZMYM4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in the regulation of cell morphology and cytoskeletal organization.1 Publication

Miscellaneous

The 3'-UTR region of the mRNA encoding this protein contains a motif called CDIR (for cell death inhibiting RNA) that binds HNRPD/AUF1 and HSPB1/HSP27. It is able to inhibit interferon-gamma induced apoptosis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri362 – 402MYM-type 1Add BLAST41
Zinc fingeri414 – 457MYM-type 2Add BLAST44
Zinc fingeri464 – 499MYM-type 3Add BLAST36
Zinc fingeri510 – 544MYM-type 4Add BLAST35
Zinc fingeri554 – 592MYM-type 5Add BLAST39
Zinc fingeri600 – 631MYM-type 6Add BLAST32
Zinc fingeri708 – 742MYM-type 7Add BLAST35
Zinc fingeri749 – 788MYM-type 8Add BLAST40
Zinc fingeri795 – 829MYM-type 9Add BLAST35

GO - Molecular functioni

  • DNA binding Source: ProtInc
  • DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
  • zinc ion binding Source: InterPro

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger MYM-type protein 4
Alternative name(s):
Zinc finger protein 262
Gene namesi
Name:ZMYM4
Synonyms:KIAA0425, ZNF262
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000146463.11
HGNCiHGNC:13055 ZMYM4
MIMi613568 gene
neXtProtiNX_Q5VZL5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi9202
OpenTargetsiENSG00000146463
PharmGKBiPA37633

Polymorphism and mutation databases

BioMutaiZMYM4
DMDMi74762280

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002990172 – 1548Zinc finger MYM-type protein 4Add BLAST1547

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei107PhosphothreonineCombined sources1
Modified residuei110PhosphoserineCombined sources1
Modified residuei122PhosphoserineCombined sources1
Cross-linki140Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki149Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei162PhosphoserineCombined sources1
Cross-linki195Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei197PhosphoserineCombined sources1
Cross-linki201Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki232Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei242PhosphoserineCombined sources1
Cross-linki250Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki250Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linki260Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki271Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki273Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki289Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki327Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki400Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki428Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki430Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1030PhosphoserineCombined sources1
Cross-linki1035Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1061Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1064PhosphoserineCombined sources1
Modified residuei1071PhosphoserineCombined sources1
Cross-linki1080Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1127Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1181PhosphoserineCombined sources1
Modified residuei1256PhosphoserineCombined sources1
Cross-linki1431Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1539PhosphoserineCombined sources1
Modified residuei1542PhosphoserineCombined sources1
Modified residuei1547PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ5VZL5
MaxQBiQ5VZL5
PaxDbiQ5VZL5
PeptideAtlasiQ5VZL5
PRIDEiQ5VZL5
ProteomicsDBi65706
65707 [Q5VZL5-2]
65708 [Q5VZL5-3]
65709 [Q5VZL5-4]

PTM databases

iPTMnetiQ5VZL5
PhosphoSitePlusiQ5VZL5

Miscellaneous databases

PMAP-CutDBiQ5VZL5

Expressioni

Tissue specificityi

Expressed at higher level in heart, skeletal muscle, kidney and liver.1 Publication

Gene expression databases

BgeeiENSG00000146463 Expressed in 238 organ(s), highest expression level in kidney
CleanExiHS_ZMYM4
ExpressionAtlasiQ5VZL5 baseline and differential
GenevisibleiQ5VZL5 HS

Organism-specific databases

HPAiHPA051301
HPA054802

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi114636, 50 interactors
IntActiQ5VZL5, 40 interactors
MINTiQ5VZL5
STRINGi9606.ENSP00000322915

Structurei

3D structure databases

ProteinModelPortaliQ5VZL5
SMRiQ5VZL5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri362 – 402MYM-type 1Add BLAST41
Zinc fingeri414 – 457MYM-type 2Add BLAST44
Zinc fingeri464 – 499MYM-type 3Add BLAST36
Zinc fingeri510 – 544MYM-type 4Add BLAST35
Zinc fingeri554 – 592MYM-type 5Add BLAST39
Zinc fingeri600 – 631MYM-type 6Add BLAST32
Zinc fingeri708 – 742MYM-type 7Add BLAST35
Zinc fingeri749 – 788MYM-type 8Add BLAST40
Zinc fingeri795 – 829MYM-type 9Add BLAST35

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IE8I Eukaryota
ENOG410XQR6 LUCA
GeneTreeiENSGT00550000074408
HOVERGENiHBG106731
InParanoidiQ5VZL5
OMAiCNQQSMC
OrthoDBiEOG091G033V
PhylomeDBiQ5VZL5
TreeFamiTF336988

Family and domain databases

InterProiView protein in InterPro
IPR021893 DUF3504
IPR026625 TFII-I-rel
IPR011017 TRASH_dom
IPR010507 Znf_MYM
PANTHERiPTHR11697 PTHR11697, 1 hit
PfamiView protein in Pfam
PF12012 DUF3504, 1 hit
PF06467 zf-FCS, 5 hits
SMARTiView protein in SMART
SM00746 TRASH, 10 hits

Sequences (4+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5VZL5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAEREVESGP RKRFEQKSGA VFDEIVENCG GIMDTEMSED IDHNLTPTLD
60 70 80 90 100
SMSYGMPNQT GSENSLLDED DYFLNSGDLA GIPVVGSDNE DEQDFSSKDN
110 120 130 140 150
LVSSIHTDDS LEVERRVTQH ESDNENEIQI QNKLKKDFPK QFDQVSVFKS
160 170 180 190 200
IRKDFSLVRE NSKETFSGKE KNRDLTYERE KRLDKPHKDL DSRLKSSFFD
210 220 230 240 250
KAANQVEETL HTHLPQTPET NFRDSSYPFA NKESIGSELG NSFASNIRIK
260 270 280 290 300
EEPLDDEYDK AMAPQQGLLD KIKDEPDNAQ EYSHGQQQKT QEGELKISAV
310 320 330 340 350
FSVSGSPLAP QLTTGFQPSL ASSGMNKMLP SVPATAVRVS CSGCKKILQK
360 370 380 390 400
GQTAYQRKGS TQLFCSTLCL TGYTVPPARP PPPLTKKTCS SCSKDILNPK
410 420 430 440 450
DVISAQFENT TTSKDFCSQS CLSTYELKKK PIVTINTNSI STKCSMCQKN
460 470 480 490 500
AVIRHEVNYQ NVVHKLCSDA CFSKFRSANN LTMNCCENCG GYCYSGSGQC
510 520 530 540 550
HMLQIEGQSK KFCSSSCITA YKQKSAKITP CALCKSLRSS AEMIENTNSL
560 570 580 590 600
GKTELFCSVN CLSAYRVKMV TSAGVQVQCN SCKTSAIPQY HLAMSDGSIR
610 620 630 640 650
NFCSYSCVVA FQNLFNKPTG MNSSVVPLSQ GQVIVSIPTG STVSAGGGST
660 670 680 690 700
SAVSPTSISS SAAAGLQRLA AQSQHVGFAR SVVKLKCQHC NRLFATKPEL
710 720 730 740 750
LDYKGKMFQF CGKNCSDEYK KINNVMAMCE YCKIEKIVKE TVRFSGADKS
760 770 780 790 800
FCSEGCKLLY KHDLAKRWGN HCKMCSYCLQ TSPKLVQNNL GGKVEEFCCE
810 820 830 840 850
ECMSKYTVLF YQMAKCDACK RQGKLSESLK WRGEMKHFCN LLCILMFCNQ
860 870 880 890 900
QSVCDPPSQN NAANISMVQA ASAGPPSLRK DSTPVIANVV SLASAPAAQP
910 920 930 940 950
TVNSNSVLQG AVPTVTAKII GDASTQTDAL KLPPSQPPRL LKNKALLCKP
960 970 980 990 1000
ITQTKATSCK PHTQNKECQT EDTPSQPQII VVPVPVPVFV PIPLHLYTQY
1010 1020 1030 1040 1050
APVPFGIPVP MPVPMLIPSS MDSEDKVTES IEDIKEKLPT HPFEADLLEM
1060 1070 1080 1090 1100
AEMIAEDEEK KTLSQGESQT SEHELFLDTK IFEKDQGSTY SGDLESEAVS
1110 1120 1130 1140 1150
TPHSWEEELN HYALKSNAVQ EADSELKQFS KGETEQDLEA DFPSDSFDPL
1160 1170 1180 1190 1200
NKGQGIQARS RTRRRHRDGF PQPRRRGRKK SIVAVEPRSL IQGAFQGCSV
1210 1220 1230 1240 1250
SGMTLKYMYG VNAWKNWVQW KNAKEEQGDL KCGGVEQASS SPRSDPLGST
1260 1270 1280 1290 1300
QDHALSQESS EPGCRVRSIK LKEDILSCTF AELSLGLCQF IQEVRRPNGE
1310 1320 1330 1340 1350
KYDPDSILYL CLGIQQYLFE NGRIDNIFTE PYSRFMIELT KLLKIWEPTI
1360 1370 1380 1390 1400
LPNGYMFSRI EEEHLWECKQ LGAYSPIVLL NTLLFFNTKY FQLKNVTEHL
1410 1420 1430 1440 1450
KLSFAHVMRR TRTLKYSTKM TYLRFFPPLQ KQESEPDKLT VGKRKRNEDD
1460 1470 1480 1490 1500
EVPVGVEMAE NTDNPLRCPV RLYEFYLSKC SESVKQRNDV FYLQPERSCV
1510 1520 1530 1540
PNSPMWYSTF PIDPGTLDTM LTRILMVREV HEELAKAKSE DSDVELSD
Length:1,548
Mass (Da):172,788
Last modified:December 7, 2004 - v1
Checksum:i3B5B730EA9B9882B
GO
Isoform 2 (identifier: Q5VZL5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     524-612: Missing.

Note: Gene prediction based on EST data.
Show »
Length:1,459
Mass (Da):163,194
Checksum:iC03E97C233E69C62
GO
Isoform 3 (identifier: Q5VZL5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-324: Missing.

Note: No experimental confirmation available.
Show »
Length:1,224
Mass (Da):136,330
Checksum:i98D348234B1300DE
GO
Isoform 4 (identifier: Q5VZL5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-32: Missing.

Note: No experimental confirmation available.
Show »
Length:1,516
Mass (Da):169,237
Checksum:i707C9F213EEEEE91
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C1I7H7C1I7_HUMAN
Zinc finger MYM-type protein 4
ZMYM4
1,207Annotation score:
A0A0A0MSN3A0A0A0MSN3_HUMAN
Zinc finger MYM-type protein 4
ZMYM4
98Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti279 – 280AQ → RT in BAA24855 (PubMed:9455477).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034764452V → I1 PublicationCorresponds to variant dbSNP:rs34924462Ensembl.1
Natural variantiVAR_0356721410R → W in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs191217255Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0275121 – 324Missing in isoform 3. 1 PublicationAdd BLAST324
Alternative sequenceiVSP_0275131 – 32Missing in isoform 4. 1 PublicationAdd BLAST32
Alternative sequenceiVSP_027514524 – 612Missing in isoform 2. CuratedAdd BLAST89

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL160000 Genomic DNA No translation available.
AL356362 Genomic DNA No translation available.
AL590434 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07417.1
BC012093 mRNA Translation: AAH12093.2
BC127113 mRNA Translation: AAI27114.1
BC127114 mRNA Translation: AAI27115.1
AB007885 mRNA Translation: BAA24855.2
CCDSiCCDS389.1 [Q5VZL5-1]
PIRiT00059
RefSeqiNP_005086.2, NM_005095.2 [Q5VZL5-1]
XP_005271388.1, XM_005271331.2 [Q5VZL5-3]
XP_011540725.1, XM_011542423.2
XP_011540727.1, XM_011542425.2
XP_016858292.1, XM_017002803.1 [Q5VZL5-4]
XP_016858293.1, XM_017002804.1
UniGeneiHs.269211

Genome annotation databases

EnsembliENST00000314607; ENSP00000322915; ENSG00000146463 [Q5VZL5-1]
GeneIDi9202
KEGGihsa:9202
UCSCiuc001byt.3 human [Q5VZL5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL160000 Genomic DNA No translation available.
AL356362 Genomic DNA No translation available.
AL590434 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07417.1
BC012093 mRNA Translation: AAH12093.2
BC127113 mRNA Translation: AAI27114.1
BC127114 mRNA Translation: AAI27115.1
AB007885 mRNA Translation: BAA24855.2
CCDSiCCDS389.1 [Q5VZL5-1]
PIRiT00059
RefSeqiNP_005086.2, NM_005095.2 [Q5VZL5-1]
XP_005271388.1, XM_005271331.2 [Q5VZL5-3]
XP_011540725.1, XM_011542423.2
XP_011540727.1, XM_011542425.2
XP_016858292.1, XM_017002803.1 [Q5VZL5-4]
XP_016858293.1, XM_017002804.1
UniGeneiHs.269211

3D structure databases

ProteinModelPortaliQ5VZL5
SMRiQ5VZL5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114636, 50 interactors
IntActiQ5VZL5, 40 interactors
MINTiQ5VZL5
STRINGi9606.ENSP00000322915

PTM databases

iPTMnetiQ5VZL5
PhosphoSitePlusiQ5VZL5

Polymorphism and mutation databases

BioMutaiZMYM4
DMDMi74762280

Proteomic databases

EPDiQ5VZL5
MaxQBiQ5VZL5
PaxDbiQ5VZL5
PeptideAtlasiQ5VZL5
PRIDEiQ5VZL5
ProteomicsDBi65706
65707 [Q5VZL5-2]
65708 [Q5VZL5-3]
65709 [Q5VZL5-4]

Protocols and materials databases

DNASUi9202
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314607; ENSP00000322915; ENSG00000146463 [Q5VZL5-1]
GeneIDi9202
KEGGihsa:9202
UCSCiuc001byt.3 human [Q5VZL5-1]

Organism-specific databases

CTDi9202
DisGeNETi9202
EuPathDBiHostDB:ENSG00000146463.11
GeneCardsiZMYM4
HGNCiHGNC:13055 ZMYM4
HPAiHPA051301
HPA054802
MIMi613568 gene
neXtProtiNX_Q5VZL5
OpenTargetsiENSG00000146463
PharmGKBiPA37633
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE8I Eukaryota
ENOG410XQR6 LUCA
GeneTreeiENSGT00550000074408
HOVERGENiHBG106731
InParanoidiQ5VZL5
OMAiCNQQSMC
OrthoDBiEOG091G033V
PhylomeDBiQ5VZL5
TreeFamiTF336988

Miscellaneous databases

ChiTaRSiZMYM4 human
GenomeRNAii9202
PMAP-CutDBiQ5VZL5
PROiPR:Q5VZL5
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000146463 Expressed in 238 organ(s), highest expression level in kidney
CleanExiHS_ZMYM4
ExpressionAtlasiQ5VZL5 baseline and differential
GenevisibleiQ5VZL5 HS

Family and domain databases

InterProiView protein in InterPro
IPR021893 DUF3504
IPR026625 TFII-I-rel
IPR011017 TRASH_dom
IPR010507 Znf_MYM
PANTHERiPTHR11697 PTHR11697, 1 hit
PfamiView protein in Pfam
PF12012 DUF3504, 1 hit
PF06467 zf-FCS, 5 hits
SMARTiView protein in SMART
SM00746 TRASH, 10 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZMYM4_HUMAN
AccessioniPrimary (citable) accession number: Q5VZL5
Secondary accession number(s): A0JP19
, A0JP20, O43308, Q5T5E1, Q5T5E2, Q7L3Q4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: December 7, 2004
Last modified: November 7, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again