Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 130 (13 Feb 2019)
Sequence version 1 (07 Dec 2004)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

Zinc finger MYM-type protein 4

Gene

ZMYM4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in the regulation of cell morphology and cytoskeletal organization.1 Publication

Miscellaneous

The 3'-UTR region of the mRNA encoding this protein contains a motif called CDIR (for cell death inhibiting RNA) that binds HNRPD/AUF1 and HSPB1/HSP27. It is able to inhibit interferon-gamma induced apoptosis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri362 – 402MYM-type 1Add BLAST41
Zinc fingeri414 – 457MYM-type 2Add BLAST44
Zinc fingeri464 – 499MYM-type 3Add BLAST36
Zinc fingeri510 – 544MYM-type 4Add BLAST35
Zinc fingeri554 – 592MYM-type 5Add BLAST39
Zinc fingeri600 – 631MYM-type 6Add BLAST32
Zinc fingeri708 – 742MYM-type 7Add BLAST35
Zinc fingeri749 – 788MYM-type 8Add BLAST40
Zinc fingeri795 – 829MYM-type 9Add BLAST35

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger MYM-type protein 4
Alternative name(s):
Zinc finger protein 262
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZMYM4
Synonyms:KIAA0425, ZNF262
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000146463.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13055 ZMYM4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
613568 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5VZL5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
9202

Open Targets

More...
OpenTargetsi
ENSG00000146463

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37633

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZMYM4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74762280

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002990172 – 1548Zinc finger MYM-type protein 4Add BLAST1547

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei107PhosphothreonineCombined sources1
Modified residuei110PhosphoserineCombined sources1
Modified residuei122PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki140Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki149Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei162PhosphoserineCombined sources1
Cross-linki195Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei197PhosphoserineCombined sources1
Cross-linki201Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki232Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei242PhosphoserineCombined sources1
Cross-linki250Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki250Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linki260Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki271Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki273Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki289Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki327Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki400Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki428Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki430Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1030PhosphoserineCombined sources1
Cross-linki1035Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1061Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1064PhosphoserineCombined sources1
Modified residuei1071PhosphoserineCombined sources1
Cross-linki1080Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1127Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1181PhosphoserineCombined sources1
Modified residuei1256PhosphoserineCombined sources1
Cross-linki1431Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1539PhosphoserineCombined sources1
Modified residuei1542PhosphoserineCombined sources1
Modified residuei1547PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5VZL5

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5VZL5

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q5VZL5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5VZL5

PeptideAtlas

More...
PeptideAtlasi
Q5VZL5

PRoteomics IDEntifications database

More...
PRIDEi
Q5VZL5

ProteomicsDB human proteome resource

More...
ProteomicsDBi
65706
65707 [Q5VZL5-2]
65708 [Q5VZL5-3]
65709 [Q5VZL5-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5VZL5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5VZL5

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
Q5VZL5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed at higher level in heart, skeletal muscle, kidney and liver.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000146463 Expressed in 238 organ(s), highest expression level in kidney

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5VZL5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5VZL5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA051301
HPA054802

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114636, 68 interactors

Protein interaction database and analysis system

More...
IntActi
Q5VZL5, 43 interactors

Molecular INTeraction database

More...
MINTi
Q5VZL5

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000322915

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q5VZL5

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5VZL5

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri362 – 402MYM-type 1Add BLAST41
Zinc fingeri414 – 457MYM-type 2Add BLAST44
Zinc fingeri464 – 499MYM-type 3Add BLAST36
Zinc fingeri510 – 544MYM-type 4Add BLAST35
Zinc fingeri554 – 592MYM-type 5Add BLAST39
Zinc fingeri600 – 631MYM-type 6Add BLAST32
Zinc fingeri708 – 742MYM-type 7Add BLAST35
Zinc fingeri749 – 788MYM-type 8Add BLAST40
Zinc fingeri795 – 829MYM-type 9Add BLAST35

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IE8I Eukaryota
ENOG410XQR6 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159550

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG106731

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5VZL5

Identification of Orthologs from Complete Genome Data

More...
OMAi
CNQQSMC

Database of Orthologous Groups

More...
OrthoDBi
587724at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5VZL5

TreeFam database of animal gene trees

More...
TreeFami
TF336988

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR021893 DUF3504
IPR026625 TFII-I-rel
IPR011017 TRASH_dom
IPR010507 Znf_MYM

The PANTHER Classification System

More...
PANTHERi
PTHR11697 PTHR11697, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12012 DUF3504, 1 hit
PF06467 zf-FCS, 5 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00746 TRASH, 10 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5VZL5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAEREVESGP RKRFEQKSGA VFDEIVENCG GIMDTEMSED IDHNLTPTLD
60 70 80 90 100
SMSYGMPNQT GSENSLLDED DYFLNSGDLA GIPVVGSDNE DEQDFSSKDN
110 120 130 140 150
LVSSIHTDDS LEVERRVTQH ESDNENEIQI QNKLKKDFPK QFDQVSVFKS
160 170 180 190 200
IRKDFSLVRE NSKETFSGKE KNRDLTYERE KRLDKPHKDL DSRLKSSFFD
210 220 230 240 250
KAANQVEETL HTHLPQTPET NFRDSSYPFA NKESIGSELG NSFASNIRIK
260 270 280 290 300
EEPLDDEYDK AMAPQQGLLD KIKDEPDNAQ EYSHGQQQKT QEGELKISAV
310 320 330 340 350
FSVSGSPLAP QLTTGFQPSL ASSGMNKMLP SVPATAVRVS CSGCKKILQK
360 370 380 390 400
GQTAYQRKGS TQLFCSTLCL TGYTVPPARP PPPLTKKTCS SCSKDILNPK
410 420 430 440 450
DVISAQFENT TTSKDFCSQS CLSTYELKKK PIVTINTNSI STKCSMCQKN
460 470 480 490 500
AVIRHEVNYQ NVVHKLCSDA CFSKFRSANN LTMNCCENCG GYCYSGSGQC
510 520 530 540 550
HMLQIEGQSK KFCSSSCITA YKQKSAKITP CALCKSLRSS AEMIENTNSL
560 570 580 590 600
GKTELFCSVN CLSAYRVKMV TSAGVQVQCN SCKTSAIPQY HLAMSDGSIR
610 620 630 640 650
NFCSYSCVVA FQNLFNKPTG MNSSVVPLSQ GQVIVSIPTG STVSAGGGST
660 670 680 690 700
SAVSPTSISS SAAAGLQRLA AQSQHVGFAR SVVKLKCQHC NRLFATKPEL
710 720 730 740 750
LDYKGKMFQF CGKNCSDEYK KINNVMAMCE YCKIEKIVKE TVRFSGADKS
760 770 780 790 800
FCSEGCKLLY KHDLAKRWGN HCKMCSYCLQ TSPKLVQNNL GGKVEEFCCE
810 820 830 840 850
ECMSKYTVLF YQMAKCDACK RQGKLSESLK WRGEMKHFCN LLCILMFCNQ
860 870 880 890 900
QSVCDPPSQN NAANISMVQA ASAGPPSLRK DSTPVIANVV SLASAPAAQP
910 920 930 940 950
TVNSNSVLQG AVPTVTAKII GDASTQTDAL KLPPSQPPRL LKNKALLCKP
960 970 980 990 1000
ITQTKATSCK PHTQNKECQT EDTPSQPQII VVPVPVPVFV PIPLHLYTQY
1010 1020 1030 1040 1050
APVPFGIPVP MPVPMLIPSS MDSEDKVTES IEDIKEKLPT HPFEADLLEM
1060 1070 1080 1090 1100
AEMIAEDEEK KTLSQGESQT SEHELFLDTK IFEKDQGSTY SGDLESEAVS
1110 1120 1130 1140 1150
TPHSWEEELN HYALKSNAVQ EADSELKQFS KGETEQDLEA DFPSDSFDPL
1160 1170 1180 1190 1200
NKGQGIQARS RTRRRHRDGF PQPRRRGRKK SIVAVEPRSL IQGAFQGCSV
1210 1220 1230 1240 1250
SGMTLKYMYG VNAWKNWVQW KNAKEEQGDL KCGGVEQASS SPRSDPLGST
1260 1270 1280 1290 1300
QDHALSQESS EPGCRVRSIK LKEDILSCTF AELSLGLCQF IQEVRRPNGE
1310 1320 1330 1340 1350
KYDPDSILYL CLGIQQYLFE NGRIDNIFTE PYSRFMIELT KLLKIWEPTI
1360 1370 1380 1390 1400
LPNGYMFSRI EEEHLWECKQ LGAYSPIVLL NTLLFFNTKY FQLKNVTEHL
1410 1420 1430 1440 1450
KLSFAHVMRR TRTLKYSTKM TYLRFFPPLQ KQESEPDKLT VGKRKRNEDD
1460 1470 1480 1490 1500
EVPVGVEMAE NTDNPLRCPV RLYEFYLSKC SESVKQRNDV FYLQPERSCV
1510 1520 1530 1540
PNSPMWYSTF PIDPGTLDTM LTRILMVREV HEELAKAKSE DSDVELSD
Length:1,548
Mass (Da):172,788
Last modified:December 7, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3B5B730EA9B9882B
GO
Isoform 2 (identifier: Q5VZL5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     524-612: Missing.

Note: Gene prediction based on EST data.
Show »
Length:1,459
Mass (Da):163,194
Checksum:iC03E97C233E69C62
GO
Isoform 3 (identifier: Q5VZL5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-324: Missing.

Note: No experimental confirmation available.
Show »
Length:1,224
Mass (Da):136,330
Checksum:i98D348234B1300DE
GO
Isoform 4 (identifier: Q5VZL5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-32: Missing.

Note: No experimental confirmation available.
Show »
Length:1,516
Mass (Da):169,237
Checksum:i707C9F213EEEEE91
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C1I7H7C1I7_HUMAN
Zinc finger MYM-type protein 4
ZMYM4
1,207Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MSN3A0A0A0MSN3_HUMAN
Zinc finger MYM-type protein 4
ZMYM4
98Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti279 – 280AQ → RT in BAA24855 (PubMed:9455477).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_034764452V → I1 PublicationCorresponds to variant dbSNP:rs34924462Ensembl.1
Natural variantiVAR_0356721410R → W in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs191217255Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0275121 – 324Missing in isoform 3. 1 PublicationAdd BLAST324
Alternative sequenceiVSP_0275131 – 32Missing in isoform 4. 1 PublicationAdd BLAST32
Alternative sequenceiVSP_027514524 – 612Missing in isoform 2. CuratedAdd BLAST89

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL160000 Genomic DNA No translation available.
AL356362 Genomic DNA No translation available.
AL590434 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07417.1
BC012093 mRNA Translation: AAH12093.2
BC127113 mRNA Translation: AAI27114.1
BC127114 mRNA Translation: AAI27115.1
AB007885 mRNA Translation: BAA24855.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS389.1 [Q5VZL5-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
T00059

NCBI Reference Sequences

More...
RefSeqi
NP_005086.2, NM_005095.2 [Q5VZL5-1]
XP_005271388.1, XM_005271331.2 [Q5VZL5-3]
XP_011540725.1, XM_011542423.2
XP_011540727.1, XM_011542425.2
XP_016858292.1, XM_017002803.1 [Q5VZL5-4]
XP_016858293.1, XM_017002804.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.269211

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000314607; ENSP00000322915; ENSG00000146463 [Q5VZL5-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
9202

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9202

UCSC genome browser

More...
UCSCi
uc001byt.3 human [Q5VZL5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL160000 Genomic DNA No translation available.
AL356362 Genomic DNA No translation available.
AL590434 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07417.1
BC012093 mRNA Translation: AAH12093.2
BC127113 mRNA Translation: AAI27114.1
BC127114 mRNA Translation: AAI27115.1
AB007885 mRNA Translation: BAA24855.2
CCDSiCCDS389.1 [Q5VZL5-1]
PIRiT00059
RefSeqiNP_005086.2, NM_005095.2 [Q5VZL5-1]
XP_005271388.1, XM_005271331.2 [Q5VZL5-3]
XP_011540725.1, XM_011542423.2
XP_011540727.1, XM_011542425.2
XP_016858292.1, XM_017002803.1 [Q5VZL5-4]
XP_016858293.1, XM_017002804.1
UniGeneiHs.269211

3D structure databases

ProteinModelPortaliQ5VZL5
SMRiQ5VZL5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114636, 68 interactors
IntActiQ5VZL5, 43 interactors
MINTiQ5VZL5
STRINGi9606.ENSP00000322915

PTM databases

iPTMnetiQ5VZL5
PhosphoSitePlusiQ5VZL5

Polymorphism and mutation databases

BioMutaiZMYM4
DMDMi74762280

Proteomic databases

EPDiQ5VZL5
jPOSTiQ5VZL5
MaxQBiQ5VZL5
PaxDbiQ5VZL5
PeptideAtlasiQ5VZL5
PRIDEiQ5VZL5
ProteomicsDBi65706
65707 [Q5VZL5-2]
65708 [Q5VZL5-3]
65709 [Q5VZL5-4]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
9202
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314607; ENSP00000322915; ENSG00000146463 [Q5VZL5-1]
GeneIDi9202
KEGGihsa:9202
UCSCiuc001byt.3 human [Q5VZL5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9202
DisGeNETi9202
EuPathDBiHostDB:ENSG00000146463.11

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ZMYM4
HGNCiHGNC:13055 ZMYM4
HPAiHPA051301
HPA054802
MIMi613568 gene
neXtProtiNX_Q5VZL5
OpenTargetsiENSG00000146463
PharmGKBiPA37633

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IE8I Eukaryota
ENOG410XQR6 LUCA
GeneTreeiENSGT00940000159550
HOVERGENiHBG106731
InParanoidiQ5VZL5
OMAiCNQQSMC
OrthoDBi587724at2759
PhylomeDBiQ5VZL5
TreeFamiTF336988

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ZMYM4 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
9202
PMAP-CutDBiQ5VZL5

Protein Ontology

More...
PROi
PR:Q5VZL5

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000146463 Expressed in 238 organ(s), highest expression level in kidney
ExpressionAtlasiQ5VZL5 baseline and differential
GenevisibleiQ5VZL5 HS

Family and domain databases

InterProiView protein in InterPro
IPR021893 DUF3504
IPR026625 TFII-I-rel
IPR011017 TRASH_dom
IPR010507 Znf_MYM
PANTHERiPTHR11697 PTHR11697, 1 hit
PfamiView protein in Pfam
PF12012 DUF3504, 1 hit
PF06467 zf-FCS, 5 hits
SMARTiView protein in SMART
SM00746 TRASH, 10 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZMYM4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5VZL5
Secondary accession number(s): A0JP19
, A0JP20, O43308, Q5T5E1, Q5T5E2, Q7L3Q4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: December 7, 2004
Last modified: February 13, 2019
This is version 130 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again