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Protein

N-alpha-acetyltransferase 35, NatC auxiliary subunit

Gene

NAA35

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues. Involved in regulation of apoptosis and proliferation of smooth muscle cells.1 Publication

GO - Molecular functioni

  • peptide alpha-N-acetyltransferase activity Source: GO_Central

GO - Biological processi

  • negative regulation of apoptotic process Source: UniProtKB
  • N-terminal protein amino acid acetylation Source: GO_Central
  • smooth muscle cell proliferation Source: UniProtKB

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000135040-MONOMER
ReactomeiR-HSA-6811440 Retrograde transport at the Trans-Golgi-Network

Names & Taxonomyi

Protein namesi
Recommended name:
N-alpha-acetyltransferase 35, NatC auxiliary subunit
Alternative name(s):
Embryonic growth-associated protein homolog
Protein MAK10 homolog
Gene namesi
Name:NAA35
Synonyms:EGAP, MAK10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000135040.15
HGNCiHGNC:24340 NAA35
neXtProtiNX_Q5VZE5

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi60560
OpenTargetsiENSG00000135040
PharmGKBiPA165585932

Polymorphism and mutation databases

BioMutaiNAA35
DMDMi74747795

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003086141 – 725N-alpha-acetyltransferase 35, NatC auxiliary subunitAdd BLAST725

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei187PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ5VZE5
MaxQBiQ5VZE5
PaxDbiQ5VZE5
PeptideAtlasiQ5VZE5
PRIDEiQ5VZE5
ProteomicsDBi65692

PTM databases

iPTMnetiQ5VZE5
PhosphoSitePlusiQ5VZE5

Expressioni

Gene expression databases

BgeeiENSG00000135040 Expressed in 223 organ(s), highest expression level in secondary oocyte
CleanExiHS_MAK10
GenevisibleiQ5VZE5 HS

Organism-specific databases

HPAiHPA021547
HPA051586

Interactioni

Subunit structurei

Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
NAA30Q147X32EBI-9106478,EBI-9106461

Protein-protein interaction databases

BioGridi121941, 9 interactors
IntActiQ5VZE5, 3 interactors
STRINGi9606.ENSP00000354972

Structurei

3D structure databases

ProteinModelPortaliQ5VZE5
SMRiQ5VZE5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MAK10 family.Curated

Phylogenomic databases

eggNOGiKOG2343 Eukaryota
ENOG410XS3T LUCA
GeneTreeiENSGT00390000002445
HOGENOMiHOG000068098
HOVERGENiHBG099871
InParanoidiQ5VZE5
KOiK20823
OMAiASYQFLE
OrthoDBiEOG091G06Y3
PhylomeDBiQ5VZE5
TreeFamiTF320627

Family and domain databases

InterProiView protein in InterPro
IPR007244 NatC_AcTrfase_Mak10
PANTHERiPTHR21373 PTHR21373, 1 hit
PfamiView protein in Pfam
PF04112 Mak10, 2 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q5VZE5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVMKASVDDD DSGWELSMPE KMEKSNTNWV DITQDFEEAC RELKLGELLH
60 70 80 90 100
DKLFGLFEAM SAIEMMDPKM DAGMIGNQVN RKVLNFEQAI KDGTIKIKDL
110 120 130 140 150
TLPELIGIMD TCFCCLITWL EGHSLAQTVF TCLYIHNPDF IEDPAMKAFA
160 170 180 190 200
LGILKICDIA REKVNKAAVF EEEDFQSMTY GFKMANSVTD LRVTGMLKDV
210 220 230 240 250
EDDMQRRVKS TRSRQGEERD PEVELEHQQC LAVFSRVKFT RVLLTVLIAF
260 270 280 290 300
TKKETSAVAE AQKLMVQAAD LLSAIHNSLH HGIQAQNDTT KGDHPIMMGF
310 320 330 340 350
EPLVNQRLLP PTFPRYAKII KREEMVNYFA RLIDRIKTVC EVVNLTNLHC
360 370 380 390 400
ILDFFCEFSE QSPCVLSRSL LQTTFLVDNK KVFGTHLMQD MVKDALRSFV
410 420 430 440 450
SPPVLSPKCY LYNNHQAKDC IDSFVTHCVR PFCSLIQIHG HNRARQRDKL
460 470 480 490 500
GHILEEFATL QDEAEKVDAA LHTMLLKQEP QRQHLACLGT WVLYHNLRIM
510 520 530 540 550
IQYLLSGFEL ELYSMHEYYY IYWYLSEFLY AWLMSTLSRA DGSQMAEERI
560 570 580 590 600
MEEQQKGRSS KKTKKKKKVR PLSREITMSQ AYQNMCAGMF KTMVAFDMDG
610 620 630 640 650
KVRKPKFELD SEQVRYEHRF APFNSVMTPP PVHYLQFKEM SDLNKYSPPP
660 670 680 690 700
QSPELYVAAS KHFQQAKMIL ENIPNPDHEV NRILKVAKPN FVVMKLLAGG
710 720
HKKESKVPPE FDFSAHKYFP VVKLV
Length:725
Mass (Da):83,639
Last modified:December 7, 2004 - v1
Checksum:iA5612BA0CE1BAE3F
GO
Isoform 2 (identifier: Q5VZE5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     293-294: DH → GL
     295-725: Missing.

Note: No experimental confirmation available.
Show »
Length:294
Mass (Da):33,165
Checksum:iD50F844F5309E00B
GO

Sequence cautioni

The sequence BAB15097 differs from that shown. Reason: Frameshift at position 518.Curated
The sequence BAB15435 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti229Q → R in BAB15097 (PubMed:14702039).Curated1
Sequence conflicti487C → W in BAB15097 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056098293 – 294DH → GL in isoform 2. 1 Publication2
Alternative sequenceiVSP_056099295 – 725Missing in isoform 2. 1 PublicationAdd BLAST431

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK025266 mRNA Translation: BAB15097.1 Frameshift.
AK026296 mRNA Translation: BAB15435.1 Different initiation.
AK056059 mRNA Translation: BAG51612.1
AL161447 Genomic DNA No translation available.
AL353743 Genomic DNA No translation available.
AL161453 Genomic DNA No translation available.
CH471089 Genomic DNA Translation: EAW62702.1
CH471089 Genomic DNA Translation: EAW62703.1
BC117427 mRNA Translation: AAI17428.1
BC117429 mRNA Translation: AAI17430.1
CCDSiCCDS6673.1 [Q5VZE5-1]
RefSeqiNP_001308810.1, NM_001321881.1 [Q5VZE5-1]
NP_001308811.1, NM_001321882.1 [Q5VZE5-1]
NP_078911.3, NM_024635.3 [Q5VZE5-1]
XP_005252184.1, XM_005252127.3 [Q5VZE5-1]
UniGeneiHs.436098
Hs.732442

Genome annotation databases

EnsembliENST00000361671; ENSP00000354972; ENSG00000135040 [Q5VZE5-1]
ENST00000376040; ENSP00000365208; ENSG00000135040 [Q5VZE5-2]
GeneIDi60560
KEGGihsa:60560
UCSCiuc004aoi.5 human [Q5VZE5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK025266 mRNA Translation: BAB15097.1 Frameshift.
AK026296 mRNA Translation: BAB15435.1 Different initiation.
AK056059 mRNA Translation: BAG51612.1
AL161447 Genomic DNA No translation available.
AL353743 Genomic DNA No translation available.
AL161453 Genomic DNA No translation available.
CH471089 Genomic DNA Translation: EAW62702.1
CH471089 Genomic DNA Translation: EAW62703.1
BC117427 mRNA Translation: AAI17428.1
BC117429 mRNA Translation: AAI17430.1
CCDSiCCDS6673.1 [Q5VZE5-1]
RefSeqiNP_001308810.1, NM_001321881.1 [Q5VZE5-1]
NP_001308811.1, NM_001321882.1 [Q5VZE5-1]
NP_078911.3, NM_024635.3 [Q5VZE5-1]
XP_005252184.1, XM_005252127.3 [Q5VZE5-1]
UniGeneiHs.436098
Hs.732442

3D structure databases

ProteinModelPortaliQ5VZE5
SMRiQ5VZE5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121941, 9 interactors
IntActiQ5VZE5, 3 interactors
STRINGi9606.ENSP00000354972

PTM databases

iPTMnetiQ5VZE5
PhosphoSitePlusiQ5VZE5

Polymorphism and mutation databases

BioMutaiNAA35
DMDMi74747795

Proteomic databases

EPDiQ5VZE5
MaxQBiQ5VZE5
PaxDbiQ5VZE5
PeptideAtlasiQ5VZE5
PRIDEiQ5VZE5
ProteomicsDBi65692

Protocols and materials databases

DNASUi60560
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361671; ENSP00000354972; ENSG00000135040 [Q5VZE5-1]
ENST00000376040; ENSP00000365208; ENSG00000135040 [Q5VZE5-2]
GeneIDi60560
KEGGihsa:60560
UCSCiuc004aoi.5 human [Q5VZE5-1]

Organism-specific databases

CTDi60560
DisGeNETi60560
EuPathDBiHostDB:ENSG00000135040.15
GeneCardsiNAA35
HGNCiHGNC:24340 NAA35
HPAiHPA021547
HPA051586
neXtProtiNX_Q5VZE5
OpenTargetsiENSG00000135040
PharmGKBiPA165585932
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2343 Eukaryota
ENOG410XS3T LUCA
GeneTreeiENSGT00390000002445
HOGENOMiHOG000068098
HOVERGENiHBG099871
InParanoidiQ5VZE5
KOiK20823
OMAiASYQFLE
OrthoDBiEOG091G06Y3
PhylomeDBiQ5VZE5
TreeFamiTF320627

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000135040-MONOMER
ReactomeiR-HSA-6811440 Retrograde transport at the Trans-Golgi-Network

Miscellaneous databases

ChiTaRSiNAA35 human
GenomeRNAii60560
PROiPR:Q5VZE5

Gene expression databases

BgeeiENSG00000135040 Expressed in 223 organ(s), highest expression level in secondary oocyte
CleanExiHS_MAK10
GenevisibleiQ5VZE5 HS

Family and domain databases

InterProiView protein in InterPro
IPR007244 NatC_AcTrfase_Mak10
PANTHERiPTHR21373 PTHR21373, 1 hit
PfamiView protein in Pfam
PF04112 Mak10, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiNAA35_HUMAN
AccessioniPrimary (citable) accession number: Q5VZE5
Secondary accession number(s): Q5VZE6, Q9H631, Q9H703
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: December 7, 2004
Last modified: November 7, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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