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Entry version 147 (12 Aug 2020)
Sequence version 3 (07 Jun 2017)
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Protein

DENN domain-containing protein 4C

Gene

DENND4C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor
Biological processProtein transport, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q5VZ89

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8876198, RAB GEFs exchange GTP for GDP on RABs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DENN domain-containing protein 4C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DENND4C
Synonyms:C9orf55, C9orf55B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000137145.20

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26079, DENND4C

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5VZ89

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoplasmic vesicle, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000137145

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134939495

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q5VZ89, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DENND4C

Domain mapping of disease mutations (DMDM)

More...
DMDMi
158937337

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000896971 – 1909DENN domain-containing protein 4CAdd BLAST1909

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei703PhosphoserineCombined sources1
Modified residuei737PhosphoserineCombined sources1
Modified residuei741PhosphoserineCombined sources1
Modified residuei965PhosphoserineCombined sources1
Modified residuei968PhosphoserineCombined sources1
Modified residuei973PhosphoserineCombined sources1
Modified residuei975PhosphothreonineCombined sources1
Modified residuei989PhosphoserineCombined sources1
Modified residuei996PhosphoserineCombined sources1
Modified residuei1003PhosphoserineCombined sources1
Modified residuei1046PhosphoserineCombined sources1
Modified residuei1061PhosphoserineCombined sources1
Modified residuei1099PhosphoserineCombined sources1
Modified residuei1126PhosphoserineCombined sources1
Modified residuei1184PhosphoserineCombined sources1
Modified residuei1225PhosphoserineCombined sources1
Modified residuei1244PhosphoserineCombined sources1
Modified residuei1252PhosphoserineBy similarity1
Modified residuei1278PhosphoserineCombined sources1
Modified residuei1325PhosphoserineCombined sources1
Modified residuei1337PhosphoserineCombined sources1
Modified residuei1346PhosphoserineCombined sources1
Modified residuei1623PhosphoserineCombined sources1
Modified residuei1627PhosphoserineCombined sources1
Modified residuei1629PhosphoserineCombined sources1
Modified residuei1640PhosphoserineBy similarity1
Modified residuei1799PhosphoserineCombined sources1
Isoform 2 (identifier: Q5VZ89-7)
Modified residuei953PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated in response to insulin.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q5VZ89

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q5VZ89

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q5VZ89

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q5VZ89

PeptideAtlas

More...
PeptideAtlasi
Q5VZ89

PRoteomics IDEntifications database

More...
PRIDEi
Q5VZ89

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
65680 [Q5VZ89-1]
65682 [Q5VZ89-3]
65684 [Q5VZ89-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5VZ89

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5VZ89

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000137145, Expressed in colon and 237 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q5VZ89, baseline and differential

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000137145, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
120799, 80 interactors

Protein interaction database and analysis system

More...
IntActi
Q5VZ89, 18 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000473565

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q5VZ89, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5VZ89

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini40 – 199MABPPROSITE-ProRule annotationAdd BLAST160
Domaini191 – 364uDENNPROSITE-ProRule annotationAdd BLAST174
Domaini385 – 521cDENNPROSITE-ProRule annotationAdd BLAST137
Domaini523 – 641dDENNPROSITE-ProRule annotationAdd BLAST119
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati821 – 855PPRAdd BLAST35

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2127, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158215

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5VZ89

KEGG Orthology (KO)

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KOi
K20163

Identification of Orthologs from Complete Genome Data

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OMAi
SQWPSDS

Database of Orthologous Groups

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OrthoDBi
75304at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5VZ89

TreeFam database of animal gene trees

More...
TreeFami
TF313237

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 1 hit
3.40.50.11500, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001194, cDENN_dom
IPR005112, dDENN_dom
IPR043153, DENN_C
IPR023341, MABP
IPR011990, TPR-like_helical_dom_sf
IPR037516, Tripartite_DENN
IPR005113, uDENN_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03455, dDENN, 1 hit
PF02141, DENN, 1 hit
PF03456, uDENN, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00801, dDENN, 1 hit
SM00799, DENN, 1 hit
SM00800, uDENN, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50211, DENN, 1 hit
PS51498, MABP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5VZ89-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MIEDKGPRVT DYFVVAGLTD TSTLLDQEIN RLDTKSTGPK APITDIAIII
60 70 80 90 100
KSAGETVPEG YTCVEATPSA LQANLNYGSL KSPELFLCYK RGRDKPPLTD
110 120 130 140 150
IGVLYEGKER LIPGCEVILA TPYGRCANVN NSSTTSQRIF ITYRRAPPVR
160 170 180 190 200
PQNSLAVTDI CVIVTSKGET PPHTFCKVDK NLNCGMWGSS VFLCYKKSVP
210 220 230 240 250
ASNAIAYKAG LIFRYPEEDY ESFPLSESDV PLFCLPMGAT IECWDPETKY
260 270 280 290 300
PLPVFSTFVL TGSSAKKVYG AAIQFYEPYS RELLSEKQLM HLGLLTPVER
310 320 330 340 350
KMVSKSINTN KCICLLSHWP FFEAFRKFLM FIYKLSVSGP HPLPIEKHIS
360 370 380 390 400
HFMQNIPFPS PQRPRILVQL SVHDALILSQ PVSTPLPLSG ANFSTLLMNL
410 420 430 440 450
GPENCATLLL FVLLESKILL HSLRPAVLTG VAEAVVAMIF PFQWQCPYIP
460 470 480 490 500
LCPLSLAAVL SAPLPFIVGV DSRYFDLHDP PQDVVCIDLD TNMLYVSDEK
510 520 530 540 550
KNMNWKQLPK KPCKNLLSTL KKLYPQLSSV HQKTQEGSAI DMTPIEADFS
560 570 580 590 600
WQKKMTQLEM EIQEAFLRFM ASILKGYRTY LRPITEAPSN KATAADSLFD
610 620 630 640 650
RQGFLKSRDR AYAKFYTLLS KTQIFIRFIE ECSFVSDKDT GLAFFDDCIE
660 670 680 690 700
KLFPDKGTEK TDKVDFDSAE DTRLIELDDS QKSEHTVFIM PPEPPPDDGK
710 720 730 740 750
DLSPKYSYKY FPRLDLKLFD RPQELKLCFS RHPTGNSITK SPPLMAKRTK
760 770 780 790 800
QEIKTAHKLA KRCYTNPPQW AKCLFSHCYS LWFICLPAYV RVSHPKVRAL
810 820 830 840 850
QQAYDVLIKM RKTDVDPLDE VCYRVVMQLC GLWGHPVLAV RVLFEMKTAR
860 870 880 890 900
IKPNAITYGY YNKVVLESPW PSSTRSGIFL WTKVRNVVRG LAQFRQPLKK
910 920 930 940 950
TVQRSQVSSI SGGQSDQGYG SKDELIKDDA EIHVPEEQAA RELITKTKMQ
960 970 980 990 1000
TEEVCDASAI VAKHSQPSPE PHSPTEPPAW GSSIVKVPSG IFDVNSRKSS
1010 1020 1030 1040 1050
TGSISNVLFS TQDPVEDAVF GEATNLKKNG DRGEKRQKHF PERSCSFSSE
1060 1070 1080 1090 1100
SRAGMLLKKS SLDSNSSEMA IMMGADAKIL TAALTCPKTS LLHIARTHSF
1110 1120 1130 1140 1150
ENVSCHLPDS RTCMSESTWN PEHRSSPVPE MLEESQELLE PVVDDVPKTT
1160 1170 1180 1190 1200
ATVDTYESLL SDSNSNQSRD LKTVSKDLRN KRSSLYGIAK VVQREDVETG
1210 1220 1230 1240 1250
LDPLSLLATE CTGGKTPDSE DKLFSPVIAR NLADEIESYM NLKSPLGSKS
1260 1270 1280 1290 1300
SSMELHREEN RESGMTTAFI HALERRSSLP LDHGSPAQEN PESEKSSPAV
1310 1320 1330 1340 1350
SRSKTFTGRF KQQTPSRTHK ERSTSLSALV RSSPHGSLGS VVNSLSGLKL
1360 1370 1380 1390 1400
DNILSGPKID VLKSGMKQAA TVASKMWVAV ASAYSYSDDE EETNRDYSFP
1410 1420 1430 1440 1450
AGLEDHILGE NISPNTSISG LVPSELTQSN TSLGSSSSSG DVGKLHYPTG
1460 1470 1480 1490 1500
EVPFPRGMKG QDFEKSDHGS SQNTSMSSIY QNCAMEVLMS SCSQCRACGA
1510 1520 1530 1540 1550
LVYDEEIMAG WTADDSNLNT ACPFCKSNFL PLLNIEFKDL RGSASFFLKP
1560 1570 1580 1590 1600
STSGDSLQSG SIPLANESLE HKPVSSLAEP DLINFMDFPK HNQIITEETG
1610 1620 1630 1640 1650
SAVEPSDEIK RASGDVQTMK ISSVPNSLSK RNVSLTRSHS VGGPLQNIDF
1660 1670 1680 1690 1700
TQRPFHGIST VSLPNSLQEV VDPLGKRPNP PPVSVPYLSP LVLRKELESL
1710 1720 1730 1740 1750
LENEGDQVIH TSSFINQHPI IFWNLVWYFR RLDLPSNLPG LILTSEHCNE
1760 1770 1780 1790 1800
GVQLPLSSLS QDSKLVYIQL LWDNINLHQE PREPLYVSWR NFNSEKKSSL
1810 1820 1830 1840 1850
LSEEQQETST LVETIRQSIQ HNNVLKPINL LSQQMKPGMK RQRSLYREIL
1860 1870 1880 1890 1900
FLSLVSLGRE NIDIEAFDNE YGIAYNSLSS EILERLQKID APPSASVEWC

RKCFGAPLI
Length:1,909
Mass (Da):212,711
Last modified:June 7, 2017 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3AB522323299D990
GO
Isoform 3 (identifier: Q5VZ89-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1844-1845: SL → GI
     1846-1909: Missing.

Show »
Length:1,845
Mass (Da):205,433
Checksum:iB901F629D17DAE00
GO
Isoform 5 (identifier: Q5VZ89-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1606-1623: SDEIKRASGDVQTMKISS → RYQRVQRPLYVVINGVPL
     1624-1909: Missing.

Show »
Length:1,623
Mass (Da):180,333
Checksum:iFB5FBDACEA776B2D
GO
Isoform 2 (identifier: Q5VZ89-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     911-911: S → SALQNVTGGSDGDTVSHGSVDSSNDANNGEHTVFVRDLIRLESIDNHSST

Show »
Length:1,958
Mass (Da):217,819
Checksum:iD8BDDDCA43A36BEC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
X6RAE7X6RAE7_HUMAN
DENN domain-containing protein 4C
DENND4C
881Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X6R5W5X6R5W5_HUMAN
DENN domain-containing protein 4C
DENND4C
696Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MRX3A0A0A0MRX3_HUMAN
DENN domain-containing protein 4C
DENND4C
353Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
R4GMN2R4GMN2_HUMAN
DENN domain-containing protein 4C
DENND4C
378Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA91294 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAA91478 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAA92039 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB15221 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAC86313 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence CAH10466 differs from that shown. Probable cloning artifact.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti683S → G in BAC86313 (PubMed:14702039).Curated1
Sequence conflicti1297S → P in BAA91294 (PubMed:14702039).Curated1
Sequence conflicti1656H → R in BAA91478 (PubMed:14702039).Curated1
Sequence conflicti1769Q → H in BAA92039 (PubMed:14702039).Curated1
Sequence conflicti1862I → V in CAH10466 (PubMed:17974005).Curated1
Sequence conflicti1868D → G in CAH10466 (PubMed:17974005).Curated1
Sequence conflicti1893P → A in CAD39177 (PubMed:17974005).Curated1
Sequence conflicti1897V → A in CAH10466 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0616401227V → G. Corresponds to variant dbSNP:rs34267952Ensembl.1
Natural variantiVAR_0228911266T → A. Corresponds to variant dbSNP:rs17818730Ensembl.1
Natural variantiVAR_0228921343N → H. Corresponds to variant dbSNP:rs6475322Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_027379911S → SALQNVTGGSDGDTVSHGSV DSSNDANNGEHTVFVRDLIR LESIDNHSST in isoform 2. Curated1
Alternative sequenceiVSP_0273821606 – 1623SDEIK…MKISS → RYQRVQRPLYVVINGVPL in isoform 5. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_0273831624 – 1909Missing in isoform 5. 1 PublicationAdd BLAST286
Alternative sequenceiVSP_0273841844 – 1845SL → GI in isoform 3. 1 Publication2
Alternative sequenceiVSP_0273861846 – 1909Missing in isoform 3. 1 PublicationAdd BLAST64

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL161909 Genomic DNA No translation available.
AL391834 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58645.1
AK000627 mRNA Translation: BAA91294.1 Different initiation.
AK001046 mRNA Translation: BAA91478.1 Different initiation.
AK002020 mRNA Translation: BAA92039.1 Different initiation.
AK025705 mRNA Translation: BAB15221.1 Different initiation.
AK125842 mRNA Translation: BAC86313.1 Different initiation.
AL834521 mRNA Translation: CAD39177.1
CR627367 mRNA Translation: CAH10466.1 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6491.3 [Q5VZ89-1]
CCDS83349.1 [Q5VZ89-7]

NCBI Reference Sequences

More...
RefSeqi
NP_001317569.1, NM_001330640.1 [Q5VZ89-7]
NP_060395.5, NM_017925.6 [Q5VZ89-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000434457; ENSP00000473469; ENSG00000137145 [Q5VZ89-7]
ENST00000602925; ENSP00000473565; ENSG00000137145 [Q5VZ89-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
55667

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:55667

UCSC genome browser

More...
UCSCi
uc031tcw.2, human

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL161909 Genomic DNA No translation available.
AL391834 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58645.1
AK000627 mRNA Translation: BAA91294.1 Different initiation.
AK001046 mRNA Translation: BAA91478.1 Different initiation.
AK002020 mRNA Translation: BAA92039.1 Different initiation.
AK025705 mRNA Translation: BAB15221.1 Different initiation.
AK125842 mRNA Translation: BAC86313.1 Different initiation.
AL834521 mRNA Translation: CAD39177.1
CR627367 mRNA Translation: CAH10466.1 Sequence problems.
CCDSiCCDS6491.3 [Q5VZ89-1]
CCDS83349.1 [Q5VZ89-7]
RefSeqiNP_001317569.1, NM_001330640.1 [Q5VZ89-7]
NP_060395.5, NM_017925.6 [Q5VZ89-1]

3D structure databases

SMRiQ5VZ89
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi120799, 80 interactors
IntActiQ5VZ89, 18 interactors
STRINGi9606.ENSP00000473565

PTM databases

iPTMnetiQ5VZ89
PhosphoSitePlusiQ5VZ89

Polymorphism and mutation databases

BioMutaiDENND4C
DMDMi158937337

Proteomic databases

EPDiQ5VZ89
jPOSTiQ5VZ89
MassIVEiQ5VZ89
PaxDbiQ5VZ89
PeptideAtlasiQ5VZ89
PRIDEiQ5VZ89
ProteomicsDBi65680 [Q5VZ89-1]
65682 [Q5VZ89-3]
65684 [Q5VZ89-5]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
10280, 81 antibodies

Genome annotation databases

EnsembliENST00000434457; ENSP00000473469; ENSG00000137145 [Q5VZ89-7]
ENST00000602925; ENSP00000473565; ENSG00000137145 [Q5VZ89-1]
GeneIDi55667
KEGGihsa:55667
UCSCiuc031tcw.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55667
EuPathDBiHostDB:ENSG00000137145.20

GeneCards: human genes, protein and diseases

More...
GeneCardsi
DENND4C
HGNCiHGNC:26079, DENND4C
HPAiENSG00000137145, Low tissue specificity
neXtProtiNX_Q5VZ89
OpenTargetsiENSG00000137145
PharmGKBiPA134939495

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2127, Eukaryota
GeneTreeiENSGT00940000158215
InParanoidiQ5VZ89
KOiK20163
OMAiSQWPSDS
OrthoDBi75304at2759
PhylomeDBiQ5VZ89
TreeFamiTF313237

Enzyme and pathway databases

PathwayCommonsiQ5VZ89
ReactomeiR-HSA-8876198, RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
55667, 8 hits in 872 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
DENND4C, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
55667
PharosiQ5VZ89, Tbio

Protein Ontology

More...
PROi
PR:Q5VZ89
RNActiQ5VZ89, protein

Gene expression databases

BgeeiENSG00000137145, Expressed in colon and 237 other tissues
ExpressionAtlasiQ5VZ89, baseline and differential

Family and domain databases

Gene3Di1.25.40.10, 1 hit
3.40.50.11500, 1 hit
InterProiView protein in InterPro
IPR001194, cDENN_dom
IPR005112, dDENN_dom
IPR043153, DENN_C
IPR023341, MABP
IPR011990, TPR-like_helical_dom_sf
IPR037516, Tripartite_DENN
IPR005113, uDENN_dom
PfamiView protein in Pfam
PF03455, dDENN, 1 hit
PF02141, DENN, 1 hit
PF03456, uDENN, 1 hit
SMARTiView protein in SMART
SM00801, dDENN, 1 hit
SM00799, DENN, 1 hit
SM00800, uDENN, 1 hit
PROSITEiView protein in PROSITE
PS50211, DENN, 1 hit
PS51498, MABP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDEN4C_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5VZ89
Secondary accession number(s): A2A3R1
, A2A3R2, A2A3R3, A2A3R9, Q6AI48, Q6ZUB3, Q8NCY7, Q9H6N4, Q9NUT1, Q9NWA5, Q9NWT3, R4GN35, R4GNB2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: June 7, 2017
Last modified: August 12, 2020
This is version 147 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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