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Protein

Janus kinase and microtubule-interacting protein 3

Gene

JAKMIP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Janus kinase and microtubule-interacting protein 3
Alternative name(s):
Neuroendocrine long coiled-coil protein 2
Gene namesi
Name:JAKMIP3
Synonyms:C10orf14, C10orf39, JAMIP3, NECC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000188385.11
HGNCiHGNC:23523 JAKMIP3
MIMi611198 gene
neXtProtiNX_Q5VZ66

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Golgi apparatus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000188385

Polymorphism and mutation databases

BioMutaiJAKMIP3
DMDMi172045962

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003230111 – 844Janus kinase and microtubule-interacting protein 3Add BLAST844

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei384PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ5VZ66
MaxQBiQ5VZ66
PaxDbiQ5VZ66
PeptideAtlasiQ5VZ66
PRIDEiQ5VZ66
ProteomicsDBi65673
65674 [Q5VZ66-2]

PTM databases

iPTMnetiQ5VZ66
PhosphoSitePlusiQ5VZ66

Expressioni

Tissue specificityi

Specifically expressed in the CNS and endocrine tissues. Also detected in other tissues including heart, testis and prostate.1 Publication

Gene expression databases

BgeeiENSG00000188385 Expressed in 107 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExiHS_JAKMIP3
GenevisibleiQ5VZ66 HS

Organism-specific databases

HPAiHPA022872

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9606.ENSP00000298622

Structurei

3D structure databases

ProteinModelPortaliQ5VZ66
SMRiQ5VZ66
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili8 – 258Sequence analysisAdd BLAST251
Coiled coili289 – 421Sequence analysisAdd BLAST133
Coiled coili493 – 621Sequence analysisAdd BLAST129
Coiled coili683 – 834Sequence analysisAdd BLAST152

Sequence similaritiesi

Belongs to the JAKMIP family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410II6X Eukaryota
ENOG4110F4A LUCA
GeneTreeiENSGT00390000002812
HOGENOMiHOG000060161
HOVERGENiHBG054249
InParanoidiQ5VZ66
OMAiEGQKRQI
OrthoDBiEOG091G024X
PhylomeDBiQ5VZ66
TreeFamiTF331900

Family and domain databases

InterProiView protein in InterPro
IPR024836 JAKMIP
IPR031994 JAKMIP_C
PANTHERiPTHR18935 PTHR18935, 1 hit
PfamiView protein in Pfam
PF16034 JAKMIP_CC3, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q5VZ66-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSKRGMSSRA KGDKAEALAA LQAANEDLRA KLTDIQIELQ QEKSKVSKVE
60 70 80 90 100
REKNQELRQV REHEQHKTAV LLTELKTKLH EEKMKELQAV RETLLRQHEA
110 120 130 140 150
ELLRVIKIKD NENQRLQALL SALRDGGPEK VKTVLLSEAK EEAKKGFEVE
160 170 180 190 200
KVKMQQEISE LKGAKRQVEE ALTLVIQADK IKAAEIRSVY HLHQEEITRI
210 220 230 240 250
KKECEREIRR LMEEIKFKDR AVFVLERELG VQAGHAQRLQ LQKEALDEQL
260 270 280 290 300
SQVREADRHP GSPRRELPHA AGAGDASDHS GSPEQQLDEK DARRFQLKIA
310 320 330 340 350
ELSAIIRKLE DRNALLSEER NELLKRVREA ESQYKPLLDK NKRLSRKNED
360 370 380 390 400
LSHALRRMEN KLKFVTQENI EMRQRAGIIR RPSSLNDLDQ SQDEREVDFL
410 420 430 440 450
KLQIVEQQNL IDELSKTLET AGYVKSVLER DKLLRFRKQR KKMAKLPKPV
460 470 480 490 500
VVETFFGYDE EASLESDGSS VSYQTDRTDQ TPCTPDDDLE EGMAKEETEL
510 520 530 540 550
RFRQLTMEYQ ALQRAYALLQ EQVGGTLDAE REVKTREQLQ AEVQRAQARI
560 570 580 590 600
EDLEKALAEQ GQDMKWIEEK QALYRRNQEL VEKIKQMETE EARLRHEVQD
610 620 630 640 650
ARDQNELLEF RILELEERER KSPAISFHHT PFVDGKSPLQ VYCEAEGVTD
660 670 680 690 700
IVVAELMKKL DILGDNANLT NEEQVVVIQA RTVLTLAEKW LQQIEETEAA
710 720 730 740 750
LQRKMVDLES EKELFSKQKG YLDEELDYRK QALDQANKHI LELEAMLYDA
760 770 780 790 800
LQQEAGAKVA ELLSEEEREK LKVAVEQWKR QVMSELRERD AQILRERMEL
810 820 830 840
LQLAQQRIKE LEERIEAQKR QIKELEEKFL FLFLFFSLAF ILWS
Note: No experimental confirmation available.
Length:844
Mass (Da):98,529
Last modified:August 21, 2007 - v2
Checksum:iCBB47F31B3E5BD27
GO
Isoform 2 (identifier: Q5VZ66-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-563: Missing.
     829-844: FLFLFLFFSLAFILWS → LSFSGHSPSW...KIFRNNRGLA

Note: No experimental confirmation available.
Show »
Length:425
Mass (Da):48,807
Checksum:i33E46BCEA9B72992
GO

Sequence cautioni

The sequence BAC86766 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAH10388 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAH10388 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_054016493M → V. Corresponds to variant dbSNP:rs11592585Ensembl.1
Natural variantiVAR_039473795R → G in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0319981 – 563Missing in isoform 2. 1 PublicationAdd BLAST563
Alternative sequenceiVSP_031999829 – 844FLFLF…FILWS → LSFSGHSPSWHPDVPHIESD PFPPVGPESRDKMGRRVSIL KTQGDLVSARPSRGGRVRRG SVWGVELPSTWDVPELELAL PTSRGLLRDRPGLGCWTLGP FSRTAAPIPFPGMCSIPCQA GVRTASVQKHQPRVPSSLLV LTVAATGVWRKIFRNNRGLA in isoform 2. 1 PublicationAdd BLAST16

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL832756 mRNA Translation: CAH10388.1 Sequence problems.
AL512622 Genomic DNA No translation available.
AL162274 Genomic DNA No translation available.
AK126964 mRNA Translation: BAC86766.1 Different initiation.
CCDSiCCDS44494.1 [Q5VZ66-1]
RefSeqiNP_001098991.1, NM_001105521.3 [Q5VZ66-1]
NP_001310019.1, NM_001323090.1 [Q5VZ66-1]
XP_016871585.1, XM_017016096.1 [Q5VZ66-1]
UniGeneiHs.106254

Genome annotation databases

EnsembliENST00000298622; ENSP00000298622; ENSG00000188385 [Q5VZ66-1]
GeneIDi282973
KEGGihsa:282973
UCSCiuc001lkx.5 human [Q5VZ66-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL832756 mRNA Translation: CAH10388.1 Sequence problems.
AL512622 Genomic DNA No translation available.
AL162274 Genomic DNA No translation available.
AK126964 mRNA Translation: BAC86766.1 Different initiation.
CCDSiCCDS44494.1 [Q5VZ66-1]
RefSeqiNP_001098991.1, NM_001105521.3 [Q5VZ66-1]
NP_001310019.1, NM_001323090.1 [Q5VZ66-1]
XP_016871585.1, XM_017016096.1 [Q5VZ66-1]
UniGeneiHs.106254

3D structure databases

ProteinModelPortaliQ5VZ66
SMRiQ5VZ66
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000298622

PTM databases

iPTMnetiQ5VZ66
PhosphoSitePlusiQ5VZ66

Polymorphism and mutation databases

BioMutaiJAKMIP3
DMDMi172045962

Proteomic databases

EPDiQ5VZ66
MaxQBiQ5VZ66
PaxDbiQ5VZ66
PeptideAtlasiQ5VZ66
PRIDEiQ5VZ66
ProteomicsDBi65673
65674 [Q5VZ66-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000298622; ENSP00000298622; ENSG00000188385 [Q5VZ66-1]
GeneIDi282973
KEGGihsa:282973
UCSCiuc001lkx.5 human [Q5VZ66-1]

Organism-specific databases

CTDi282973
EuPathDBiHostDB:ENSG00000188385.11
GeneCardsiJAKMIP3
HGNCiHGNC:23523 JAKMIP3
HPAiHPA022872
MIMi611198 gene
neXtProtiNX_Q5VZ66
OpenTargetsiENSG00000188385
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410II6X Eukaryota
ENOG4110F4A LUCA
GeneTreeiENSGT00390000002812
HOGENOMiHOG000060161
HOVERGENiHBG054249
InParanoidiQ5VZ66
OMAiEGQKRQI
OrthoDBiEOG091G024X
PhylomeDBiQ5VZ66
TreeFamiTF331900

Miscellaneous databases

ChiTaRSiJAKMIP3 human
GenomeRNAii282973
PROiPR:Q5VZ66
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000188385 Expressed in 107 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExiHS_JAKMIP3
GenevisibleiQ5VZ66 HS

Family and domain databases

InterProiView protein in InterPro
IPR024836 JAKMIP
IPR031994 JAKMIP_C
PANTHERiPTHR18935 PTHR18935, 1 hit
PfamiView protein in Pfam
PF16034 JAKMIP_CC3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiJKIP3_HUMAN
AccessioniPrimary (citable) accession number: Q5VZ66
Secondary accession number(s): A6PW00, Q69YM6, Q6ZT29
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: August 21, 2007
Last modified: September 12, 2018
This is version 100 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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