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Entry version 108 (07 Apr 2021)
Sequence version 3 (18 May 2010)
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Protein

Uncharacterized protein KIAA1614

Gene

KIAA1614

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • protein kinase C binding Source: GO_Central

GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q5VZ46

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Uncharacterized protein KIAA1614
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29327, KIAA1614

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5VZ46

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000135835.10

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
57710

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142671595

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q5VZ46, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KIAA1614

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296439321

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003136451 – 1190Uncharacterized protein KIAA1614Add BLAST1190

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5VZ46

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5VZ46

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q5VZ46

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5VZ46

PeptideAtlas

More...
PeptideAtlasi
Q5VZ46

PRoteomics IDEntifications database

More...
PRIDEi
Q5VZ46

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
65670 [Q5VZ46-1]
65671 [Q5VZ46-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5VZ46

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5VZ46

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000135835, Expressed in sural nerve and 121 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5VZ46, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5VZ46, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000135835, Group enriched (brain, retina)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
121734, 3 interactors

Protein interaction database and analysis system

More...
IntActi
Q5VZ46, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000356560

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q5VZ46, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi943 – 1081Ser-richAdd BLAST139

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3606, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000013003

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_010586_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5VZ46

Identification of Orthologs from Complete Genome Data

More...
OMAi
KQGVSPC

Database of Orthologous Groups

More...
OrthoDBi
561663at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5VZ46

TreeFam database of animal gene trees

More...
TreeFami
TF332517

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032756, DUF4685

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15737, DUF4685, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5VZ46-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEGTEAAAAK PAGGSPQGPK TGSGTASPVE GTSAVEWSGP EPQLDNGHPP
60 70 80 90 100
RPWPCPQENR TSSLMAPQPP RVWGVQLQGP SVLESKVRAL KEKMTVAKQG
110 120 130 140 150
VSPCSASQEW SSPKKPQCRR GKAGRAGTPS EGSFLPGAVV APRTQNLPDG
160 170 180 190 200
QLDGSINEEQ PARDGGPRLP RPPAPGREYC NRGSPWPPEA EWTLPDHDRG
210 220 230 240 250
PLLGPSSLQQ SPIHGVTPGR PGGPGHCNKI IHIPSPRTGR SYPFPDGVVT
260 270 280 290 300
EADLDSTSLT SEEVFVPRTA LLGERWRAGD LEALGAGSSV LSLSDRVERN
310 320 330 340 350
RLLLQEMLNV SGQSPRKVGT PAWTPSWDTA APERPVGDVD WASGTSLQDS
360 370 380 390 400
GQNRTVGPNP EPVLSPRHEE ATHLLQRARM KARTRPLRAS HDIVPTITQG
410 420 430 440 450
SRDGHRSPAR DPRTTPACRD SLQNGHTSDS SSGESSGGHR PRRGPSPSHV
460 470 480 490 500
RFEDESAREA EFRHLERLQQ RQRQVLSTVL QAADQGPLRS KPDLADYING
510 520 530 540 550
APRLRDAGQG TFHRLVGSLD RRGHPAPPAP GSERRCQACG SCIDDPRPAQ
560 570 580 590 600
GKAPPVPRTL QELQAACGME RVLGGLSSPL RLLPAEPRLH MEWIRETHIG
610 620 630 640 650
DTVCPAEVDS ALDSTDNSDN CRTDSEEAGT SQAGWACGRT QGSSPRLRLR
660 670 680 690 700
GSRPRGHRWS KKAEAELPWG LQAQQHLPRA DDVEVENEVK EGRGHTPEGT
710 720 730 740 750
LFLREDAKPP DLELKRVSLG PQWQPGPGLG SHQPHPLDSR TPCRTAYATT
760 770 780 790 800
APMTPESSGP GGQAQVTESH ESLEIVSPSS LQQSHAEPSA PHQAWQPTAS
810 820 830 840 850
LCPEGWAPTP PPSRKTTSPV SHRKAALAGL LRLGDQTEPV GIPRPPSRSA
860 870 880 890 900
VLRTCELPPS QTQPSRPQVR HPLLALSTNN CNNSAPRGLQ EPYGGAVHEG
910 920 930 940 950
RVERGPCSRE PEPPLENSRD GGPQGFLGSA DVATINSTGI TLSLSSEESE
960 970 980 990 1000
SSKESEGSLQ RTGSGSGGHV LSRASAGAGT GPGSPSAAPL DQNKKRSSSI
1010 1020 1030 1040 1050
ASTLGLKKLF SALGQSSRPK LGKSRSYSVE QLQPAPPGLT SQSRAPSLQS
1060 1070 1080 1090 1100
LHPVSPSHQR RKAASFQNLH SLLSSKGNRS SLYLVAGPGD HSAAGRPAKT
1110 1120 1130 1140 1150
SPRRALSVED VGAPSLARTV GRLVEVFPDG TSQLQLQRSP GGTFGFCVAS
1160 1170 1180 1190
GNGRPDSGMP SPLPQPHGWG GLSKQGRAFW LWSEAFLVFG
Length:1,190
Mass (Da):126,604
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7C76CC6A2C181E77
GO
Isoform 2 (identifier: Q5VZ46-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-379: Missing.

Show »
Length:811
Mass (Da):86,395
Checksum:i917DBA8F691DD549
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1W2PPL5A0A1W2PPL5_HUMAN
Uncharacterized protein KIAA1614
KIAA1614
199Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PNT5A0A1W2PNT5_HUMAN
Uncharacterized protein KIAA1614
KIAA1614
222Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB13440 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti574G → D in AK090668 (PubMed:14702039).Curated1
Sequence conflicti1157S → L in AK090668 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06311864L → P1 PublicationCorresponds to variant dbSNP:rs10732273Ensembl.1
Natural variantiVAR_037682214H → Y. Corresponds to variant dbSNP:rs3747959Ensembl.1
Natural variantiVAR_037683740R → W. Corresponds to variant dbSNP:rs17302207Ensembl.1
Natural variantiVAR_037684801L → F2 PublicationsCorresponds to variant dbSNP:rs3795504Ensembl.1
Natural variantiVAR_0376851078N → D2 PublicationsCorresponds to variant dbSNP:rs2331995Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0300811 – 379Missing in isoform 2. 1 PublicationAdd BLAST379

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB046834 mRNA Translation: BAB13440.1 Different initiation.
AK090668 mRNA No translation available.
AL162431 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS41442.1 [Q5VZ46-1]

NCBI Reference Sequences

More...
RefSeqi
NP_066001.1, NM_020950.1 [Q5VZ46-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000367587; ENSP00000356559; ENSG00000135835 [Q5VZ46-2]
ENST00000367588; ENSP00000356560; ENSG00000135835 [Q5VZ46-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
57710

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:57710

UCSC genome browser

More...
UCSCi
uc001gok.3, human [Q5VZ46-1]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046834 mRNA Translation: BAB13440.1 Different initiation.
AK090668 mRNA No translation available.
AL162431 Genomic DNA No translation available.
CCDSiCCDS41442.1 [Q5VZ46-1]
RefSeqiNP_066001.1, NM_020950.1 [Q5VZ46-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi121734, 3 interactors
IntActiQ5VZ46, 2 interactors
STRINGi9606.ENSP00000356560

PTM databases

iPTMnetiQ5VZ46
PhosphoSitePlusiQ5VZ46

Genetic variation databases

BioMutaiKIAA1614
DMDMi296439321

Proteomic databases

EPDiQ5VZ46
jPOSTiQ5VZ46
MassIVEiQ5VZ46
PaxDbiQ5VZ46
PeptideAtlasiQ5VZ46
PRIDEiQ5VZ46
ProteomicsDBi65670 [Q5VZ46-1]
65671 [Q5VZ46-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
34429, 29 antibodies

Genome annotation databases

EnsembliENST00000367587; ENSP00000356559; ENSG00000135835 [Q5VZ46-2]
ENST00000367588; ENSP00000356560; ENSG00000135835 [Q5VZ46-1]
GeneIDi57710
KEGGihsa:57710
UCSCiuc001gok.3, human [Q5VZ46-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57710
DisGeNETi57710

GeneCards: human genes, protein and diseases

More...
GeneCardsi
KIAA1614
HGNCiHGNC:29327, KIAA1614
HPAiENSG00000135835, Group enriched (brain, retina)
neXtProtiNX_Q5VZ46
PharmGKBiPA142671595
VEuPathDBiHostDB:ENSG00000135835.10

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3606, Eukaryota
GeneTreeiENSGT00390000013003
HOGENOMiCLU_010586_0_0_1
InParanoidiQ5VZ46
OMAiKQGVSPC
OrthoDBi561663at2759
PhylomeDBiQ5VZ46
TreeFamiTF332517

Enzyme and pathway databases

PathwayCommonsiQ5VZ46

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
57710, 25 hits in 990 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
KIAA1614, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
57710
PharosiQ5VZ46, Tdark

Protein Ontology

More...
PROi
PR:Q5VZ46
RNActiQ5VZ46, protein

Gene expression databases

BgeeiENSG00000135835, Expressed in sural nerve and 121 other tissues
ExpressionAtlasiQ5VZ46, baseline and differential
GenevisibleiQ5VZ46, HS

Family and domain databases

InterProiView protein in InterPro
IPR032756, DUF4685
PfamiView protein in Pfam
PF15737, DUF4685, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiK1614_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5VZ46
Secondary accession number(s): Q5VZ45, Q9HCF8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 18, 2010
Last modified: April 7, 2021
This is version 108 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
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