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Protein

SH2 domain-containing adapter protein E

Gene

SHE

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

SignaLinkiQ5VZ18

Names & Taxonomyi

Protein namesi
Recommended name:
SH2 domain-containing adapter protein E
Gene namesi
Name:SHE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000169291.9
HGNCiHGNC:27004 SHE
MIMi610482 gene
neXtProtiNX_Q5VZ18

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000169291
PharmGKBiPA142670919

Polymorphism and mutation databases

BioMutaiSHE
DMDMi74747744

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002467751 – 495SH2 domain-containing adapter protein EAdd BLAST495

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei107PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5VZ18
PeptideAtlasiQ5VZ18
PRIDEiQ5VZ18
ProteomicsDBi65663

PTM databases

iPTMnetiQ5VZ18
PhosphoSitePlusiQ5VZ18

Expressioni

Gene expression databases

BgeeiENSG00000169291
CleanExiHS_SHE
ExpressionAtlasiQ5VZ18 baseline and differential
GenevisibleiQ5VZ18 HS

Organism-specific databases

HPAiHPA037417

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ARP102753EBI-3956977,EBI-608057

GO - Molecular functioni

Protein-protein interaction databases

BioGridi126009, 3 interactors
IntActiQ5VZ18, 5 interactors

Structurei

3D structure databases

ProteinModelPortaliQ5VZ18
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini395 – 490SH2PROSITE-ProRule annotationAdd BLAST96

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi159 – 181Ser-richAdd BLAST23

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiENOG410IGWI Eukaryota
ENOG410XQJ2 LUCA
GeneTreeiENSGT00390000015203
HOGENOMiHOG000038038
HOVERGENiHBG066172
InParanoidiQ5VZ18
OMAiPEVVHYY
OrthoDBiEOG091G0I06
PhylomeDBiQ5VZ18
TreeFamiTF325799

Family and domain databases

CDDicd10391 SH2_SHE, 1 hit
Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR035041 SHE
IPR035042 SHE_SH2
PANTHERiPTHR15127:SF29 PTHR15127:SF29, 1 hit
PfamiView protein in Pfam
PF00017 SH2, 1 hit
PRINTSiPR00401 SH2DOMAIN
SMARTiView protein in SMART
SM00252 SH2, 1 hit
SUPFAMiSSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001 SH2, 1 hit

Sequencei

Sequence statusi: Complete.

Q5VZ18-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQWSPTPGAS ACLGWASSLA CSTAPTLLGR AGRGPLMAAK WFKEFPLNLK
60 70 80 90 100
TVSERAKPGG GGGKLRKNSE AGGAGPGPGK GRKNSAAELG SGRAGVGPKD
110 120 130 140 150
SRLSRDSLQG LIQAAAGKGR KNSRATEEEP HRGATKSSGC STYINRLIKV
160 170 180 190 200
DTQEKNGKSN YPSSSSSSSS SSSSASSSPS SLGPELDKGK IIKQQETVII
210 220 230 240 250
LEDYADPYDA KRTKGQRDAE RVGENDGYME PYDAQQMITE IRRRGSKDPL
260 270 280 290 300
VKALQLLDSP CEPADGGLKS ETLAKRRSSK DLLGKPPQLY DTPYEPAEGG
310 320 330 340 350
PRAEGKARPP DSRLPENDER PAAEYEQPWE WKKEQIVRAL SVQFEGAERP
360 370 380 390 400
SFREETVRQH HRQKSWTQKI LKPALSDHSE GEKVDPGLPL EKQPWYHGAI
410 420 430 440 450
SRAEAESRLQ PCKEAGYLVR NSESGNSRYS IALKTSQGCV HIIVAQTKDN
460 470 480 490
KYTLNQTSAV FDSIPEVVHY YSNEKLPFKG AEHMTLLYPV HSKLH
Length:495
Mass (Da):53,950
Last modified:December 7, 2004 - v1
Checksum:i7E1E3D9645B00536
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL162591 Genomic DNA No translation available.
BC117210 mRNA Translation: AAI17211.1
AK074067 mRNA Translation: BAB84893.1
CCDSiCCDS30877.1
RefSeqiNP_001010846.1, NM_001010846.2
XP_011507465.1, XM_011509163.2
UniGeneiHs.591481

Genome annotation databases

EnsembliENST00000304760; ENSP00000307369; ENSG00000169291
GeneIDi126669
KEGGihsa:126669
UCSCiuc001ffb.4 human

Similar proteinsi

Entry informationi

Entry nameiSHE_HUMAN
AccessioniPrimary (citable) accession number: Q5VZ18
Secondary accession number(s): Q8TEQ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: December 7, 2004
Last modified: June 20, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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