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Protein

Ankyrin repeat domain-containing protein 22

Gene

ANKRD22

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 22
Gene namesi
Name:ANKRD22
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000152766.5
HGNCiHGNC:28321 ANKRD22
neXtProtiNX_Q5VYY1

Pathology & Biotechi

Organism-specific databases

DisGeNETi118932
OpenTargetsiENSG00000152766
PharmGKBiPA134954600

Polymorphism and mutation databases

BioMutaiANKRD22
DMDMi74747727

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002408381 – 191Ankyrin repeat domain-containing protein 22Add BLAST191

Proteomic databases

EPDiQ5VYY1
MaxQBiQ5VYY1
PaxDbiQ5VYY1
PeptideAtlasiQ5VYY1
PRIDEiQ5VYY1
ProteomicsDBi65657

PTM databases

iPTMnetiQ5VYY1
PhosphoSitePlusiQ5VYY1

Expressioni

Gene expression databases

BgeeiENSG00000152766
CleanExiHS_ANKRD22
GenevisibleiQ5VYY1 HS

Organism-specific databases

HPAiHPA012922

Interactioni

Protein-protein interaction databases

BioGridi125627, 14 interactors
STRINGi9606.ENSP00000360998

Structurei

3D structure databases

ProteinModelPortaliQ5VYY1
SMRiQ5VYY1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati39 – 68ANK 1Add BLAST30
Repeati72 – 100ANK 2Add BLAST29
Repeati101 – 130ANK 3Add BLAST30
Repeati134 – 163ANK 4Add BLAST30

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00390000009005
HOGENOMiHOG000033955
HOVERGENiHBG059313
InParanoidiQ5VYY1
OMAiRFTFFDY
OrthoDBiEOG091G0N93
PhylomeDBiQ5VYY1
TreeFamiTF332383

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 2 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 3 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 2 hits

Sequencei

Sequence statusi: Complete.

Q5VYY1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGILYSEPIC QAAYQNDFGQ VWRWVKEDSS YANVQDGFNG DTPLICACRR
60 70 80 90 100
GHVRIVSFLL RRNANVNLKN QKERTCLHYA VKKKFTFIDY LLIILLMPVL
110 120 130 140 150
LIGYFLMVSK TKQNEALVRM LLDAGVEVNA TDCYGCTALH YACEMKNQSL
160 170 180 190
IPLLLEARAD PTIKNKHGES SLDIARRLKF SQIELMLRKA L
Length:191
Mass (Da):21,849
Last modified:December 7, 2004 - v1
Checksum:i6F997DAEDB97161D
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02762873E → G1 PublicationCorresponds to variant dbSNP:rs17113412Ensembl.1
Natural variantiVAR_02762979Y → H1 PublicationCorresponds to variant dbSNP:rs17851907Ensembl.1
Natural variantiVAR_027630148Q → P1 PublicationCorresponds to variant dbSNP:rs2304804Ensembl.1
Natural variantiVAR_027631177R → I1 PublicationCorresponds to variant dbSNP:rs7912706Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK313969 mRNA Translation: BAG36684.1
AL353113 Genomic DNA No translation available.
AL157394 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW50159.1
BC021671 mRNA Translation: AAH21671.1
CCDSiCCDS7390.1
RefSeqiNP_653191.2, NM_144590.2
UniGeneiHs.217484

Genome annotation databases

EnsembliENST00000371930; ENSP00000360998; ENSG00000152766
GeneIDi118932
KEGGihsa:118932
UCSCiuc001kfj.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiANR22_HUMAN
AccessioniPrimary (citable) accession number: Q5VYY1
Secondary accession number(s): B2R9Y7, Q8WU06
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: December 7, 2004
Last modified: June 20, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

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