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Protein

Renalase

Gene

RNLS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the oxidation of the less abundant 1,2-dihydro-beta-NAD(P) and 1,6-dihydro-beta-NAD(P) to form beta-NAD(P)+. The enzyme hormone is secreted by the kidney, and circulates in blood and modulates cardiac function and systemic blood pressure. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis.3 Publications

Catalytic activityi

1,2-dihydro-beta-NAD(P) + H+ + O2 = beta-NAD(P)+ + H2O2.2 Publications
1,6-dihydro-beta-NAD(P) + H+ + O2 = beta-NAD(P)+ + H2O2.2 Publications

Cofactori

FAD1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei12FAD1
Binding sitei42FAD1

GO - Molecular functioni

  • epinephrine binding Source: UniProtKB
  • monoamine oxidase activity Source: UniProtKB
  • NADH binding Source: UniProtKB
  • oxidoreductase activity, acting on NAD(P)H Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein, NAD, NADP

Enzyme and pathway databases

BioCyciMetaCyc:G66-32717-MONOMER
BRENDAi1.6.3.5 2681
ReactomeiR-HSA-197264 Nicotinamide salvaging

Names & Taxonomyi

Protein namesi
Recommended name:
Renalase1 Publication (EC:1.6.3.52 Publications)
Alternative name(s):
Monoamine oxidase-C
Short name:
MAO-C
Gene namesi
Name:RNLS
Synonyms:C10orf59
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000184719.11
HGNCiHGNC:25641 RNLS
MIMi609360 gene
neXtProtiNX_Q5VYX0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi55328
OpenTargetsiENSG00000184719
PharmGKBiPA165549084

Polymorphism and mutation databases

BioMutaiRNLS
DMDMi73914006

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000001958818 – 342RenalaseAdd BLAST325

Proteomic databases

PaxDbiQ5VYX0
PeptideAtlasiQ5VYX0
PRIDEiQ5VYX0
ProteomicsDBi65655
65656 [Q5VYX0-2]

PTM databases

iPTMnetiQ5VYX0
PhosphoSitePlusiQ5VYX0

Expressioni

Tissue specificityi

Secreted into the blood by the kidney. Highly expressed in the kidney, expressed at lower level in heart, skeletal muscle and small intestine. Its plasma concentration is markedly reduced in patients with end-stage renal disease, as compared with healthy subjects.1 Publication

Gene expression databases

BgeeiENSG00000184719 Expressed in 180 organ(s), highest expression level in buccal mucosa cell
CleanExiHS_C10orf59
ExpressionAtlasiQ5VYX0 baseline and differential
GenevisibleiQ5VYX0 HS

Interactioni

Protein-protein interaction databases

BioGridi120609, 2 interactors
IntActiQ5VYX0, 1 interactor

Structurei

Secondary structure

1342
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ5VYX0
SMRiQ5VYX0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni61 – 62FAD-binding2

Sequence similaritiesi

Belongs to the renalase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IE15 Eukaryota
ENOG410XV8B LUCA
GeneTreeiENSGT00390000016052
HOGENOMiHOG000007721
InParanoidiQ5VYX0
KOiK18208
OMAiGQMTLHH
OrthoDBiEOG091G0AJR
PhylomeDBiQ5VYX0
TreeFamiTF332799

Family and domain databases

Gene3Di3.50.50.60, 3 hits
InterProiView protein in InterPro
IPR002937 Amino_oxidase
IPR036188 FAD/NAD-bd_sf
PfamiView protein in Pfam
PF01593 Amino_oxidase, 1 hit
SUPFAMiSSF51905 SSF51905, 2 hits

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5VYX0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAQVLIVGAG MTGSLCAALL RRQTSGPLYL AVWDKAEDSG GRMTTACSPH
60 70 80 90 100
NPQCTADLGA QYITCTPHYA KKHQRFYDEL LAYGVLRPLS SPIEGMVMKE
110 120 130 140 150
GDCNFVAPQG ISSIIKHYLK ESGAEVYFRH RVTQINLRDD KWEVSKQTGS
160 170 180 190 200
PEQFDLIVLT MPVPEILQLQ GDITTLISEC QRQQLEAVSY SSRYALGLFY
210 220 230 240 250
EAGTKIDVPW AGQYITSNPC IRFVSIDNKK RNIESSEIGP SLVIHTTVPF
260 270 280 290 300
GVTYLEHSIE DVQELVFQQL ENILPGLPQP IATKCQKWRH SQVTNAAANC
310 320 330 340
PGQMTLHHKP FLACGGDGFT QSNFDGCITS ALCVLEALKN YI
Length:342
Mass (Da):37,847
Last modified:December 7, 2004 - v1
Checksum:i952827FF7926AF48
GO
Isoform 2 (identifier: Q5VYX0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     294-315: TNAAANCPGQMTLHHKPFLACG → PSAGVILGCAKSPWMMAIGFPI
     316-342: Missing.

Note: No experimental confirmation available.
Show »
Length:315
Mass (Da):34,949
Checksum:i8C1EBF93073E4690
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6XA08F6XA08_HUMAN
Renalase
RNLS
175Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02331037E → D1 PublicationCorresponds to variant dbSNP:rs2296545Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_015211294 – 315TNAAA…FLACG → PSAGVILGCAKSPWMMAIGF PI in isoform 2. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_015212316 – 342Missing in isoform 2. 1 PublicationAdd BLAST27

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002080 mRNA Translation: BAA92073.1
AL353149 Genomic DNA No translation available.
AL365185 Genomic DNA No translation available.
AL139406 Genomic DNA No translation available.
BC005364 mRNA Translation: AAH05364.1
CCDSiCCDS31239.1 [Q5VYX0-1]
CCDS7388.1 [Q5VYX0-2]
RefSeqiNP_001026879.2, NM_001031709.2 [Q5VYX0-1]
NP_060833.1, NM_018363.3 [Q5VYX0-2]
XP_011538226.1, XM_011539924.2 [Q5VYX0-2]
XP_016871869.1, XM_017016380.1 [Q5VYX0-2]
UniGeneiHs.149849

Genome annotation databases

EnsembliENST00000331772; ENSP00000332530; ENSG00000184719 [Q5VYX0-1]
ENST00000371947; ENSP00000361015; ENSG00000184719 [Q5VYX0-2]
GeneIDi55328
KEGGihsa:55328
UCSCiuc001kfd.3 human [Q5VYX0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002080 mRNA Translation: BAA92073.1
AL353149 Genomic DNA No translation available.
AL365185 Genomic DNA No translation available.
AL139406 Genomic DNA No translation available.
BC005364 mRNA Translation: AAH05364.1
CCDSiCCDS31239.1 [Q5VYX0-1]
CCDS7388.1 [Q5VYX0-2]
RefSeqiNP_001026879.2, NM_001031709.2 [Q5VYX0-1]
NP_060833.1, NM_018363.3 [Q5VYX0-2]
XP_011538226.1, XM_011539924.2 [Q5VYX0-2]
XP_016871869.1, XM_017016380.1 [Q5VYX0-2]
UniGeneiHs.149849

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3QJ4X-ray2.50A/B1-342[»]
ProteinModelPortaliQ5VYX0
SMRiQ5VYX0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120609, 2 interactors
IntActiQ5VYX0, 1 interactor

PTM databases

iPTMnetiQ5VYX0
PhosphoSitePlusiQ5VYX0

Polymorphism and mutation databases

BioMutaiRNLS
DMDMi73914006

Proteomic databases

PaxDbiQ5VYX0
PeptideAtlasiQ5VYX0
PRIDEiQ5VYX0
ProteomicsDBi65655
65656 [Q5VYX0-2]

Protocols and materials databases

DNASUi55328
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000331772; ENSP00000332530; ENSG00000184719 [Q5VYX0-1]
ENST00000371947; ENSP00000361015; ENSG00000184719 [Q5VYX0-2]
GeneIDi55328
KEGGihsa:55328
UCSCiuc001kfd.3 human [Q5VYX0-1]

Organism-specific databases

CTDi55328
DisGeNETi55328
EuPathDBiHostDB:ENSG00000184719.11
GeneCardsiRNLS
HGNCiHGNC:25641 RNLS
MIMi609360 gene
neXtProtiNX_Q5VYX0
OpenTargetsiENSG00000184719
PharmGKBiPA165549084
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE15 Eukaryota
ENOG410XV8B LUCA
GeneTreeiENSGT00390000016052
HOGENOMiHOG000007721
InParanoidiQ5VYX0
KOiK18208
OMAiGQMTLHH
OrthoDBiEOG091G0AJR
PhylomeDBiQ5VYX0
TreeFamiTF332799

Enzyme and pathway databases

BioCyciMetaCyc:G66-32717-MONOMER
BRENDAi1.6.3.5 2681
ReactomeiR-HSA-197264 Nicotinamide salvaging

Miscellaneous databases

ChiTaRSiRNLS human
GeneWikiiRenalase
GenomeRNAii55328
PROiPR:Q5VYX0
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000184719 Expressed in 180 organ(s), highest expression level in buccal mucosa cell
CleanExiHS_C10orf59
ExpressionAtlasiQ5VYX0 baseline and differential
GenevisibleiQ5VYX0 HS

Family and domain databases

Gene3Di3.50.50.60, 3 hits
InterProiView protein in InterPro
IPR002937 Amino_oxidase
IPR036188 FAD/NAD-bd_sf
PfamiView protein in Pfam
PF01593 Amino_oxidase, 1 hit
SUPFAMiSSF51905 SSF51905, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiRNLS_HUMAN
AccessioniPrimary (citable) accession number: Q5VYX0
Secondary accession number(s): Q9BS33, Q9NUP8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: December 7, 2004
Last modified: September 12, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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