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Protein

Protein SLX4IP

Gene

SLX4IP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SLX4IP
Alternative name(s):
SLX4-interacting protein
Gene namesi
Name:SLX4IP
Synonyms:C20orf94
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000149346.14
HGNCiHGNC:16225 SLX4IP
MIMi615958 gene
neXtProtiNX_Q5VYV7

Pathology & Biotechi

Involvement in diseasei

Chromosomal aberrations involving SLX4IP are found in acute lymphoblastic leukemia. A site-specific deletion within the 5' region of SLX4IP is found in 30% of childhood acute lymphoblastic leukemia in general and more than 60% of ETV6/RUNX1-rearranged acute lymphoblastic leukemia. Breakpoints within SLX4IP reveal junctions with typical characteristics of illegitimate V(D)J mediated recombination. SLX4IP deletions are significantly associated with male gender and ETV6/RUNX1-rearranged acute lymphoblastic leukemia.1 Publication

Organism-specific databases

DisGeNETi128710
OpenTargetsiENSG00000149346
PharmGKBiPA25801

Polymorphism and mutation databases

BioMutaiSLX4IP
DMDMi74747720

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003061191 – 408Protein SLX4IPAdd BLAST408

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki61Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki79Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei130PhosphoserineCombined sources1
Cross-linki167Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki176Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei213PhosphoserineCombined sources1
Cross-linki239Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki242Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki256Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki291Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki347Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki356Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki372Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei392PhosphothreonineCombined sources1
Cross-linki399Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ5VYV7
MaxQBiQ5VYV7
PaxDbiQ5VYV7
PeptideAtlasiQ5VYV7
PRIDEiQ5VYV7
ProteomicsDBi65652

PTM databases

iPTMnetiQ5VYV7
PhosphoSitePlusiQ5VYV7

Expressioni

Gene expression databases

BgeeiENSG00000149346 Expressed in 194 organ(s), highest expression level in caput epididymis
CleanExiHS_C20orf94
ExpressionAtlasiQ5VYV7 baseline and differential
GenevisibleiQ5VYV7 HS

Organism-specific databases

HPAiHPA046372

Interactioni

Subunit structurei

Interacts with SLX4/BTBD12; subunit of different structure-specific endonucleases.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SLX4Q8IY924EBI-2370881,EBI-2370740

Protein-protein interaction databases

BioGridi126147, 22 interactors
IntActiQ5VYV7, 22 interactors
STRINGi9606.ENSP00000335557

Structurei

3D structure databases

ProteinModelPortaliQ5VYV7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SLX4IP family.Curated

Phylogenomic databases

eggNOGiENOG410IK12 Eukaryota
ENOG4111ZEV LUCA
GeneTreeiENSGT00390000016400
HOGENOMiHOG000112024
HOVERGENiHBG094893
InParanoidiQ5VYV7
OMAiQKRRNCS
OrthoDBiEOG091G07FA
PhylomeDBiQ5VYV7
TreeFamiTF330769

Family and domain databases

InterProiView protein in InterPro
IPR031479 SLX4IP
PANTHERiPTHR28557 PTHR28557, 1 hit
PfamiView protein in Pfam
PF15744 UPF0492, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q5VYV7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASKKFAVKC GNFAVLVDLH ILPQGSNKDT SWFSEQKKEE VCLLLKETID
60 70 80 90 100
SRVQEYLEVR KQHRPSNAEF TRSNPLSLKG YGFQITAYFL KRGIRLRCIR
110 120 130 140 150
STQNAELCVF PDRFVVCVSQ LAFSRDLLAS QNEDLTERVL HGVSDYFAEC
160 170 180 190 200
AESSLPPSAK LRRNALKEIV KRTETKSSVT SKSQTRRDTV ETSSDSVIAE
210 220 230 240 250
IARRRNDGQA SSSPPSESMG QAKDSIKAAE SHWGLPVQKL EKVNQTQPED
260 270 280 290 300
TSGQQKPHPG ERLKTGLLSR SPVCSCESAS PCPKQSPRVA KTQQKRRNCS
310 320 330 340 350
SAEDFDHHGR VSLGSDRLVP REIIVEKSKA VRVLPASELS DPGLLLKQDL
360 370 380 390 400
AKTTSKEELH VLESLSSRHL MKNNPGQAQQ TGLATNTERL STIQNSPTKK

RKKYERGH
Length:408
Mass (Da):45,552
Last modified:December 7, 2004 - v1
Checksum:i4CBC9DF90E3B14E9
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YD23H0YD23_HUMAN
Protein SLX4IP
SLX4IP
78Annotation score:

Sequence cautioni

The sequence AAH20787 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH26094 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035277317R → Q. Corresponds to variant dbSNP:rs6077853Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL133340 Genomic DNA No translation available.
AL353599 Genomic DNA No translation available.
AL035456 Genomic DNA No translation available.
BC020787 mRNA Translation: AAH20787.1 Sequence problems.
BC026094 mRNA Translation: AAH26094.1 Sequence problems.
CCDSiCCDS33439.1
RefSeqiNP_001009608.1, NM_001009608.2
UniGeneiHs.668782
Hs.744930

Genome annotation databases

EnsembliENST00000334534; ENSP00000335557; ENSG00000149346
GeneIDi128710
KEGGihsa:128710
UCSCiuc010zre.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL133340 Genomic DNA No translation available.
AL353599 Genomic DNA No translation available.
AL035456 Genomic DNA No translation available.
BC020787 mRNA Translation: AAH20787.1 Sequence problems.
BC026094 mRNA Translation: AAH26094.1 Sequence problems.
CCDSiCCDS33439.1
RefSeqiNP_001009608.1, NM_001009608.2
UniGeneiHs.668782
Hs.744930

3D structure databases

ProteinModelPortaliQ5VYV7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126147, 22 interactors
IntActiQ5VYV7, 22 interactors
STRINGi9606.ENSP00000335557

PTM databases

iPTMnetiQ5VYV7
PhosphoSitePlusiQ5VYV7

Polymorphism and mutation databases

BioMutaiSLX4IP
DMDMi74747720

Proteomic databases

EPDiQ5VYV7
MaxQBiQ5VYV7
PaxDbiQ5VYV7
PeptideAtlasiQ5VYV7
PRIDEiQ5VYV7
ProteomicsDBi65652

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334534; ENSP00000335557; ENSG00000149346
GeneIDi128710
KEGGihsa:128710
UCSCiuc010zre.3 human

Organism-specific databases

CTDi128710
DisGeNETi128710
EuPathDBiHostDB:ENSG00000149346.14
GeneCardsiSLX4IP
H-InvDBiHIX0027687
HGNCiHGNC:16225 SLX4IP
HPAiHPA046372
MIMi615958 gene
neXtProtiNX_Q5VYV7
OpenTargetsiENSG00000149346
PharmGKBiPA25801
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IK12 Eukaryota
ENOG4111ZEV LUCA
GeneTreeiENSGT00390000016400
HOGENOMiHOG000112024
HOVERGENiHBG094893
InParanoidiQ5VYV7
OMAiQKRRNCS
OrthoDBiEOG091G07FA
PhylomeDBiQ5VYV7
TreeFamiTF330769

Miscellaneous databases

ChiTaRSiSLX4IP human
GenomeRNAii128710
PROiPR:Q5VYV7
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000149346 Expressed in 194 organ(s), highest expression level in caput epididymis
CleanExiHS_C20orf94
ExpressionAtlasiQ5VYV7 baseline and differential
GenevisibleiQ5VYV7 HS

Family and domain databases

InterProiView protein in InterPro
IPR031479 SLX4IP
PANTHERiPTHR28557 PTHR28557, 1 hit
PfamiView protein in Pfam
PF15744 UPF0492, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSLX4I_HUMAN
AccessioniPrimary (citable) accession number: Q5VYV7
Secondary accession number(s): Q05CG2, Q05CT9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: December 7, 2004
Last modified: November 7, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  6. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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