UniProtKB - Q5VYS8 (TUT7_HUMAN)
Terminal uridylyltransferase 7
TUT7
Functioni
Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay (PubMed:19703396, PubMed:25480299).
Essential for both oocyte maturation and fertility. Through 3' terminal uridylation of mRNA, sculpts, with TUT7, the maternal transcriptome by eliminating transcripts during oocyte growth (By similarity).
Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets (PubMed:25480299).
Also functions as an integral regulator of microRNA biogenesiS using 3 different uridylation mechanisms (PubMed:25979828).
Acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7 (pre-let-7). Uridylated pre-let-7 RNA is not processed by Dicer and undergo degradation. Pre-let-7 uridylation is strongly enhanced in the presence of LIN28A (PubMed:22898984).
In the absence of LIN28A, TUT7 and TUT4 monouridylate group II pre-miRNAs, which includes most of pre-let7 members, that shapes an optimal 3' end overhang for efficient processing (PubMed:25979828, PubMed:28671666).
Add oligo-U tails to truncated pre-miRNAS with a 5' overhang which may promote rapid degradation of non-functional pre-miRNA species (PubMed:25979828).
Does not play a role in replication-dependent histone mRNA degradation (PubMed:18172165).
Due to functional redundancy between TUT4 and TUT7, the identification of the specific role of each of these proteins is difficult (PubMed:25979828, PubMed:25480299, PubMed:19703396, PubMed:22898984, PubMed:18172165, PubMed:28671666).
TUT4 and TUT7 restrict retrotransposition of long interspersed element-1 (LINE-1) in cooperation with MOV10 counteracting the RNA chaperonne activity of L1RE1. TUT7 uridylates LINE-1 mRNAs in the cytoplasm which inhibits initiation of reverse transcription once in the nucleus, whereas uridylation by TUT4 destabilizes mRNAs in cytoplasmic ribonucleoprotein granules (PubMed:30122351).
By similarity7 PublicationsCatalytic activityi
- EC:2.7.7.521 Publication
Cofactori
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 1058 | Magnesium or manganese; catalyticBy similarity | 1 | |
Metal bindingi | 1060 | Magnesium or manganese; catalyticBy similarity | 1 | |
Binding sitei | 1130 | UTPCombined sources | 1 | |
Binding sitei | 1152 | UTPCombined sources | 1 | |
Binding sitei | 1286 | UTPCombined sources | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 244 – 274 | Matrin-typePROSITE-ProRule annotationAdd BLAST | 31 | |
Zinc fingeri | 963 – 980 | CCHC-type 1PROSITE-ProRule annotationAdd BLAST | 18 | |
Zinc fingeri | 1345 – 1362 | CCHC-type 2PROSITE-ProRule annotationCombined sources1 PublicationAdd BLAST | 18 | |
Zinc fingeri | 1451 – 1468 | CCHC-type 3PROSITE-ProRule annotationAdd BLAST | 18 |
GO - Molecular functioni
- miRNA binding Source: UniProtKB
- nucleotidyltransferase activity Source: GO_Central
- RNA binding Source: UniProtKB
- RNA uridylyltransferase activity Source: UniProtKB
- uridylyltransferase activity Source: UniProtKB
- zinc ion binding Source: InterPro
GO - Biological processi
- miRNA metabolic process Source: UniProtKB
- negative regulation of transposition, RNA-mediated Source: UniProtKB
- nuclear-transcribed mRNA poly(A) tail shortening Source: Reactome
- oocyte maturation Source: UniProtKB
- polyuridylation-dependent mRNA catabolic process Source: UniProtKB
- pre-miRNA processing Source: UniProtKB
- RNA 3'-end processing Source: UniProtKB
- RNA 3' uridylation Source: UniProtKB
Keywordsi
Molecular function | Nucleotidyltransferase, Transferase |
Ligand | Magnesium, Manganese, Metal-binding, Zinc |
Enzyme and pathway databases
BRENDAi | 2.7.7.52, 2681 |
PathwayCommonsi | Q5VYS8 |
Reactomei | R-HSA-429947, Deadenylation of mRNA |
SignaLinki | Q5VYS8 |
Names & Taxonomyi
Protein namesi | Recommended name: Terminal uridylyltransferase 7Curated (EC:2.7.7.521 Publication)Short name: TUTase 7Curated Alternative name(s): Zinc finger CCHC domain-containing protein 6 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:25817, TUT7 |
MIMi | 613467, gene |
neXtProti | NX_Q5VYS8 |
VEuPathDBi | HostDB:ENSG00000083223 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 2 Publications
Note: Expression is pancytoplasmic in contrast with TUT4 expression which is enriched in cytoplasmic ribonucleoprotein granules.1 Publication
Cytosol
- cytosol Source: HPA
Nucleus
- nucleoplasm Source: HPA
Other locations
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 1060 | D → A: Abolishes inhibition of LIRE1 retrotransposition. 1 Publication | 1 | |
Mutagenesisi | 1097 – 1099 | LPI → WPW: Abolishes monouridylation activity. 1 Publication | 3 |
Organism-specific databases
DisGeNETi | 79670 |
OpenTargetsi | ENSG00000083223 |
PharmGKBi | PA134971144 |
Miscellaneous databases
Pharosi | Q5VYS8, Tbio |
Genetic variation databases
BioMutai | ZCCHC6 |
DMDMi | 67462100 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000150957 | 1 – 1495 | Terminal uridylyltransferase 7Add BLAST | 1495 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 57 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 64 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 132 | PhosphoserineBy similarity | 1 | |
Modified residuei | 172 | PhosphoserineCombined sources | 1 | |
Modified residuei | 600 | PhosphoserineCombined sources | 1 | |
Modified residuei | 844 | PhosphoserineCombined sources | 1 | |
Modified residuei | 893 | PhosphoserineBy similarity | 1 | |
Modified residuei | 939 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q5VYS8 |
jPOSTi | Q5VYS8 |
MassIVEi | Q5VYS8 |
MaxQBi | Q5VYS8 |
PaxDbi | Q5VYS8 |
PeptideAtlasi | Q5VYS8 |
PRIDEi | Q5VYS8 |
ProteomicsDBi | 65642 [Q5VYS8-1] 65643 [Q5VYS8-2] 65644 [Q5VYS8-3] 65645 [Q5VYS8-4] 65646 [Q5VYS8-5] 65647 [Q5VYS8-6] |
PTM databases
iPTMneti | Q5VYS8 |
PhosphoSitePlusi | Q5VYS8 |
Expressioni
Gene expression databases
Bgeei | ENSG00000083223, Expressed in tendon and 228 other tissues |
ExpressionAtlasi | Q5VYS8, baseline and differential |
Genevisiblei | Q5VYS8, HS |
Organism-specific databases
HPAi | ENSG00000083223, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with MOV10; the interaction is RNA-dependent.
1 PublicationBinary interactionsi
Isoform 5 [Q5VYS8-5]
Protein-protein interaction databases
BioGRIDi | 122795, 112 interactors |
IntActi | Q5VYS8, 43 interactors |
STRINGi | 9606.ENSP00000365130 |
Miscellaneous databases
RNActi | Q5VYS8, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q5VYS8 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 551 – 600 | PAP-associated 1Add BLAST | 50 | |
Domaini | 1233 – 1286 | PAP-associated 2Add BLAST | 54 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 30 | DisorderedSequence analysisAdd BLAST | 30 | |
Regioni | 43 – 69 | DisorderedSequence analysisAdd BLAST | 27 | |
Regioni | 89 – 140 | DisorderedSequence analysisAdd BLAST | 52 | |
Regioni | 162 – 205 | DisorderedSequence analysisAdd BLAST | 44 | |
Regioni | 734 – 757 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 831 – 898 | DisorderedSequence analysisAdd BLAST | 68 | |
Regioni | 951 – 1495 | Sufficient for monouridylation activity1 PublicationAdd BLAST | 545 | |
Regioni | 1047 – 1050 | UTP bindingCombined sources | 4 | |
Regioni | 1057 – 1060 | UTP bindingCombined sources | 4 | |
Regioni | 1170 – 1174 | UTP bindingCombined sources | 5 | |
Regioni | 1367 – 1424 | DisorderedSequence analysisAdd BLAST | 58 | |
Regioni | 1466 – 1495 | DisorderedSequence analysisAdd BLAST | 30 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 8 – 30 | Basic and acidic residuesSequence analysisAdd BLAST | 23 | |
Compositional biasi | 93 – 112 | Basic and acidic residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 842 – 859 | Acidic residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 1367 – 1408 | Basic and acidic residuesSequence analysisAdd BLAST | 42 | |
Compositional biasi | 1470 – 1495 | Polar residuesSequence analysisAdd BLAST | 26 |
Domaini
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 244 – 274 | Matrin-typePROSITE-ProRule annotationAdd BLAST | 31 | |
Zinc fingeri | 963 – 980 | CCHC-type 1PROSITE-ProRule annotationAdd BLAST | 18 | |
Zinc fingeri | 1345 – 1362 | CCHC-type 2PROSITE-ProRule annotationCombined sources1 PublicationAdd BLAST | 18 | |
Zinc fingeri | 1451 – 1468 | CCHC-type 3PROSITE-ProRule annotationAdd BLAST | 18 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG2277, Eukaryota |
GeneTreei | ENSGT00940000156859 |
HOGENOMi | CLU_003287_1_0_1 |
InParanoidi | Q5VYS8 |
OMAi | SKSDCMF |
OrthoDBi | 803033at2759 |
PhylomeDBi | Q5VYS8 |
TreeFami | TF315661 |
Family and domain databases
Gene3Di | 3.30.460.10, 2 hits |
InterProi | View protein in InterPro IPR003604, Matrin/U1-like-C_Znf_C2H2 IPR043519, NT_sf IPR002058, PAP_assoc IPR045100, TUTase_dom IPR001878, Znf_CCHC IPR036875, Znf_CCHC_sf |
Pfami | View protein in Pfam PF03828, PAP_assoc, 2 hits PF19088, TUTase, 2 hits PF00098, zf-CCHC, 3 hits |
SMARTi | View protein in SMART SM00343, ZnF_C2HC, 3 hits SM00451, ZnF_U1, 1 hit |
SUPFAMi | SSF57756, SSF57756, 3 hits SSF81301, SSF81301, 2 hits |
PROSITEi | View protein in PROSITE PS50158, ZF_CCHC, 3 hits PS00028, ZINC_FINGER_C2H2_1, 1 hit |
s (6+)i Sequence
Sequence statusi: Complete.
This entry describes 6 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 6 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGDTAKPYFV KRTKDRGTMD DDDFRRGHPQ QDYLIIDDHA KGHGSKMEKG
60 70 80 90 100
LQKKKITPGN YGNTPRKGPC AVSSNPYAFK NPIYSQPAWM NDSHKDQSKR
110 120 130 140 150
WLSDEHTGNS DNWREFKPGP RIPVINRQRK DSFQENEDGY RWQDTRGCRT
160 170 180 190 200
VRRLFHKDLT SLETTSEMEA GSPENKKQRS RPRKPRKTRN EENEQDGDLE
210 220 230 240 250
GPVIDESVLS TKELLGLQQA EERLKRDCID RLKRRPRNYP TAKYTCRLCD
260 270 280 290 300
VLIESIAFAH KHIKEKRHKK NIKEKQEEEL LTTLPPPTPS QINAVGIAID
310 320 330 340 350
KVVQEFGLHN ENLEQRLEIK RIMENVFQHK LPDCSLRLYG SSCSRLGFKN
360 370 380 390 400
SDVNIDIQFP AIMSQPDVLL LVQECLKNSD SFIDVDADFH ARVPVVVCRE
410 420 430 440 450
KQSGLLCKVS AGNENACLTT KHLTALGKLE PKLVPLVIAF RYWAKLCSID
460 470 480 490 500
RPEEGGLPPY VFALMAIFFL QQRKEPLLPV YLGSWIEGFS LSKLGNFNLQ
510 520 530 540 550
DIEKDVVIWE HTDSAAGDTG ITKEEAPRET PIKRGQVSLI LDVKHQPSVP
560 570 580 590 600
VGQLWVELLR FYALEFNLAD LVISIRVKEL VSRELKDWPK KRIAIEDPYS
610 620 630 640 650
VKRNVARTLN SQPVFEYILH CLRTTYKYFA LPHKITKSSL LKPLNAITCI
660 670 680 690 700
SEHSKEVINH HPDVQTKDDK LKNSVLAQGP GATSSAANTC KVQPLTLKET
710 720 730 740 750
AESFGSPPKE EMGNEHISVH PENSDCIQAD VNSDDYKGDK VYHPETGRKN
760 770 780 790 800
EKEKVGRKGK HLLTVDQKRG EHVVCGSTRN NESESTLDLE GFQNPTAKEC
810 820 830 840 850
EGLATLDNKA DLDGESTEGT EELEDSLNHF THSVQGQTSE MIPSDEEEED
860 870 880 890 900
DEEEEEEEEP RLTINQREDE DGMANEDELD NTYTGSGDED ALSEEDDELG
910 920 930 940 950
EAAKYEDVKE CGKHVERALL VELNKISLKE ENVCEEKNSP VDQSDFFYEF
960 970 980 990 1000
SKLIFTKGKS PTVVCSLCKR EGHLKKDCPE DFKRIQLEPL PPLTPKFLNI
1010 1020 1030 1040 1050
LDQVCIQCYK DFSPTIIEDQ AREHIRQNLE SFIRQDFPGT KLSLFGSSKN
1060 1070 1080 1090 1100
GFGFKQSDLD VCMTINGLET AEGLDCVRTI EELARVLRKH SGLRNILPIT
1110 1120 1130 1140 1150
TAKVPIVKFF HLRSGLEVDI SLYNTLALHN TRLLSAYSAI DPRVKYLCYT
1160 1170 1180 1190 1200
MKVFTKMCDI GDASRGSLSS YAYTLMVLYF LQQRNPPVIP VLQEIYKGEK
1210 1220 1230 1240 1250
KPEIFVDGWN IYFFDQIDEL PTYWSECGKN TESVGQLWLG LLRFYTEEFD
1260 1270 1280 1290 1300
FKEHVISIRR KSLLTTFKKQ WTSKYIVIED PFDLNHNLGA GLSRKMTNFI
1310 1320 1330 1340 1350
MKAFINGRRV FGIPVKGFPK DYPSKMEYFF DPDVLTEGEL APNDRCCRIC
1360 1370 1380 1390 1400
GKIGHFMKDC PMRRKVRRRR DQEDALNQRY PENKEKRSKE DKEIHNKYTE
1410 1420 1430 1440 1450
REVSTKEDKP IQCTPQKAKP MRAAADLGRE KILRPPVEKW KRQDDKDLRE
1460 1470 1480 1490
KRCFICGREG HIKKECPQFK GSSGSLSSKY MTQGKASAKR TQQES
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketX6R3Q3 | X6R3Q3_HUMAN | Terminal uridylyltransferase 7 | TUT7 | 784 | Annotation score: | ||
A0A0C4DFW3 | A0A0C4DFW3_HUMAN | Terminal uridylyltransferase 7 | TUT7 | 395 | Annotation score: | ||
Q5VYS9 | Q5VYS9_HUMAN | Terminal uridylyltransferase 7 | TUT7 | 168 | Annotation score: | ||
Q5VYT0 | Q5VYT0_HUMAN | Terminal uridylyltransferase 7 | TUT7 | 124 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 157 | K → R in BAB70951 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 316 | R → T in CAE46038 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 514 | S → N in CAE46038 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 900 | G → V in CAI45944 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 937 | Missing in CAI45944 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 937 | Missing in CAH56219 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 1104 | V → M in CAH56219 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 1319 | P → S in CAH56219 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 1474 | G → D in CAI45944 (PubMed:17974005).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_053753 | 40 | A → V. Corresponds to variant dbSNP:rs2378695Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_013832 | 363 – 486 | MSQPD…LGSWI → I in isoform 4. 1 PublicationAdd BLAST | 124 | |
Alternative sequenceiVSP_013833 | 403 – 412 | SGLLCKVSAG → RSHFFKLFIY in isoform 5. 1 Publication | 10 | |
Alternative sequenceiVSP_013834 | 413 – 1495 | Missing in isoform 5. 1 PublicationAdd BLAST | 1083 | |
Alternative sequenceiVSP_013835 | 538 – 544 | SLILDVK → VSSLLCR in isoform 3. 1 Publication | 7 | |
Alternative sequenceiVSP_013836 | 545 – 1495 | Missing in isoform 3. 1 PublicationAdd BLAST | 951 | |
Alternative sequenceiVSP_013837 | 597 – 615 | DPYSV…SQPVF → GISKCLSYSPPLFFLKVPV in isoform 2. 1 PublicationAdd BLAST | 19 | |
Alternative sequenceiVSP_013838 | 616 – 1495 | Missing in isoform 2. 1 PublicationAdd BLAST | 880 | |
Alternative sequenceiVSP_013839 | 960 – 1072 | Missing in isoform 4. 1 PublicationAdd BLAST | 113 | |
Alternative sequenceiVSP_013840 | 1157 – 1194 | Missing in isoform 6. 1 PublicationAdd BLAST | 38 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL832026 mRNA Translation: CAH56219.1 AL832193 mRNA Translation: CAH56214.1 BX641077 mRNA Translation: CAE46038.1 CR933643 mRNA Translation: CAI45944.1 CR933644 mRNA Translation: CAI45945.1 CR936608 mRNA Translation: CAI56753.1 AL137849 Genomic DNA No translation available. AL353678 Genomic DNA No translation available. BC032456 mRNA Translation: AAH32456.1 AK023471 mRNA Translation: BAB14584.1 Different initiation. AK055546 mRNA Translation: BAB70951.1 AK055948 mRNA Translation: BAB71052.1 Different initiation. AB051498 mRNA Translation: BAB21802.1 |
CCDSi | CCDS35057.1 [Q5VYS8-1] CCDS55323.1 [Q5VYS8-4] |
RefSeqi | NP_001171988.1, NM_001185059.1 [Q5VYS8-1] NP_001172003.1, NM_001185074.1 [Q5VYS8-4] NP_001317647.1, NM_001330718.1 NP_078893.2, NM_024617.3 [Q5VYS8-1] XP_016870619.1, XM_017015130.1 [Q5VYS8-1] XP_016870620.1, XM_017015131.1 [Q5VYS8-1] |
Genome annotation databases
Ensembli | ENST00000375960; ENSP00000365127; ENSG00000083223 [Q5VYS8-4] ENST00000375963; ENSP00000365130; ENSG00000083223 |
GeneIDi | 79670 |
KEGGi | hsa:79670 |
MANE-Selecti | ENST00000375963.8; ENSP00000365130.3; NM_024617.4; NP_078893.2 |
UCSCi | uc004aoq.4, human [Q5VYS8-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL832026 mRNA Translation: CAH56219.1 AL832193 mRNA Translation: CAH56214.1 BX641077 mRNA Translation: CAE46038.1 CR933643 mRNA Translation: CAI45944.1 CR933644 mRNA Translation: CAI45945.1 CR936608 mRNA Translation: CAI56753.1 AL137849 Genomic DNA No translation available. AL353678 Genomic DNA No translation available. BC032456 mRNA Translation: AAH32456.1 AK023471 mRNA Translation: BAB14584.1 Different initiation. AK055546 mRNA Translation: BAB70951.1 AK055948 mRNA Translation: BAB71052.1 Different initiation. AB051498 mRNA Translation: BAB21802.1 |
CCDSi | CCDS35057.1 [Q5VYS8-1] CCDS55323.1 [Q5VYS8-4] |
RefSeqi | NP_001171988.1, NM_001185059.1 [Q5VYS8-1] NP_001172003.1, NM_001185074.1 [Q5VYS8-4] NP_001317647.1, NM_001330718.1 NP_078893.2, NM_024617.3 [Q5VYS8-1] XP_016870619.1, XM_017015130.1 [Q5VYS8-1] XP_016870620.1, XM_017015131.1 [Q5VYS8-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5W0B | X-ray | 2.61 | A/B/C | 983-1365 | [»] | |
5W0M | X-ray | 2.30 | A/B/C | 983-1365 | [»] | |
5W0N | X-ray | 2.50 | A/B/C | 963-1365 | [»] | |
5W0O | X-ray | 2.49 | A/B | 983-1365 | [»] | |
SMRi | Q5VYS8 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 122795, 112 interactors |
IntActi | Q5VYS8, 43 interactors |
STRINGi | 9606.ENSP00000365130 |
PTM databases
iPTMneti | Q5VYS8 |
PhosphoSitePlusi | Q5VYS8 |
Genetic variation databases
BioMutai | ZCCHC6 |
DMDMi | 67462100 |
Proteomic databases
EPDi | Q5VYS8 |
jPOSTi | Q5VYS8 |
MassIVEi | Q5VYS8 |
MaxQBi | Q5VYS8 |
PaxDbi | Q5VYS8 |
PeptideAtlasi | Q5VYS8 |
PRIDEi | Q5VYS8 |
ProteomicsDBi | 65642 [Q5VYS8-1] 65643 [Q5VYS8-2] 65644 [Q5VYS8-3] 65645 [Q5VYS8-4] 65646 [Q5VYS8-5] 65647 [Q5VYS8-6] |
Protocols and materials databases
Antibodypediai | 13297, 36 antibodies from 13 providers |
DNASUi | 79670 |
Genome annotation databases
Ensembli | ENST00000375960; ENSP00000365127; ENSG00000083223 [Q5VYS8-4] ENST00000375963; ENSP00000365130; ENSG00000083223 |
GeneIDi | 79670 |
KEGGi | hsa:79670 |
MANE-Selecti | ENST00000375963.8; ENSP00000365130.3; NM_024617.4; NP_078893.2 |
UCSCi | uc004aoq.4, human [Q5VYS8-1] |
Organism-specific databases
CTDi | 79670 |
DisGeNETi | 79670 |
GeneCardsi | TUT7 |
HGNCi | HGNC:25817, TUT7 |
HPAi | ENSG00000083223, Low tissue specificity |
MIMi | 613467, gene |
neXtProti | NX_Q5VYS8 |
OpenTargetsi | ENSG00000083223 |
PharmGKBi | PA134971144 |
VEuPathDBi | HostDB:ENSG00000083223 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2277, Eukaryota |
GeneTreei | ENSGT00940000156859 |
HOGENOMi | CLU_003287_1_0_1 |
InParanoidi | Q5VYS8 |
OMAi | SKSDCMF |
OrthoDBi | 803033at2759 |
PhylomeDBi | Q5VYS8 |
TreeFami | TF315661 |
Enzyme and pathway databases
BRENDAi | 2.7.7.52, 2681 |
PathwayCommonsi | Q5VYS8 |
Reactomei | R-HSA-429947, Deadenylation of mRNA |
SignaLinki | Q5VYS8 |
Miscellaneous databases
BioGRID-ORCSi | 79670, 29 hits in 1049 CRISPR screens |
ChiTaRSi | ZCCHC6, human |
GeneWikii | ZCCHC6 |
GenomeRNAii | 79670 |
Pharosi | Q5VYS8, Tbio |
PROi | PR:Q5VYS8 |
RNActi | Q5VYS8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000083223, Expressed in tendon and 228 other tissues |
ExpressionAtlasi | Q5VYS8, baseline and differential |
Genevisiblei | Q5VYS8, HS |
Family and domain databases
Gene3Di | 3.30.460.10, 2 hits |
InterProi | View protein in InterPro IPR003604, Matrin/U1-like-C_Znf_C2H2 IPR043519, NT_sf IPR002058, PAP_assoc IPR045100, TUTase_dom IPR001878, Znf_CCHC IPR036875, Znf_CCHC_sf |
Pfami | View protein in Pfam PF03828, PAP_assoc, 2 hits PF19088, TUTase, 2 hits PF00098, zf-CCHC, 3 hits |
SMARTi | View protein in SMART SM00343, ZnF_C2HC, 3 hits SM00451, ZnF_U1, 1 hit |
SUPFAMi | SSF57756, SSF57756, 3 hits SSF81301, SSF81301, 2 hits |
PROSITEi | View protein in PROSITE PS50158, ZF_CCHC, 3 hits PS00028, ZINC_FINGER_C2H2_1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TUT7_HUMAN | |
Accessioni | Q5VYS8Primary (citable) accession number: Q5VYS8 Secondary accession number(s): Q5H9T0 Q9H8M6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 7, 2005 |
Last sequence update: | December 7, 2004 | |
Last modified: | February 23, 2022 | |
This is version 149 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families