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UniProtKB - Q5VYS8 (TUT7_HUMAN)

Entry version 145 (10 Feb 2021)
Sequence version 1 (07 Dec 2004)
Previous versions | rss
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Protein

Terminal uridylyltransferase 7

Gene

TUT7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay (PubMed:19703396, PubMed:25480299). Essential for both oocyte maturation and fertility. Through 3' terminal uridylation of mRNA, sculpts, with TUT7, the maternal transcriptome by eliminating transcripts during oocyte growth (By similarity). Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets (PubMed:25480299). Also functions as an integral regulator of microRNA biogenesiS using 3 different uridylation mechanisms (PubMed:25979828). Acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7 (pre-let-7). Uridylated pre-let-7 RNA is not processed by Dicer and undergo degradation. Pre-let-7 uridylation is strongly enhanced in the presence of LIN28A (PubMed:22898984). In the absence of LIN28A, TUT7 and TUT4 monouridylate group II pre-miRNAs, which includes most of pre-let7 members, that shapes an optimal 3' end overhang for efficient processing (PubMed:25979828, PubMed:28671666). Add oligo-U tails to truncated pre-miRNAS with a 5' overhang which may promote rapid degradation of non-functional pre-miRNA species (PubMed:25979828). Does not play a role in replication-dependent histone mRNA degradation (PubMed:18172165). Due to functional redundancy between TUT4 and TUT7, the identification of the specific role of each of these proteins is difficult (PubMed:25979828, PubMed:25480299, PubMed:19703396, PubMed:22898984, PubMed:18172165, PubMed:28671666). TUT4 and TUT7 restrict retrotransposition of long interspersed element-1 (LINE-1) in cooperation with MOV10 counteracting the RNA chaperonne activity of L1RE1. TUT7 uridylates LINE-1 mRNAs in the cytoplasm which inhibits initiation of reverse transcription once in the nucleus, whereas uridylation by TUT4 destabilizes mRNAs in cytoplasmic ribonucleoprotein granules (PubMed:30122351).By similarity7 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarity, Mn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi1058Magnesium or manganese; catalyticBy similarity1
Metal bindingi1060Magnesium or manganese; catalyticBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei1130UTPCombined sources1
Binding sitei1152UTPCombined sources1
Binding sitei1286UTPCombined sources1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri244 – 274Matrin-typePROSITE-ProRule annotationAdd BLAST31
Zinc fingeri963 – 980CCHC-type 1PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri1345 – 1362CCHC-type 2PROSITE-ProRule annotationCombined sources1 PublicationAdd BLAST18
Zinc fingeri1451 – 1468CCHC-type 3PROSITE-ProRule annotationAdd BLAST18

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionNucleotidyltransferase, Transferase
LigandMagnesium, Manganese, Metal-binding, Zinc

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.7.7.52, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q5VYS8

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-429947, Deadenylation of mRNA

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Terminal uridylyltransferase 7Curated (EC:2.7.7.521 Publication)
Short name:
TUTase 7Curated
Alternative name(s):
Zinc finger CCHC domain-containing protein 6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TUT7Imported
Synonyms:HS2, KIAA1711, ZCCHC6Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:25817, TUT7

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		613467, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q5VYS8

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000083223.17

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1060D → A: Abolishes inhibition of LIRE1 retrotransposition. 1 Publication1
Mutagenesisi1097 – 1099LPI → WPW: Abolishes monouridylation activity. 1 Publication3

Organism-specific databases

DisGeNET

More...DisGeNETi		79670

Open Targets

More...OpenTargetsi		ENSG00000083223

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134971144

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q5VYS8, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZCCHC6

Domain mapping of disease mutations (DMDM)

More...DMDMi		67462100

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001509571 – 1495Terminal uridylyltransferase 7Add BLAST1495

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei57PhosphothreonineCombined sources1
Modified residuei64PhosphothreonineCombined sources1
Modified residuei132PhosphoserineBy similarity1
Modified residuei172PhosphoserineCombined sources1
Modified residuei600PhosphoserineCombined sources1
Modified residuei844PhosphoserineCombined sources1
Modified residuei893PhosphoserineBy similarity1
Modified residuei939PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q5VYS8

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q5VYS8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q5VYS8

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q5VYS8

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q5VYS8

PeptideAtlas

More...PeptideAtlasi		Q5VYS8

PRoteomics IDEntifications database

More...PRIDEi		Q5VYS8

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		65642 [Q5VYS8-1]
65643 [Q5VYS8-2]
65644 [Q5VYS8-3]
65645 [Q5VYS8-4]
65646 [Q5VYS8-5]
65647 [Q5VYS8-6]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q5VYS8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q5VYS8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000083223, Expressed in tendon and 227 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q5VYS8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q5VYS8, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000083223, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MOV10; the interaction is RNA-dependent.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		122795, 59 interactors

Protein interaction database and analysis system

More...IntActi		Q5VYS8, 42 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000365130

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q5VYS8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11495
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q5VYS8

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini551 – 600PAP-associated 1Add BLAST50
Domaini1233 – 1286PAP-associated 2Add BLAST54

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni951 – 1495Sufficient for monouridylation activity1 PublicationAdd BLAST545
Regioni1047 – 1050UTP bindingCombined sources4
Regioni1057 – 1060UTP bindingCombined sources4
Regioni1170 – 1174UTP bindingCombined sources5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi20 – 23Poly-Asp4
Compositional biasi815 – 936Glu-richAdd BLAST122
Compositional biasi1367 – 1370Poly-Arg4

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Utilizes two multidomain functional modules during the switch from monouridylation to oligouridylation. The catalytic module (containing the 3 CCHC-type Zinc finger domains) is essential for both activities while the Lin28-interacting module (LIM) at the N-termail part is indispensable for oligouridylation.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DNA polymerase type-B-like family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri244 – 274Matrin-typePROSITE-ProRule annotationAdd BLAST31
Zinc fingeri963 – 980CCHC-type 1PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri1345 – 1362CCHC-type 2PROSITE-ProRule annotationCombined sources1 PublicationAdd BLAST18
Zinc fingeri1451 – 1468CCHC-type 3PROSITE-ProRule annotationAdd BLAST18

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2277, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156859

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_003287_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q5VYS8

Identification of Orthologs from Complete Genome Data

More...OMAi		YALEFNM

Database of Orthologous Groups

More...OrthoDBi		803033at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q5VYS8

TreeFam database of animal gene trees

More...TreeFami		TF315661

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.460.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003604, Matrin/U1-like-C_Znf_C2H2
IPR043519, NT_sf
IPR002058, PAP_assoc
IPR001878, Znf_CCHC
IPR036875, Znf_CCHC_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03828, PAP_assoc, 2 hits
PF00098, zf-CCHC, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00343, ZnF_C2HC, 3 hits
SM00451, ZnF_U1, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57756, SSF57756, 3 hits
SSF81301, SSF81301, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50158, ZF_CCHC, 3 hits
PS00028, ZINC_FINGER_C2H2_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5VYS8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGDTAKPYFV KRTKDRGTMD DDDFRRGHPQ QDYLIIDDHA KGHGSKMEKG 
        60         70         80         90        100
LQKKKITPGN YGNTPRKGPC AVSSNPYAFK NPIYSQPAWM NDSHKDQSKR 
       110        120        130        140        150
WLSDEHTGNS DNWREFKPGP RIPVINRQRK DSFQENEDGY RWQDTRGCRT 
       160        170        180        190        200
VRRLFHKDLT SLETTSEMEA GSPENKKQRS RPRKPRKTRN EENEQDGDLE 
       210        220        230        240        250
GPVIDESVLS TKELLGLQQA EERLKRDCID RLKRRPRNYP TAKYTCRLCD 
       260        270        280        290        300
VLIESIAFAH KHIKEKRHKK NIKEKQEEEL LTTLPPPTPS QINAVGIAID 
       310        320        330        340        350
KVVQEFGLHN ENLEQRLEIK RIMENVFQHK LPDCSLRLYG SSCSRLGFKN 
       360        370        380        390        400
SDVNIDIQFP AIMSQPDVLL LVQECLKNSD SFIDVDADFH ARVPVVVCRE 
       410        420        430        440        450
KQSGLLCKVS AGNENACLTT KHLTALGKLE PKLVPLVIAF RYWAKLCSID 
       460        470        480        490        500
RPEEGGLPPY VFALMAIFFL QQRKEPLLPV YLGSWIEGFS LSKLGNFNLQ 
       510        520        530        540        550
DIEKDVVIWE HTDSAAGDTG ITKEEAPRET PIKRGQVSLI LDVKHQPSVP 
       560        570        580        590        600
VGQLWVELLR FYALEFNLAD LVISIRVKEL VSRELKDWPK KRIAIEDPYS 
       610        620        630        640        650
VKRNVARTLN SQPVFEYILH CLRTTYKYFA LPHKITKSSL LKPLNAITCI 
       660        670        680        690        700
SEHSKEVINH HPDVQTKDDK LKNSVLAQGP GATSSAANTC KVQPLTLKET 
       710        720        730        740        750
AESFGSPPKE EMGNEHISVH PENSDCIQAD VNSDDYKGDK VYHPETGRKN 
       760        770        780        790        800
EKEKVGRKGK HLLTVDQKRG EHVVCGSTRN NESESTLDLE GFQNPTAKEC 
       810        820        830        840        850
EGLATLDNKA DLDGESTEGT EELEDSLNHF THSVQGQTSE MIPSDEEEED 
       860        870        880        890        900
DEEEEEEEEP RLTINQREDE DGMANEDELD NTYTGSGDED ALSEEDDELG 
       910        920        930        940        950
EAAKYEDVKE CGKHVERALL VELNKISLKE ENVCEEKNSP VDQSDFFYEF 
       960        970        980        990       1000
SKLIFTKGKS PTVVCSLCKR EGHLKKDCPE DFKRIQLEPL PPLTPKFLNI 
      1010       1020       1030       1040       1050
LDQVCIQCYK DFSPTIIEDQ AREHIRQNLE SFIRQDFPGT KLSLFGSSKN 
      1060       1070       1080       1090       1100
GFGFKQSDLD VCMTINGLET AEGLDCVRTI EELARVLRKH SGLRNILPIT 
      1110       1120       1130       1140       1150
TAKVPIVKFF HLRSGLEVDI SLYNTLALHN TRLLSAYSAI DPRVKYLCYT 
      1160       1170       1180       1190       1200
MKVFTKMCDI GDASRGSLSS YAYTLMVLYF LQQRNPPVIP VLQEIYKGEK 
      1210       1220       1230       1240       1250
KPEIFVDGWN IYFFDQIDEL PTYWSECGKN TESVGQLWLG LLRFYTEEFD 
      1260       1270       1280       1290       1300
FKEHVISIRR KSLLTTFKKQ WTSKYIVIED PFDLNHNLGA GLSRKMTNFI 
      1310       1320       1330       1340       1350
MKAFINGRRV FGIPVKGFPK DYPSKMEYFF DPDVLTEGEL APNDRCCRIC 
      1360       1370       1380       1390       1400
GKIGHFMKDC PMRRKVRRRR DQEDALNQRY PENKEKRSKE DKEIHNKYTE 
      1410       1420       1430       1440       1450
REVSTKEDKP IQCTPQKAKP MRAAADLGRE KILRPPVEKW KRQDDKDLRE 
      1460       1470       1480       1490 
KRCFICGREG HIKKECPQFK GSSGSLSSKY MTQGKASAKR TQQES
Length:1,495
Mass (Da):171,229
Last modified:December 7, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1AAB0F5B37266FF9
GO
Isoform 2 (identifier: Q5VYS8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     597-615: DPYSVKRNVARTLNSQPVF → GISKCLSYSPPLFFLKVPV
     616-1495: Missing.

Show »
Length:615
Mass (Da):70,475
Checksum:iE3B7FEE22E438BBD
GO
Isoform 3 (identifier: Q5VYS8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     538-544: SLILDVK → VSSLLCR
     545-1495: Missing.

Show »
Length:544
Mass (Da):62,261
Checksum:iDE285E0532C43340
GO
Isoform 4 (identifier: Q5VYS8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     363-486: MSQPDVLLLV...LLPVYLGSWI → I
     960-1072: Missing.

Show »
Length:1,259
Mass (Da):144,656
Checksum:i2DFDA89240222042
GO
Isoform 5 (identifier: Q5VYS8-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     403-412: SGLLCKVSAG → RSHFFKLFIY
     413-1495: Missing.

Show »
Length:412
Mass (Da):47,903
Checksum:i73F48669DDBD99CB
GO
Isoform 6 (identifier: Q5VYS8-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1157-1194: Missing.

Show »
Length:1,457
Mass (Da):166,970
Checksum:iF5F376C95EF2CEE5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
X6R3Q3X6R3Q3_HUMAN
Terminal uridylyltransferase 7
TUT7
784Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4DFW3A0A0C4DFW3_HUMAN
Terminal uridylyltransferase 7
TUT7
395Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5VYS9Q5VYS9_HUMAN
Terminal uridylyltransferase 7
TUT7
168Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5VYT0Q5VYT0_HUMAN
Terminal uridylyltransferase 7
TUT7
124Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB14584 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB71052 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti157K → R in BAB70951 (PubMed:14702039).Curated1
Sequence conflicti316R → T in CAE46038 (PubMed:17974005).Curated1
Sequence conflicti514S → N in CAE46038 (PubMed:17974005).Curated1
Sequence conflicti900G → V in CAI45944 (PubMed:17974005).Curated1
Sequence conflicti937Missing in CAI45944 (PubMed:17974005).Curated1
Sequence conflicti937Missing in CAH56219 (PubMed:17974005).Curated1
Sequence conflicti1104V → M in CAH56219 (PubMed:17974005).Curated1
Sequence conflicti1319P → S in CAH56219 (PubMed:17974005).Curated1
Sequence conflicti1474G → D in CAI45944 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05375340A → V. Corresponds to variant dbSNP:rs2378695Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_013832363 – 486MSQPD…LGSWI → I in isoform 4. 1 PublicationAdd BLAST124
Alternative sequenceiVSP_013833403 – 412SGLLCKVSAG → RSHFFKLFIY in isoform 5. 1 Publication10
Alternative sequenceiVSP_013834413 – 1495Missing in isoform 5. 1 PublicationAdd BLAST1083
Alternative sequenceiVSP_013835538 – 544SLILDVK → VSSLLCR in isoform 3. 1 Publication7
Alternative sequenceiVSP_013836545 – 1495Missing in isoform 3. 1 PublicationAdd BLAST951
Alternative sequenceiVSP_013837597 – 615DPYSV…SQPVF → GISKCLSYSPPLFFLKVPV in isoform 2. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_013838616 – 1495Missing in isoform 2. 1 PublicationAdd BLAST880
Alternative sequenceiVSP_013839960 – 1072Missing in isoform 4. 1 PublicationAdd BLAST113
Alternative sequenceiVSP_0138401157 – 1194Missing in isoform 6. 1 PublicationAdd BLAST38

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AL832026 mRNA Translation: CAH56219.1
AL832193 mRNA Translation: CAH56214.1
BX641077 mRNA Translation: CAE46038.1
CR933643 mRNA Translation: CAI45944.1
CR933644 mRNA Translation: CAI45945.1
CR936608 mRNA Translation: CAI56753.1
AL137849 Genomic DNA No translation available.
AL353678 Genomic DNA No translation available.
BC032456 mRNA Translation: AAH32456.1
AK023471 mRNA Translation: BAB14584.1 Different initiation.
AK055546 mRNA Translation: BAB70951.1
AK055948 mRNA Translation: BAB71052.1 Different initiation.
AB051498 mRNA Translation: BAB21802.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS35057.1 [Q5VYS8-1]
CCDS55323.1 [Q5VYS8-4]

NCBI Reference Sequences

More...RefSeqi		NP_001171988.1, NM_001185059.1 [Q5VYS8-1]
NP_001172003.1, NM_001185074.1 [Q5VYS8-4]
NP_001317647.1, NM_001330718.1
NP_078893.2, NM_024617.3 [Q5VYS8-1]
XP_016870619.1, XM_017015130.1 [Q5VYS8-1]
XP_016870620.1, XM_017015131.1 [Q5VYS8-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000375960; ENSP00000365127; ENSG00000083223 [Q5VYS8-4]
ENST00000375963; ENSP00000365130; ENSG00000083223 [Q5VYS8-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		79670

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:79670

UCSC genome browser

More...UCSCi		uc004aoq.4, human [Q5VYS8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL832026 mRNA Translation: CAH56219.1
AL832193 mRNA Translation: CAH56214.1
BX641077 mRNA Translation: CAE46038.1
CR933643 mRNA Translation: CAI45944.1
CR933644 mRNA Translation: CAI45945.1
CR936608 mRNA Translation: CAI56753.1
AL137849 Genomic DNA No translation available.
AL353678 Genomic DNA No translation available.
BC032456 mRNA Translation: AAH32456.1
AK023471 mRNA Translation: BAB14584.1 Different initiation.
AK055546 mRNA Translation: BAB70951.1
AK055948 mRNA Translation: BAB71052.1 Different initiation.
AB051498 mRNA Translation: BAB21802.1
CCDSiCCDS35057.1 [Q5VYS8-1]
CCDS55323.1 [Q5VYS8-4]
RefSeqiNP_001171988.1, NM_001185059.1 [Q5VYS8-1]
NP_001172003.1, NM_001185074.1 [Q5VYS8-4]
NP_001317647.1, NM_001330718.1
NP_078893.2, NM_024617.3 [Q5VYS8-1]
XP_016870619.1, XM_017015130.1 [Q5VYS8-1]
XP_016870620.1, XM_017015131.1 [Q5VYS8-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5W0BX-ray2.61A/B/C983-1365[»]
5W0MX-ray2.30A/B/C983-1365[»]
5W0NX-ray2.50A/B/C963-1365[»]
5W0OX-ray2.49A/B983-1365[»]
SMRiQ5VYS8
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi122795, 59 interactors
IntActiQ5VYS8, 42 interactors
STRINGi9606.ENSP00000365130

PTM databases

iPTMnetiQ5VYS8
PhosphoSitePlusiQ5VYS8

Genetic variation databases

BioMutaiZCCHC6
DMDMi67462100

Proteomic databases

EPDiQ5VYS8
jPOSTiQ5VYS8
MassIVEiQ5VYS8
MaxQBiQ5VYS8
PaxDbiQ5VYS8
PeptideAtlasiQ5VYS8
PRIDEiQ5VYS8
ProteomicsDBi65642 [Q5VYS8-1]
65643 [Q5VYS8-2]
65644 [Q5VYS8-3]
65645 [Q5VYS8-4]
65646 [Q5VYS8-5]
65647 [Q5VYS8-6]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		13297, 35 antibodies

The DNASU plasmid repository

More...DNASUi		79670

Genome annotation databases

EnsembliENST00000375960; ENSP00000365127; ENSG00000083223 [Q5VYS8-4]
ENST00000375963; ENSP00000365130; ENSG00000083223 [Q5VYS8-1]
GeneIDi79670
KEGGihsa:79670
UCSCiuc004aoq.4, human [Q5VYS8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		79670
DisGeNETi79670

GeneCards: human genes, protein and diseases

More...GeneCardsi		TUT7
HGNCiHGNC:25817, TUT7
HPAiENSG00000083223, Low tissue specificity
MIMi613467, gene
neXtProtiNX_Q5VYS8
OpenTargetsiENSG00000083223
PharmGKBiPA134971144
VEuPathDBiHostDB:ENSG00000083223.17

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2277, Eukaryota
GeneTreeiENSGT00940000156859
HOGENOMiCLU_003287_1_0_1
InParanoidiQ5VYS8
OMAiYALEFNM
OrthoDBi803033at2759
PhylomeDBiQ5VYS8
TreeFamiTF315661

Enzyme and pathway databases

BRENDAi2.7.7.52, 2681
PathwayCommonsiQ5VYS8
ReactomeiR-HSA-429947, Deadenylation of mRNA

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		79670, 24 hits in 878 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ZCCHC6, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		ZCCHC6

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		79670
PharosiQ5VYS8, Tbio

Protein Ontology

More...PROi		PR:Q5VYS8
RNActiQ5VYS8, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000083223, Expressed in tendon and 227 other tissues
ExpressionAtlasiQ5VYS8, baseline and differential
GenevisibleiQ5VYS8, HS

Family and domain databases

Gene3Di3.30.460.10, 2 hits
InterProiView protein in InterPro
IPR003604, Matrin/U1-like-C_Znf_C2H2
IPR043519, NT_sf
IPR002058, PAP_assoc
IPR001878, Znf_CCHC
IPR036875, Znf_CCHC_sf
PfamiView protein in Pfam
PF03828, PAP_assoc, 2 hits
PF00098, zf-CCHC, 3 hits
SMARTiView protein in SMART
SM00343, ZnF_C2HC, 3 hits
SM00451, ZnF_U1, 1 hit
SUPFAMiSSF57756, SSF57756, 3 hits
SSF81301, SSF81301, 2 hits
PROSITEiView protein in PROSITE
PS50158, ZF_CCHC, 3 hits
PS00028, ZINC_FINGER_C2H2_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTUT7_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5VYS8
Secondary accession number(s): Q5H9T0
, Q5VYS5, Q5VYS7, Q658Z9, Q659A2, Q6MZJ3, Q8N5F0, Q96N57, Q96NE8, Q9C0F2, Q9H8M6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: December 7, 2004
Last modified: February 10, 2021
This is version 145 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human variants curated from literature reports
    Index of human variants curated from literature reports
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
  6. Human entries with genetic variants
    List of human entries with genetic variants
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