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Protein

Terminal uridylyltransferase 7

Gene

TUT7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay (PubMed:19703396, PubMed:25480299). Essential for both oocyte maturation and fertility. Through 3' terminal uridylation of mRNA, sculpts, with TUT7, the maternal transcriptome by eliminating transcripts during oocyte growth (By similarity). Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets (PubMed:25480299). Also functions as an integral regulator of microRNA biogenesiS using 3 different uridylation mechanisms (PubMed:25979828). Acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7 (pre-let-7). Uridylated pre-let-7 RNA is not processed by Dicer and undergo degradation. Pre-let-7 uridylation is strongly enhanced in the presence of LIN28A (PubMed:22898984). In the absence of LIN28A, TUT7 and TUT4 monouridylate group II pre-miRNAs, which includes most of pre-let7 members, that shapes an optimal 3' end overhang for efficient processing (PubMed:25979828, PubMed:28671666). Add oligo-U tails to truncated pre-miRNAS with a 5' overhang which may promote rapid degradation of non-functional pre-miRNA species (PubMed:25979828). Does not play a role in replication-dependent histone mRNA degradation (PubMed:18172165). Due to functional redundancy between TUT4 and TUT7, the identification of the specific role of each of these proteins is difficult (PubMed:25979828, PubMed:25480299, PubMed:19703396, PubMed:22898984, PubMed:18172165, PubMed:28671666). TUT4 and TUT7 restrict retrotransposition of long interspersed element-1 (LINE-1) in cooperation with MOV10 counteracting the RNA chaperonne activity of L1RE1. TUT7 uridylates LINE-1 mRNAs in the cytoplasm which inhibits initiation of reverse transcription once in the nucleus, whereas uridylation by TUT4 destabilizes mRNAs in cytoplasmic ribonucleoprotein granules (PubMed:30122351).By similarity7 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarity, Mn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi1058Magnesium or manganese; catalyticBy similarity1
Metal bindingi1060Magnesium or manganese; catalyticBy similarity1
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei1130UTPCombined sources1
Binding sitei1152UTPCombined sources1
Binding sitei1286UTPCombined sources1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri244 – 274Matrin-typePROSITE-ProRule annotationAdd BLAST31
Zinc fingeri963 – 980CCHC-type 1PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri1345 – 1362CCHC-type 2PROSITE-ProRule annotationCombined sources1 PublicationAdd BLAST18
Zinc fingeri1451 – 1468CCHC-type 3PROSITE-ProRule annotationAdd BLAST18

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionNucleotidyltransferase, Transferase
LigandMagnesium, Manganese, Metal-binding, Zinc

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.7.7.52 2681

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-429947 Deadenylation of mRNA

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Terminal uridylyltransferase 7Curated (EC:2.7.7.521 Publication)
Short name:
TUTase 7Curated
Alternative name(s):
Zinc finger CCHC domain-containing protein 6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TUT7Imported
Synonyms:HS2, KIAA1711, ZCCHC6Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000083223.17

Human Gene Nomenclature Database

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HGNCi
HGNC:25817 TUT7

Online Mendelian Inheritance in Man (OMIM)

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MIMi
613467 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5VYS8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1060D → A: Abolishes inhibition of LIRE1 retrotransposition. 1 Publication1
Mutagenesisi1097 – 1099LPI → WPW: Abolishes monouridylation activity. 1 Publication3

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000083223

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA134971144

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZCCHC6

Domain mapping of disease mutations (DMDM)

More...
DMDMi
67462100

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001509571 – 1495Terminal uridylyltransferase 7Add BLAST1495

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei57PhosphothreonineCombined sources1
Modified residuei64PhosphothreonineCombined sources1
Modified residuei132PhosphoserineBy similarity1
Modified residuei172PhosphoserineCombined sources1
Modified residuei600PhosphoserineCombined sources1
Modified residuei844PhosphoserineCombined sources1
Modified residuei893PhosphoserineBy similarity1
Modified residuei939PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q5VYS8

MaxQB - The MaxQuant DataBase

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MaxQBi
Q5VYS8

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q5VYS8

PeptideAtlas

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PeptideAtlasi
Q5VYS8

PRoteomics IDEntifications database

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PRIDEi
Q5VYS8

ProteomicsDB human proteome resource

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ProteomicsDBi
65642
65643 [Q5VYS8-2]
65644 [Q5VYS8-3]
65645 [Q5VYS8-4]
65646 [Q5VYS8-5]
65647 [Q5VYS8-6]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5VYS8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q5VYS8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000083223 Expressed in 215 organ(s), highest expression level in tendon

CleanEx database of gene expression profiles

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CleanExi
HS_ZCCHC6

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q5VYS8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q5VYS8 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA020615
HPA020620

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MOV10; the interaction is RNA-dependent.1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
122795, 43 interactors

Protein interaction database and analysis system

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IntActi
Q5VYS8, 18 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000365130

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11495
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q5VYS8

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q5VYS8

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini551 – 600PAP-associated 1Add BLAST50
Domaini1233 – 1286PAP-associated 2Add BLAST54

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni951 – 1495Sufficient for monouridylation activity1 PublicationAdd BLAST545
Regioni1047 – 1050UTP bindingCombined sources4
Regioni1057 – 1060UTP bindingCombined sources4
Regioni1170 – 1174UTP bindingCombined sources5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi20 – 23Poly-Asp4
Compositional biasi815 – 936Glu-richAdd BLAST122
Compositional biasi1367 – 1370Poly-Arg4

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Utilizes two multidomain functional modules during the switch from monouridylation to oligouridylation. The catalytic module (containing the 3 CCHC-type Zinc finger domains) is essential for both activites while the Lin28-interacting module (LIM) at the N-termail part is indispensable for oligouridylation.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DNA polymerase type-B-like family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri244 – 274Matrin-typePROSITE-ProRule annotationAdd BLAST31
Zinc fingeri963 – 980CCHC-type 1PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri1345 – 1362CCHC-type 2PROSITE-ProRule annotationCombined sources1 PublicationAdd BLAST18
Zinc fingeri1451 – 1468CCHC-type 3PROSITE-ProRule annotationAdd BLAST18

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2277 Eukaryota
COG5260 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000156859

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q5VYS8

KEGG Orthology (KO)

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KOi
K13291

Identification of Orthologs from Complete Genome Data

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OMAi
WINDNHK

Database of Orthologous Groups

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OrthoDBi
EOG091G01G7

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5VYS8

TreeFam database of animal gene trees

More...
TreeFami
TF315661

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR003604 Matrin/U1-like-C_Znf_C2H2
IPR002058 PAP_assoc
IPR002934 Polymerase_NTP_transf_dom
IPR001878 Znf_CCHC
IPR036875 Znf_CCHC_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01909 NTP_transf_2, 1 hit
PF03828 PAP_assoc, 2 hits
PF00098 zf-CCHC, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00343 ZnF_C2HC, 3 hits
SM00451 ZnF_U1, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF57756 SSF57756, 3 hits

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50158 ZF_CCHC, 3 hits
PS00028 ZINC_FINGER_C2H2_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5VYS8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGDTAKPYFV KRTKDRGTMD DDDFRRGHPQ QDYLIIDDHA KGHGSKMEKG
60 70 80 90 100
LQKKKITPGN YGNTPRKGPC AVSSNPYAFK NPIYSQPAWM NDSHKDQSKR
110 120 130 140 150
WLSDEHTGNS DNWREFKPGP RIPVINRQRK DSFQENEDGY RWQDTRGCRT
160 170 180 190 200
VRRLFHKDLT SLETTSEMEA GSPENKKQRS RPRKPRKTRN EENEQDGDLE
210 220 230 240 250
GPVIDESVLS TKELLGLQQA EERLKRDCID RLKRRPRNYP TAKYTCRLCD
260 270 280 290 300
VLIESIAFAH KHIKEKRHKK NIKEKQEEEL LTTLPPPTPS QINAVGIAID
310 320 330 340 350
KVVQEFGLHN ENLEQRLEIK RIMENVFQHK LPDCSLRLYG SSCSRLGFKN
360 370 380 390 400
SDVNIDIQFP AIMSQPDVLL LVQECLKNSD SFIDVDADFH ARVPVVVCRE
410 420 430 440 450
KQSGLLCKVS AGNENACLTT KHLTALGKLE PKLVPLVIAF RYWAKLCSID
460 470 480 490 500
RPEEGGLPPY VFALMAIFFL QQRKEPLLPV YLGSWIEGFS LSKLGNFNLQ
510 520 530 540 550
DIEKDVVIWE HTDSAAGDTG ITKEEAPRET PIKRGQVSLI LDVKHQPSVP
560 570 580 590 600
VGQLWVELLR FYALEFNLAD LVISIRVKEL VSRELKDWPK KRIAIEDPYS
610 620 630 640 650
VKRNVARTLN SQPVFEYILH CLRTTYKYFA LPHKITKSSL LKPLNAITCI
660 670 680 690 700
SEHSKEVINH HPDVQTKDDK LKNSVLAQGP GATSSAANTC KVQPLTLKET
710 720 730 740 750
AESFGSPPKE EMGNEHISVH PENSDCIQAD VNSDDYKGDK VYHPETGRKN
760 770 780 790 800
EKEKVGRKGK HLLTVDQKRG EHVVCGSTRN NESESTLDLE GFQNPTAKEC
810 820 830 840 850
EGLATLDNKA DLDGESTEGT EELEDSLNHF THSVQGQTSE MIPSDEEEED
860 870 880 890 900
DEEEEEEEEP RLTINQREDE DGMANEDELD NTYTGSGDED ALSEEDDELG
910 920 930 940 950
EAAKYEDVKE CGKHVERALL VELNKISLKE ENVCEEKNSP VDQSDFFYEF
960 970 980 990 1000
SKLIFTKGKS PTVVCSLCKR EGHLKKDCPE DFKRIQLEPL PPLTPKFLNI
1010 1020 1030 1040 1050
LDQVCIQCYK DFSPTIIEDQ AREHIRQNLE SFIRQDFPGT KLSLFGSSKN
1060 1070 1080 1090 1100
GFGFKQSDLD VCMTINGLET AEGLDCVRTI EELARVLRKH SGLRNILPIT
1110 1120 1130 1140 1150
TAKVPIVKFF HLRSGLEVDI SLYNTLALHN TRLLSAYSAI DPRVKYLCYT
1160 1170 1180 1190 1200
MKVFTKMCDI GDASRGSLSS YAYTLMVLYF LQQRNPPVIP VLQEIYKGEK
1210 1220 1230 1240 1250
KPEIFVDGWN IYFFDQIDEL PTYWSECGKN TESVGQLWLG LLRFYTEEFD
1260 1270 1280 1290 1300
FKEHVISIRR KSLLTTFKKQ WTSKYIVIED PFDLNHNLGA GLSRKMTNFI
1310 1320 1330 1340 1350
MKAFINGRRV FGIPVKGFPK DYPSKMEYFF DPDVLTEGEL APNDRCCRIC
1360 1370 1380 1390 1400
GKIGHFMKDC PMRRKVRRRR DQEDALNQRY PENKEKRSKE DKEIHNKYTE
1410 1420 1430 1440 1450
REVSTKEDKP IQCTPQKAKP MRAAADLGRE KILRPPVEKW KRQDDKDLRE
1460 1470 1480 1490
KRCFICGREG HIKKECPQFK GSSGSLSSKY MTQGKASAKR TQQES
Length:1,495
Mass (Da):171,229
Last modified:December 7, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1AAB0F5B37266FF9
GO
Isoform 2 (identifier: Q5VYS8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     597-615: DPYSVKRNVARTLNSQPVF → GISKCLSYSPPLFFLKVPV
     616-1495: Missing.

Note: No experimental confirmation available.
Show »
Length:615
Mass (Da):70,475
Checksum:iE3B7FEE22E438BBD
GO
Isoform 3 (identifier: Q5VYS8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     538-544: SLILDVK → VSSLLCR
     545-1495: Missing.

Note: No experimental confirmation available.
Show »
Length:544
Mass (Da):62,261
Checksum:iDE285E0532C43340
GO
Isoform 4 (identifier: Q5VYS8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     363-486: MSQPDVLLLV...LLPVYLGSWI → I
     960-1072: Missing.

Note: No experimental confirmation available.
Show »
Length:1,259
Mass (Da):144,656
Checksum:i2DFDA89240222042
GO
Isoform 5 (identifier: Q5VYS8-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     403-412: SGLLCKVSAG → RSHFFKLFIY
     413-1495: Missing.

Note: No experimental confirmation available.
Show »
Length:412
Mass (Da):47,903
Checksum:i73F48669DDBD99CB
GO
Isoform 6 (identifier: Q5VYS8-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1157-1194: Missing.

Note: No experimental confirmation available.
Show »
Length:1,457
Mass (Da):166,970
Checksum:iF5F376C95EF2CEE5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
X6R3Q3X6R3Q3_HUMAN
Terminal uridylyltransferase 7
TUT7
784Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5VYS9Q5VYS9_HUMAN
Terminal uridylyltransferase 7
TUT7
168Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4DFW3A0A0C4DFW3_HUMAN
Terminal uridylyltransferase 7
TUT7
395Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5VYT0Q5VYT0_HUMAN
Terminal uridylyltransferase 7
TUT7
124Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB14584 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB71052 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti157K → R in BAB70951 (PubMed:14702039).Curated1
Sequence conflicti316R → T in CAE46038 (PubMed:17974005).Curated1
Sequence conflicti514S → N in CAE46038 (PubMed:17974005).Curated1
Sequence conflicti900G → V in CAI45944 (PubMed:17974005).Curated1
Sequence conflicti937Missing in CAI45944 (PubMed:17974005).Curated1
Sequence conflicti937Missing in CAH56219 (PubMed:17974005).Curated1
Sequence conflicti1104V → M in CAH56219 (PubMed:17974005).Curated1
Sequence conflicti1319P → S in CAH56219 (PubMed:17974005).Curated1
Sequence conflicti1474G → D in CAI45944 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05375340A → V. Corresponds to variant dbSNP:rs2378695Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_013832363 – 486MSQPD…LGSWI → I in isoform 4. 1 PublicationAdd BLAST124
Alternative sequenceiVSP_013833403 – 412SGLLCKVSAG → RSHFFKLFIY in isoform 5. 1 Publication10
Alternative sequenceiVSP_013834413 – 1495Missing in isoform 5. 1 PublicationAdd BLAST1083
Alternative sequenceiVSP_013835538 – 544SLILDVK → VSSLLCR in isoform 3. 1 Publication7
Alternative sequenceiVSP_013836545 – 1495Missing in isoform 3. 1 PublicationAdd BLAST951
Alternative sequenceiVSP_013837597 – 615DPYSV…SQPVF → GISKCLSYSPPLFFLKVPV in isoform 2. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_013838616 – 1495Missing in isoform 2. 1 PublicationAdd BLAST880
Alternative sequenceiVSP_013839960 – 1072Missing in isoform 4. 1 PublicationAdd BLAST113
Alternative sequenceiVSP_0138401157 – 1194Missing in isoform 6. 1 PublicationAdd BLAST38

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL832026 mRNA Translation: CAH56219.1
AL832193 mRNA Translation: CAH56214.1
BX641077 mRNA Translation: CAE46038.1
CR933643 mRNA Translation: CAI45944.1
CR933644 mRNA Translation: CAI45945.1
CR936608 mRNA Translation: CAI56753.1
AL137849 Genomic DNA No translation available.
AL353678 Genomic DNA No translation available.
BC032456 mRNA Translation: AAH32456.1
AK023471 mRNA Translation: BAB14584.1 Different initiation.
AK055546 mRNA Translation: BAB70951.1
AK055948 mRNA Translation: BAB71052.1 Different initiation.
AB051498 mRNA Translation: BAB21802.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS35057.1 [Q5VYS8-1]
CCDS55323.1 [Q5VYS8-4]

NCBI Reference Sequences

More...
RefSeqi
NP_001171988.1, NM_001185059.1 [Q5VYS8-1]
NP_001172003.1, NM_001185074.1 [Q5VYS8-4]
NP_001317647.1, NM_001330718.1
NP_078893.2, NM_024617.3 [Q5VYS8-1]
XP_016870619.1, XM_017015130.1 [Q5VYS8-1]
XP_016870620.1, XM_017015131.1 [Q5VYS8-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.597057

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000375960; ENSP00000365127; ENSG00000083223 [Q5VYS8-4]
ENST00000375963; ENSP00000365130; ENSG00000083223 [Q5VYS8-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
79670

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:79670

UCSC genome browser

More...
UCSCi
uc004aoq.4 human [Q5VYS8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL832026 mRNA Translation: CAH56219.1
AL832193 mRNA Translation: CAH56214.1
BX641077 mRNA Translation: CAE46038.1
CR933643 mRNA Translation: CAI45944.1
CR933644 mRNA Translation: CAI45945.1
CR936608 mRNA Translation: CAI56753.1
AL137849 Genomic DNA No translation available.
AL353678 Genomic DNA No translation available.
BC032456 mRNA Translation: AAH32456.1
AK023471 mRNA Translation: BAB14584.1 Different initiation.
AK055546 mRNA Translation: BAB70951.1
AK055948 mRNA Translation: BAB71052.1 Different initiation.
AB051498 mRNA Translation: BAB21802.1
CCDSiCCDS35057.1 [Q5VYS8-1]
CCDS55323.1 [Q5VYS8-4]
RefSeqiNP_001171988.1, NM_001185059.1 [Q5VYS8-1]
NP_001172003.1, NM_001185074.1 [Q5VYS8-4]
NP_001317647.1, NM_001330718.1
NP_078893.2, NM_024617.3 [Q5VYS8-1]
XP_016870619.1, XM_017015130.1 [Q5VYS8-1]
XP_016870620.1, XM_017015131.1 [Q5VYS8-1]
UniGeneiHs.597057

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5W0BX-ray2.61A/B/C983-1365[»]
5W0MX-ray2.30A/B/C983-1365[»]
5W0NX-ray2.50A/B/C963-1365[»]
5W0OX-ray2.49A/B983-1365[»]
ProteinModelPortaliQ5VYS8
SMRiQ5VYS8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122795, 43 interactors
IntActiQ5VYS8, 18 interactors
STRINGi9606.ENSP00000365130

PTM databases

iPTMnetiQ5VYS8
PhosphoSitePlusiQ5VYS8

Polymorphism and mutation databases

BioMutaiZCCHC6
DMDMi67462100

Proteomic databases

EPDiQ5VYS8
MaxQBiQ5VYS8
PaxDbiQ5VYS8
PeptideAtlasiQ5VYS8
PRIDEiQ5VYS8
ProteomicsDBi65642
65643 [Q5VYS8-2]
65644 [Q5VYS8-3]
65645 [Q5VYS8-4]
65646 [Q5VYS8-5]
65647 [Q5VYS8-6]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
79670
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375960; ENSP00000365127; ENSG00000083223 [Q5VYS8-4]
ENST00000375963; ENSP00000365130; ENSG00000083223 [Q5VYS8-1]
GeneIDi79670
KEGGihsa:79670
UCSCiuc004aoq.4 human [Q5VYS8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
79670
EuPathDBiHostDB:ENSG00000083223.17

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TUT7

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0008144
HGNCiHGNC:25817 TUT7
HPAiHPA020615
HPA020620
MIMi613467 gene
neXtProtiNX_Q5VYS8
OpenTargetsiENSG00000083223
PharmGKBiPA134971144

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2277 Eukaryota
COG5260 LUCA
GeneTreeiENSGT00940000156859
InParanoidiQ5VYS8
KOiK13291
OMAiWINDNHK
OrthoDBiEOG091G01G7
PhylomeDBiQ5VYS8
TreeFamiTF315661

Enzyme and pathway databases

BRENDAi2.7.7.52 2681
ReactomeiR-HSA-429947 Deadenylation of mRNA

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ZCCHC6 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
ZCCHC6

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
79670

Protein Ontology

More...
PROi
PR:Q5VYS8

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000083223 Expressed in 215 organ(s), highest expression level in tendon
CleanExiHS_ZCCHC6
ExpressionAtlasiQ5VYS8 baseline and differential
GenevisibleiQ5VYS8 HS

Family and domain databases

InterProiView protein in InterPro
IPR003604 Matrin/U1-like-C_Znf_C2H2
IPR002058 PAP_assoc
IPR002934 Polymerase_NTP_transf_dom
IPR001878 Znf_CCHC
IPR036875 Znf_CCHC_sf
PfamiView protein in Pfam
PF01909 NTP_transf_2, 1 hit
PF03828 PAP_assoc, 2 hits
PF00098 zf-CCHC, 3 hits
SMARTiView protein in SMART
SM00343 ZnF_C2HC, 3 hits
SM00451 ZnF_U1, 1 hit
SUPFAMiSSF57756 SSF57756, 3 hits
PROSITEiView protein in PROSITE
PS50158 ZF_CCHC, 3 hits
PS00028 ZINC_FINGER_C2H2_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTUT7_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5VYS8
Secondary accession number(s): Q5H9T0
, Q5VYS5, Q5VYS7, Q658Z9, Q659A2, Q6MZJ3, Q8N5F0, Q96N57, Q96NE8, Q9C0F2, Q9H8M6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: December 7, 2004
Last modified: December 5, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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