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Protein
Submitted name:

Abnormal spindle-like microcephaly-associated protein

Gene

ASPM

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Abnormal spindle-like microcephaly-associated proteinImported
Submitted name:
Asp (Abnormal spindle)-like, microcephaly associated (Drosophila), isoform CRA_dImported
Gene namesi
Name:ASPMImported
ORF Names:hCG_2039667Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000066279.16
HGNCiHGNC:19048 ASPM

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000066279

PTM / Processingi

Proteomic databases

EPDiQ5VYL4
MaxQBiQ5VYL4
PRIDEiQ5VYL4

Expressioni

Gene expression databases

BgeeiENSG00000066279

Interactioni

Protein-protein interaction databases

IntActiQ5VYL4, 1 interactor

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini170 – 306Calponin-homology (CH)InterPro annotationAdd BLAST137
Domaini360 – 511Calponin-homology (CH)InterPro annotationAdd BLAST152

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili586 – 606Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

GeneTreeiENSGT00560000077332

Family and domain databases

Gene3Di1.10.418.10, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR029955 ASPM
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR000048 IQ_motif_EF-hand-BS
IPR027417 P-loop_NTPase
PANTHERiPTHR44613 PTHR44613, 2 hits
PfamiView protein in Pfam
PF00307 CH, 1 hit
PF00612 IQ, 8 hits
SMARTiView protein in SMART
SM00033 CH, 2 hits
SM00015 IQ, 12 hits
SUPFAMiSSF47576 SSF47576, 3 hits
SSF48371 SSF48371, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50021 CH, 2 hits
PS50096 IQ, 6 hits

Sequencei

Sequence statusi: Complete.

Q5VYL4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLRAYTARC RLNRLRRAAC RLFTSEKMVK AIKKLEIEIE ARRLIVRKDR
60 70 80 90 100
HLWKDVGERQ KVLNWLLSYN PLWLRIGLET TYGELISLED NSDVTGLAMF
110 120 130 140 150
ILNRLLWNPD IAAEYRHPTV PHLYRDGHEE ALSKFTLKKL LLLVCFLDYA
160 170 180 190 200
KISRLIDHDP CLFCKDAEFK ASKEILLAFS RDFLSGEGDL SRHLGLLGLP
210 220 230 240 250
VNHVQTPFDE FDFAVTNLAV DLQCGVRLVR TMELLTQNWD LSKKLRIPAI
260 270 280 290 300
SRLQKMHNVD IVLQVLKSRG IELSDEHGNT ILSKDIVDRH REKTLRLLWK
310 320 330 340 350
IAFAFQVDIS LNLDQLKEEI AFLKHTKSIK KTISLLSCHS DDLINKKKGK
360 370 380 390 400
RDSGSFEQYS ENIKLLMDWV NAVCAFYNKK VENFTVSFSD GRVLCYLIHH
410 420 430 440 450
YHPCYVPFDA ICQRTTQTVE CTQTGSVVLN SSSESDDSSL DMSLKAFDHE
460 470 480 490 500
NTSELYKELL ENEKKNFHLV RSAVRDLGGI PAMINHSDMS NTIPDEKVVI
510 520 530 540 550
TYLSFLCARL LDLRKEIRAA RLIQTTWRKY KLKTDLKRHQ EREKAARIIQ
560 570 580 590 600
LAVINFLAKQ RLRKRVNAAL VIQKYWRRVL AQRKLLMLKK EKLEKVQNKA
610 620 630 640 650
ASLIQAMWRR YRAKKYLCKV KAACKIQAWY RCWRAHKEYL AILKAVKIIQ
660 670 680 690 700
GCFYTKLERT RFLNVRASAI IIQRKWRAIL PAKIAHEHFL MIKRHRAACL
710 720 730 740 750
IQAHYRGYKG RQVFLRQKSA ALIIQKYIRA REAGKHERIK YIEFKKSTVI
760 770 780 790 800
LQALVRGWLV RKRFLEQRAK IRLLHFTAAA YYHLNAVRIQ RAYKLYLAVK
810 820 830 840 850
NANKQVNSVI CIQRWFRARL QEKRFIQKYH SIKKIEHEGQ ECLSQRNRAA
860 870 880 890 900
SVIQKAVRHF LLRKKQEKFT SGIIKIQALW RGYSWRKKND CTKIKAIRLS
910 920 930 940 950
LQVVNREIRE ENKLYKRTAL ALHYLLTYKH LSAILEALKH LEVVTRLSPL
960 970 980 990 1000
CCENMAQSGA ISKIFVLIRS CNRSIPCMEV IRYAVQVLLN VSKYEKTTSA
1010 1020 1030 1040 1050
VYDVENCIDI LLELLQIYRE KPGNKVADKG GSIFTKTCCL LAILLKTTNR
1060 1070 1080 1090 1100
ASDVRSRSKV VDRIYSLYKL TAHKHKMNTE RILYKQKKNS SISIPFIPET
1110 1120 1130 1140
PVRTRIVSRL KPDWVLRRDN MEEITNPLQA IQMVMDTLGI PY
Length:1,142
Mass (Da):133,558
Last modified:December 7, 2004 - v1
Checksum:iAEE45A1534FC3DF8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL353809 Genomic DNA No translation available.
AL627208 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW91273.1
UniGeneiHs.121028

Genome annotation databases

EnsembliENST00000367408; ENSP00000356378; ENSG00000066279
UCSCiuc057odd.1 human

Similar proteinsi

Entry informationi

Entry nameiQ5VYL4_HUMAN
AccessioniPrimary (citable) accession number: Q5VYL4
Entry historyiIntegrated into UniProtKB/TrEMBL: December 7, 2004
Last sequence update: December 7, 2004
Last modified: July 18, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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