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Entry version 152 (16 Oct 2019)
Sequence version 2 (15 Mar 2005)
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Protein

Proteasome adapter and scaffold protein ECM29

Gene

ECPAS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Adapter/scaffolding protein that binds to the 26S proteasome, motor proteins and other compartment specific proteins. May couple the proteasome to different compartments including endosome, endoplasmic reticulum and centrosome. May play a role in ERAD and other enhanced proteolyis (PubMed:15496406). Promotes proteasome dissociation under oxidative stress (By similarity).By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • proteasome assembly Source: InterPro
  • ubiquitin-dependent ERAD pathway Source: UniProtKB

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Proteasome adapter and scaffold protein ECM29Curated
Alternative name(s):
Ecm29 proteasome adapter and scaffoldImported
Proteasome-associated protein ECM29 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ECPASImported
Synonyms:ECM29, KIAA0368
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29020 ECPAS

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
616694 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5VYK3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Endoplasmic reticulum, Endosome, Nucleus, Proteasome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
23392

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q5VYK3

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KIAA0368

Domain mapping of disease mutations (DMDM)

More...
DMDMi
61212960

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002125592 – 1845Proteasome adapter and scaffold protein ECM29Add BLAST1844

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei830PhosphoserineCombined sources1
Modified residuei836PhosphothreonineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki1039Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5VYK3

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5VYK3

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q5VYK3

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q5VYK3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5VYK3

PeptideAtlas

More...
PeptideAtlasi
Q5VYK3

PRoteomics IDEntifications database

More...
PRIDEi
Q5VYK3

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
65635

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5VYK3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5VYK3

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q5VYK3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000136813 Expressed in 240 organ(s), highest expression level in epithelium of mammary gland

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5VYK3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5VYK3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA021646
HPA059795

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Non-stoichiometric component of the proteasome; associates with the 26S proteasome.

Interacts (via N-terminus) with VPS11, VPS26A, VPS36, RAB11FIP4 and RABEP1.

Interacts (via C-terminus) with DCTN1, DCTN2, KIF5B, MYH7, MYH10, MYO10 and ARF6.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116966, 169 interactors

Protein interaction database and analysis system

More...
IntActi
Q5VYK3, 61 interactors

Molecular INTeraction database

More...
MINTi
Q5VYK3

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000259335

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati34 – 71HEAT 1Add BLAST38
Repeati113 – 150HEAT 2Add BLAST38
Repeati168 – 211HEAT 3Add BLAST44
Repeati332 – 368HEAT 4Add BLAST37
Repeati393 – 432HEAT 5Add BLAST40
Repeati435 – 472HEAT 6Add BLAST38
Repeati475 – 513HEAT 7Add BLAST39
Repeati689 – 726HEAT 8Add BLAST38
Repeati727 – 765HEAT 9Add BLAST39
Repeati789 – 826HEAT 10Add BLAST38
Repeati835 – 874HEAT 11Add BLAST40
Repeati876 – 913HEAT 12Add BLAST38
Repeati937 – 975HEAT 13Add BLAST39
Repeati981 – 1018HEAT 14Add BLAST38
Repeati1019 – 1056HEAT 15Add BLAST38
Repeati1118 – 1155HEAT 16Add BLAST38
Repeati1158 – 1195HEAT 17Add BLAST38
Repeati1200 – 1237HEAT 18Add BLAST38
Repeati1249 – 1287HEAT 19Add BLAST39
Repeati1291 – 1329HEAT 20Add BLAST39
Repeati1354 – 1392HEAT 21Add BLAST39
Repeati1396 – 1433HEAT 22Add BLAST38
Repeati1523 – 1560HEAT 23Add BLAST38
Repeati1564 – 1601HEAT 24Add BLAST38
Repeati1611 – 1648HEAT 25Add BLAST38
Repeati1652 – 1689HEAT 26Add BLAST38
Repeati1785 – 1828HEAT 27Add BLAST44

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ECM29 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0915 Eukaryota
ENOG410XPYT LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231642

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5VYK3

Database of Orthologous Groups

More...
OrthoDBi
167285at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5VYK3

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR024372 Ecm29
IPR032878 Vac14_Fab1-bd

The PANTHER Classification System

More...
PANTHERi
PTHR23346:SF19 PTHR23346:SF19, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13001 Ecm29, 1 hit
PF12755 Vac14_Fab1_bd, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q5VYK3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAAAASASQ DELNQLERVF LRLGHAETDE QLQNIISKFL PPVLLKLSST
60 70 80 90 100
QEGVRKKVME LLVHLNKRIK SRPKIQLPVE TLLVQYQDPA AVSFVTNFTI
110 120 130 140 150
IYVKMGYPRL PVEKQCELAP TLLTAMEGKP QPQQDSLMHL LIPTLFHMKY
160 170 180 190 200
PVESSKSASP FNLAEKPKTV QLLLDFMLDV LLMPYGYVLN ESQSRQNSSS
210 220 230 240 250
AQGSSSNSGG GSGIPQPPPG MSFYAAKRVI GDNPWTPEQL EQCKLGIVKF
260 270 280 290 300
IEAEQVPELE AVLHLVIASS DTRHSVATAA DLELKSKQSL IDWNNPAIIN
310 320 330 340 350
KMYKVYLGDI PLKTKEGAVL KPELKRDPVS TRVKLKIVPH LLRSRQAAET
360 370 380 390 400
FPANIQVVYD GLFGTNTNSK LRTLSLQFVH HICITCPEIK IKPLGPMLLN
410 420 430 440 450
GLTKLINEYK EDPKLLSMAY SAVGKLSSRM PHLFTKDIAL VQQLFEALCK
460 470 480 490 500
EEPETRLAIQ EALSMMVGAY STLEGAQRTL MEALVASYLI KPEVQVRQVA
510 520 530 540 550
VKFASTVFPS DHIPSRYLLL LAAGDPREEV HGEAQRVLRC LPGRNRKEST
560 570 580 590 600
SEQMPSFPEM VYYIQEKASH RMKTPVKYMT GTTVLPFNPA AFGEIVLYLR
610 620 630 640 650
MCLAHSAGVV PTSQSLADMQ DHAPAIGRYI RTLMSSGQMA PSSSNKSGET
660 670 680 690 700
NPVQIYIGLL QQLLAGVGGL PVMYCLLEAV SVYPEKLATK FVDKTEWIKS
710 720 730 740 750
LMNNSKEEMR ELAALFYSVV VSTVSGNELK SMIEQLIKTT KDNHSPEIQH
760 770 780 790 800
GSLLALGFTV GRYLAKKKMR MSEQQDLERN ADTLPDQEEL IQSATETIGS
810 820 830 840 850
FLDSTSPLLA IAACTALGEI GRNGPLPIPS EGSGFTKLHL VESLLSRIPS
860 870 880 890 900
SKETNKMKER AIQTLGYFPV GDGDFPHQKL LLQGLMDSVE AKQIELQFTI
910 920 930 940 950
GEAITSAAIG TSSVAARDAW QMTEEEYTPP AGAKVNDVVP WVLDVILNKH
960 970 980 990 1000
IISPNPHVRQ AACIWLLSLV RKLSTHKEVK SHLKEIQSAF VSVLSENDEL
1010 1020 1030 1040 1050
SQDVASKGLG LVYELGNEQD QQELVSTLVE TLMTGKRVKH EVSGETVVFQ
1060 1070 1080 1090 1100
GGALGKTPDG QGLSTYKELC SLASDLSQPD LVYKFMNLAN HHAMWNSRKG
1110 1120 1130 1140 1150
AAFGFNVIAT RAGEQLAPFL PQLVPRLYRY QFDPNLGIRQ AMTSIWNALV
1160 1170 1180 1190 1200
TDKSMVDKYL KEILQDLVKN LTSNMWRVRE SSCLALNDLL RGRPLDDIID
1210 1220 1230 1240 1250
KLPEIWETLF RVQDDIKESV RKAAELALKT LSKVCVKMCD PAKGAAGQRT
1260 1270 1280 1290 1300
IAALLPCLLD KGMMSTVTEV RALSINTLVK ISKSAGAMLK PHAPKLIPAL
1310 1320 1330 1340 1350
LESLSVLEPQ VLNYLSLRAT EQEKAAMDSA RLSAAKSSPM METINMCLQY
1360 1370 1380 1390 1400
LDVSVLGELV PRLCELIRSG VGLGTKGGCA SVIVSLTTQC PQDLTPYSGK
1410 1420 1430 1440 1450
LMSALLSGLT DRNSVIQKSC AFAMGHLVRT SRDSSTEKLL QKLNGWYMEK
1460 1470 1480 1490 1500
EEPIYKTSCA LTIHAIGRYS PDVLKNHAKE VLPLAFLGMH EIADEEKSEK
1510 1520 1530 1540 1550
EECNLWTEVW QENVPGSFGG IRLYLQELIT ITQKALQSQS WKMKAQGAIA
1560 1570 1580 1590 1600
MASIAKQTSS LVPPYLGMIL TALLQGLAGR TWAGKEELLK AIACVVTACS
1610 1620 1630 1640 1650
AELEKSVPNQ PSTNEILQAV LKECSKENVK YKIVAISCAA DILKATKEDR
1660 1670 1680 1690 1700
FQEFSNIVIP LIKKNSLESS GVRTTKNEEE NEKEKELQLE YLLGAFESLG
1710 1720 1730 1740 1750
KAWPRNAETQ RCYRQELCKL MCERLKLSTW KVQLGVLQSM NAFFQGLMLL
1760 1770 1780 1790 1800
EEEHADPEAL AEILLETCKS ITYSLENKTY SSVRTEALSV IELLLKKLEE
1810 1820 1830 1840
SKQWECLTSE CRVLLIESLA TMEPDSRPEL QEKAALLKKT LENLE
Length:1,845
Mass (Da):204,291
Last modified:March 15, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5809A9208F5B4441
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KN16J3KN16_HUMAN
Proteasome adapter and scaffold pro...
ECPAS
2,017Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
R4GMY1R4GMY1_HUMAN
Proteasome adapter and scaffold pro...
ECPAS
890Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6XAQ5F6XAQ5_HUMAN
Proteasome adapter and scaffold pro...
ECPAS
142Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
R4GMY3R4GMY3_HUMAN
Proteasome adapter and scaffold pro...
ECPAS
128Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH21127 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti101I → N in AI916718 (Ref. 2) Curated1
Sequence conflicti101I → N in AK127247 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_055702472T → S. Corresponds to variant dbSNP:rs16916091Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL354661 Genomic DNA No translation available.
AL159168 Genomic DNA No translation available.
AI916718 mRNA No translation available.
AK127247 mRNA No translation available.
AB002366 mRNA Translation: BAA20823.1
BC021127 mRNA Translation: AAH21127.1 Different initiation.

NCBI Reference Sequences

More...
RefSeqi
XP_005251907.1, XM_005251850.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000338205; ENSP00000339889; ENSG00000136813

UCSC genome browser

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UCSCi
uc064vau.1 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL354661 Genomic DNA No translation available.
AL159168 Genomic DNA No translation available.
AI916718 mRNA No translation available.
AK127247 mRNA No translation available.
AB002366 mRNA Translation: BAA20823.1
BC021127 mRNA Translation: AAH21127.1 Different initiation.
RefSeqiXP_005251907.1, XM_005251850.3

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi116966, 169 interactors
IntActiQ5VYK3, 61 interactors
MINTiQ5VYK3
STRINGi9606.ENSP00000259335

PTM databases

iPTMnetiQ5VYK3
PhosphoSitePlusiQ5VYK3
SwissPalmiQ5VYK3

Polymorphism and mutation databases

BioMutaiKIAA0368
DMDMi61212960

Proteomic databases

EPDiQ5VYK3
jPOSTiQ5VYK3
MassIVEiQ5VYK3
MaxQBiQ5VYK3
PaxDbiQ5VYK3
PeptideAtlasiQ5VYK3
PRIDEiQ5VYK3
ProteomicsDBi65635

Genome annotation databases

EnsembliENST00000338205; ENSP00000339889; ENSG00000136813
UCSCiuc064vau.1 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23392
DisGeNETi23392

GeneCards: human genes, protein and diseases

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GeneCardsi
ECPAS
HGNCiHGNC:29020 ECPAS
HPAiHPA021646
HPA059795
MIMi616694 gene
neXtProtiNX_Q5VYK3

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0915 Eukaryota
ENOG410XPYT LUCA
HOGENOMiHOG000231642
InParanoidiQ5VYK3
OrthoDBi167285at2759
PhylomeDBiQ5VYK3

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
KIAA0368 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
KIAA0368

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
23392
PharosiQ5VYK3

Protein Ontology

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PROi
PR:Q5VYK3

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000136813 Expressed in 240 organ(s), highest expression level in epithelium of mammary gland
ExpressionAtlasiQ5VYK3 baseline and differential
GenevisibleiQ5VYK3 HS

Family and domain databases

Gene3Di1.25.10.10, 3 hits
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR024372 Ecm29
IPR032878 Vac14_Fab1-bd
PANTHERiPTHR23346:SF19 PTHR23346:SF19, 1 hit
PfamiView protein in Pfam
PF13001 Ecm29, 1 hit
PF12755 Vac14_Fab1_bd, 1 hit
SUPFAMiSSF48371 SSF48371, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiECM29_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5VYK3
Secondary accession number(s): O15074, Q8WU82
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: October 16, 2019
This is version 152 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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