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Entry version 123 (13 Feb 2019)
Sequence version 1 (07 Dec 2004)
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Protein

Platelet endothelial aggregation receptor 1

Gene

PEAR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

When overexpressed, reduces the number of both early and late non-adherent myeloid progenitor cells.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Platelet endothelial aggregation receptor 1
Short name:
hPEAR1
Alternative name(s):
Multiple epidermal growth factor-like domains protein 12
Short name:
Multiple EGF-like domains protein 12
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PEAR1
Synonyms:MEGF12
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000187800.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:33631 PEAR1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610278 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5VY43

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini21 – 755ExtracellularSequence analysisAdd BLAST735
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei756 – 776HelicalSequence analysisAdd BLAST21
Topological domaini777 – 1037CytoplasmicSequence analysisAdd BLAST261

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
375033

Open Targets

More...
OpenTargetsi
ENSG00000187800

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162399233

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PEAR1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74757035

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000030973721 – 1037Platelet endothelial aggregation receptor 1Add BLAST1017

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi29 ↔ 91Sequence analysis
Disulfide bondi55 ↔ 65Sequence analysis
Disulfide bondi90 ↔ 101Sequence analysis
Disulfide bondi105 ↔ 114By similarity
Disulfide bondi109 ↔ 120By similarity
Disulfide bondi122 ↔ 131By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi152N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi235 ↔ 248By similarity
Disulfide bondi250 ↔ 259By similarity
Glycosylationi271N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi272 ↔ 284By similarity
Disulfide bondi278 ↔ 291By similarity
Disulfide bondi293 ↔ 302By similarity
Disulfide bondi315 ↔ 327By similarity
Disulfide bondi321 ↔ 334By similarity
Disulfide bondi336 ↔ 345By similarity
Disulfide bondi404 ↔ 416By similarity
Disulfide bondi410 ↔ 423By similarity
Disulfide bondi425 ↔ 434By similarity
Glycosylationi476N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi490 ↔ 502By similarity
Disulfide bondi496 ↔ 509By similarity
Disulfide bondi511 ↔ 520By similarity
Glycosylationi575N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi580 ↔ 588By similarity
Disulfide bondi582 ↔ 595By similarity
Disulfide bondi597 ↔ 606By similarity
Disulfide bondi619 ↔ 630By similarity
Disulfide bondi624 ↔ 637By similarity
Glycosylationi634N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi639 ↔ 648By similarity
Disulfide bondi661 ↔ 673By similarity
Disulfide bondi667 ↔ 680By similarity
Disulfide bondi682 ↔ 691By similarity
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei925Phosphotyrosine1 Publication1
Modified residuei953Phosphoserine1 Publication1
Modified residuei1029Phosphoserine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated in the intracellular domain on tyrosine residues (By similarity). Phosphorylated on tyrosine residues by SRC. Tyrosine phosphorylation is detected upon platelet aggregation stimulated by collagen, TRAP and thrombin and platelet-platelet contacts but not after platelet activation. Tyrosine phosphorylation enhanced its association with SHC1 and SHC2.By similarity1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5VY43

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5VY43

PeptideAtlas

More...
PeptideAtlasi
Q5VY43

PRoteomics IDEntifications database

More...
PRIDEi
Q5VY43

ProteomicsDB human proteome resource

More...
ProteomicsDBi
65621

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5VY43

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5VY43

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in umbilical vein endothelial cells and platelets (at protein level). Expressed in heart, kidney, skeletal muscle, pancreas, ovary, breast, lung, brain cortex, hypothalamus, spinal cord, dorsal root ganglion, endothelial cells of umbilical cord artery and vein, megakaryocytes, osteoblasts, coronary muscle and erythroid cells. Weakly expressed in peripheral blood leukocytes and macrophages.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000187800 Expressed in 176 organ(s), highest expression level in right coronary artery

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5VY43 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5VY43 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA035217

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SHC2 upon its aggregation-induced tyrosine phosphorylation.1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
131950, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q5VY43, 5 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000292357

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q5VY43

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5VY43

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini25 – 103EMIPROSITE-ProRule annotationAdd BLAST79
Domaini102 – 132EGF-like 1PROSITE-ProRule annotationAdd BLAST31
Domaini225 – 260EGF-like 2PROSITE-ProRule annotationAdd BLAST36
Domaini268 – 303EGF-like 3PROSITE-ProRule annotationAdd BLAST36
Domaini311 – 346EGF-like 4PROSITE-ProRule annotationAdd BLAST36
Domaini400 – 435EGF-like 5PROSITE-ProRule annotationAdd BLAST36
Domaini486 – 521EGF-like 6PROSITE-ProRule annotationAdd BLAST36
Domaini577 – 607EGF-like 7PROSITE-ProRule annotationAdd BLAST31
Domaini615 – 649EGF-like 8PROSITE-ProRule annotationAdd BLAST35
Domaini657 – 692EGF-like 9PROSITE-ProRule annotationAdd BLAST36

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi807 – 1031Pro-richAdd BLAST225

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MEGF family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1218 Eukaryota
ENOG410XQWV LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154225

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000294130

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG108333

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5VY43

Identification of Orthologs from Complete Genome Data

More...
OMAi
TCIPENG

Database of Orthologous Groups

More...
OrthoDBi
561378at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5VY43

TreeFam database of animal gene trees

More...
TreeFami
TF332598

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR011489 EMI_domain
IPR002049 Laminin_EGF

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00053 Laminin_EGF, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181 EGF, 15 hits
SM00180 EGF_Lam, 12 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00022 EGF_1, 13 hits
PS01186 EGF_2, 12 hits
PS50026 EGF_3, 9 hits
PS51041 EMI, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q5VY43-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSPPLCPLLL LAVGLRLAGT LNPSDPNTCS FWESFTTTTK ESHSRPFSLL
60 70 80 90 100
PSEPCERPWE GPHTCPQPTV VYRTVYRQVV KTDHRQRLQC CHGFYESRGF
110 120 130 140 150
CVPLCAQECV HGRCVAPNQC QCVPGWRGDD CSSECAPGMW GPQCDKPCSC
160 170 180 190 200
GNNSSCDPKS GVCSCPSGLQ PPNCLQPCTP GYYGPACQFR CQCHGAPCDP
210 220 230 240 250
QTGACFCPAE RTGPSCDVSC SQGTSGFFCP STHSCQNGGV FQTPQGSCSC
260 270 280 290 300
PPGWMGTICS LPCPEGFHGP NCSQECRCHN GGLCDRFTGQ CRCAPGYTGD
310 320 330 340 350
RCREECPVGR FGQDCAETCD CAPDARCFPA NGACLCEHGF TGDRCTDRLC
360 370 380 390 400
PDGFYGLSCQ APCTCDREHS LSCHPMNGEC SCLPGWAGLH CNESCPQDTH
410 420 430 440 450
GPGCQEHCLC LHGGVCQATS GLCQCAPGYT GPHCASLCPP DTYGVNCSAR
460 470 480 490 500
CSCENAIACS PIDGECVCKE GWQRGNCSVP CPPGTWGFSC NASCQCAHEA
510 520 530 540 550
VCSPQTGACT CTPGWHGAHC QLPCPKGQFG EGCASRCDCD HSDGCDPVHG
560 570 580 590 600
RCQCQAGWMG ARCHLSCPEG LWGVNCSNTC TCKNGGTCLP ENGNCVCAPG
610 620 630 640 650
FRGPSCQRSC QPGRYGKRCV PCKCANHSFC HPSNGTCYCL AGWTGPDCSQ
660 670 680 690 700
PCPPGHWGEN CAQTCQCHHG GTCHPQDGSC ICPLGWTGHH CLEGCPLGTF
710 720 730 740 750
GANCSQPCQC GPGEKCHPET GACVCPPGHS GAPCRIGIQE PFTVMPTTPV
760 770 780 790 800
AYNSLGAVIG IAVLGSLVVA LVALFIGYRH WQKGKEHHHL AVAYSSGRLD
810 820 830 840 850
GSEYVMPDVP PSYSHYYSNP SYHTLSQCSP NPPPPNKVPG PLFASLQNPE
860 870 880 890 900
RPGGAQGHDN HTTLPADWKH RREPPPGPLD RGSSRLDRSY SYSYSNGPGP
910 920 930 940 950
FYNKGLISEE ELGASVASLS SENPYATIRD LPSLPGGPRE SSYMEMKGPP
960 970 980 990 1000
SGSPPRQPPQ FWDSQRRRQP QPQRDSGTYE QPSPLIHDRD SVGSQPPLPP
1010 1020 1030
GLPPGHYDSP KNSHIPGHYD LPPVRHPPSP PLRRQDR
Length:1,037
Mass (Da):110,666
Last modified:December 7, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD0DBB323D5F8C7E3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A6PVP2A6PVP2_HUMAN
Platelet endothelial aggregation re...
PEAR1
173Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F2Z2F7F2Z2F7_HUMAN
Platelet endothelial aggregation re...
PEAR1
77Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB84947 differs from that shown. Reason: Frameshift at position 557.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_048978234S → P. Corresponds to variant dbSNP:rs1952294Ensembl.1
Natural variantiVAR_061158848N → K. Corresponds to variant dbSNP:rs822442Ensembl.1
Natural variantiVAR_048979885R → H. Corresponds to variant dbSNP:rs11264581Ensembl.1
Natural variantiVAR_048980903N → D. Corresponds to variant dbSNP:rs12137505Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL158169 Genomic DNA No translation available.
AL356104 Genomic DNA No translation available.
AK074121 mRNA Translation: BAB84947.1 Frameshift.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS30892.1

NCBI Reference Sequences

More...
RefSeqi
NP_001073940.1, NM_001080471.1
XP_005245198.1, XM_005245141.3
XP_011507812.1, XM_011509510.2
XP_016856725.1, XM_017001236.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.142003

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000292357; ENSP00000292357; ENSG00000187800
ENST00000338302; ENSP00000344465; ENSG00000187800

Database of genes from NCBI RefSeq genomes

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GeneIDi
375033

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:375033

UCSC genome browser

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UCSCi
uc001fqj.1 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL158169 Genomic DNA No translation available.
AL356104 Genomic DNA No translation available.
AK074121 mRNA Translation: BAB84947.1 Frameshift.
CCDSiCCDS30892.1
RefSeqiNP_001073940.1, NM_001080471.1
XP_005245198.1, XM_005245141.3
XP_011507812.1, XM_011509510.2
XP_016856725.1, XM_017001236.1
UniGeneiHs.142003

3D structure databases

ProteinModelPortaliQ5VY43
SMRiQ5VY43
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131950, 2 interactors
IntActiQ5VY43, 5 interactors
STRINGi9606.ENSP00000292357

PTM databases

iPTMnetiQ5VY43
PhosphoSitePlusiQ5VY43

Polymorphism and mutation databases

BioMutaiPEAR1
DMDMi74757035

Proteomic databases

jPOSTiQ5VY43
PaxDbiQ5VY43
PeptideAtlasiQ5VY43
PRIDEiQ5VY43
ProteomicsDBi65621

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
375033
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000292357; ENSP00000292357; ENSG00000187800
ENST00000338302; ENSP00000344465; ENSG00000187800
GeneIDi375033
KEGGihsa:375033
UCSCiuc001fqj.1 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
375033
DisGeNETi375033
EuPathDBiHostDB:ENSG00000187800.13

GeneCards: human genes, protein and diseases

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GeneCardsi
PEAR1

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0001178
HGNCiHGNC:33631 PEAR1
HPAiHPA035217
MIMi610278 gene
neXtProtiNX_Q5VY43
OpenTargetsiENSG00000187800
PharmGKBiPA162399233

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1218 Eukaryota
ENOG410XQWV LUCA
GeneTreeiENSGT00940000154225
HOGENOMiHOG000294130
HOVERGENiHBG108333
InParanoidiQ5VY43
OMAiTCIPENG
OrthoDBi561378at2759
PhylomeDBiQ5VY43
TreeFamiTF332598

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
375033

Protein Ontology

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PROi
PR:Q5VY43

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000187800 Expressed in 176 organ(s), highest expression level in right coronary artery
ExpressionAtlasiQ5VY43 baseline and differential
GenevisibleiQ5VY43 HS

Family and domain databases

InterProiView protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR011489 EMI_domain
IPR002049 Laminin_EGF
PfamiView protein in Pfam
PF00053 Laminin_EGF, 3 hits
SMARTiView protein in SMART
SM00181 EGF, 15 hits
SM00180 EGF_Lam, 12 hits
PROSITEiView protein in PROSITE
PS00022 EGF_1, 13 hits
PS01186 EGF_2, 12 hits
PS50026 EGF_3, 9 hits
PS51041 EMI, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPEAR1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5VY43
Secondary accession number(s): Q8TEK2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: December 7, 2004
Last modified: February 13, 2019
This is version 123 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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