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Protein

Immediate early response gene 5 protein

Gene

IER5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role as a transcription factor (PubMed:22132193, PubMed:25355627). Mediates positive transcriptional regulation of several chaperone genes during the heat shock response in a HSF1-dependent manner (PubMed:25355627, PubMed:25816751). Mediates negative transcriptional regulation of CDC25B expression (PubMed:22132193). Plays a role in the dephosphorylation of the heat shock factor HSF1 and ribosomal protein S6 kinase (S6K) by the protein phosphatase PP2A (PubMed:25816751, PubMed:26496226). Involved in the regulation of cell proliferation and resistance to thermal stress (PubMed:22132193, PubMed:25355627, PubMed:26496226). Involved in the cell cycle checkpoint and survival in response to ionizing radiation (PubMed:19238419, PubMed:22132193). Associates with chromatin to the CDC25B promoter (PubMed:22132193).5 Publications

GO - Molecular functioni

  • identical protein binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionActivator, Repressor
Biological processStress response, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Immediate early response gene 5 protein
Gene namesi
Name:IER5
ORF Names:PP4583, SBBI48
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000162783.10
HGNCiHGNC:5393 IER5
MIMi607177 gene
neXtProtiNX_Q5VY09

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi51278
OpenTargetsiENSG00000162783
PharmGKBiPA29640

Polymorphism and mutation databases

BioMutaiIER5
DMDMi116242521

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001904381 – 327Immediate early response gene 5 proteinAdd BLAST327

Proteomic databases

EPDiQ5VY09
MaxQBiQ5VY09
PaxDbiQ5VY09
PeptideAtlasiQ5VY09
PRIDEiQ5VY09
ProteomicsDBi65619

PTM databases

iPTMnetiQ5VY09
PhosphoSitePlusiQ5VY09

Expressioni

Tissue specificityi

Expressed in acute myeloid leukemia (AML) cells.1 Publication

Inductioni

Up-regulated by heat shock in a heat shock HSF1-dependent manner (PubMed:25355627). Up-regulated by ionizing radiation (PubMed:19238419).2 Publications

Gene expression databases

BgeeiENSG00000162783 Expressed in 235 organ(s), highest expression level in amniotic fluid
CleanExiHS_IER5
GenevisibleiQ5VY09 HS

Organism-specific databases

HPAiHPA029894

Interactioni

Subunit structurei

Monomer (PubMed:26496226). Homodimer (PubMed:26496226). Associates with the catalytic subunit of protein phosphatase PP2A (PubMed:25816751, PubMed:26496226). Interacts (via N- and C-terminal regions) with PPP2R2B (PubMed:25816751, PubMed:26496226). Interacts with PPP2R2A, PPP2R2C and PPP2R2D (PubMed:25816751). Interacts (via N-terminus) with RPS6KB1 (PubMed:26496226). Interacts (via central region) with HSF1; this interaction promotes PPP2CA-induced HSF1 dephosphorylation, leading to enhanced HSF1 transcriptional activity (PubMed:25816751, PubMed:26496226, PubMed:26754925).3 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi119430, 5 interactors
IntActiQ5VY09, 10 interactors
MINTiQ5VY09
STRINGi9606.ENSP00000356549

Structurei

3D structure databases

ProteinModelPortaliQ5VY09
SMRiQ5VY09
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IER family.Curated

Phylogenomic databases

eggNOGiENOG410J10V Eukaryota
ENOG4111NZJ LUCA
GeneTreeiENSGT00900000141021
HOGENOMiHOG000112999
HOVERGENiHBG105469
InParanoidiQ5VY09
OMAiMNPWSTA
OrthoDBiEOG091G0HLK
PhylomeDBiQ5VY09
TreeFamiTF331376

Family and domain databases

InterProiView protein in InterPro
IPR008653 IER
PANTHERiPTHR15895 PTHR15895, 1 hit
PfamiView protein in Pfam
PF05760 IER, 2 hits

Sequencei

Sequence statusi: Complete.

Q5VY09-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEFKLEAHRI VSISLGKIYN SRVQRGGIKL HKNLLVSLVL RSARQVYLSD
60 70 80 90 100
PCPGLYLAGP AGTPAPPPQQ QPGEPAAGPP AGWGEPPPPA ARASWPETEP
110 120 130 140 150
QPERSSVSDA PRVGDEVPVA TVTGVGDVFQ GGEADATEAA WSRVEGPRQA
160 170 180 190 200
AAREAEGTAG GWGVFPEVSR AARRPCGCPL GGEDPPGTPA ATPRAACCCA
210 220 230 240 250
PQPAEDEPPA PPAVCPRKRC AAGVGGGPAG CPAPGSTPLK KPRRNLEQPP
260 270 280 290 300
SGGEDDDAEE METGNVANLI SIFGSSFSGL LRKSPGGGRE EEEGEESGPE
310 320
AAEPGQICCD KPVLRDMNPW STAIVAF
Length:327
Mass (Da):33,704
Last modified:October 17, 2006 - v3
Checksum:iE841C5FAF6520A12
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti161G → A in CAB91983 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02840492R → H1 PublicationCorresponds to variant dbSNP:rs3747955Ensembl.1
Natural variantiVAR_028405168V → I. Corresponds to variant dbSNP:rs3747954Ensembl.1
Natural variantiVAR_028406194R → G1 PublicationCorresponds to variant dbSNP:rs1416829Ensembl.1
Natural variantiVAR_028407202Q → R5 PublicationsCorresponds to variant dbSNP:rs1361365Ensembl.1
Natural variantiVAR_028408285P → S. Corresponds to variant dbSNP:rs3747951Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF178984 mRNA Translation: AAF44348.1
AJ251089 mRNA Translation: CAB91983.1
AF258581 mRNA Translation: AAG23784.1
AK314830 mRNA Translation: BAG37350.1
AL356267 Genomic DNA No translation available.
BC000128 mRNA Translation: AAH00128.1
CCDSiCCDS1343.1
RefSeqiNP_057629.2, NM_016545.4
UniGeneiHs.15725

Genome annotation databases

EnsembliENST00000367577; ENSP00000356549; ENSG00000162783
GeneIDi51278
KEGGihsa:51278
UCSCiuc001got.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF178984 mRNA Translation: AAF44348.1
AJ251089 mRNA Translation: CAB91983.1
AF258581 mRNA Translation: AAG23784.1
AK314830 mRNA Translation: BAG37350.1
AL356267 Genomic DNA No translation available.
BC000128 mRNA Translation: AAH00128.1
CCDSiCCDS1343.1
RefSeqiNP_057629.2, NM_016545.4
UniGeneiHs.15725

3D structure databases

ProteinModelPortaliQ5VY09
SMRiQ5VY09
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119430, 5 interactors
IntActiQ5VY09, 10 interactors
MINTiQ5VY09
STRINGi9606.ENSP00000356549

PTM databases

iPTMnetiQ5VY09
PhosphoSitePlusiQ5VY09

Polymorphism and mutation databases

BioMutaiIER5
DMDMi116242521

Proteomic databases

EPDiQ5VY09
MaxQBiQ5VY09
PaxDbiQ5VY09
PeptideAtlasiQ5VY09
PRIDEiQ5VY09
ProteomicsDBi65619

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367577; ENSP00000356549; ENSG00000162783
GeneIDi51278
KEGGihsa:51278
UCSCiuc001got.5 human

Organism-specific databases

CTDi51278
DisGeNETi51278
EuPathDBiHostDB:ENSG00000162783.10
GeneCardsiIER5
HGNCiHGNC:5393 IER5
HPAiHPA029894
MIMi607177 gene
neXtProtiNX_Q5VY09
OpenTargetsiENSG00000162783
PharmGKBiPA29640
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J10V Eukaryota
ENOG4111NZJ LUCA
GeneTreeiENSGT00900000141021
HOGENOMiHOG000112999
HOVERGENiHBG105469
InParanoidiQ5VY09
OMAiMNPWSTA
OrthoDBiEOG091G0HLK
PhylomeDBiQ5VY09
TreeFamiTF331376

Miscellaneous databases

ChiTaRSiIER5 human
GenomeRNAii51278
PROiPR:Q5VY09
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000162783 Expressed in 235 organ(s), highest expression level in amniotic fluid
CleanExiHS_IER5
GenevisibleiQ5VY09 HS

Family and domain databases

InterProiView protein in InterPro
IPR008653 IER
PANTHERiPTHR15895 PTHR15895, 1 hit
PfamiView protein in Pfam
PF05760 IER, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiIER5_HUMAN
AccessioniPrimary (citable) accession number: Q5VY09
Secondary accession number(s): B2RBV3
, Q8WY68, Q9NY49, Q9NZP9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: October 17, 2006
Last modified: November 7, 2018
This is version 102 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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