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Protein
Submitted name:

Rho guanine nucleotide exchange factor 10-like protein

Gene

ARHGEF10L

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • GTPase activator activity Source: HGNC
  • Rho guanyl-nucleotide exchange factor activity Source: InterPro

GO - Biological processi

  • positive regulation of stress fiber assembly Source: HGNC
  • regulation of Rho protein signal transduction Source: InterPro
  • SREBP signaling pathway Source: HGNC

Names & Taxonomyi

Protein namesi
Submitted name:
Rho guanine nucleotide exchange factor 10-like proteinImported
Gene namesi
Name:ARHGEF10LImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000074964.16
HGNCiHGNC:25540 ARHGEF10L

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000074964

PTM / Processingi

Proteomic databases

EPDiQ5VXI4
PeptideAtlasiQ5VXI4
PRIDEiQ5VXI4

Expressioni

Gene expression databases

BgeeiENSG00000074964
ExpressionAtlasiQ5VXI4 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ5VXI4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini94 – 281DHInterPro annotationAdd BLAST188

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili261 – 294Sequence analysisAdd BLAST34

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG3522 Eukaryota
KOG3524 Eukaryota
ENOG410ZJK1 LUCA
GeneTreeiENSGT00670000097546
HOGENOMiHOG000232060
HOVERGENiHBG050570

Family and domain databases

CDDicd00160 RhoGEF, 1 hit
Gene3Di1.20.900.10, 1 hit
2.130.10.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR011993 PH-like_dom_sf
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00621 RhoGEF, 1 hit
SMARTiView protein in SMART
SM00325 RhoGEF, 1 hit
SUPFAMiSSF48065 SSF48065, 1 hit
SSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50010 DH_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q5VXI4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPSSSWGKR KLRGRLGWVR SDARGVMWAR QEGLHHPHPH AVIRCPSSSS
60 70 80 90 100
SSVSCSGDSE EEDMGLLEVS VSDIKPPAPE LGPMPEGLSP QQVVRRHILG
110 120 130 140 150
SIVQSEGSYV ESLKRILQDY RNPLMEMEPK ALSARKCQVV FFRVKEILHC
160 170 180 190 200
HSMFQIALSS RVAEWDSTEK IGDLFVASFS KSMVLDVYSD YVNNFTSAMS
210 220 230 240 250
IIKKACLTKP AFLEFLKRRQ VCSPDRVTLY GLMVKPIQRF PQFILLLQDM
260 270 280 290 300
LKNTPRGHPD RLSLQLALTE LETLAEKLNE QKRLADQVAE IQQLTKSVSD
310 320 330 340 350
RSSLNKLLTS GQRQLLLCET LTETVYGDRG QLIKSKERRV FLLNDMLVCA
360 370 380 390 400
NINFKGQLEI SSLVPLGPKY VVKWNTALPQ VQVVEVGQDG GTYDKDNVLI
410 420 430 440 450
QHSGAKKASA SGQAQNKVYL GPPRLFQELQ DLQKDLAVVE QITLLISTLH
460 470 480 490 500
GTYQNLNMTV AQDWCLALQR LMRVKEEEIH SANKCRLRLL LPGKPDKSGR
510 520 530 540 550
PISFMVVFIT PNPLSKISWV NRLHLAKIGL REENQPGWLC PDEDKKSKAP
560 570 580 590 600
FWCPILACCI PAFSSRALSL QLGALVHSPV NCPLLGFSAV STSLPQGYLW
610 620 630 640 650
VGGGQEGAGG QVEIFSLNRP SPRTVKSFPL AAPVLCMEYI PELEEEAESR
660 670 680 690 700
DESPTVADPS ATVHPTICLG LQDGSILLYS SVDTGTQCLV SCRSPGLQPV
710 720 730 740 750
LCLRHSPFHL LAGLQDGTLA AYPRTSGGVL WDLESPPVCL TVGPGPVRTL
760 770 780 790 800
LSLEDAVWAS CGPRVTVLEA TTLQPQQSFE AHQDEAVSVT HMVKAGSGVW
810 820 830 840 850
MAFSSGTSIR LFHTETLEHL QEINIATRTT FLLPGQKHLC VTSLLICQGL
860 870 880 890 900
LWVGTDQGVI VLLPVPRLEG IPKITGKGMV SLNGHCGPVA FLAVATSILA
910 920 930 940 950
PDILRSDQEE AEGPRAEEDK PDGQAHEPMP DSHVGRELTR KKGILLQYRL
960 970 980 990 1000
RSTAHLPGPL LSMREPAPAD GAALEHSEED GSIYEMADDP DIWVRSRPCA
1010 1020 1030 1040 1050
RDAHRKEICS VAIISGGQGY RNFGSALGSS GRQAPCGETD STLLIWQVPL

ML
Length:1,052
Mass (Da):115,568
Last modified:October 29, 2014 - v2
Checksum:i38BF19D3CBD9B8B9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL139250 Genomic DNA No translation available.
AL358593 Genomic DNA No translation available.
AL390994 Genomic DNA No translation available.
KF495877 Genomic DNA No translation available.
RefSeqiXP_005245986.2, XM_005245929.2
UniGeneiHs.443460

Genome annotation databases

EnsembliENST00000375408; ENSP00000364557; ENSG00000074964
GeneIDi55160
UCSCiuc010ocs.3 human

Similar proteinsi

Entry informationi

Entry nameiQ5VXI4_HUMAN
AccessioniPrimary (citable) accession number: Q5VXI4
Entry historyiIntegrated into UniProtKB/TrEMBL: December 7, 2004
Last sequence update: October 29, 2014
Last modified: May 23, 2018
This is version 109 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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