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Protein
Submitted name:

Poly [ADP-ribose] polymerase 1

Gene

PARP1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
Poly [ADP-ribose] polymerase 1Imported
Gene namesi
Name:PARP1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000143799.12
HGNCiHGNC:270 PARP1

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000143799

PTM / Processingi

Proteomic databases

MaxQBiQ5VX84
PRIDEiQ5VX84

Expressioni

Gene expression databases

BgeeiENSG00000143799 Expressed in 233 organ(s), highest expression level in heart left ventricle

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 93PARP-typeInterPro annotationAdd BLAST85

Phylogenomic databases

eggNOGiKOG1037 Eukaryota
ENOG410XP18 LUCA
GeneTreeiENSGT00390000017341

Family and domain databases

Gene3Di3.30.1740.10, 1 hit
InterProiView protein in InterPro
IPR001510 Znf_PARP
IPR036957 Znf_PARP_sf
PfamiView protein in Pfam
PF00645 zf-PARP, 1 hit
SMARTiView protein in SMART
SM01336 zf-PARP, 1 hit
PROSITEiView protein in PROSITE
PS00347 PARP_ZN_FINGER_1, 1 hit
PS50064 PARP_ZN_FINGER_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.iShow all

Q5VX84-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAESSDKLYR VEYAKSGRAS CKKCSESIPK DSLRMAIMVQ SPMFDGKVPH
60 70 80 90 100
WYHFSCFWKV GHSIRHPDVE VDGFSELRWD DQQKVKKTAE AGGVTEPPIP

CGIEVMGR
Length:108
Mass (Da):12,234
Last modified:December 7, 2004 - v1
Checksum:i808D6FE19BF17A83
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P09874PARP1_HUMAN
Poly [ADP-ribose] polymerase 1
PARP1 ADPRT, PPOL
1,014Annotation score:
Q5VX85Q5VX85_HUMAN
Poly [ADP-ribose] polymerase 1
PARP1
155Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL359704 Genomic DNA No translation available.
AL359742 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000366792; ENSP00000355757; ENSG00000143799
ENST00000629232; ENSP00000485852; ENSG00000143799
UCSCiuc057pyp.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL359704 Genomic DNA No translation available.
AL359742 Genomic DNA No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiQ5VX84
PRIDEiQ5VX84

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000366792; ENSP00000355757; ENSG00000143799
ENST00000629232; ENSP00000485852; ENSG00000143799
UCSCiuc057pyp.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000143799.12
HGNCiHGNC:270 PARP1
OpenTargetsiENSG00000143799
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1037 Eukaryota
ENOG410XP18 LUCA
GeneTreeiENSGT00390000017341

Miscellaneous databases

ChiTaRSiPARP1 human

Gene expression databases

BgeeiENSG00000143799 Expressed in 233 organ(s), highest expression level in heart left ventricle

Family and domain databases

Gene3Di3.30.1740.10, 1 hit
InterProiView protein in InterPro
IPR001510 Znf_PARP
IPR036957 Znf_PARP_sf
PfamiView protein in Pfam
PF00645 zf-PARP, 1 hit
SMARTiView protein in SMART
SM01336 zf-PARP, 1 hit
PROSITEiView protein in PROSITE
PS00347 PARP_ZN_FINGER_1, 1 hit
PS50064 PARP_ZN_FINGER_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ5VX84_HUMAN
AccessioniPrimary (citable) accession number: Q5VX84
Entry historyiIntegrated into UniProtKB/TrEMBL: December 7, 2004
Last sequence update: December 7, 2004
Last modified: September 12, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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