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Entry version 131 (02 Jun 2021)
Sequence version 1 (07 Dec 2004)
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Protein

Sushi domain-containing protein 4

Gene

SUSD4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as complement inhibitor by disrupting the formation of the classical C3 convertase. Isoform 3 inhibits the classical complement pathway, while membrane-bound isoform 1 inhibits deposition of C3b via both the classical and alternative complement pathways.

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processComplement pathway, Immunity, Innate immunity

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q5VX71

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sushi domain-containing protein 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SUSD4
ORF Names:UNQ196/PRO222
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25470, SUSD4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
615827, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5VX71

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000143502.14

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini42 – 319ExtracellularSequence analysisAdd BLAST278
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei320 – 340HelicalSequence analysisAdd BLAST21
Topological domaini341 – 490CytoplasmicSequence analysisAdd BLAST150

Keywords - Cellular componenti

Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
55061

Open Targets

More...
OpenTargetsi
ENSG00000143502

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142670855

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q5VX71, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SUSD4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74747494

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 41Sequence analysisAdd BLAST41
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000025197542 – 490Sushi domain-containing protein 4Add BLAST449

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi57 ↔ 99PROSITE-ProRule annotation
Disulfide bondi85 ↔ 117PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi104N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi122 ↔ 165PROSITE-ProRule annotation
Glycosylationi134N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi147 ↔ 177PROSITE-ProRule annotation
Disulfide bondi180 ↔ 224PROSITE-ProRule annotation
Glycosylationi192N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi210 ↔ 237PROSITE-ProRule annotation
Disulfide bondi243 ↔ 289PROSITE-ProRule annotation
Disulfide bondi274 ↔ 302PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5VX71

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5VX71

PeptideAtlas

More...
PeptideAtlasi
Q5VX71

PRoteomics IDEntifications database

More...
PRIDEi
Q5VX71

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
65576 [Q5VX71-1]
65577 [Q5VX71-2]
65578 [Q5VX71-3]
65579 [Q5VX71-4]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q5VX71, 3 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5VX71

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5VX71

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 3 is the predominant isoform in all tissues except cortex, cerebellum, kidney, and breast. Isoform 1 is found primarily in the esophagus and the brain.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000143502, Expressed in right ovary and 200 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5VX71, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5VX71, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000143502, Tissue enhanced (brain, esophagus)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
120379, 47 interactors

Protein interaction database and analysis system

More...
IntActi
Q5VX71, 36 interactors

Molecular INTeraction database

More...
MINTi
Q5VX71

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000344219

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q5VX71, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5VX71

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini55 – 119Sushi 1PROSITE-ProRule annotationAdd BLAST65
Domaini120 – 179Sushi 2PROSITE-ProRule annotationAdd BLAST60
Domaini178 – 239Sushi 3PROSITE-ProRule annotationAdd BLAST62
Domaini241 – 304Sushi 4PROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 21DisorderedSequence analysisAdd BLAST21
Regioni401 – 490DisorderedSequence analysisAdd BLAST90

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi422 – 472Polar residuesSequence analysisAdd BLAST51

Keywords - Domaini

Repeat, Signal, Sushi, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QU1F, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160410

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_077058_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5VX71

Identification of Orthologs from Complete Genome Data

More...
OMAi
EAQVCPL

Database of Orthologous Groups

More...
OrthoDBi
560016at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5VX71

TreeFam database of animal gene trees

More...
TreeFami
TF332459

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00033, CCP, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR042985, SUSD4
IPR035976, Sushi/SCR/CCP_sf
IPR000436, Sushi_SCR_CCP_dom

The PANTHER Classification System

More...
PANTHERi
PTHR47007, PTHR47007, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00084, Sushi, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00032, CCP, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57535, SSF57535, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50923, SUSHI, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5VX71-1) [UniParc]FASTAAdd to basket
Also known as: SUSD4a1 Publication

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MYHGMNPSNG DGFLEQQQQQ QQPQSPQRLL AVILWFQLAL CFGPAQLTGG
60 70 80 90 100
FDDLQVCADP GIPENGFRTP SGGVFFEGSV ARFHCQDGFK LKGATKRLCL
110 120 130 140 150
KHFNGTLGWI PSDNSICVQE DCRIPQIEDA EIHNKTYRHG EKLIITCHEG
160 170 180 190 200
FKIRYPDLHN MVSLCRDDGT WNNLPICQGC LRPLASSNGY VNISELQTSF
210 220 230 240 250
PVGTVISYRC FPGFKLDGSA YLECLQNLIW SSSPPRCLAL EVCPLPPMVS
260 270 280 290 300
HGDFVCHPRP CERYNHGTVV EFYCDPGYSL TSDYKYITCQ YGEWFPSYQV
310 320 330 340 350
YCIKSEQTWP STHETLLTTW KIVAFTATSV LLVLLLVILA RMFQTKFKAH
360 370 380 390 400
FPPRGPPRSS SSDPDFVVVD GVPVMLPSYD EAVSGGLSAL GPGYMASVGQ
410 420 430 440 450
GCPLPVDDQS PPAYPGSGDT DTGPGESETC DSVSGSSELL QSLYSPPRCQ
460 470 480 490
ESTHPASDNP DIIASTAEEV ASTSPGIDIA DEIPLMEEDP
Length:490
Mass (Da):53,778
Last modified:December 7, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i15392C2774BEFF22
GO
Isoform 2 (identifier: Q5VX71-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     241-241: E → EAQ
     478-490: DIADEIPLMEEDP → HHAHWVLFLRN

Show »
Length:490
Mass (Da):53,920
Checksum:i950254448E4267D1
GO
Isoform 3 (identifier: Q5VX71-3) [UniParc]FASTAAdd to basket
Also known as: SUSD4b1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     242-290: VCPLPPMVSH...TSDYKYITCQ → GGRPEHLFPV...SSTSTTTSLF
     291-490: Missing.

Show »
Length:290
Mass (Da):32,165
Checksum:i58181E7BA44EE4CD
GO
Isoform 4 (identifier: Q5VX71-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     186-236: SSNGYVNISE...NLIWSSSPPR → PQHTPAQGTR...APTLLRTTLT
     237-490: Missing.

Show »
Length:236
Mass (Da):26,094
Checksum:i9417D03CAEA973BA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
V9GZ49V9GZ49_HUMAN
Sushi domain-containing protein 4
SUSD4
463Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B7Z369B7Z369_HUMAN
Sushi domain-containing protein 4
SUSD4
421Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GYN8V9GYN8_HUMAN
Sushi domain-containing protein 4
SUSD4
488Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7P0T864A0A7P0T864_HUMAN
Sushi domain-containing protein 4
SUSD4
529Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7P0T8V7A0A7P0T8V7_HUMAN
Sushi domain-containing protein 4
SUSD4
277Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7P0Z409A0A7P0Z409_HUMAN
Sushi domain-containing protein 4
SUSD4
129Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7P0Z457A0A7P0Z457_HUMAN
Sushi domain-containing protein 4
SUSD4
562Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_020838186 – 236SSNGY…SSPPR → PQHTPAQGTRTQAQGSQKPV TASQALLSCSKVCIHLPGAK RAPTLLRTTLT in isoform 4. 1 PublicationAdd BLAST51
Alternative sequenceiVSP_020839237 – 490Missing in isoform 4. 1 PublicationAdd BLAST254
Alternative sequenceiVSP_020840241E → EAQ in isoform 2. 1 Publication1
Alternative sequenceiVSP_020841242 – 290VCPLP…YITCQ → GGRPEHLFPVLYFPHIRLAA AVLYFCPVLKSSPTPAPTCS STSTTTSLF in isoform 3. 1 PublicationAdd BLAST49
Alternative sequenceiVSP_020842291 – 490Missing in isoform 3. 1 PublicationAdd BLAST200
Alternative sequenceiVSP_020843478 – 490DIADE…MEEDP → HHAHWVLFLRN in isoform 2. 1 PublicationAdd BLAST13

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AY358495 mRNA Translation: AAQ88859.1
AK000914 mRNA Translation: BAA91421.1
AL359733 Genomic DNA No translation available.
AL359979 Genomic DNA No translation available.
CH471100 Genomic DNA Translation: EAW93260.1
CH471100 Genomic DNA Translation: EAW93261.1
BC004888 mRNA Translation: AAH04888.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS31034.1 [Q5VX71-3]
CCDS41471.1 [Q5VX71-1]

NCBI Reference Sequences

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RefSeqi
NP_001032252.1, NM_001037175.2 [Q5VX71-3]
NP_060452.3, NM_017982.3 [Q5VX71-1]
XP_016857076.1, XM_017001587.1 [Q5VX71-1]
XP_016857077.1, XM_017001588.1 [Q5VX71-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000343846; ENSP00000344219; ENSG00000143502 [Q5VX71-1]
ENST00000344029; ENSP00000339926; ENSG00000143502 [Q5VX71-3]
ENST00000366878; ENSP00000355843; ENSG00000143502 [Q5VX71-1]
ENST00000681305; ENSP00000505262; ENSG00000143502 [Q5VX71-1]
ENST00000681669; ENSP00000505495; ENSG00000143502 [Q5VX71-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
55061

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:55061

UCSC genome browser

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UCSCi
uc001hnx.3, human [Q5VX71-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358495 mRNA Translation: AAQ88859.1
AK000914 mRNA Translation: BAA91421.1
AL359733 Genomic DNA No translation available.
AL359979 Genomic DNA No translation available.
CH471100 Genomic DNA Translation: EAW93260.1
CH471100 Genomic DNA Translation: EAW93261.1
BC004888 mRNA Translation: AAH04888.1
CCDSiCCDS31034.1 [Q5VX71-3]
CCDS41471.1 [Q5VX71-1]
RefSeqiNP_001032252.1, NM_001037175.2 [Q5VX71-3]
NP_060452.3, NM_017982.3 [Q5VX71-1]
XP_016857076.1, XM_017001587.1 [Q5VX71-1]
XP_016857077.1, XM_017001588.1 [Q5VX71-1]

3D structure databases

SMRiQ5VX71
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi120379, 47 interactors
IntActiQ5VX71, 36 interactors
MINTiQ5VX71
STRINGi9606.ENSP00000344219

PTM databases

GlyGeniQ5VX71, 3 sites
iPTMnetiQ5VX71
PhosphoSitePlusiQ5VX71

Genetic variation databases

BioMutaiSUSD4
DMDMi74747494

Proteomic databases

jPOSTiQ5VX71
PaxDbiQ5VX71
PeptideAtlasiQ5VX71
PRIDEiQ5VX71
ProteomicsDBi65576 [Q5VX71-1]
65577 [Q5VX71-2]
65578 [Q5VX71-3]
65579 [Q5VX71-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
34634, 76 antibodies

The DNASU plasmid repository

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DNASUi
55061

Genome annotation databases

EnsembliENST00000343846; ENSP00000344219; ENSG00000143502 [Q5VX71-1]
ENST00000344029; ENSP00000339926; ENSG00000143502 [Q5VX71-3]
ENST00000366878; ENSP00000355843; ENSG00000143502 [Q5VX71-1]
ENST00000681305; ENSP00000505262; ENSG00000143502 [Q5VX71-1]
ENST00000681669; ENSP00000505495; ENSG00000143502 [Q5VX71-1]
GeneIDi55061
KEGGihsa:55061
UCSCiuc001hnx.3, human [Q5VX71-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
55061
DisGeNETi55061

GeneCards: human genes, protein and diseases

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GeneCardsi
SUSD4
HGNCiHGNC:25470, SUSD4
HPAiENSG00000143502, Tissue enhanced (brain, esophagus)
MIMi615827, gene
neXtProtiNX_Q5VX71
OpenTargetsiENSG00000143502
PharmGKBiPA142670855
VEuPathDBiHostDB:ENSG00000143502.14

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG502QU1F, Eukaryota
GeneTreeiENSGT00940000160410
HOGENOMiCLU_077058_0_0_1
InParanoidiQ5VX71
OMAiEAQVCPL
OrthoDBi560016at2759
PhylomeDBiQ5VX71
TreeFamiTF332459

Enzyme and pathway databases

PathwayCommonsiQ5VX71

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
55061, 5 hits in 981 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SUSD4, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
55061
PharosiQ5VX71, Tbio

Protein Ontology

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PROi
PR:Q5VX71
RNActiQ5VX71, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000143502, Expressed in right ovary and 200 other tissues
ExpressionAtlasiQ5VX71, baseline and differential
GenevisibleiQ5VX71, HS

Family and domain databases

CDDicd00033, CCP, 4 hits
InterProiView protein in InterPro
IPR042985, SUSD4
IPR035976, Sushi/SCR/CCP_sf
IPR000436, Sushi_SCR_CCP_dom
PANTHERiPTHR47007, PTHR47007, 1 hit
PfamiView protein in Pfam
PF00084, Sushi, 4 hits
SMARTiView protein in SMART
SM00032, CCP, 4 hits
SUPFAMiSSF57535, SSF57535, 4 hits
PROSITEiView protein in PROSITE
PS50923, SUSHI, 4 hits

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSUSD4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5VX71
Secondary accession number(s): D3DTB9
, Q6UX62, Q9BSR0, Q9NWG0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: December 7, 2004
Last modified: June 2, 2021
This is version 131 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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