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Entry version 99 (11 Dec 2019)
Sequence version 4 (28 Mar 2018)
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Protein

Spermatogenesis-associated protein 1

Gene

SPATA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

It is uncertain whether Met-1 or Met-23 is the initiator.Curated

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Spermatogenesis-associated protein 1
Alternative name(s):
Sperm-specific protein SP-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SPATA1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14682 SPATA1

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5VX52

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
100505741

Open Targets

More...
OpenTargetsi
ENSG00000122432

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37910

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q5VX52 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SPATA1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
205830058

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003492151 – 459Spermatogenesis-associated protein 1Add BLAST459

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5VX52

PeptideAtlas

More...
PeptideAtlasi
Q5VX52

PRoteomics IDEntifications database

More...
PRIDEi
Q5VX52

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
65572 [Q5VX52-1]
65573 [Q5VX52-2]
65574 [Q5VX52-4]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q5VX52-1 [Q5VX52-1]
Q5VX52-2 [Q5VX52-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5VX52

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5VX52

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
122096, 29 interactors

Protein interaction database and analysis system

More...
IntActi
Q5VX52, 26 interactors

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q5VX52 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5VX52

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili287 – 374Sequence analysisAdd BLAST88
Coiled coili400 – 453Sequence analysisAdd BLAST54

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coil

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000003298

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000090217

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5VX52

Database of Orthologous Groups

More...
OrthoDBi
657461at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5VX52

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039062 SPAT1
IPR031478 SPATA1_C

The PANTHER Classification System

More...
PANTHERi
PTHR14421 PTHR14421, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15743 SPATA1_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q5VX52-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKKDKKRNKI PIDNYPIQTL VNMSLNPSRP SSSELVELHV FYVPEGSWNY
60 70 80 90 100
KLNTISTEVV NKFISAGFLR VSPQLTLRAL RERLGEFLGE DAIAEKFLFL
110 120 130 140 150
KCIGNNLAVV KEKQESELKL KSFAPPYALQ PELYLLPVMD HLGNVYSPST
160 170 180 190 200
VILDERQTNN GVNEADGTIH RPISVTLFKE ELGRDPSLLE NTLKELPNKN
210 220 230 240 250
QEEAGGKATA EKSQIAKNQI GNSELPGSLE DSNNDCFGTK KSQCLWENED
260 270 280 290 300
DTAISRRQDN QTAEKEYITL PDHPSLPCQP VLSSGITDIS LLQTEREKII
310 320 330 340 350
KQMKQVKEER RYLERNREEL VKTVEKLFEQ SKLKRYHAYN GWKKKYLETK
360 370 380 390 400
KVTASMEEVL TKLREDLELY YKKLLMQLEA REIKMRPKNL ANITDSKNYL
410 420 430 440 450
IIQITEVQHA IDQLKRKLDT DKMKLIVEVK MRKQAVSDLR TLKTELAQKK

KIIHLYNLN
Length:459
Mass (Da):52,946
Last modified:March 28, 2018 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD7AC541D2688144B
GO
Isoform 2 (identifier: Q5VX52-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     243-284: QCLWENEDDT...SLPCQPVLSS → VFGKMKMIQL...FLVNLFFLQE
     285-459: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:284
Mass (Da):32,043
Checksum:i55C826D844C86948
GO
Isoform 3 (identifier: Q5VX52-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     359-459: Missing.

Show »
Length:358
Mass (Da):40,902
Checksum:iD5BC02577DABE99D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti3K → R in AAG22047 (Ref. 1) Curated1
Sequence conflicti129L → P in AAG22047 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_046284175V → L1 PublicationCorresponds to variant dbSNP:rs10493753Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_035223243 – 284QCLWE…PVLSS → VFGKMKMIQLSVEDRTIRQL KKSTSPYQITLHFLVNLFFL QE in isoform 2. 2 PublicationsAdd BLAST42
Alternative sequenceiVSP_035224285 – 459Missing in isoform 2. 2 PublicationsAdd BLAST175
Alternative sequenceiVSP_039875359 – 459Missing in isoform 3. 1 PublicationAdd BLAST101

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF306347 mRNA Translation: AAG22047.1
AL359762 Genomic DNA No translation available.
BC119641 mRNA Translation: AAI19642.1
BC119642 mRNA Translation: AAI19643.1
BC127634 mRNA Translation: AAI27635.1

NCBI Reference Sequences

More...
RefSeqi
NP_001297085.1, NM_001310156.1
XP_011540818.1, XM_011542516.1 [Q5VX52-2]
XP_011540819.1, XM_011542517.1 [Q5VX52-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000490879; ENSP00000492019; ENSG00000122432 [Q5VX52-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100505741

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:100505741

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF306347 mRNA Translation: AAG22047.1
AL359762 Genomic DNA No translation available.
BC119641 mRNA Translation: AAI19642.1
BC119642 mRNA Translation: AAI19643.1
BC127634 mRNA Translation: AAI27635.1
RefSeqiNP_001297085.1, NM_001310156.1
XP_011540818.1, XM_011542516.1 [Q5VX52-2]
XP_011540819.1, XM_011542517.1 [Q5VX52-2]

3D structure databases

SMRiQ5VX52
ModBaseiSearch...

Protein-protein interaction databases

BioGridi122096, 29 interactors
IntActiQ5VX52, 26 interactors

PTM databases

iPTMnetiQ5VX52
PhosphoSitePlusiQ5VX52

Polymorphism and mutation databases

BioMutaiSPATA1
DMDMi205830058

Proteomic databases

jPOSTiQ5VX52
PeptideAtlasiQ5VX52
PRIDEiQ5VX52
ProteomicsDBi65572 [Q5VX52-1]
65573 [Q5VX52-2]
65574 [Q5VX52-4]
TopDownProteomicsiQ5VX52-1 [Q5VX52-1]
Q5VX52-2 [Q5VX52-2]

Genome annotation databases

EnsembliENST00000490879; ENSP00000492019; ENSG00000122432 [Q5VX52-1]
GeneIDi100505741
KEGGihsa:100505741

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
100505741
DisGeNETi100505741

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SPATA1
HGNCiHGNC:14682 SPATA1
neXtProtiNX_Q5VX52
OpenTargetsiENSG00000122432
PharmGKBiPA37910

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00390000003298
HOGENOMiHOG000090217
InParanoidiQ5VX52
OrthoDBi657461at2759
PhylomeDBiQ5VX52

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SPATA1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
100505741
PharosiQ5VX52 Tdark

Protein Ontology

More...
PROi
PR:Q5VX52
RNActiQ5VX52 protein

Family and domain databases

InterProiView protein in InterPro
IPR039062 SPAT1
IPR031478 SPATA1_C
PANTHERiPTHR14421 PTHR14421, 1 hit
PfamiView protein in Pfam
PF15743 SPATA1_C, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPAT1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5VX52
Secondary accession number(s): A0A1W2PQB0
, A0PJU9, Q0VDJ9, Q0VDK0, Q6P386, Q9HAR4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: March 28, 2018
Last modified: December 11, 2019
This is version 99 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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