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Protein

Lysophospholipase-like protein 1

Gene

LYPLAL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has depalmitoylating activity toward KCNMA1. Does not exhibit phospholipase nor triacylglycerol lipase activity, able to hydrolyze only short chain substrates due to its shallow active site.2 Publications

Catalytic activityi

Palmitoyl-protein + H2O = palmitate + protein.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei124Charge relay systemBy similarity1
Active sitei179Charge relay systemBy similarity1
Active sitei211Charge relay systemBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Protein family/group databases

ESTHERihuman-LYPLAL1 LYsophospholipase_carboxylesterase

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase-like protein 1 (EC:3.1.2.-)
Gene namesi
Name:LYPLAL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000143353.11
HGNCiHGNC:20440 LYPLAL1
MIMi616548 gene
neXtProtiNX_Q5VWZ2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi127018
OpenTargetsiENSG00000143353
PharmGKBiPA134986975

Chemistry databases

ChEMBLiCHEMBL2189133

Polymorphism and mutation databases

BioMutaiLYPLAL1
DMDMi74762275

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00002275572 – 237Lysophospholipase-like protein 1Add BLAST236

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ5VWZ2
MaxQBiQ5VWZ2
PaxDbiQ5VWZ2
PeptideAtlasiQ5VWZ2
PRIDEiQ5VWZ2
ProteomicsDBi65567
65568 [Q5VWZ2-2]

PTM databases

iPTMnetiQ5VWZ2
PhosphoSitePlusiQ5VWZ2

Expressioni

Gene expression databases

BgeeiENSG00000143353
CleanExiHS_LYPLAL1
GenevisibleiQ5VWZ2 HS

Organism-specific databases

HPAiHPA045806

Interactioni

Protein-protein interaction databases

BioGridi126031, 2 interactors
IntActiQ5VWZ2, 8 interactors
MINTiQ5VWZ2
STRINGi9606.ENSP00000355895

Chemistry databases

BindingDBiQ5VWZ2

Structurei

Secondary structure

1237
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi11 – 14Combined sources4
Beta strandi22 – 27Combined sources6
Helixi34 – 45Combined sources12
Beta strandi52 – 59Combined sources8
Beta strandi63 – 65Combined sources3
Helixi67 – 69Combined sources3
Beta strandi73 – 75Combined sources3
Beta strandi81 – 87Combined sources7
Helixi91 – 110Combined sources20
Helixi115 – 117Combined sources3
Beta strandi118 – 123Combined sources6
Helixi125 – 137Combined sources13
Beta strandi141 – 148Combined sources8
Helixi156 – 163Combined sources8
Beta strandi171 – 176Combined sources6
Beta strandi180 – 182Combined sources3
Helixi184 – 196Combined sources13
Beta strandi201 – 206Combined sources6
Helixi215 – 228Combined sources14

3D structure databases

ProteinModelPortaliQ5VWZ2
SMRiQ5VWZ2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2112 Eukaryota
COG0400 LUCA
GeneTreeiENSGT00390000009648
HOGENOMiHOG000260139
HOVERGENiHBG105375
InParanoidiQ5VWZ2
KOiK06999
OMAiNVWFDRF
OrthoDBiEOG091G0G77
PhylomeDBiQ5VWZ2
TreeFamiTF314619

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR003140 PLipase/COase/thioEstase
PfamiView protein in Pfam
PF02230 Abhydrolase_2, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5VWZ2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAASGSVLQ RCIVSPAGRH SASLIFLHGS GDSGQGLRMW IKQVLNQDLT
60 70 80 90 100
FQHIKIIYPT APPRSYTPMK GGISNVWFDR FKITNDCPEH LESIDVMCQV
110 120 130 140 150
LTDLIDEEVK SGIKKNRILI GGFSMGGCMA IHLAYRNHQD VAGVFALSSF
160 170 180 190 200
LNKASAVYQA LQKSNGVLPE LFQCHGTADE LVLHSWAEET NSMLKSLGVT
210 220 230
TKFHSFPNVY HELSKTELDI LKLWILTKLP GEMEKQK
Length:237
Mass (Da):26,316
Last modified:January 23, 2007 - v3
Checksum:iA813A55DADDAF55E
GO
Isoform 2 (identifier: Q5VWZ2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     65-80: Missing.

Note: May be due to a competing acceptor splice site. No experimental confirmation available.
Show »
Length:221
Mass (Da):24,476
Checksum:iFD2558A6BB7B1017
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti32D → G in BAF84231 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_025607131I → M3 PublicationsCorresponds to variant dbSNP:rs940570Ensembl.1
Natural variantiVAR_060992197L → V. Corresponds to variant dbSNP:rs34201999Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01755665 – 80Missing in isoform 2. 1 PublicationAdd BLAST16

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY341430 mRNA Translation: AAQ17077.1
AK291542 mRNA Translation: BAF84231.1
AL360093 Genomic DNA No translation available.
BC016711 mRNA Translation: AAH16711.1
CCDSiCCDS1522.1 [Q5VWZ2-1]
CCDS73032.1 [Q5VWZ2-2]
RefSeqiNP_001287698.1, NM_001300769.1
NP_001287699.1, NM_001300770.1 [Q5VWZ2-2]
NP_001287700.1, NM_001300771.1
NP_001287701.1, NM_001300772.1
NP_620149.2, NM_138794.4 [Q5VWZ2-1]
UniGeneiHs.657617

Genome annotation databases

EnsembliENST00000366927; ENSP00000355894; ENSG00000143353 [Q5VWZ2-2]
ENST00000366928; ENSP00000355895; ENSG00000143353 [Q5VWZ2-1]
GeneIDi127018
KEGGihsa:127018
UCSCiuc001hlq.5 human [Q5VWZ2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiLYPL1_HUMAN
AccessioniPrimary (citable) accession number: Q5VWZ2
Secondary accession number(s): A8K677
, Q5VWZ3, Q7Z4A3, Q96AV0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: January 23, 2007
Last modified: July 18, 2018
This is version 129 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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