KHDRBS2

Functionⁱ

RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds both poly(A) and poly(U) homopolymers. Phosphorylation by PTK6 inhibits its RNA-binding ability (By similarity). Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer. Can regulate alternative splicing of NRXN1 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners. Regulates cell-type specific alternative splicing of NRXN1 at AS4 and acts synergystically with SAM68 in exon skipping. In contrast acts antagonistically with SAM68 in NRXN3 exon skipping at AS4. Its phosphorylation by FYN inhibits its ability to regulate splice site selection. May function as an adapter protein for Src kinases during mitosis.By similarity

GO - Molecular functionⁱ

identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 21516116
- 25416956
poly(A) binding Source: Ensembl
poly(U) RNA binding Source: Ensembl
protein heterodimerization activity Source: Ensembl
SH2 domain binding Source: Ensembl
SH3 domain binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

mRNA processing Source: UniProtKB-KW
regulation of mRNA splicing, via spliceosome Source: Ensembl
regulation of transcription, DNA-templated Source: UniProtKB-KW
transcription, DNA-templated Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	RNA-binding
Biological process	mRNA processing, Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-8849468 PTK6 Regulates Proteins Involved in RNA Processing

Reactomeⁱ

R-HSA-8849468 PTK6 Regulates Proteins Involved in RNA Processing

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: KH domain-containing, RNA-binding, signal transduction-associated protein 2 Alternative name(s): Sam68-like mammalian protein 1 Short name: SLM-1 Short name: hSLM-1
Gene namesⁱ	Name:KHDRBS2 Synonyms:SLM1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000112232.8
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:18114 KHDRBS2
MIMⁱ	610487 gene
neXtProtⁱ	NX_Q5VWX1

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	202559
Open Targets More...OpenTargetsⁱ	ENSG00000112232
PharmGKBⁱ	PA30093

Polymorphism and mutation databases

BioMutaⁱ	KHDRBS2
DMDMⁱ	74762274

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000308953	1 – 349	KH domain-containing, RNA-binding, signal transduction-associated protein 2Add BLAST		349

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	230	Omega-N-methylarginineBy similarity		1
Modified residueⁱ	240	Omega-N-methylarginineBy similarity		1

Post-translational modificationⁱ

Methylated.1 Publication

Tyrosine phosphorylated by FYN, PTK6 and SRC. Tyrosine phosphorylated by SRC during mitosis (By similarity).By similarity

Keywords - PTMⁱ

Methylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q5VWX1
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q5VWX1
PaxDbⁱ	Q5VWX1
PeptideAtlas More...PeptideAtlasⁱ	Q5VWX1
PRIDEⁱ	Q5VWX1
ProteomicsDBⁱ	65566

PTM databases

iPTMnetⁱ	Q5VWX1
PhosphoSitePlusⁱ	Q5VWX1

Expressionⁱ

Tissue specificityⁱ

Highly expressed in brain, lung, kidney and small intestine. Weakly expressed in placenta, liver, spleen, thymus, ovary and colon.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000112232 Expressed in 64 organ(s), highest expression level in corpus callosum
CleanExⁱ	HS_KHDRBS2
Genevisibleⁱ	Q5VWX1 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA000500 HPA029392

HPAⁱ

HPA000500
HPA029392

Interactionⁱ

Subunit structureⁱ

Self-associates to form homooligomers (By similarity). Interacts with KHDRBS1/SAM68; heterooligomer formation of KHDRBS family proteins may modulate RNA substrate specificity (By similarity). Interacts with RBMX (PubMed:19282290). Interacts with SAFB, SFRS9 and YTHDC1. Interacts with FYN and PLCG1 (via SH3 domain). Interacts (phosphorylated) with FYN, GRB2, PLCG1 and RASA1 (via SH2 domain) (By similarity).By similarity1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
itself		4	EBI-742808,EBI-742808
AEN	Q8WTP8	3	EBI-742808,EBI-8637627
CATSPER1	Q8NEC5	5	EBI-742808,EBI-744545
CHTOP	Q9Y3Y2	3	EBI-742808,EBI-347794
CIRBP	Q14011	3	EBI-742808,EBI-538850
DOCK2	Q92608	5	EBI-742808,EBI-448771
HBZ	P02008	3	EBI-742808,EBI-719843
HNRNPR	O43390	3	EBI-742808,EBI-713419
KHDRBS3	O75525	3	EBI-742808,EBI-722504
MTA1	Q13330	3	EBI-742808,EBI-714236
NABP1	Q96AH0	3	EBI-742808,EBI-2889252
NPDC1	Q9NQX5	5	EBI-742808,EBI-748927
PRPF31	Q8WWY3	8	EBI-742808,EBI-1567797
PRR3	P79522	5	EBI-742808,EBI-2803328
PTK6	Q13882	3	EBI-742808,EBI-1383632
RBM10	P98175	3	EBI-742808,EBI-721525
RBM3	P98179	5	EBI-742808,EBI-2949699
RBMX	P38159	11	EBI-742808,EBI-743526
SDCBP	O00560	5	EBI-742808,EBI-727004
SPG7	Q9UQ90	3	EBI-742808,EBI-717201
SULT1A3	P0DMM9	3	EBI-742808,EBI-10196922
TYK2	P29597	6	EBI-742808,EBI-1383454
TYMSOS	Q8TAI1	5	EBI-742808,EBI-742060
YTHDC1	Q96MU7	5	EBI-742808,EBI-2849854
ZFC3H1	G3V1X1	3	EBI-742808,EBI-6448783
ZNF688	A0A0S2Z5X4	3	EBI-742808,EBI-16429014

GO - Molecular functionⁱ

identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 21516116
- 25416956
protein heterodimerization activity Source: Ensembl
SH2 domain binding Source: Ensembl
SH3 domain binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	128436, 101 interactors
IntActⁱ	Q5VWX1, 46 interactors
Molecular INTeraction database More...MINTⁱ	Q5VWX1
STRINGⁱ	9606.ENSP00000281156

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q5VWX1
SMRⁱ	Q5VWX1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	65 – 135	KHPROSITE-ProRule annotationAdd BLAST		71

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	211 – 262	Pro-richAdd BLAST		52

Sequence similaritiesⁱ

Belongs to the KHDRBS family.Curated

Keywords - Domainⁱ

SH3-binding

Phylogenomic databases

eggNOGⁱ	KOG1588 Eukaryota COG5176 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074434
HOGENOMⁱ	HOG000230771
HOVERGENⁱ	HBG079164
InParanoidⁱ	Q5VWX1
KEGG Orthology (KO) More...KOⁱ	K17843
OMAⁱ	EAYDNSY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0EED
PhylomeDBⁱ	Q5VWX1
TreeFamⁱ	TF314878

Family and domain databases

Gene3Dⁱ	3.30.1370.10, 1 hit
InterProⁱ	View protein in InterPro IPR004087 KH_dom IPR004088 KH_dom_type_1 IPR036612 KH_dom_type_1_sf IPR032571 Qua1_dom IPR032335 Sam68-YY
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00013 KH_1, 1 hit PF16274 Qua1, 1 hit PF16568 Sam68-YY, 1 hit
SMARTⁱ	View protein in SMART SM00322 KH, 1 hit
SUPFAMⁱ	SSF54791 SSF54791, 1 hit
PROSITEⁱ	View protein in PROSITE PS50084 KH_TYPE_1, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q5VWX1-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEEEKYLPEL MAEKDSLDPS FVHASRLLAE EIEKFQGSDG KKEDEEKKYL 
        60         70         80         90        100
DVISNKNIKL SERVLIPVKQ YPKFNFVGKL LGPRGNSLKR LQEETGAKMS 
       110        120        130        140        150
ILGKGSMRDK AKEEELRKSG EAKYAHLSDE LHVLIEVFAP PGEAYSRMSH 
       160        170        180        190        200
ALEEIKKFLV PDYNDEIRQE QLRELSYLNG SEDSGRGRGI RGRGIRIAPT 
       210        220        230        240        250
APSRGRGGAI PPPPPPGRGV LTPRGSTVTR GALPVPPVAR GVPTPRARGA 
       260        270        280        290        300
PTVPGYRAPP PPAHEAYEEY GYDDGYGGEY DDQTYETYDN SYATQTQSVP 
       310        320        330        340 
EYYDYGHGVS EDAYDSYAPE EWATTRSSLK APPQRSARGG YREHPYGRY

Length:349

Mass (Da):38,927

Last modified:December 7, 2004 - v1

Checksum:ⁱEF16E301D8A12164

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	65	L → P in AAL77219 (PubMed:12549823).Curated	1
Sequence conflictⁱ	232	A → V in AAL77219 (PubMed:12549823).Curated	1
Sequence conflictⁱ	326	R → S in AAH34043 (PubMed:15489334).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_036885	308	G → A. Corresponds to variant dbSNP:rs7449840Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY077838 mRNA Translation: AAL77219.1 AK292043 mRNA Translation: BAF84732.1 AL360220 Genomic DNA No translation available. AL355347 Genomic DNA No translation available. AL391644 Genomic DNA No translation available. AL138882 Genomic DNA No translation available. AL049544 Genomic DNA No translation available. Z93021 Genomic DNA No translation available. CH471143 Genomic DNA Translation: EAW88490.1 BC034043 mRNA Translation: AAH34043.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4963.1
NCBI Reference Sequences More...RefSeqⁱ	NP_689901.2, NM_152688.3
UniGeneⁱ	Hs.519794

Genome annotation databases

Ensemblⁱ	ENST00000281156; ENSP00000281156; ENSG00000112232
GeneIDⁱ	202559
KEGGⁱ	hsa:202559
UCSC genome browser More...UCSCⁱ	uc003peg.3 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q5VWX1	KH RNA binding domain containing, signal transduction associated 2		PANTR		349	UniRef100_Q5VWX1
KH RNA binding domain containing, signal transduction associated 2		GORGO		349
UPI0007DC53EA		HUMAN		251

Protein	Similar proteins		Species	Score	Length	Source
Q5VWX1	KH domain-containing, RNA-binding, signal transduction-associated protein 2		RAT		349	UniRef90_Q5VWX1
KH domain-containing, RNA-binding, signal transduction-associated protein 2		MOUSE		349
KH RNA binding domain containing, signal transduction associated 2		PANTR		349
KH RNA binding domain containing, signal transduction associated 2		GORGO		349
KH domain-containing, RNA-binding, signal transduction-associated protein 2 isoform X1		NEOSC		366
+91

Protein	Similar proteins		Species	Score	Length	Source
Q5VWX1	KH domain-containing, RNA-binding, signal transduction-associated protein 2		MOUSE		349	UniRef50_Q5VWX1
KH domain-containing, RNA-binding, signal transduction-associated protein 2		RAT		349
KH RNA binding domain containing, signal transduction associated 2		PANTR		349
KH RNA binding domain containing, signal transduction associated 2		GORGO		349
KH domain-containing, RNA-binding, signal transduction-associated protein 2 isoform X1		NEOSC		366
+123

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY077838 mRNA Translation: AAL77219.1 AK292043 mRNA Translation: BAF84732.1 AL360220 Genomic DNA No translation available. AL355347 Genomic DNA No translation available. AL391644 Genomic DNA No translation available. AL138882 Genomic DNA No translation available. AL049544 Genomic DNA No translation available. Z93021 Genomic DNA No translation available. CH471143 Genomic DNA Translation: EAW88490.1 BC034043 mRNA Translation: AAH34043.1
CCDSⁱ	CCDS4963.1
RefSeqⁱ	NP_689901.2, NM_152688.3
UniGeneⁱ	Hs.519794

3D structure databases

ProteinModelPortalⁱ	Q5VWX1
SMRⁱ	Q5VWX1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	128436, 101 interactors
IntActⁱ	Q5VWX1, 46 interactors
MINTⁱ	Q5VWX1
STRINGⁱ	9606.ENSP00000281156

PTM databases

iPTMnetⁱ	Q5VWX1
PhosphoSitePlusⁱ	Q5VWX1

Polymorphism and mutation databases

BioMutaⁱ	KHDRBS2
DMDMⁱ	74762274

Proteomic databases

EPDⁱ	Q5VWX1
MaxQBⁱ	Q5VWX1
PaxDbⁱ	Q5VWX1
PeptideAtlasⁱ	Q5VWX1
PRIDEⁱ	Q5VWX1
ProteomicsDBⁱ	65566

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	202559
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000281156; ENSP00000281156; ENSG00000112232
GeneIDⁱ	202559
KEGGⁱ	hsa:202559
UCSCⁱ	uc003peg.3 human

Organism-specific databases

CTDⁱ	202559
DisGeNETⁱ	202559
EuPathDBⁱ	HostDB:ENSG00000112232.8
GeneCardsⁱ	KHDRBS2
H-InvDBⁱ	HIX0005989
HGNCⁱ	HGNC:18114 KHDRBS2
HPAⁱ	HPA000500 HPA029392
MIMⁱ	610487 gene
neXtProtⁱ	NX_Q5VWX1
OpenTargetsⁱ	ENSG00000112232
PharmGKBⁱ	PA30093
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1588 Eukaryota COG5176 LUCA
GeneTreeⁱ	ENSGT00550000074434
HOGENOMⁱ	HOG000230771
HOVERGENⁱ	HBG079164
InParanoidⁱ	Q5VWX1
KOⁱ	K17843
OMAⁱ	EAYDNSY
OrthoDBⁱ	EOG091G0EED
PhylomeDBⁱ	Q5VWX1
TreeFamⁱ	TF314878

Enzyme and pathway databases

Reactomeⁱ	R-HSA-8849468 PTK6 Regulates Proteins Involved in RNA Processing

Reactomeⁱ

R-HSA-8849468 PTK6 Regulates Proteins Involved in RNA Processing

Miscellaneous databases

ChiTaRSⁱ	KHDRBS2 human
GenomeRNAiⁱ	202559
Protein Ontology More...PROⁱ	PR:Q5VWX1
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000112232 Expressed in 64 organ(s), highest expression level in corpus callosum
CleanExⁱ	HS_KHDRBS2
Genevisibleⁱ	Q5VWX1 HS

Family and domain databases

Gene3Dⁱ	3.30.1370.10, 1 hit
InterProⁱ	View protein in InterPro IPR004087 KH_dom IPR004088 KH_dom_type_1 IPR036612 KH_dom_type_1_sf IPR032571 Qua1_dom IPR032335 Sam68-YY
Pfamⁱ	View protein in Pfam PF00013 KH_1, 1 hit PF16274 Qua1, 1 hit PF16568 Sam68-YY, 1 hit
SMARTⁱ	View protein in SMART SM00322 KH, 1 hit
SUPFAMⁱ	SSF54791 SSF54791, 1 hit
PROSITEⁱ	View protein in PROSITE PS50084 KH_TYPE_1, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	KHDR2_HUMAN
Accessionⁱ	Q5VWX1Primary (citable) accession number: Q5VWX1 Secondary accession number(s): A8K7M8, Q8N4I4, Q8TCZ4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 13, 2007
	Last sequence update:	December 7, 2004
	Last modified:	September 12, 2018
	This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

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Supporting data

UniProtKB - Q5VWX1 (KHDR2_HUMAN)

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KH domain-containing, RNA-binding, signal transduction-associated protein 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ