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Entry version 114 (13 Feb 2019)
Sequence version 2 (01 Sep 2009)
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Protein

Lysine-specific demethylase 9

Gene

RSBN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Histone demethylase that specifically demethylates dimethylated 'Lys-20' of histone H4 (H4K20me2), thereby modulating chromosome architecture.By similarity

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Fe2+By similarityNote: Binds 1 Fe2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei579Alpha-ketoglutarateBy similarity1
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi582Iron, catalyticBy similarity1
Metal bindingi584Iron, catalyticBy similarity1
Binding sitei676Alpha-ketoglutarateBy similarity1
Metal bindingi684Iron, catalyticBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, Dioxygenase, Oxidoreductase
LigandIron, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Lysine-specific demethylase 9By similarity (EC:1.14.11.-By similarity)
Short name:
KDM9By similarity
Alternative name(s):
Round spermatid basic protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RSBN1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000081019.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25642 RSBN1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
615858 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5VWQ0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
54665

Open Targets

More...
OpenTargetsi
ENSG00000081019

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134869532

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RSBN1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
257050986

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002994121 – 802Lysine-specific demethylase 9Add BLAST802

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei81PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki290Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki313Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki740Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki781Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by PKA.By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5VWQ0

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5VWQ0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q5VWQ0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5VWQ0

PeptideAtlas

More...
PeptideAtlasi
Q5VWQ0

PRoteomics IDEntifications database

More...
PRIDEi
Q5VWQ0

ProteomicsDB human proteome resource

More...
ProteomicsDBi
65552
65553 [Q5VWQ0-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5VWQ0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5VWQ0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000081019 Expressed in 233 organ(s), highest expression level in blood

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5VWQ0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5VWQ0 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA042124
HPA049484

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120094, 58 interactors

Protein interaction database and analysis system

More...
IntActi
Q5VWQ0, 6 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000261441

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q5VWQ0

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5VWQ0

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi252 – 263Nuclear localization signalSequence analysisAdd BLAST12

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi103 – 165Pro-richAdd BLAST63
Compositional biasi114 – 117Poly-Arg4
Compositional biasi185 – 197His-richAdd BLAST13
Compositional biasi252 – 261Poly-Lys10

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4425 Eukaryota
ENOG410XSZP LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000001969

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000043117

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG094904

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5VWQ0

KEGG Orthology (KO)

More...
KOi
K22610

Identification of Orthologs from Complete Genome Data

More...
OMAi
AGERLQC

Database of Orthologous Groups

More...
OrthoDBi
930910at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5VWQ0

TreeFam database of animal gene trees

More...
TreeFami
TF323256

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026306 RSBN1/Dpy-21

The PANTHER Classification System

More...
PANTHERi
PTHR13354 PTHR13354, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5VWQ0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFISGRRTAD KWRAEERLQC PAGSARAALA RCADGGAVGP FKCVFVGEMA
60 70 80 90 100
AQVGAVRVVR AVAAQEEPDK EGKEKPHAGV SPRGVKRQRR SSSGGSQEKR
110 120 130 140 150
GRPSQEPPLA PPHRRRRSRQ HPGPLPPTNA APTVPGPVEP LLLPPPPPPS
160 170 180 190 200
LAPAGPAVAA PLPAPSTSAL FTFSPLTVSA AGPKHKGHKE RHKHHHHRGP
210 220 230 240 250
DGDPSSCGTD LKHKDKQENG ERTGGVPLIK APKRETPDEN GKTQRADDFV
260 270 280 290 300
LKKIKKKKKK KHREDMRGRR LKMYNKEVQT VCAGLTRISK EILTQGQINS
310 320 330 340 350
TSGLNKESFR YLKDEQLCRL NLGMQEYRVP QGVQTPFMTH QEHSIRRNFL
360 370 380 390 400
KTGTKFSNFI HEEHQSNGGA LVLHAYMDEL SFLSPMEMER FSEEFLALTF
410 420 430 440 450
SENEKNAAYY ALAIVHGAAA YLPDFLDYFA FNFPNTPVKM EILGKKDIET
460 470 480 490 500
TTISNFHTQV NRTYCCGTYR AGPMRQISLV GAVDEEVGDY FPEFLDMLEE
510 520 530 540 550
SPFLKMTLPW GTLSSLRLQC RSQSDDGPIM WVRPGEQMIP TADMPKSPFK
560 570 580 590 600
RRRSMNEIKN LQYLPRTSEP REVLFEDRTR AHADHVGQGF DWQSTAAVGV
610 620 630 640 650
LKAVQFGEWS DQPRITKDVI CFHAEDFTDV VQRLQLDLHE PPVSQCVQWV
660 670 680 690 700
DEAKLNQMRR EGIRYARIQL CDNDIYFIPR NVIHQFKTVS AVCSLAWHIR
710 720 730 740 750
LKQYHPVVEA TQNTESNSNM DCGLTGKREL EVDSQCVRIK TESEEACTEI
760 770 780 790 800
QLLTTASSSF PPASELNLQQ DQKTQPIPVL KVESRLDSDQ QHNLQEHSTT

SV
Length:802
Mass (Da):90,072
Last modified:September 1, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i78F229AB6A0FABD1
GO
Isoform 4 (identifier: Q5VWQ0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     460-802: Missing.

Show »
Length:459
Mass (Da):50,802
Checksum:i9B1EA055DF7807A1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0C4DGT8A0A0C4DGT8_HUMAN
Lysine-specific demethylase 9
RSBN1
685Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WWP8A0A087WWP8_HUMAN
Lysine-specific demethylase 9
RSBN1
754Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4DH79A0A0C4DH79_HUMAN
Lysine-specific demethylase 9
RSBN1 hCG_38641
411Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH26155 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA92075 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB13974 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAH10493 differs from that shown. Aberrant splicing.Curated
The sequence CAH10493 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti39 – 40GP → SG in AAH26155 (PubMed:15489334).Curated2
Sequence conflicti106E → G in BAF85241 (PubMed:14702039).Curated1
Sequence conflicti120Q → R in BAA92075 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_027656460 – 802Missing in isoform 4. 1 PublicationAdd BLAST343

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK002082 mRNA Translation: BAA92075.1 Different initiation.
AK292552 mRNA Translation: BAF85241.1
AK022166 mRNA Translation: BAB13974.1 Different initiation.
AL137856 Genomic DNA No translation available.
AL365321 Genomic DNA No translation available.
BC026155 mRNA Translation: AAH26155.1 Different initiation.
CR627402 mRNA Translation: CAH10493.1 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS862.1 [Q5VWQ0-1]

NCBI Reference Sequences

More...
RefSeqi
NP_060834.2, NM_018364.4 [Q5VWQ0-1]
XP_016857007.1, XM_017001518.1 [Q5VWQ0-4]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.486285

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000261441; ENSP00000261441; ENSG00000081019 [Q5VWQ0-1]
ENST00000612242; ENSP00000479490; ENSG00000081019 [Q5VWQ0-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
54665

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:54665

UCSC genome browser

More...
UCSCi
uc001edq.4 human [Q5VWQ0-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002082 mRNA Translation: BAA92075.1 Different initiation.
AK292552 mRNA Translation: BAF85241.1
AK022166 mRNA Translation: BAB13974.1 Different initiation.
AL137856 Genomic DNA No translation available.
AL365321 Genomic DNA No translation available.
BC026155 mRNA Translation: AAH26155.1 Different initiation.
CR627402 mRNA Translation: CAH10493.1 Sequence problems.
CCDSiCCDS862.1 [Q5VWQ0-1]
RefSeqiNP_060834.2, NM_018364.4 [Q5VWQ0-1]
XP_016857007.1, XM_017001518.1 [Q5VWQ0-4]
UniGeneiHs.486285

3D structure databases

ProteinModelPortaliQ5VWQ0
SMRiQ5VWQ0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120094, 58 interactors
IntActiQ5VWQ0, 6 interactors
STRINGi9606.ENSP00000261441

PTM databases

iPTMnetiQ5VWQ0
PhosphoSitePlusiQ5VWQ0

Polymorphism and mutation databases

BioMutaiRSBN1
DMDMi257050986

Proteomic databases

EPDiQ5VWQ0
jPOSTiQ5VWQ0
MaxQBiQ5VWQ0
PaxDbiQ5VWQ0
PeptideAtlasiQ5VWQ0
PRIDEiQ5VWQ0
ProteomicsDBi65552
65553 [Q5VWQ0-4]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
54665
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261441; ENSP00000261441; ENSG00000081019 [Q5VWQ0-1]
ENST00000612242; ENSP00000479490; ENSG00000081019 [Q5VWQ0-1]
GeneIDi54665
KEGGihsa:54665
UCSCiuc001edq.4 human [Q5VWQ0-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
54665
DisGeNETi54665
EuPathDBiHostDB:ENSG00000081019.13

GeneCards: human genes, protein and diseases

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GeneCardsi
RSBN1

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0000902
HGNCiHGNC:25642 RSBN1
HPAiHPA042124
HPA049484
MIMi615858 gene
neXtProtiNX_Q5VWQ0
OpenTargetsiENSG00000081019
PharmGKBiPA134869532

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG4425 Eukaryota
ENOG410XSZP LUCA
GeneTreeiENSGT00390000001969
HOGENOMiHOG000043117
HOVERGENiHBG094904
InParanoidiQ5VWQ0
KOiK22610
OMAiAGERLQC
OrthoDBi930910at2759
PhylomeDBiQ5VWQ0
TreeFamiTF323256

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
RSBN1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
54665

Protein Ontology

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PROi
PR:Q5VWQ0

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000081019 Expressed in 233 organ(s), highest expression level in blood
ExpressionAtlasiQ5VWQ0 baseline and differential
GenevisibleiQ5VWQ0 HS

Family and domain databases

InterProiView protein in InterPro
IPR026306 RSBN1/Dpy-21
PANTHERiPTHR13354 PTHR13354, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRSBN1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5VWQ0
Secondary accession number(s): A8K937
, Q6AI21, Q8TC33, Q9HA80, Q9NUP6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 1, 2009
Last modified: February 13, 2019
This is version 114 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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