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UniProtKB - Q5VWP2 (TET5C_HUMAN)

Entry version 119 (25 May 2022)
Sequence version 1 (30 Aug 2005)
Previous versions | rss
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Protein

Terminal nucleotidyltransferase 5C

Gene

TENT5C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the transfer of one adenosine molecule from an ATP to an mRNA poly(A) tail bearing a 3'-OH terminal group and enhances mRNA stability and gene expression (PubMed:32009146, PubMed:28931820, PubMed:34048638).

Can also elongate RNA oligos ending with uridine molecule, provided that the sequence is adenosine-rich (PubMed:34048638).

Mainly targets mRNAs encoding endoplasmic reticulum-targeted protein (PubMed:28931820).

3 Publications

(Microbial infection) Seems to enhance replication of some viruses, including yellow fever virus, in response to type I interferon.

1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionNucleotidyltransferase, RNA-binding, Transferase
Biological processHost-virus interaction

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q5VWP2

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q5VWP2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Terminal nucleotidyltransferase 5CCurated (EC:2.7.7.192 Publications)
Alternative name(s):
Non-canonical poly(A) polymerase FAM46C1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TENT5CImported
Synonyms:FAM46CImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:24712, TENT5C

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		613952, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q5VWP2

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000183508

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi90 – 92DLD → ALA: Loss of poly(a) polymerase activity. 1 Publication3
Mutagenesisi144K → P: Decreases substantially the interaction with PLK4. Weakens binding to PLK4; when associated with E-230 and E-321. Abolishes the inhibitory effect of TENT5C on the cell viability; when associated with E-320 and E-321. 1 Publication1
Mutagenesisi146C → P: Decreases substantially the interaction with PLK4. Weakens binding to PLK4; when associated with E-230 and E-321. 1 Publication1
Mutagenesisi166E → Q: Does not affect colocalization with PLK4 in centrosome. Increases cell viability. 1 Publication1
Mutagenesisi320C → E: Slightly decreases the binding to PLK4; when associated with E-321. Abolishes the inhibitory effect of TENT5C on the cell viability; when associated with P-144 and E-321. 1 Publication1
Mutagenesisi321L → E: Slightly decreases the binding to PLK4; when associated with E-320. Abolishes the inhibitory effect of TENT5C on the cell viability; when associated with P-144 and E-320. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		54855

Open Targets

More...OpenTargetsi		ENSG00000183508

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134955264

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q5VWP2, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		FAM46C

Domain mapping of disease mutations (DMDM)

More...DMDMi		117940143

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002599331 – 391Terminal nucleotidyltransferase 5CAdd BLAST391

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q5VWP2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q5VWP2

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q5VWP2

PeptideAtlas

More...PeptideAtlasi		Q5VWP2

PRoteomics IDEntifications database

More...PRIDEi		Q5VWP2

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		65547

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q5VWP2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q5VWP2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By type I interferons.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000183508, Expressed in secondary oocyte and 208 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q5VWP2, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000183508, Tissue enhanced (bone)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with BCCIP and PABPC1; the interaction has no effect on TENT5C poly(A) polymerase function (PubMed:28931820).

Interacts with PLK4; this interaction leads to the TENT5C recruitment into the centrosome (PubMed:32433990).

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		120205, 11 interactors

Protein interaction database and analysis system

More...IntActi		Q5VWP2, 9 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000358458

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q5VWP2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1391
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q5VWP2

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q5VWP2

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TENT family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3852, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158856

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_008115_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q5VWP2

Identification of Orthologs from Complete Genome Data

More...OMAi		NTRDCMS

Database of Orthologous Groups

More...OrthoDBi		612201at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q5VWP2

TreeFam database of animal gene trees

More...TreeFami		TF315239

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR012937, TET5

The PANTHER Classification System

More...PANTHERi		PTHR12974, PTHR12974, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07984, NTP_transf_7, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01153, DUF1693, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5VWP2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEESSCTRD CMSFSVLNWD QVSRLHEVLT EVVPIHGRGN FPTLEITLKD 
        60         70         80         90        100
IVQTVRSRLE EAGIKVHDVR LNGSAAGHVL VKDNGLGCKD LDLIFHVALP 
       110        120        130        140        150
TEAEFQLVRD VVLCSLLNFL PEGVNKLKIS PVTLKEAYVQ KLVKVCTDTD 
       160        170        180        190        200
RWSLISLSNK NGKNVELKFV DSIRRQFEFS VDSFQIILDS LLFFYDCSNN 
       210        220        230        240        250
PISEHFHPTV IGESMYGDFE EAFDHLQNRL IATKNPEEIR GGGLLKYSNL 
       260        270        280        290        300
LVRDFRPTDQ EEIKTLERYM CSRFFIDFPD ILEQQRKLET YLQNHFAEEE 
       310        320        330        340        350
RSKYDYLMIL RRVVNESTVC LMGHERRQTL NLISLLALRV LAEQNIIPSA 
       360        370        380        390 
TNVTCYYQPA PYVSDGNFSN YYVAHPPVTY SQPYPTWLPC N
Length:391
Mass (Da):44,944
Last modified:August 30, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1B73C6688284F8AC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti150D → V in BAA91010 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06013267H → Q. Corresponds to variant dbSNP:rs1630312EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK000209 mRNA Translation: BAA91010.1
AL365331 Genomic DNA No translation available.
BC036516 mRNA Translation: AAH36516.3
BC131726 mRNA Translation: AAI31727.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS896.1

NCBI Reference Sequences

More...RefSeqi		NP_060179.2, NM_017709.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000369448.4; ENSP00000358458.3; ENSG00000183508.5

Database of genes from NCBI RefSeq genomes

More...GeneIDi		54855

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:54855

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000369448.4; ENSP00000358458.3; NM_017709.4; NP_060179.2

UCSC genome browser

More...UCSCi		uc001ehe.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000209 mRNA Translation: BAA91010.1
AL365331 Genomic DNA No translation available.
BC036516 mRNA Translation: AAH36516.3
BC131726 mRNA Translation: AAI31727.1
CCDSiCCDS896.1
RefSeqiNP_060179.2, NM_017709.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6W36X-ray2.85A14-358[»]
6W38X-ray4.48A14-358[»]
6W3IX-ray3.80A14-358[»]
6W3JX-ray4.38A14-358[»]
AlphaFoldDBiQ5VWP2
SMRiQ5VWP2
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi120205, 11 interactors
IntActiQ5VWP2, 9 interactors
STRINGi9606.ENSP00000358458

PTM databases

iPTMnetiQ5VWP2
PhosphoSitePlusiQ5VWP2

Genetic variation databases

BioMutaiFAM46C
DMDMi117940143

Proteomic databases

jPOSTiQ5VWP2
MassIVEiQ5VWP2
PaxDbiQ5VWP2
PeptideAtlasiQ5VWP2
PRIDEiQ5VWP2
ProteomicsDBi65547

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		33893, 108 antibodies from 20 providers

The DNASU plasmid repository

More...DNASUi		54855

Genome annotation databases

EnsembliENST00000369448.4; ENSP00000358458.3; ENSG00000183508.5
GeneIDi54855
KEGGihsa:54855
MANE-SelectiENST00000369448.4; ENSP00000358458.3; NM_017709.4; NP_060179.2
UCSCiuc001ehe.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		54855
DisGeNETi54855

GeneCards: human genes, protein and diseases

More...GeneCardsi		TENT5C
HGNCiHGNC:24712, TENT5C
HPAiENSG00000183508, Tissue enhanced (bone)
MIMi613952, gene
neXtProtiNX_Q5VWP2
OpenTargetsiENSG00000183508
PharmGKBiPA134955264
VEuPathDBiHostDB:ENSG00000183508

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3852, Eukaryota
GeneTreeiENSGT00940000158856
HOGENOMiCLU_008115_2_0_1
InParanoidiQ5VWP2
OMAiNTRDCMS
OrthoDBi612201at2759
PhylomeDBiQ5VWP2
TreeFamiTF315239

Enzyme and pathway databases

PathwayCommonsiQ5VWP2
SignaLinkiQ5VWP2

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		54855, 10 hits in 1078 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		54855
PharosiQ5VWP2, Tbio

Protein Ontology

More...PROi		PR:Q5VWP2
RNActiQ5VWP2, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000183508, Expressed in secondary oocyte and 208 other tissues
GenevisibleiQ5VWP2, HS

Family and domain databases

InterProiView protein in InterPro
IPR012937, TET5
PANTHERiPTHR12974, PTHR12974, 1 hit
PfamiView protein in Pfam
PF07984, NTP_transf_7, 1 hit
SMARTiView protein in SMART
SM01153, DUF1693, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTET5C_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5VWP2
Secondary accession number(s): A3KMG2, Q8NE25, Q9NXK0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 14, 2006
Last sequence update: August 30, 2005
Last modified: May 25, 2022
This is version 119 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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