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Protein

Terminal nucleotidyltransferase 5C

Gene

TENT5C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Nucleotidyltransferase that act as a non-canonical poly(A) RNA polymerase which enhances mRNA stability and gene expression. Mainly targets mRNAs encoding endoplasmic reticulum-targeted protein and may be involved in induction of cell death.2 Publications
(Microbial infection) Seems to enhance replication of some viruses, including yellow fever virus, in response to type I interferon.1 Publication

Catalytic activityi

ATP + RNA(n) = diphosphate + RNA(n+1).1 Publication

GO - Molecular functioni

  • RNA adenylyltransferase activity Source: UniProtKB
  • RNA binding Source: UniProtKB-KW

GO - Biological processi

  • mRNA stabilization Source: UniProtKB

Keywordsi

Molecular functionNucleotidyltransferase, RNA-binding, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Terminal nucleotidyltransferase 5CCurated (EC:2.7.7.191 Publication1 Publication)
Alternative name(s):
Non-canonical poly(A) polymerase FAM46C1 Publication
Gene namesi
Name:TENT5CImported
Synonyms:FAM46CImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000183508.4
HGNCiHGNC:24712 TENT5C
MIMi613952 gene
neXtProtiNX_Q5VWP2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi90 – 92DLD → ALA: Loss of poly(a) polymerase activity. 1 Publication3

Organism-specific databases

DisGeNETi54855
OpenTargetsiENSG00000183508
PharmGKBiPA134955264

Polymorphism and mutation databases

BioMutaiFAM46C
DMDMi117940143

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002599331 – 391Terminal nucleotidyltransferase 5CAdd BLAST391

Proteomic databases

PaxDbiQ5VWP2
PeptideAtlasiQ5VWP2
PRIDEiQ5VWP2
ProteomicsDBi65547

PTM databases

iPTMnetiQ5VWP2
PhosphoSitePlusiQ5VWP2

Expressioni

Inductioni

By type I interferons.1 Publication

Gene expression databases

BgeeiENSG00000183508
CleanExiHS_FAM46C
GenevisibleiQ5VWP2 HS

Organism-specific databases

HPAiHPA054049

Interactioni

Subunit structurei

Interacts with BCCIP and PABPC1; the interaction has no effect on TENT5C poly(A) polymerase function.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
RHOXF2Q9BQY43EBI-741787,EBI-372094

Protein-protein interaction databases

BioGridi120205, 8 interactors
IntActiQ5VWP2, 6 interactors
STRINGi9606.ENSP00000358458

Structurei

3D structure databases

ProteinModelPortaliQ5VWP2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TENT family.Curated

Phylogenomic databases

eggNOGiKOG3852 Eukaryota
ENOG410XTG4 LUCA
GeneTreeiENSGT00500000044785
HOGENOMiHOG000234733
HOVERGENiHBG057969
InParanoidiQ5VWP2
OMAiFFYDCSS
OrthoDBiEOG091G06T9
PhylomeDBiQ5VWP2
TreeFamiTF315239

Family and domain databases

InterProiView protein in InterPro
IPR012937 DUF1693
PfamiView protein in Pfam
PF07984 NTP_transf_7, 1 hit
SMARTiView protein in SMART
SM01153 DUF1693, 1 hit

Sequencei

Sequence statusi: Complete.

Q5VWP2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEESSCTRD CMSFSVLNWD QVSRLHEVLT EVVPIHGRGN FPTLEITLKD
60 70 80 90 100
IVQTVRSRLE EAGIKVHDVR LNGSAAGHVL VKDNGLGCKD LDLIFHVALP
110 120 130 140 150
TEAEFQLVRD VVLCSLLNFL PEGVNKLKIS PVTLKEAYVQ KLVKVCTDTD
160 170 180 190 200
RWSLISLSNK NGKNVELKFV DSIRRQFEFS VDSFQIILDS LLFFYDCSNN
210 220 230 240 250
PISEHFHPTV IGESMYGDFE EAFDHLQNRL IATKNPEEIR GGGLLKYSNL
260 270 280 290 300
LVRDFRPTDQ EEIKTLERYM CSRFFIDFPD ILEQQRKLET YLQNHFAEEE
310 320 330 340 350
RSKYDYLMIL RRVVNESTVC LMGHERRQTL NLISLLALRV LAEQNIIPSA
360 370 380 390
TNVTCYYQPA PYVSDGNFSN YYVAHPPVTY SQPYPTWLPC N
Length:391
Mass (Da):44,944
Last modified:August 30, 2005 - v1
Checksum:i1B73C6688284F8AC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti150D → V in BAA91010 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06013267H → Q. Corresponds to variant dbSNP:rs1630312EnsemblClinVar.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000209 mRNA Translation: BAA91010.1
AL365331 Genomic DNA No translation available.
BC036516 mRNA Translation: AAH36516.3
BC131726 mRNA Translation: AAI31727.1
CCDSiCCDS896.1
RefSeqiNP_060179.2, NM_017709.3
UniGeneiHs.356216

Genome annotation databases

EnsembliENST00000369448; ENSP00000358458; ENSG00000183508
GeneIDi54855
KEGGihsa:54855
UCSCiuc001ehe.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTET5C_HUMAN
AccessioniPrimary (citable) accession number: Q5VWP2
Secondary accession number(s): A3KMG2, Q8NE25, Q9NXK0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 14, 2006
Last sequence update: August 30, 2005
Last modified: July 18, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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