TENT5C

Functionⁱ

Nucleotidyltransferase that act as a non-canonical poly(A) RNA polymerase which enhances mRNA stability and gene expression. Mainly targets mRNAs encoding endoplasmic reticulum-targeted protein and may be involved in induction of cell death.2 Publications

(Microbial infection) Seems to enhance replication of some viruses, including yellow fever virus, in response to type I interferon.1 Publication

Catalytic activityⁱ

ATP + RNA(n) = diphosphate + RNA(n+1).1 Publication

GO - Molecular functionⁱ

RNA adenylyltransferase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 28931820
RNA binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

mRNA stabilization
Source: UniProtKB
Inferred from direct assayⁱ
- 28931820

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Nucleotidyltransferase, RNA-binding, Transferase

Molecular function

Nucleotidyltransferase, RNA-binding, Transferase

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Terminal nucleotidyltransferase 5CCurated (EC:2.7.7.191 Publication1 Publication) Alternative name(s): Non-canonical poly(A) polymerase FAM46C1 Publication
Gene namesⁱ	Name:TENT5CImported Synonyms:FAM46CImported
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000183508.4
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:24712 TENT5C
MIMⁱ	613952 gene
neXtProtⁱ	NX_Q5VWP2

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	90 – 92	DLD → ALA: Loss of poly(a) polymerase activity. 1 Publication		3

Organism-specific databases

DisGeNET More...DisGeNETⁱ	54855
Open Targets More...OpenTargetsⁱ	ENSG00000183508
PharmGKBⁱ	PA134955264

Polymorphism and mutation databases

BioMutaⁱ	FAM46C
DMDMⁱ	117940143

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000259933	1 – 391	Terminal nucleotidyltransferase 5CAdd BLAST		391

Proteomic databases

PaxDbⁱ	Q5VWP2
PeptideAtlas More...PeptideAtlasⁱ	Q5VWP2
PRIDEⁱ	Q5VWP2
ProteomicsDBⁱ	65547

PTM databases

iPTMnetⁱ	Q5VWP2
PhosphoSitePlusⁱ	Q5VWP2

Expressionⁱ

Inductionⁱ

By type I interferons.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000183508
CleanExⁱ	HS_FAM46C
Genevisibleⁱ	Q5VWP2 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA054049

HPAⁱ

HPA054049

Interactionⁱ

Subunit structureⁱ

Interacts with BCCIP and PABPC1; the interaction has no effect on TENT5C poly(A) polymerase function.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
RHOXF2	Q9BQY4	3	EBI-741787,EBI-372094

With

Entry

#Exp.

IntAct

Notes

RHOXF2

Q9BQY4

3

EBI-741787,EBI-372094

Protein-protein interaction databases

BioGridⁱ	120205, 8 interactors
IntActⁱ	Q5VWP2, 6 interactors
STRINGⁱ	9606.ENSP00000358458

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q5VWP2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the TENT family.Curated

Phylogenomic databases

eggNOGⁱ	KOG3852 Eukaryota ENOG410XTG4 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00500000044785
HOGENOMⁱ	HOG000234733
HOVERGENⁱ	HBG057969
InParanoidⁱ	Q5VWP2
OMAⁱ	FFYDCSS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06T9
PhylomeDBⁱ	Q5VWP2
TreeFamⁱ	TF315239

Family and domain databases

InterProⁱ	View protein in InterPro IPR012937 DUF1693
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07984 NTP_transf_7, 1 hit
SMARTⁱ	View protein in SMART SM01153 DUF1693, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q5VWP2-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAEESSCTRD CMSFSVLNWD QVSRLHEVLT EVVPIHGRGN FPTLEITLKD 
        60         70         80         90        100
IVQTVRSRLE EAGIKVHDVR LNGSAAGHVL VKDNGLGCKD LDLIFHVALP 
       110        120        130        140        150
TEAEFQLVRD VVLCSLLNFL PEGVNKLKIS PVTLKEAYVQ KLVKVCTDTD 
       160        170        180        190        200
RWSLISLSNK NGKNVELKFV DSIRRQFEFS VDSFQIILDS LLFFYDCSNN 
       210        220        230        240        250
PISEHFHPTV IGESMYGDFE EAFDHLQNRL IATKNPEEIR GGGLLKYSNL 
       260        270        280        290        300
LVRDFRPTDQ EEIKTLERYM CSRFFIDFPD ILEQQRKLET YLQNHFAEEE 
       310        320        330        340        350
RSKYDYLMIL RRVVNESTVC LMGHERRQTL NLISLLALRV LAEQNIIPSA 
       360        370        380        390 
TNVTCYYQPA PYVSDGNFSN YYVAHPPVTY SQPYPTWLPC N

Length:391

Mass (Da):44,944

Last modified:August 30, 2005 - v1

Checksum:ⁱ1B73C6688284F8AC

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	150	D → V in BAA91010 (PubMed:14702039).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_060132	67	H → Q. Corresponds to variant dbSNP:rs1630312EnsemblClinVar.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK000209 mRNA Translation: BAA91010.1 AL365331 Genomic DNA No translation available. BC036516 mRNA Translation: AAH36516.3 BC131726 mRNA Translation: AAI31727.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS896.1
NCBI Reference Sequences More...RefSeqⁱ	NP_060179.2, NM_017709.3
UniGeneⁱ	Hs.356216

Genome annotation databases

Ensemblⁱ	ENST00000369448; ENSP00000358458; ENSG00000183508
GeneIDⁱ	54855
KEGGⁱ	hsa:54855
UCSC genome browser More...UCSCⁱ	uc001ehe.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q5VWP2	Family with sequence similarity 46 member C		MONDO		397
UPI00072DFB22		ACIJB		396
UPI00032B007A		OCHPR		393
UPI0002C62484		southern white rhinoceros		393
Uncharacterized protein (Fragment)		DESRO		393
+78

Protein	Similar proteins		Species	Score	Length
Q5VWP2	Family with sequence similarity 46 member C		MONDO		397
UPI00072DFB22		ACIJB		396
UPI00032B007A		OCHPR		393
UPI0002C62484		southern white rhinoceros		393
Uncharacterized protein (Fragment)		DESRO		393
+207

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK000209 mRNA Translation: BAA91010.1 AL365331 Genomic DNA No translation available. BC036516 mRNA Translation: AAH36516.3 BC131726 mRNA Translation: AAI31727.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS896.1
NCBI Reference Sequences More...RefSeqⁱ	NP_060179.2, NM_017709.3
UniGeneⁱ	Hs.356216

3D structure databases

ProteinModelPortalⁱ	Q5VWP2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	120205, 8 interactors
IntActⁱ	Q5VWP2, 6 interactors
STRINGⁱ	9606.ENSP00000358458

PTM databases

iPTMnetⁱ	Q5VWP2
PhosphoSitePlusⁱ	Q5VWP2

Polymorphism and mutation databases

BioMutaⁱ	FAM46C
DMDMⁱ	117940143

Proteomic databases

PaxDbⁱ	Q5VWP2
PeptideAtlas More...PeptideAtlasⁱ	Q5VWP2
PRIDEⁱ	Q5VWP2
ProteomicsDBⁱ	65547

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000369448; ENSP00000358458; ENSG00000183508
GeneIDⁱ	54855
KEGGⁱ	hsa:54855
UCSC genome browser More...UCSCⁱ	uc001ehe.4 human

Organism-specific databases

CTDⁱ	54855
DisGeNET More...DisGeNETⁱ	54855
EuPathDBⁱ	HostDB:ENSG00000183508.4
GeneCardsⁱ	FAM46C
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:24712 TENT5C
Human Protein Atlas More...HPAⁱ	HPA054049
MIMⁱ	613952 gene
neXtProtⁱ	NX_Q5VWP2
Open Targets More...OpenTargetsⁱ	ENSG00000183508
PharmGKBⁱ	PA134955264
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3852 Eukaryota ENOG410XTG4 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00500000044785
HOGENOMⁱ	HOG000234733
HOVERGENⁱ	HBG057969
InParanoidⁱ	Q5VWP2
OMAⁱ	FFYDCSS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06T9
PhylomeDBⁱ	Q5VWP2
TreeFamⁱ	TF315239

Miscellaneous databases

ChiTaRSⁱ	FAM46C human
GenomeRNAiⁱ	54855
Protein Ontology More...PROⁱ	PR:Q5VWP2
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000183508
CleanExⁱ	HS_FAM46C
Genevisibleⁱ	Q5VWP2 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR012937 DUF1693
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07984 NTP_transf_7, 1 hit
SMARTⁱ	View protein in SMART SM01153 DUF1693, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TET5C_HUMAN
Accessionⁱ	Q5VWP2Primary (citable) accession number: Q5VWP2 Secondary accession number(s): A3KMG2, Q8NE25, Q9NXK0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 14, 2006
	Last sequence update:	August 30, 2005
	Last modified:	July 18, 2018
	This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

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UniProtKB - Q5VWP2 (TET5C_HUMAN)

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Terminal nucleotidyltransferase 5C

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Nucleus

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ