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UniProtKB - Q5VWN6 (TASO2_HUMAN)

Entry version 135 (07 Apr 2021)
Sequence version 1 (07 Dec 2004)
Previous versions | rss
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Protein

Protein TASOR 2

Gene

TASOR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q5VWN6

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein TASOR 2Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TASOR2Imported
Synonyms:C10orf18, FAM208B, KIAA2006
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:23484, TASOR2

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q5VWN6

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000108021.19

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		54906

Open Targets

More...OpenTargetsi		ENSG00000108021

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q5VWN6, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		FAM208B

Domain mapping of disease mutations (DMDM)

More...DMDMi		74747424

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002995421 – 2430Protein TASOR 2Add BLAST2430

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei19PhosphoserineCombined sources1
Modified residuei219PhosphoserineCombined sources1
Modified residuei384PhosphoserineCombined sources1
Modified residuei685PhosphoserineCombined sources1
Modified residuei1025PhosphoserineCombined sources1
Modified residuei1087PhosphoserineCombined sources1
Modified residuei1172PhosphoserineCombined sources1
Modified residuei1541PhosphoserineCombined sources1
Modified residuei1848PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki2007Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei2009PhosphoserineCombined sources1
Modified residuei2037PhosphoserineCombined sources1
Modified residuei2062PhosphoserineBy similarity1
Modified residuei2066PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q5VWN6

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q5VWN6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q5VWN6

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q5VWN6

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q5VWN6

PeptideAtlas

More...PeptideAtlasi		Q5VWN6

PRoteomics IDEntifications database

More...PRIDEi		Q5VWN6

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		65545 [Q5VWN6-1]
65546 [Q5VWN6-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q5VWN6, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q5VWN6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q5VWN6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000108021, Expressed in secondary oocyte and 239 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q5VWN6, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q5VWN6, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000108021, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q5VWN6
With#Exp.IntAct
ARMC7 [Q9H6L4]3EBI-745958,EBI-742909
BHLHB9 [Q6PI77]3EBI-745958,EBI-11519926
C1orf109 [Q9NX04]3EBI-745958,EBI-8643161
CARD9 - isoform 2 [Q9H257-2]3EBI-745958,EBI-11530605
CFAP206 [Q8IYR0]3EBI-745958,EBI-749051
COX5B [P10606]4EBI-745958,EBI-1053725
CTNNA3 - isoform 2 [Q9UI47-2]3EBI-745958,EBI-11962928
DMWD [G5E9A7]3EBI-745958,EBI-10976677
ERH [P84090]6EBI-745958,EBI-711389
GFAP [P14136]3EBI-745958,EBI-744302
GPSM1 - isoform 3 [Q86YR5-3]3EBI-745958,EBI-10261098
GRN [P28799]3EBI-745958,EBI-747754
HGS [A0A0S2Z4Q4]3EBI-745958,EBI-16429135
HSF2BP [O75031]3EBI-745958,EBI-7116203
HSPB1 [P04792]3EBI-745958,EBI-352682
HTRA2 [O43464]3EBI-745958,EBI-517086
HTT [P42858]12EBI-745958,EBI-466029
JPH3 [Q8WXH2]3EBI-745958,EBI-1055254
KCTD9 [Q7L273]3EBI-745958,EBI-4397613
KIF1B - isoform 2 [O60333-2]3EBI-745958,EBI-10975473
KIFC3 - isoform 4 [Q9BVG8-5]6EBI-745958,EBI-14069005
KLHL40 [Q2TBA0]3EBI-745958,EBI-7851314
LONRF1 [Q17RB8]3EBI-745958,EBI-2341787
MDFI [Q99750]3EBI-745958,EBI-724076
MEOX2 [Q6FHY5]3EBI-745958,EBI-16439278
MID2 - isoform 2 [Q9UJV3-2]3EBI-745958,EBI-10172526
MKRN3 [Q13064]3EBI-745958,EBI-2340269
MLH1 [P40692]6EBI-745958,EBI-744248
NEFL [P07196]3EBI-745958,EBI-475646
NEK6 - isoform 4 [Q9HC98-4]3EBI-745958,EBI-11750983
PACRGL - isoform 2 [Q8N7B6-2]3EBI-745958,EBI-10694433
PIH1D2 [Q8WWB5]5EBI-745958,EBI-10232538
PIK3R3 [Q92569]5EBI-745958,EBI-79893
PNMA1 [Q8ND90]3EBI-745958,EBI-302345
PRKAR1B [P31321]3EBI-745958,EBI-2805516
PRPS1 [P60891]3EBI-745958,EBI-749195
RFC5 [P40937]3EBI-745958,EBI-712376
RNF11 [Q9Y3C5]3EBI-745958,EBI-396669
SERTAD3 [Q9UJW9]3EBI-745958,EBI-748621
SPRED1 [Q7Z699]3EBI-745958,EBI-5235340
TARDBP [Q13148]6EBI-745958,EBI-372899
TRIM74 - isoform 2 [Q86UV6-2]3EBI-745958,EBI-10259086
TSEN15 [Q8WW01]3EBI-745958,EBI-372432
USHBP1 [Q8N6Y0]3EBI-745958,EBI-739895
ZNF76 [P36508]3EBI-745958,EBI-7254550
Isoform 2 [Q5VWN6-2]
With#Exp.IntAct
ATRIP [Q8WXE1]3EBI-10172380,EBI-747353
CARD9 [Q9H257]3EBI-10172380,EBI-751319
ERH [P84090]3EBI-10172380,EBI-711389
FBF1 - isoform 6 [Q8TES7-6]3EBI-10172380,EBI-10244131
KCTD9 [Q7L273]3EBI-10172380,EBI-4397613
LDOC1 [O95751]3EBI-10172380,EBI-740738
LMO1 [P25800]3EBI-10172380,EBI-8639312
MORN3 [Q6PF18]3EBI-10172380,EBI-9675802
NEK6 [Q9HC98]3EBI-10172380,EBI-740364
POLR1C [O15160]3EBI-10172380,EBI-1055079
PPP1R16B [Q96T49]3EBI-10172380,EBI-10293968
PRKAB2 [O43741]3EBI-10172380,EBI-1053424
SCAMP1 [O15126]3EBI-10172380,EBI-954338
TRIM23 [P36406]3EBI-10172380,EBI-740098
TRIM42 [Q8IWZ5]3EBI-10172380,EBI-5235829
A8K5H93EBI-10172380,EBI-10174421
Q8N5D43EBI-10172380,EBI-10266435

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		120252, 81 interactors

Protein interaction database and analysis system

More...IntActi		Q5VWN6, 80 interactors

Molecular INTeraction database

More...MINTi		Q5VWN6

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000328426

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q5VWN6, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q5VWN6

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TASOR family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502RJQA, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00530000063735

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000681_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q5VWN6

Identification of Orthologs from Complete Genome Data

More...OMAi		DHEYHRV

Database of Orthologous Groups

More...OrthoDBi		21269at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q5VWN6

TreeFam database of animal gene trees

More...TreeFami		TF337844

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR022168, DUF3699
IPR022188, DUF3715

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12480, DUF3699, 1 hit
PF12509, DUF3715, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5VWN6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAPPAHKSIL ERSENVLMSP WKGKLIVQDR MLCDIALWST YGAMIPTQLP 
        60         70         80         90        100
QELDFKYVMK VSSLKKRLPE AAFRKQNYLE EKVCFQDLCF NLYEVELSNR 
       110        120        130        140        150
QGENIDKLTE CIKNKQLAII KCLEDRGFFI LLTSSALLSE PDFGGKQMGL 
       160        170        180        190        200
HGLHLFRSPL STGVKDLKVE DDISMKVIPI LSTLNCALLE TKKSLPEERI 
       210        220        230        240        250
HPNTLVKRHF QELYKADRSP SLSVAPQDRM KDPTFLGKLP SGFDLIPPAE 
       260        270        280        290        300
KCPSESLTQL NSYFSDPSAY ILEVSTALDL LAEHPQSPCV SDGICDAGFS 
       310        320        330        340        350
LVMTPDPEFL VSEAEVRKET ETKKDSEEML KAKKRVFPLS PASNLRVQPK 
       360        370        380        390        400
RKASMPHMVQ SKKVNLCRPF PKRTASRADN SSDSPTTLKL VKGQFPQKRK 
       410        420        430        440        450
RGAEVLTAQF VQKTKLDRKN QEAPISKDVP VPTNAKRARK QEKSPVKTVP 
       460        470        480        490        500
RAKPPVKKSP QKQRVNIVKG NENPRNRKQL QPVKGETASK LQSEISRGCQ 
       510        520        530        540        550
EDGISINSVQ PENTTAAHND LPENSIVNYD SQALNMLADL ALSSATSSTP 
       560        570        580        590        600
VSEARNLHCS SELPQNDVLL SKENSLRGTS DHEYHRGVKT QKGELLPNPS 
       610        620        630        640        650
SDRKSNSGSD LTVSQDEESL VPCSQAPAKA QSALTEEMLE SSDASQSSSV 
       660        670        680        690        700
SVEHSYALLL TEHSKKHLQE REILSPLFPR NGTKSPEAAT PVGKVMPFRH 
       710        720        730        740        750
QPGLLLQQKP PDDPVVKPKD RPPSARVKKS SCSRIVLSCD DSVKITFKCE 
       760        770        780        790        800
TEYAFSLDSK YTNNPLEKTV VRALHGPWNT DLPDNVEEVK LLLHMWVALF 
       810        820        830        840        850
YSNQNKIIRS SRKVVEHSNP AKYVSINSTL ESCELREIEE SLGLEKCSAD 
       860        870        880        890        900
SLLETNEISR AHAAEVSFRD PNCLLPFIKT PLTQGLELCV QNEQKKTFAR 
       910        920        930        940        950
ECDPDTQEDQ NFICSYNNEV TGEEAKQESL ETSNLVLSGI GSTQTNGPSV 
       960        970        980        990       1000
PSEEEIVQPL DSTRVASYSG TVTQATFTRT YDGPGSQPVI CQSSVYGTLE 
      1010       1020       1030       1040       1050
NKVDILDAAV QTKTGTLQDL IQHGSPINNE CHPSLERKDD NMGCAVINPE 
      1060       1070       1080       1090       1100
PITLTFEKNA HVPIQTEGVN TADERTTFKK ELIKQVSPAA SLRHPVSTSE 
      1110       1120       1130       1140       1150
NARTQGLRDI PSLVVAGQKG TKYLCASSVG GETLDKAVCS LQKETPLPVS 
      1160       1170       1180       1190       1200
LPSDKTMVME ALSLAKSSSH LSPSEEVRCT QDFLSQTQSL LGLSSEGLLE 
      1210       1220       1230       1240       1250
LTQVEVDSSS ASTTLGRQCS LNCISSGCHT SGDSLELRKN HKNGPNTENM 
      1260       1270       1280       1290       1300
NLEAFDSVFI KQTSLSVSRE VSLELSEEDS DIDLALTISP PTSPREEMPA 
      1310       1320       1330       1340       1350
GEIEQFEEAP FSNLELQDVA EEIGEPEEVA LTESREVSSA DNVSVYPSVS 
      1360       1370       1380       1390       1400
EEPVENKERK GDNLQPVTLI LSKENCTLEI AEEINVTSDF PFDSVIEEVS 
      1410       1420       1430       1440       1450
PASSPEPPVP VKETRPYQAV TPCILKLHGT QCEKSNQISQ CESEDLGITE 
      1460       1470       1480       1490       1500
KENVFVGPTH PVGQDNFTQV QQMQVSAEMP LILTDHPGRT GRPTLPGKVT 
      1510       1520       1530       1540       1550
EEIVSSEHDE GLSFSGKVQC YGRELNQPAS AAKCTGDFSP SPEKLVKSGN 
      1560       1570       1580       1590       1600
PLQPVSIENR NLDLKHLVLE SSEPPFGPRN VIENKSLSDT LVSTTAPSGI 
      1610       1620       1630       1640       1650
VNVSVKQQTS PKSSQNHLFP GDLKTDEGIY LQVKSLTAAS VDGAYSTQGC 
      1660       1670       1680       1690       1700
MCSVVPTLCS SSDNATLTHY VRPINAEPVF QAQEIPAGRM ASLLKNGEPE 
      1710       1720       1730       1740       1750
AELHKETTGP GTAGPQSNTT SSLKGERKAI HTLQDVSTCE TKELLNVGVS 
      1760       1770       1780       1790       1800
SLCAGPYQNT ADTKENLSKE PLASFVSESF DTSVCGIATE HVEIENSGEG 
      1810       1820       1830       1840       1850
LRAEAGSETL GRDGEVGVNS DMHYELSGDS DLDLLGDCRN PRLDLEDSYT 
      1860       1870       1880       1890       1900
LRGSYTRKKD VPTDGYESSL NFHNNNQEDW GCSSWVPGME TSLPPGHWTA 
      1910       1920       1930       1940       1950
AVKKEEKCVP PYVQIRDLHG ILRTYANFSI TKELKDTMRT SHGLRRHPSF 
      1960       1970       1980       1990       2000
SANCGLPSSW TSTWQVADDL TQNTLDLEYL RFAHKLKQTI KNGDSQHSAS 
      2010       2020       2030       2040       2050
SANVFPKESP TQISIGAFPS TKISEAPFLH PAPRSRSPLL VTVVESDPRP 
      2060       2070       2080       2090       2100
QGQPRRGYTA SSLDSSSSWR ERCSHNRDLR NSQRNHTVSF HLNKLKYNST 
      2110       2120       2130       2140       2150
VKESRNDISL ILNEYAEFNK VMKNSNQFIF QDKELNDVSG EATAQEMYLP 
      2160       2170       2180       2190       2200
FPGRSASYED IIIDVCTNLH VKLRSVVKEA CKSTFLFYLV ETEDKSFFVR 
      2210       2220       2230       2240       2250
TKNLLRKGGH TEIEPQHFCQ AFHRENDTLI IIIRNEDISS HLHQIPSLLK 
      2260       2270       2280       2290       2300
LKHFPSVIFA GVDSPGDVLD HTYQELFRAG GFVISDDKIL EAVTLVQLKE 
      2310       2320       2330       2340       2350
IIKILEKLNG NGRWKWLLHY RENKKLKEDE RVDSTAHKKN IMLKSFQSAN 
      2360       2370       2380       2390       2400
IIELLHYHQC DSRSSTKAEI LKCLLNLQIQ HIDARFAVLL TDKPTIPREV 
      2410       2420       2430
FENSGILVTD VNNFIENIEK IAAPFRSSYW
Length:2,430
Mass (Da):268,843
Last modified:December 7, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8A6A94D318280DCE
GO
Isoform 2 (identifier: Q5VWN6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     333-1137: Missing.

Show »
Length:1,625
Mass (Da):180,380
Checksum:i633F6CEAFB1585AB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8YH03A0A2R8YH03_HUMAN
Protein TASOR 2
TASOR2
2,645Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YCW7A0A2R8YCW7_HUMAN
Protein TASOR 2
TASOR2
117Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YCL4A0A2R8YCL4_HUMAN
Protein TASOR 2
TASOR2
71Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KPH3J3KPH3_HUMAN
Protein TASOR 2
TASOR2
246Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1D5RMU0A0A1D5RMU0_HUMAN
Protein TASOR 2
TASOR2
8Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA91115 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB14336 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB14993 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAC87251 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1885W → R in BAA91115 (PubMed:14702039).Curated1
Sequence conflicti2043V → A in BAA91115 (PubMed:14702039).Curated1
Sequence conflicti2065S → I in BAA91115 (PubMed:14702039).Curated1
Sequence conflicti2359Q → R in BAB14993 (PubMed:14702039).Curated1
Sequence conflicti2384A → T in BAB14993 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_050848499C → G. Corresponds to variant dbSNP:rs2254067Ensembl.1
Natural variantiVAR_050849630A → D. Corresponds to variant dbSNP:rs4748636Ensembl.1
Natural variantiVAR_061601724S → Y. Corresponds to variant dbSNP:rs56856085Ensembl.1
Natural variantiVAR_061602807I → V. Corresponds to variant dbSNP:rs45575338Ensembl.1
Natural variantiVAR_0348381075R → P1 PublicationCorresponds to variant dbSNP:rs2797491Ensembl.1
Natural variantiVAR_0508501206V → M. Corresponds to variant dbSNP:rs3814196Ensembl.1
Natural variantiVAR_0508511578P → S. Corresponds to variant dbSNP:rs17143175Ensembl.1
Natural variantiVAR_0348391679V → A3 PublicationsCorresponds to variant dbSNP:rs2669142Ensembl.1
Natural variantiVAR_0508521782T → I. Corresponds to variant dbSNP:rs11593253Ensembl.1
Natural variantiVAR_0508532288K → R. Corresponds to variant dbSNP:rs2275774Ensembl.1
Natural variantiVAR_0348402404S → N3 PublicationsCorresponds to variant dbSNP:rs2797501Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_027733333 – 1137Missing in isoform 2. 1 PublicationAdd BLAST805

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AL365356 Genomic DNA No translation available.
AL596094 Genomic DNA No translation available.
AB095927 mRNA Translation: BAC23103.1
AK000367 mRNA Translation: BAA91115.1 Different initiation.
AK022966 mRNA Translation: BAB14336.1 Different initiation.
AK024762 mRNA Translation: BAB14993.1 Different initiation.
AK027014 mRNA Translation: BAB15627.1
AK128051 mRNA Translation: BAC87251.1 Different initiation.
BC001759 mRNA Translation: AAH01759.2
BC110339 mRNA Translation: AAI10340.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS41485.1 [Q5VWN6-1]

NCBI Reference Sequences

More...RefSeqi		NP_001308712.1, NM_001321783.1 [Q5VWN6-1]
NP_001308713.1, NM_001321784.1 [Q5VWN6-1]
NP_001308714.1, NM_001321785.1
NP_060252.4, NM_017782.4 [Q5VWN6-1]
XP_005252532.1, XM_005252475.3 [Q5VWN6-1]
XP_005252537.1, XM_005252480.4 [Q5VWN6-1]
XP_005252538.1, XM_005252481.4 [Q5VWN6-1]
XP_005252539.1, XM_005252482.2 [Q5VWN6-1]
XP_011517827.1, XM_011519525.2 [Q5VWN6-1]
XP_016871852.1, XM_017016363.1 [Q5VWN6-1]
XP_016871854.1, XM_017016365.1 [Q5VWN6-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000328090; ENSP00000328426; ENSG00000108021 [Q5VWN6-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		54906

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:54906

UCSC genome browser

More...UCSCi		uc001iij.3, human [Q5VWN6-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL365356 Genomic DNA No translation available.
AL596094 Genomic DNA No translation available.
AB095927 mRNA Translation: BAC23103.1
AK000367 mRNA Translation: BAA91115.1 Different initiation.
AK022966 mRNA Translation: BAB14336.1 Different initiation.
AK024762 mRNA Translation: BAB14993.1 Different initiation.
AK027014 mRNA Translation: BAB15627.1
AK128051 mRNA Translation: BAC87251.1 Different initiation.
BC001759 mRNA Translation: AAH01759.2
BC110339 mRNA Translation: AAI10340.1
CCDSiCCDS41485.1 [Q5VWN6-1]
RefSeqiNP_001308712.1, NM_001321783.1 [Q5VWN6-1]
NP_001308713.1, NM_001321784.1 [Q5VWN6-1]
NP_001308714.1, NM_001321785.1
NP_060252.4, NM_017782.4 [Q5VWN6-1]
XP_005252532.1, XM_005252475.3 [Q5VWN6-1]
XP_005252537.1, XM_005252480.4 [Q5VWN6-1]
XP_005252538.1, XM_005252481.4 [Q5VWN6-1]
XP_005252539.1, XM_005252482.2 [Q5VWN6-1]
XP_011517827.1, XM_011519525.2 [Q5VWN6-1]
XP_016871852.1, XM_017016363.1 [Q5VWN6-1]
XP_016871854.1, XM_017016365.1 [Q5VWN6-1]

3D structure databases

SMRiQ5VWN6
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi120252, 81 interactors
IntActiQ5VWN6, 80 interactors
MINTiQ5VWN6
STRINGi9606.ENSP00000328426

PTM databases

GlyGeniQ5VWN6, 1 site, 1 O-linked glycan (1 site)
iPTMnetiQ5VWN6
PhosphoSitePlusiQ5VWN6

Genetic variation databases

BioMutaiFAM208B
DMDMi74747424

Proteomic databases

EPDiQ5VWN6
jPOSTiQ5VWN6
MassIVEiQ5VWN6
MaxQBiQ5VWN6
PaxDbiQ5VWN6
PeptideAtlasiQ5VWN6
PRIDEiQ5VWN6
ProteomicsDBi65545 [Q5VWN6-1]
65546 [Q5VWN6-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		51208, 28 antibodies

The DNASU plasmid repository

More...DNASUi		54906

Genome annotation databases

EnsembliENST00000328090; ENSP00000328426; ENSG00000108021 [Q5VWN6-1]
GeneIDi54906
KEGGihsa:54906
UCSCiuc001iij.3, human [Q5VWN6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		54906
DisGeNETi54906

GeneCards: human genes, protein and diseases

More...GeneCardsi		TASOR2
HGNCiHGNC:23484, TASOR2
HPAiENSG00000108021, Low tissue specificity
neXtProtiNX_Q5VWN6
OpenTargetsiENSG00000108021
VEuPathDBiHostDB:ENSG00000108021.19

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502RJQA, Eukaryota
GeneTreeiENSGT00530000063735
HOGENOMiCLU_000681_0_0_1
InParanoidiQ5VWN6
OMAiDHEYHRV
OrthoDBi21269at2759
PhylomeDBiQ5VWN6
TreeFamiTF337844

Enzyme and pathway databases

PathwayCommonsiQ5VWN6

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		54906, 14 hits in 1007 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		FAM208B, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		54906
PharosiQ5VWN6, Tdark

Protein Ontology

More...PROi		PR:Q5VWN6
RNActiQ5VWN6, protein

Gene expression databases

BgeeiENSG00000108021, Expressed in secondary oocyte and 239 other tissues
ExpressionAtlasiQ5VWN6, baseline and differential
GenevisibleiQ5VWN6, HS

Family and domain databases

InterProiView protein in InterPro
IPR022168, DUF3699
IPR022188, DUF3715
PfamiView protein in Pfam
PF12480, DUF3699, 1 hit
PF12509, DUF3715, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTASO2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5VWN6
Secondary accession number(s): Q2YD91
, Q5VWN5, Q6ZRQ8, Q8IVG4, Q9BUZ7, Q9H5J9, Q9H7A4, Q9H996, Q9NXA1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: December 7, 2004
Last modified: April 7, 2021
This is version 135 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. SIMILARITY comments
    Index of protein domains and families
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