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UniProtKB - Q5VWN6 (TASO2_HUMAN)
Protein
Protein TASOR 2
Gene
TASOR2
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Protein TASOR 2Curated |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:23484, TASOR2 |
neXtProti | NX_Q5VWN6 |
VEuPathDBi | HostDB:ENSG00000108021 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 54906 |
OpenTargetsi | ENSG00000108021 |
Miscellaneous databases
Pharosi | Q5VWN6, Tdark |
Genetic variation databases
BioMutai | FAM208B |
DMDMi | 74747424 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000299542 | 1 – 2430 | Protein TASOR 2Add BLAST | 2430 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 19 | PhosphoserineCombined sources | 1 | |
Modified residuei | 219 | PhosphoserineCombined sources | 1 | |
Modified residuei | 384 | PhosphoserineCombined sources | 1 | |
Modified residuei | 685 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1025 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1087 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1172 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1541 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1848 | PhosphoserineCombined sources | 1 | |
Cross-linki | 2007 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 2009 | PhosphoserineCombined sources | 1 | |
Modified residuei | 2037 | PhosphoserineCombined sources | 1 | |
Modified residuei | 2062 | PhosphoserineBy similarity | 1 | |
Modified residuei | 2066 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q5VWN6 |
jPOSTi | Q5VWN6 |
MassIVEi | Q5VWN6 |
MaxQBi | Q5VWN6 |
PaxDbi | Q5VWN6 |
PeptideAtlasi | Q5VWN6 |
PRIDEi | Q5VWN6 |
ProteomicsDBi | 65545 [Q5VWN6-1] 65546 [Q5VWN6-2] |
PTM databases
GlyGeni | Q5VWN6, 6 sites, 2 O-linked glycans (6 sites) |
iPTMneti | Q5VWN6 |
PhosphoSitePlusi | Q5VWN6 |
Expressioni
Gene expression databases
Bgeei | ENSG00000108021, Expressed in secondary oocyte and 240 other tissues |
ExpressionAtlasi | Q5VWN6, baseline and differential |
Genevisiblei | Q5VWN6, HS |
Organism-specific databases
HPAi | ENSG00000108021, Low tissue specificity |
Interactioni
Binary interactionsi
Q5VWN6
Isoform 2 [Q5VWN6-2]
Protein-protein interaction databases
BioGRIDi | 120252, 87 interactors |
IntActi | Q5VWN6, 82 interactors |
MINTi | Q5VWN6 |
STRINGi | 9606.ENSP00000328426 |
Miscellaneous databases
RNActi | Q5VWN6, protein |
Structurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 416 – 488 | DisorderedSequence analysisAdd BLAST | 73 | |
Regioni | 577 – 648 | DisorderedSequence analysisAdd BLAST | 72 | |
Regioni | 704 – 727 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 1331 – 1360 | DisorderedSequence analysisAdd BLAST | 30 | |
Regioni | 1700 – 1727 | DisorderedSequence analysisAdd BLAST | 28 | |
Regioni | 2046 – 2069 | DisorderedSequence analysisAdd BLAST | 24 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 433 – 447 | Basic and acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 464 – 488 | Polar residuesSequence analysisAdd BLAST | 25 | |
Compositional biasi | 594 – 648 | Polar residuesSequence analysisAdd BLAST | 55 | |
Compositional biasi | 713 – 727 | Basic and acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 1710 – 1727 | Polar residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 2055 – 2069 | Polar residuesSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Belongs to the TASOR family.Curated
Phylogenomic databases
eggNOGi | ENOG502RJQA, Eukaryota |
GeneTreei | ENSGT00530000063735 |
HOGENOMi | CLU_000681_0_0_1 |
InParanoidi | Q5VWN6 |
OMAi | VPCYIQI |
OrthoDBi | 21269at2759 |
PhylomeDBi | Q5VWN6 |
TreeFami | TF337844 |
Family and domain databases
InterProi | View protein in InterPro IPR022168, DUF3699 IPR022188, DUF3715 |
Pfami | View protein in Pfam PF12480, DUF3699, 1 hit PF12509, DUF3715, 2 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q5VWN6-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAPPAHKSIL ERSENVLMSP WKGKLIVQDR MLCDIALWST YGAMIPTQLP
60 70 80 90 100
QELDFKYVMK VSSLKKRLPE AAFRKQNYLE EKVCFQDLCF NLYEVELSNR
110 120 130 140 150
QGENIDKLTE CIKNKQLAII KCLEDRGFFI LLTSSALLSE PDFGGKQMGL
160 170 180 190 200
HGLHLFRSPL STGVKDLKVE DDISMKVIPI LSTLNCALLE TKKSLPEERI
210 220 230 240 250
HPNTLVKRHF QELYKADRSP SLSVAPQDRM KDPTFLGKLP SGFDLIPPAE
260 270 280 290 300
KCPSESLTQL NSYFSDPSAY ILEVSTALDL LAEHPQSPCV SDGICDAGFS
310 320 330 340 350
LVMTPDPEFL VSEAEVRKET ETKKDSEEML KAKKRVFPLS PASNLRVQPK
360 370 380 390 400
RKASMPHMVQ SKKVNLCRPF PKRTASRADN SSDSPTTLKL VKGQFPQKRK
410 420 430 440 450
RGAEVLTAQF VQKTKLDRKN QEAPISKDVP VPTNAKRARK QEKSPVKTVP
460 470 480 490 500
RAKPPVKKSP QKQRVNIVKG NENPRNRKQL QPVKGETASK LQSEISRGCQ
510 520 530 540 550
EDGISINSVQ PENTTAAHND LPENSIVNYD SQALNMLADL ALSSATSSTP
560 570 580 590 600
VSEARNLHCS SELPQNDVLL SKENSLRGTS DHEYHRGVKT QKGELLPNPS
610 620 630 640 650
SDRKSNSGSD LTVSQDEESL VPCSQAPAKA QSALTEEMLE SSDASQSSSV
660 670 680 690 700
SVEHSYALLL TEHSKKHLQE REILSPLFPR NGTKSPEAAT PVGKVMPFRH
710 720 730 740 750
QPGLLLQQKP PDDPVVKPKD RPPSARVKKS SCSRIVLSCD DSVKITFKCE
760 770 780 790 800
TEYAFSLDSK YTNNPLEKTV VRALHGPWNT DLPDNVEEVK LLLHMWVALF
810 820 830 840 850
YSNQNKIIRS SRKVVEHSNP AKYVSINSTL ESCELREIEE SLGLEKCSAD
860 870 880 890 900
SLLETNEISR AHAAEVSFRD PNCLLPFIKT PLTQGLELCV QNEQKKTFAR
910 920 930 940 950
ECDPDTQEDQ NFICSYNNEV TGEEAKQESL ETSNLVLSGI GSTQTNGPSV
960 970 980 990 1000
PSEEEIVQPL DSTRVASYSG TVTQATFTRT YDGPGSQPVI CQSSVYGTLE
1010 1020 1030 1040 1050
NKVDILDAAV QTKTGTLQDL IQHGSPINNE CHPSLERKDD NMGCAVINPE
1060 1070 1080 1090 1100
PITLTFEKNA HVPIQTEGVN TADERTTFKK ELIKQVSPAA SLRHPVSTSE
1110 1120 1130 1140 1150
NARTQGLRDI PSLVVAGQKG TKYLCASSVG GETLDKAVCS LQKETPLPVS
1160 1170 1180 1190 1200
LPSDKTMVME ALSLAKSSSH LSPSEEVRCT QDFLSQTQSL LGLSSEGLLE
1210 1220 1230 1240 1250
LTQVEVDSSS ASTTLGRQCS LNCISSGCHT SGDSLELRKN HKNGPNTENM
1260 1270 1280 1290 1300
NLEAFDSVFI KQTSLSVSRE VSLELSEEDS DIDLALTISP PTSPREEMPA
1310 1320 1330 1340 1350
GEIEQFEEAP FSNLELQDVA EEIGEPEEVA LTESREVSSA DNVSVYPSVS
1360 1370 1380 1390 1400
EEPVENKERK GDNLQPVTLI LSKENCTLEI AEEINVTSDF PFDSVIEEVS
1410 1420 1430 1440 1450
PASSPEPPVP VKETRPYQAV TPCILKLHGT QCEKSNQISQ CESEDLGITE
1460 1470 1480 1490 1500
KENVFVGPTH PVGQDNFTQV QQMQVSAEMP LILTDHPGRT GRPTLPGKVT
1510 1520 1530 1540 1550
EEIVSSEHDE GLSFSGKVQC YGRELNQPAS AAKCTGDFSP SPEKLVKSGN
1560 1570 1580 1590 1600
PLQPVSIENR NLDLKHLVLE SSEPPFGPRN VIENKSLSDT LVSTTAPSGI
1610 1620 1630 1640 1650
VNVSVKQQTS PKSSQNHLFP GDLKTDEGIY LQVKSLTAAS VDGAYSTQGC
1660 1670 1680 1690 1700
MCSVVPTLCS SSDNATLTHY VRPINAEPVF QAQEIPAGRM ASLLKNGEPE
1710 1720 1730 1740 1750
AELHKETTGP GTAGPQSNTT SSLKGERKAI HTLQDVSTCE TKELLNVGVS
1760 1770 1780 1790 1800
SLCAGPYQNT ADTKENLSKE PLASFVSESF DTSVCGIATE HVEIENSGEG
1810 1820 1830 1840 1850
LRAEAGSETL GRDGEVGVNS DMHYELSGDS DLDLLGDCRN PRLDLEDSYT
1860 1870 1880 1890 1900
LRGSYTRKKD VPTDGYESSL NFHNNNQEDW GCSSWVPGME TSLPPGHWTA
1910 1920 1930 1940 1950
AVKKEEKCVP PYVQIRDLHG ILRTYANFSI TKELKDTMRT SHGLRRHPSF
1960 1970 1980 1990 2000
SANCGLPSSW TSTWQVADDL TQNTLDLEYL RFAHKLKQTI KNGDSQHSAS
2010 2020 2030 2040 2050
SANVFPKESP TQISIGAFPS TKISEAPFLH PAPRSRSPLL VTVVESDPRP
2060 2070 2080 2090 2100
QGQPRRGYTA SSLDSSSSWR ERCSHNRDLR NSQRNHTVSF HLNKLKYNST
2110 2120 2130 2140 2150
VKESRNDISL ILNEYAEFNK VMKNSNQFIF QDKELNDVSG EATAQEMYLP
2160 2170 2180 2190 2200
FPGRSASYED IIIDVCTNLH VKLRSVVKEA CKSTFLFYLV ETEDKSFFVR
2210 2220 2230 2240 2250
TKNLLRKGGH TEIEPQHFCQ AFHRENDTLI IIIRNEDISS HLHQIPSLLK
2260 2270 2280 2290 2300
LKHFPSVIFA GVDSPGDVLD HTYQELFRAG GFVISDDKIL EAVTLVQLKE
2310 2320 2330 2340 2350
IIKILEKLNG NGRWKWLLHY RENKKLKEDE RVDSTAHKKN IMLKSFQSAN
2360 2370 2380 2390 2400
IIELLHYHQC DSRSSTKAEI LKCLLNLQIQ HIDARFAVLL TDKPTIPREV
2410 2420 2430
FENSGILVTD VNNFIENIEK IAAPFRSSYW
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A2R8YH03 | A0A2R8YH03_HUMAN | Protein TASOR 2 | TASOR2 | 2,645 | Annotation score: | ||
A0A2R8YCW7 | A0A2R8YCW7_HUMAN | Protein TASOR 2 | TASOR2 | 117 | Annotation score: | ||
A0A2R8YCL4 | A0A2R8YCL4_HUMAN | Protein TASOR 2 | TASOR2 | 71 | Annotation score: | ||
J3KPH3 | J3KPH3_HUMAN | Protein TASOR 2 | TASOR2 | 246 | Annotation score: | ||
A0A1D5RMU0 | A0A1D5RMU0_HUMAN | Protein TASOR 2 | TASOR2 | 8 | Annotation score: |
Sequence cautioni
The sequence BAA91115 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB14336 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB14993 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAC87251 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 1885 | W → R in BAA91115 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 2043 | V → A in BAA91115 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 2065 | S → I in BAA91115 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 2359 | Q → R in BAB14993 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 2384 | A → T in BAB14993 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_050848 | 499 | C → G. Corresponds to variant dbSNP:rs2254067Ensembl. | 1 | |
Natural variantiVAR_050849 | 630 | A → D. Corresponds to variant dbSNP:rs4748636Ensembl. | 1 | |
Natural variantiVAR_061601 | 724 | S → Y. Corresponds to variant dbSNP:rs56856085Ensembl. | 1 | |
Natural variantiVAR_061602 | 807 | I → V. Corresponds to variant dbSNP:rs45575338Ensembl. | 1 | |
Natural variantiVAR_034838 | 1075 | R → P1 PublicationCorresponds to variant dbSNP:rs2797491Ensembl. | 1 | |
Natural variantiVAR_050850 | 1206 | V → M. Corresponds to variant dbSNP:rs3814196Ensembl. | 1 | |
Natural variantiVAR_050851 | 1578 | P → S. Corresponds to variant dbSNP:rs17143175Ensembl. | 1 | |
Natural variantiVAR_034839 | 1679 | V → A3 PublicationsCorresponds to variant dbSNP:rs2669142Ensembl. | 1 | |
Natural variantiVAR_050852 | 1782 | T → I. Corresponds to variant dbSNP:rs11593253Ensembl. | 1 | |
Natural variantiVAR_050853 | 2288 | K → R. Corresponds to variant dbSNP:rs2275774Ensembl. | 1 | |
Natural variantiVAR_034840 | 2404 | S → N3 PublicationsCorresponds to variant dbSNP:rs2797501Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_027733 | 333 – 1137 | Missing in isoform 2. 1 PublicationAdd BLAST | 805 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000328090; ENSP00000328426; ENSG00000108021 |
GeneIDi | 54906 |
KEGGi | hsa:54906 |
UCSCi | uc001iij.3, human [Q5VWN6-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 120252, 87 interactors |
IntActi | Q5VWN6, 82 interactors |
MINTi | Q5VWN6 |
STRINGi | 9606.ENSP00000328426 |
PTM databases
GlyGeni | Q5VWN6, 6 sites, 2 O-linked glycans (6 sites) |
iPTMneti | Q5VWN6 |
PhosphoSitePlusi | Q5VWN6 |
Genetic variation databases
BioMutai | FAM208B |
DMDMi | 74747424 |
Proteomic databases
EPDi | Q5VWN6 |
jPOSTi | Q5VWN6 |
MassIVEi | Q5VWN6 |
MaxQBi | Q5VWN6 |
PaxDbi | Q5VWN6 |
PeptideAtlasi | Q5VWN6 |
PRIDEi | Q5VWN6 |
ProteomicsDBi | 65545 [Q5VWN6-1] 65546 [Q5VWN6-2] |
Protocols and materials databases
Antibodypediai | 51208, 28 antibodies from 10 providers |
DNASUi | 54906 |
Genome annotation databases
Ensembli | ENST00000328090; ENSP00000328426; ENSG00000108021 |
GeneIDi | 54906 |
KEGGi | hsa:54906 |
UCSCi | uc001iij.3, human [Q5VWN6-1] |
Organism-specific databases
CTDi | 54906 |
DisGeNETi | 54906 |
GeneCardsi | TASOR2 |
HGNCi | HGNC:23484, TASOR2 |
HPAi | ENSG00000108021, Low tissue specificity |
neXtProti | NX_Q5VWN6 |
OpenTargetsi | ENSG00000108021 |
VEuPathDBi | HostDB:ENSG00000108021 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RJQA, Eukaryota |
GeneTreei | ENSGT00530000063735 |
HOGENOMi | CLU_000681_0_0_1 |
InParanoidi | Q5VWN6 |
OMAi | VPCYIQI |
OrthoDBi | 21269at2759 |
PhylomeDBi | Q5VWN6 |
TreeFami | TF337844 |
Enzyme and pathway databases
PathwayCommonsi | Q5VWN6 |
SignaLinki | Q5VWN6 |
Miscellaneous databases
BioGRID-ORCSi | 54906, 16 hits in 1059 CRISPR screens |
ChiTaRSi | FAM208B, human |
GenomeRNAii | 54906 |
Pharosi | Q5VWN6, Tdark |
PROi | PR:Q5VWN6 |
RNActi | Q5VWN6, protein |
Gene expression databases
Bgeei | ENSG00000108021, Expressed in secondary oocyte and 240 other tissues |
ExpressionAtlasi | Q5VWN6, baseline and differential |
Genevisiblei | Q5VWN6, HS |
Family and domain databases
InterProi | View protein in InterPro IPR022168, DUF3699 IPR022188, DUF3715 |
Pfami | View protein in Pfam PF12480, DUF3699, 1 hit PF12509, DUF3715, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | TASO2_HUMAN | |
Accessioni | Q5VWN6Primary (citable) accession number: Q5VWN6 Secondary accession number(s): Q2YD91 Q9NXA1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 11, 2007 |
Last sequence update: | December 7, 2004 | |
Last modified: | February 23, 2022 | |
This is version 138 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families