UniProtKB - Q5VWN6 (F208B_HUMAN)

BLAST

>sp|Q5VWN6|F208B_HUMAN Protein FAM208B OS=Homo sapiens OX=9606 GN=FAM208B PE=1 SV=1
MAPPAHKSILERSENVLMSPWKGKLIVQDRMLCDIALWSTYGAMIPTQLPQELDFKYVMK
VSSLKKRLPEAAFRKQNYLEEKVCFQDLCFNLYEVELSNRQGENIDKLTECIKNKQLAII
KCLEDRGFFILLTSSALLSEPDFGGKQMGLHGLHLFRSPLSTGVKDLKVEDDISMKVIPI
LSTLNCALLETKKSLPEERIHPNTLVKRHFQELYKADRSPSLSVAPQDRMKDPTFLGKLP
SGFDLIPPAEKCPSESLTQLNSYFSDPSAYILEVSTALDLLAEHPQSPCVSDGICDAGFS
LVMTPDPEFLVSEAEVRKETETKKDSEEMLKAKKRVFPLSPASNLRVQPKRKASMPHMVQ
SKKVNLCRPFPKRTASRADNSSDSPTTLKLVKGQFPQKRKRGAEVLTAQFVQKTKLDRKN
QEAPISKDVPVPTNAKRARKQEKSPVKTVPRAKPPVKKSPQKQRVNIVKGNENPRNRKQL
QPVKGETASKLQSEISRGCQEDGISINSVQPENTTAAHNDLPENSIVNYDSQALNMLADL
ALSSATSSTPVSEARNLHCSSELPQNDVLLSKENSLRGTSDHEYHRGVKTQKGELLPNPS
SDRKSNSGSDLTVSQDEESLVPCSQAPAKAQSALTEEMLESSDASQSSSVSVEHSYALLL
TEHSKKHLQEREILSPLFPRNGTKSPEAATPVGKVMPFRHQPGLLLQQKPPDDPVVKPKD
RPPSARVKKSSCSRIVLSCDDSVKITFKCETEYAFSLDSKYTNNPLEKTVVRALHGPWNT
DLPDNVEEVKLLLHMWVALFYSNQNKIIRSSRKVVEHSNPAKYVSINSTLESCELREIEE
SLGLEKCSADSLLETNEISRAHAAEVSFRDPNCLLPFIKTPLTQGLELCVQNEQKKTFAR
ECDPDTQEDQNFICSYNNEVTGEEAKQESLETSNLVLSGIGSTQTNGPSVPSEEEIVQPL
DSTRVASYSGTVTQATFTRTYDGPGSQPVICQSSVYGTLENKVDILDAAVQTKTGTLQDL
IQHGSPINNECHPSLERKDDNMGCAVINPEPITLTFEKNAHVPIQTEGVNTADERTTFKK
ELIKQVSPAASLRHPVSTSENARTQGLRDIPSLVVAGQKGTKYLCASSVGGETLDKAVCS
LQKETPLPVSLPSDKTMVMEALSLAKSSSHLSPSEEVRCTQDFLSQTQSLLGLSSEGLLE
LTQVEVDSSSASTTLGRQCSLNCISSGCHTSGDSLELRKNHKNGPNTENMNLEAFDSVFI
KQTSLSVSREVSLELSEEDSDIDLALTISPPTSPREEMPAGEIEQFEEAPFSNLELQDVA
EEIGEPEEVALTESREVSSADNVSVYPSVSEEPVENKERKGDNLQPVTLILSKENCTLEI
AEEINVTSDFPFDSVIEEVSPASSPEPPVPVKETRPYQAVTPCILKLHGTQCEKSNQISQ
CESEDLGITEKENVFVGPTHPVGQDNFTQVQQMQVSAEMPLILTDHPGRTGRPTLPGKVT
EEIVSSEHDEGLSFSGKVQCYGRELNQPASAAKCTGDFSPSPEKLVKSGNPLQPVSIENR
NLDLKHLVLESSEPPFGPRNVIENKSLSDTLVSTTAPSGIVNVSVKQQTSPKSSQNHLFP
GDLKTDEGIYLQVKSLTAASVDGAYSTQGCMCSVVPTLCSSSDNATLTHYVRPINAEPVF
QAQEIPAGRMASLLKNGEPEAELHKETTGPGTAGPQSNTTSSLKGERKAIHTLQDVSTCE
TKELLNVGVSSLCAGPYQNTADTKENLSKEPLASFVSESFDTSVCGIATEHVEIENSGEG
LRAEAGSETLGRDGEVGVNSDMHYELSGDSDLDLLGDCRNPRLDLEDSYTLRGSYTRKKD
VPTDGYESSLNFHNNNQEDWGCSSWVPGMETSLPPGHWTAAVKKEEKCVPPYVQIRDLHG
ILRTYANFSITKELKDTMRTSHGLRRHPSFSANCGLPSSWTSTWQVADDLTQNTLDLEYL
RFAHKLKQTIKNGDSQHSASSANVFPKESPTQISIGAFPSTKISEAPFLHPAPRSRSPLL
VTVVESDPRPQGQPRRGYTASSLDSSSSWRERCSHNRDLRNSQRNHTVSFHLNKLKYNST
VKESRNDISLILNEYAEFNKVMKNSNQFIFQDKELNDVSGEATAQEMYLPFPGRSASYED
IIIDVCTNLHVKLRSVVKEACKSTFLFYLVETEDKSFFVRTKNLLRKGGHTEIEPQHFCQ
AFHRENDTLIIIIRNEDISSHLHQIPSLLKLKHFPSVIFAGVDSPGDVLDHTYQELFRAG
GFVISDDKILEAVTLVQLKEIIKILEKLNGNGRWKWLLHYRENKKLKEDERVDSTAHKKN
IMLKSFQSANIIELLHYHQCDSRSSTKAEILKCLLNLQIQHIDARFAVLLTDKPTIPREV
FENSGILVTDVNNFIENIEKIAAPFRSSYW

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Format
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History
Entry version 118 (07 Nov 2018)
Sequence version 1 (07 Dec 2004)
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Protein

Protein FAM208B

Gene

FAM208B

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein FAM208B
Gene namesⁱ	Name:FAM208B Synonyms:C10orf18, KIAA2006
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 10

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000108021.19
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:23484 FAM208B
neXtProtⁱ	NX_Q5VWN6

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000108021

OpenTargetsⁱ

ENSG00000108021

Polymorphism and mutation databases

BioMutaⁱ	FAM208B
DMDMⁱ	74747424

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000299542	1 – 2430	Protein FAM208BAdd BLAST		2430

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	19	PhosphoserineCombined sources	1
Modified residueⁱ	219	PhosphoserineCombined sources	1
Modified residueⁱ	384	PhosphoserineCombined sources	1
Modified residueⁱ	685	PhosphoserineCombined sources	1
Modified residueⁱ	1025	PhosphoserineCombined sources	1
Modified residueⁱ	1087	PhosphoserineCombined sources	1
Modified residueⁱ	1172	PhosphoserineCombined sources	1
Modified residueⁱ	1541	PhosphoserineCombined sources	1
Modified residueⁱ	1848	PhosphoserineCombined sources	1
Cross-linkⁱ	2007	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	2009	PhosphoserineCombined sources	1
Modified residueⁱ	2037	PhosphoserineCombined sources	1
Modified residueⁱ	2062	PhosphoserineBy similarity	1
Modified residueⁱ	2066	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q5VWN6
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q5VWN6
PaxDbⁱ	Q5VWN6
PeptideAtlas More...PeptideAtlasⁱ	Q5VWN6
PRIDEⁱ	Q5VWN6
ProteomicsDBⁱ	65545 65546 [Q5VWN6-2]

PTM databases

iPTMnetⁱ	Q5VWN6
PhosphoSitePlusⁱ	Q5VWN6

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000108021 Expressed in 229 organ(s), highest expression level in secondary oocyte
CleanExⁱ	HS_C10orf18
ExpressionAtlasⁱ	Q5VWN6 baseline and differential
Genevisibleⁱ	Q5VWN6 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA038042 HPA038043 HPA061547

HPAⁱ

HPA038042
HPA038043
HPA061547

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
	A8K5H9	3	EBI-10172380,EBI-10174421
	Q8N5D4	3	EBI-10172380,EBI-10266435
ATRIP	Q8WXE1	3	EBI-10172380,EBI-747353
CARD9	Q9H257	3	EBI-10172380,EBI-751319
COX5B	P10606	3	EBI-745958,EBI-1053725
ERH	P84090	3	EBI-10172380,EBI-711389
FBF1	Q8TES7-6	3	EBI-10172380,EBI-10244131
HGS	A0A0S2Z4Q4	3	EBI-745958,EBI-16429135
KCTD9	Q7L273	3	EBI-10172380,EBI-4397613
KIFC3	Q9BVG8-5	4	EBI-745958,EBI-14069005
LDOC1	O95751	3	EBI-10172380,EBI-740738
LMO1	P25800	3	EBI-10172380,EBI-8639312
MID2	Q9UJV3-2	4	EBI-745958,EBI-10172526
MLH1	P40692	5	EBI-745958,EBI-744248
MORN3	Q6PF18	3	EBI-10172380,EBI-9675802
NEK6	Q9HC98	3	EBI-10172380,EBI-740364
POLR1C	O15160	3	EBI-10172380,EBI-1055079
PPP1R16B	Q96T49	3	EBI-10172380,EBI-10293968
PRKAB2	O43741	3	EBI-10172380,EBI-1053424
SCAMP1	O15126	3	EBI-10172380,EBI-954338
TRIM23	P36406	3	EBI-10172380,EBI-740098
TRIM42	Q8IWZ5	3	EBI-10172380,EBI-5235829

Protein-protein interaction databases

BioGridⁱ	120252, 44 interactors
IntActⁱ	Q5VWN6, 55 interactors
Molecular INTeraction database More...MINTⁱ	Q5VWN6
STRINGⁱ	9606.ENSP00000328426

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q5VWN6
SMRⁱ	Q5VWN6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the FAM208 family.Curated

Phylogenomic databases

eggNOGⁱ	ENOG410II9C Eukaryota ENOG410YF12 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063735
HOVERGENⁱ	HBG095571
InParanoidⁱ	Q5VWN6
OMAⁱ	DFKYVMK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G00B8
PhylomeDBⁱ	Q5VWN6
TreeFamⁱ	TF337844

Family and domain databases

InterProⁱ	View protein in InterPro IPR022168 DUF3699 IPR022188 DUF3715
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12480 DUF3699, 1 hit PF12509 DUF3715, 2 hits

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q5VWN6-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPPAHKSIL ERSENVLMSP WKGKLIVQDR MLCDIALWST YGAMIPTQLP 
        60         70         80         90        100
QELDFKYVMK VSSLKKRLPE AAFRKQNYLE EKVCFQDLCF NLYEVELSNR 
       110        120        130        140        150
QGENIDKLTE CIKNKQLAII KCLEDRGFFI LLTSSALLSE PDFGGKQMGL 
       160        170        180        190        200
HGLHLFRSPL STGVKDLKVE DDISMKVIPI LSTLNCALLE TKKSLPEERI 
       210        220        230        240        250
HPNTLVKRHF QELYKADRSP SLSVAPQDRM KDPTFLGKLP SGFDLIPPAE 
       260        270        280        290        300
KCPSESLTQL NSYFSDPSAY ILEVSTALDL LAEHPQSPCV SDGICDAGFS 
       310        320        330        340        350
LVMTPDPEFL VSEAEVRKET ETKKDSEEML KAKKRVFPLS PASNLRVQPK 
       360        370        380        390        400
RKASMPHMVQ SKKVNLCRPF PKRTASRADN SSDSPTTLKL VKGQFPQKRK 
       410        420        430        440        450
RGAEVLTAQF VQKTKLDRKN QEAPISKDVP VPTNAKRARK QEKSPVKTVP 
       460        470        480        490        500
RAKPPVKKSP QKQRVNIVKG NENPRNRKQL QPVKGETASK LQSEISRGCQ 
       510        520        530        540        550
EDGISINSVQ PENTTAAHND LPENSIVNYD SQALNMLADL ALSSATSSTP 
       560        570        580        590        600
VSEARNLHCS SELPQNDVLL SKENSLRGTS DHEYHRGVKT QKGELLPNPS 
       610        620        630        640        650
SDRKSNSGSD LTVSQDEESL VPCSQAPAKA QSALTEEMLE SSDASQSSSV 
       660        670        680        690        700
SVEHSYALLL TEHSKKHLQE REILSPLFPR NGTKSPEAAT PVGKVMPFRH 
       710        720        730        740        750
QPGLLLQQKP PDDPVVKPKD RPPSARVKKS SCSRIVLSCD DSVKITFKCE 
       760        770        780        790        800
TEYAFSLDSK YTNNPLEKTV VRALHGPWNT DLPDNVEEVK LLLHMWVALF 
       810        820        830        840        850
YSNQNKIIRS SRKVVEHSNP AKYVSINSTL ESCELREIEE SLGLEKCSAD 
       860        870        880        890        900
SLLETNEISR AHAAEVSFRD PNCLLPFIKT PLTQGLELCV QNEQKKTFAR 
       910        920        930        940        950
ECDPDTQEDQ NFICSYNNEV TGEEAKQESL ETSNLVLSGI GSTQTNGPSV 
       960        970        980        990       1000
PSEEEIVQPL DSTRVASYSG TVTQATFTRT YDGPGSQPVI CQSSVYGTLE 
      1010       1020       1030       1040       1050
NKVDILDAAV QTKTGTLQDL IQHGSPINNE CHPSLERKDD NMGCAVINPE 
      1060       1070       1080       1090       1100
PITLTFEKNA HVPIQTEGVN TADERTTFKK ELIKQVSPAA SLRHPVSTSE 
      1110       1120       1130       1140       1150
NARTQGLRDI PSLVVAGQKG TKYLCASSVG GETLDKAVCS LQKETPLPVS 
      1160       1170       1180       1190       1200
LPSDKTMVME ALSLAKSSSH LSPSEEVRCT QDFLSQTQSL LGLSSEGLLE 
      1210       1220       1230       1240       1250
LTQVEVDSSS ASTTLGRQCS LNCISSGCHT SGDSLELRKN HKNGPNTENM 
      1260       1270       1280       1290       1300
NLEAFDSVFI KQTSLSVSRE VSLELSEEDS DIDLALTISP PTSPREEMPA 
      1310       1320       1330       1340       1350
GEIEQFEEAP FSNLELQDVA EEIGEPEEVA LTESREVSSA DNVSVYPSVS 
      1360       1370       1380       1390       1400
EEPVENKERK GDNLQPVTLI LSKENCTLEI AEEINVTSDF PFDSVIEEVS 
      1410       1420       1430       1440       1450
PASSPEPPVP VKETRPYQAV TPCILKLHGT QCEKSNQISQ CESEDLGITE 
      1460       1470       1480       1490       1500
KENVFVGPTH PVGQDNFTQV QQMQVSAEMP LILTDHPGRT GRPTLPGKVT 
      1510       1520       1530       1540       1550
EEIVSSEHDE GLSFSGKVQC YGRELNQPAS AAKCTGDFSP SPEKLVKSGN 
      1560       1570       1580       1590       1600
PLQPVSIENR NLDLKHLVLE SSEPPFGPRN VIENKSLSDT LVSTTAPSGI 
      1610       1620       1630       1640       1650
VNVSVKQQTS PKSSQNHLFP GDLKTDEGIY LQVKSLTAAS VDGAYSTQGC 
      1660       1670       1680       1690       1700
MCSVVPTLCS SSDNATLTHY VRPINAEPVF QAQEIPAGRM ASLLKNGEPE 
      1710       1720       1730       1740       1750
AELHKETTGP GTAGPQSNTT SSLKGERKAI HTLQDVSTCE TKELLNVGVS 
      1760       1770       1780       1790       1800
SLCAGPYQNT ADTKENLSKE PLASFVSESF DTSVCGIATE HVEIENSGEG 
      1810       1820       1830       1840       1850
LRAEAGSETL GRDGEVGVNS DMHYELSGDS DLDLLGDCRN PRLDLEDSYT 
      1860       1870       1880       1890       1900
LRGSYTRKKD VPTDGYESSL NFHNNNQEDW GCSSWVPGME TSLPPGHWTA 
      1910       1920       1930       1940       1950
AVKKEEKCVP PYVQIRDLHG ILRTYANFSI TKELKDTMRT SHGLRRHPSF 
      1960       1970       1980       1990       2000
SANCGLPSSW TSTWQVADDL TQNTLDLEYL RFAHKLKQTI KNGDSQHSAS 
      2010       2020       2030       2040       2050
SANVFPKESP TQISIGAFPS TKISEAPFLH PAPRSRSPLL VTVVESDPRP 
      2060       2070       2080       2090       2100
QGQPRRGYTA SSLDSSSSWR ERCSHNRDLR NSQRNHTVSF HLNKLKYNST 
      2110       2120       2130       2140       2150
VKESRNDISL ILNEYAEFNK VMKNSNQFIF QDKELNDVSG EATAQEMYLP 
      2160       2170       2180       2190       2200
FPGRSASYED IIIDVCTNLH VKLRSVVKEA CKSTFLFYLV ETEDKSFFVR 
      2210       2220       2230       2240       2250
TKNLLRKGGH TEIEPQHFCQ AFHRENDTLI IIIRNEDISS HLHQIPSLLK 
      2260       2270       2280       2290       2300
LKHFPSVIFA GVDSPGDVLD HTYQELFRAG GFVISDDKIL EAVTLVQLKE 
      2310       2320       2330       2340       2350
IIKILEKLNG NGRWKWLLHY RENKKLKEDE RVDSTAHKKN IMLKSFQSAN 
      2360       2370       2380       2390       2400
IIELLHYHQC DSRSSTKAEI LKCLLNLQIQ HIDARFAVLL TDKPTIPREV 
      2410       2420       2430
FENSGILVTD VNNFIENIEK IAAPFRSSYW

Length:2,430

Mass (Da):268,843

Last modified:December 7, 2004 - v1

Checksum:ⁱ8A6A94D318280DCE

Isoform 2 (identifier: Q5VWN6-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
333-1137: Missing.

« Hide

        10         20         30         40         50
MAPPAHKSIL ERSENVLMSP WKGKLIVQDR MLCDIALWST YGAMIPTQLP 
        60         70         80         90        100
QELDFKYVMK VSSLKKRLPE AAFRKQNYLE EKVCFQDLCF NLYEVELSNR 
       110        120        130        140        150
QGENIDKLTE CIKNKQLAII KCLEDRGFFI LLTSSALLSE PDFGGKQMGL 
       160        170        180        190        200
HGLHLFRSPL STGVKDLKVE DDISMKVIPI LSTLNCALLE TKKSLPEERI 
       210        220        230        240        250
HPNTLVKRHF QELYKADRSP SLSVAPQDRM KDPTFLGKLP SGFDLIPPAE 
       260        270        280        290        300
KCPSESLTQL NSYFSDPSAY ILEVSTALDL LAEHPQSPCV SDGICDAGFS 
       310        320        330        340        350
LVMTPDPEFL VSEAEVRKET ETKKDSEEML KAVCSLQKET PLPVSLPSDK 
       360        370        380        390        400
TMVMEALSLA KSSSHLSPSE EVRCTQDFLS QTQSLLGLSS EGLLELTQVE 
       410        420        430        440        450
VDSSSASTTL GRQCSLNCIS SGCHTSGDSL ELRKNHKNGP NTENMNLEAF 
       460        470        480        490        500
DSVFIKQTSL SVSREVSLEL SEEDSDIDLA LTISPPTSPR EEMPAGEIEQ 
       510        520        530        540        550
FEEAPFSNLE LQDVAEEIGE PEEVALTESR EVSSADNVSV YPSVSEEPVE 
       560        570        580        590        600
NKERKGDNLQ PVTLILSKEN CTLEIAEEIN VTSDFPFDSV IEEVSPASSP 
       610        620        630        640        650
EPPVPVKETR PYQAVTPCIL KLHGTQCEKS NQISQCESED LGITEKENVF 
       660        670        680        690        700
VGPTHPVGQD NFTQVQQMQV SAEMPLILTD HPGRTGRPTL PGKVTEEIVS 
       710        720        730        740        750
SEHDEGLSFS GKVQCYGREL NQPASAAKCT GDFSPSPEKL VKSGNPLQPV 
       760        770        780        790        800
SIENRNLDLK HLVLESSEPP FGPRNVIENK SLSDTLVSTT APSGIVNVSV 
       810        820        830        840        850
KQQTSPKSSQ NHLFPGDLKT DEGIYLQVKS LTAASVDGAY STQGCMCSVV 
       860        870        880        890        900
PTLCSSSDNA TLTHYVRPIN AEPVFQAQEI PAGRMASLLK NGEPEAELHK 
       910        920        930        940        950
ETTGPGTAGP QSNTTSSLKG ERKAIHTLQD VSTCETKELL NVGVSSLCAG 
       960        970        980        990       1000
PYQNTADTKE NLSKEPLASF VSESFDTSVC GIATEHVEIE NSGEGLRAEA 
      1010       1020       1030       1040       1050
GSETLGRDGE VGVNSDMHYE LSGDSDLDLL GDCRNPRLDL EDSYTLRGSY 
      1060       1070       1080       1090       1100
TRKKDVPTDG YESSLNFHNN NQEDWGCSSW VPGMETSLPP GHWTAAVKKE 
      1110       1120       1130       1140       1150
EKCVPPYVQI RDLHGILRTY ANFSITKELK DTMRTSHGLR RHPSFSANCG 
      1160       1170       1180       1190       1200
LPSSWTSTWQ VADDLTQNTL DLEYLRFAHK LKQTIKNGDS QHSASSANVF 
      1210       1220       1230       1240       1250
PKESPTQISI GAFPSTKISE APFLHPAPRS RSPLLVTVVE SDPRPQGQPR 
      1260       1270       1280       1290       1300
RGYTASSLDS SSSWRERCSH NRDLRNSQRN HTVSFHLNKL KYNSTVKESR 
      1310       1320       1330       1340       1350
NDISLILNEY AEFNKVMKNS NQFIFQDKEL NDVSGEATAQ EMYLPFPGRS 
      1360       1370       1380       1390       1400
ASYEDIIIDV CTNLHVKLRS VVKEACKSTF LFYLVETEDK SFFVRTKNLL 
      1410       1420       1430       1440       1450
RKGGHTEIEP QHFCQAFHRE NDTLIIIIRN EDISSHLHQI PSLLKLKHFP 
      1460       1470       1480       1490       1500
SVIFAGVDSP GDVLDHTYQE LFRAGGFVIS DDKILEAVTL VQLKEIIKIL 
      1510       1520       1530       1540       1550
EKLNGNGRWK WLLHYRENKK LKEDERVDST AHKKNIMLKS FQSANIIELL 
      1560       1570       1580       1590       1600
HYHQCDSRSS TKAEILKCLL NLQIQHIDAR FAVLLTDKPT IPREVFENSG 
      1610       1620 
ILVTDVNNFI ENIEKIAAPF RSSYW

Show »

Length:1,625

Mass (Da):180,380

Checksum:ⁱ633F6CEAFB1585AB

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

J3KPH3	J3KPH3_HUMAN	Protein FAM208B Protein FAM208B	FAM208B	246	Annotation score:
A0A2R8YCW7	A0A2R8YCW7_HUMAN	Protein FAM208B Protein FAM208B	FAM208B	117	Annotation score:
A0A1D5RMU0	A0A1D5RMU0_HUMAN	Protein FAM208B Protein FAM208B	FAM208B	8	Annotation score:
A0A2R8YH03	A0A2R8YH03_HUMAN	Protein FAM208B Protein FAM208B	FAM208B	2,645	Annotation score:
A0A2R8YCL4	A0A2R8YCL4_HUMAN	Protein FAM208B Protein FAM208B	FAM208B	71	Annotation score:

Sequence cautionⁱ

The sequence BAA91115 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence BAB14336 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence BAB14993 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence BAC87251 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	1885	W → R in BAA91115 (PubMed:14702039).Curated	1
Sequence conflictⁱ	2043	V → A in BAA91115 (PubMed:14702039).Curated	1
Sequence conflictⁱ	2065	S → I in BAA91115 (PubMed:14702039).Curated	1
Sequence conflictⁱ	2359	Q → R in BAB14993 (PubMed:14702039).Curated	1
Sequence conflictⁱ	2384	A → T in BAB14993 (PubMed:14702039).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_050848	499	C → G. Corresponds to variant dbSNP:rs2254067Ensembl.	1
Natural variantⁱVAR_050849	630	A → D. Corresponds to variant dbSNP:rs4748636Ensembl.	1
Natural variantⁱVAR_061601	724	S → Y. Corresponds to variant dbSNP:rs56856085Ensembl.	1
Natural variantⁱVAR_061602	807	I → V. Corresponds to variant dbSNP:rs45575338Ensembl.	1
Natural variantⁱVAR_034838	1075	R → P1 PublicationCorresponds to variant dbSNP:rs2797491Ensembl.	1
Natural variantⁱVAR_050850	1206	V → M. Corresponds to variant dbSNP:rs3814196Ensembl.	1
Natural variantⁱVAR_050851	1578	P → S. Corresponds to variant dbSNP:rs17143175Ensembl.	1
Natural variantⁱVAR_034839	1679	V → A3 PublicationsCorresponds to variant dbSNP:rs2669142Ensembl.	1
Natural variantⁱVAR_050852	1782	T → I. Corresponds to variant dbSNP:rs11593253Ensembl.	1
Natural variantⁱVAR_050853	2288	K → R. Corresponds to variant dbSNP:rs2275774Ensembl.	1
Natural variantⁱVAR_034840	2404	S → N3 PublicationsCorresponds to variant dbSNP:rs2797501Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_027733	333 – 1137	Missing in isoform 2. 1 PublicationAdd BLAST		805

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL365356 Genomic DNA No translation available. AL596094 Genomic DNA No translation available. AB095927 mRNA Translation: BAC23103.1 AK000367 mRNA Translation: BAA91115.1 Different initiation. AK022966 mRNA Translation: BAB14336.1 Different initiation. AK024762 mRNA Translation: BAB14993.1 Different initiation. AK027014 mRNA Translation: BAB15627.1 AK128051 mRNA Translation: BAC87251.1 Different initiation. BC001759 mRNA Translation: AAH01759.2 BC110339 mRNA Translation: AAI10340.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS41485.1 [Q5VWN6-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001308712.1, NM_001321783.1 NP_001308713.1, NM_001321784.1 NP_001308714.1, NM_001321785.1 NP_060252.4, NM_017782.4 XP_005252532.1, XM_005252475.3 [Q5VWN6-1] XP_005252537.1, XM_005252480.4 [Q5VWN6-1] XP_005252538.1, XM_005252481.4 [Q5VWN6-1] XP_005252539.1, XM_005252482.2 [Q5VWN6-1] XP_011517827.1, XM_011519525.2 [Q5VWN6-1] XP_016871852.1, XM_017016363.1 [Q5VWN6-1] XP_016871854.1, XM_017016365.1 [Q5VWN6-1]
UniGeneⁱ	Hs.610717 Hs.657238 Hs.659130 Hs.694576

Genome annotation databases

Ensemblⁱ	ENST00000328090; ENSP00000328426; ENSG00000108021 [Q5VWN6-1]
GeneIDⁱ	54906
KEGGⁱ	hsa:54906
UCSC genome browser More...UCSCⁱ	uc001iij.3 human [Q5VWN6-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
Q5VWN6	Protein FAM208B (Fragment)		HUMAN		71	UniRef100_Q5VWN6
UPI0005D0262F		HUMAN		2716

Protein	Similar proteins		Species	Score	Length	Source
Q5VWN6	Protein FAM208B (Fragment)		HUMAN		71	UniRef90_Q5VWN6
Uncharacterized protein		MACNE		2570
Uncharacterized protein		PAPAN		2520
Family with sequence similarity 208 member B		RHIBE		2438
Uncharacterized protein		MACFA		2433
+83

Protein	Similar proteins		Species	Score	Length	Source
Q5VWN6	Protein FAM208B (Fragment)		HUMAN		71	UniRef50_Q5VWN6
Uncharacterized protein		MACNE		2570
Uncharacterized protein		PAPAN		2520
Family with sequence similarity 208 member B		RHIBE		2438
Uncharacterized protein		MACMU		2433
+229

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL365356 Genomic DNA No translation available. AL596094 Genomic DNA No translation available. AB095927 mRNA Translation: BAC23103.1 AK000367 mRNA Translation: BAA91115.1 Different initiation. AK022966 mRNA Translation: BAB14336.1 Different initiation. AK024762 mRNA Translation: BAB14993.1 Different initiation. AK027014 mRNA Translation: BAB15627.1 AK128051 mRNA Translation: BAC87251.1 Different initiation. BC001759 mRNA Translation: AAH01759.2 BC110339 mRNA Translation: AAI10340.1
CCDSⁱ	CCDS41485.1 [Q5VWN6-1]
RefSeqⁱ	NP_001308712.1, NM_001321783.1 NP_001308713.1, NM_001321784.1 NP_001308714.1, NM_001321785.1 NP_060252.4, NM_017782.4 XP_005252532.1, XM_005252475.3 [Q5VWN6-1] XP_005252537.1, XM_005252480.4 [Q5VWN6-1] XP_005252538.1, XM_005252481.4 [Q5VWN6-1] XP_005252539.1, XM_005252482.2 [Q5VWN6-1] XP_011517827.1, XM_011519525.2 [Q5VWN6-1] XP_016871852.1, XM_017016363.1 [Q5VWN6-1] XP_016871854.1, XM_017016365.1 [Q5VWN6-1]
UniGeneⁱ	Hs.610717 Hs.657238 Hs.659130 Hs.694576

3D structure databases

ProteinModelPortalⁱ	Q5VWN6
SMRⁱ	Q5VWN6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	120252, 44 interactors
IntActⁱ	Q5VWN6, 55 interactors
MINTⁱ	Q5VWN6
STRINGⁱ	9606.ENSP00000328426

PTM databases

iPTMnetⁱ	Q5VWN6
PhosphoSitePlusⁱ	Q5VWN6

Polymorphism and mutation databases

BioMutaⁱ	FAM208B
DMDMⁱ	74747424

Proteomic databases

EPDⁱ	Q5VWN6
MaxQBⁱ	Q5VWN6
PaxDbⁱ	Q5VWN6
PeptideAtlasⁱ	Q5VWN6
PRIDEⁱ	Q5VWN6
ProteomicsDBⁱ	65545 65546 [Q5VWN6-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	54906
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000328090; ENSP00000328426; ENSG00000108021 [Q5VWN6-1]
GeneIDⁱ	54906
KEGGⁱ	hsa:54906
UCSCⁱ	uc001iij.3 human [Q5VWN6-1]

Organism-specific databases

CTDⁱ	54906
EuPathDBⁱ	HostDB:ENSG00000108021.19
GeneCardsⁱ	FAM208B
H-InvDBⁱ	HIX0008613
HGNCⁱ	HGNC:23484 FAM208B
HPAⁱ	HPA038042 HPA038043 HPA061547
neXtProtⁱ	NX_Q5VWN6
OpenTargetsⁱ	ENSG00000108021
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410II9C Eukaryota ENOG410YF12 LUCA
GeneTreeⁱ	ENSGT00530000063735
HOVERGENⁱ	HBG095571
InParanoidⁱ	Q5VWN6
OMAⁱ	DFKYVMK
OrthoDBⁱ	EOG091G00B8
PhylomeDBⁱ	Q5VWN6
TreeFamⁱ	TF337844

Miscellaneous databases

ChiTaRSⁱ	FAM208B human
GenomeRNAiⁱ	54906
Protein Ontology More...PROⁱ	PR:Q5VWN6

Gene expression databases

Bgeeⁱ	ENSG00000108021 Expressed in 229 organ(s), highest expression level in secondary oocyte
CleanExⁱ	HS_C10orf18
ExpressionAtlasⁱ	Q5VWN6 baseline and differential
Genevisibleⁱ	Q5VWN6 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR022168 DUF3699 IPR022188 DUF3715
Pfamⁱ	View protein in Pfam PF12480 DUF3699, 1 hit PF12509 DUF3715, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	F208B_HUMAN
Accessionⁱ	Q5VWN6Primary (citable) accession number: Q5VWN6 Secondary accession number(s): Q2YD91 Q9NXA1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
	Last sequence update:	December 7, 2004
	Last modified:	November 7, 2018
	This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM

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UniProtKB - Q5VWN6 (F208B_HUMAN)

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Protein FAM208B

FAM208B

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<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

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Keywords - Coding sequence diversityi

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Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

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Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

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Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ