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Protein

Protein FAM208B

Gene

FAM208B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM208B
Gene namesi
Name:FAM208B
Synonyms:C10orf18, KIAA2006
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000108021.19
HGNCiHGNC:23484 FAM208B
neXtProtiNX_Q5VWN6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000108021

Polymorphism and mutation databases

BioMutaiFAM208B
DMDMi74747424

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002995421 – 2430Protein FAM208BAdd BLAST2430

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei19PhosphoserineCombined sources1
Modified residuei219PhosphoserineCombined sources1
Modified residuei384PhosphoserineCombined sources1
Modified residuei685PhosphoserineCombined sources1
Modified residuei1025PhosphoserineCombined sources1
Modified residuei1087PhosphoserineCombined sources1
Modified residuei1172PhosphoserineCombined sources1
Modified residuei1541PhosphoserineCombined sources1
Modified residuei1848PhosphoserineCombined sources1
Cross-linki2007Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei2009PhosphoserineCombined sources1
Modified residuei2037PhosphoserineCombined sources1
Modified residuei2062PhosphoserineBy similarity1
Modified residuei2066PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ5VWN6
MaxQBiQ5VWN6
PaxDbiQ5VWN6
PeptideAtlasiQ5VWN6
PRIDEiQ5VWN6
ProteomicsDBi65545
65546 [Q5VWN6-2]

PTM databases

iPTMnetiQ5VWN6
PhosphoSitePlusiQ5VWN6

Expressioni

Gene expression databases

BgeeiENSG00000108021 Expressed in 229 organ(s), highest expression level in secondary oocyte
CleanExiHS_C10orf18
ExpressionAtlasiQ5VWN6 baseline and differential
GenevisibleiQ5VWN6 HS

Organism-specific databases

HPAiHPA038042
HPA038043
HPA061547

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi120252, 44 interactors
IntActiQ5VWN6, 55 interactors
MINTiQ5VWN6
STRINGi9606.ENSP00000328426

Structurei

3D structure databases

ProteinModelPortaliQ5VWN6
SMRiQ5VWN6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM208 family.Curated

Phylogenomic databases

eggNOGiENOG410II9C Eukaryota
ENOG410YF12 LUCA
GeneTreeiENSGT00530000063735
HOVERGENiHBG095571
InParanoidiQ5VWN6
OMAiDFKYVMK
OrthoDBiEOG091G00B8
PhylomeDBiQ5VWN6
TreeFamiTF337844

Family and domain databases

InterProiView protein in InterPro
IPR022168 DUF3699
IPR022188 DUF3715
PfamiView protein in Pfam
PF12480 DUF3699, 1 hit
PF12509 DUF3715, 2 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5VWN6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAPPAHKSIL ERSENVLMSP WKGKLIVQDR MLCDIALWST YGAMIPTQLP
60 70 80 90 100
QELDFKYVMK VSSLKKRLPE AAFRKQNYLE EKVCFQDLCF NLYEVELSNR
110 120 130 140 150
QGENIDKLTE CIKNKQLAII KCLEDRGFFI LLTSSALLSE PDFGGKQMGL
160 170 180 190 200
HGLHLFRSPL STGVKDLKVE DDISMKVIPI LSTLNCALLE TKKSLPEERI
210 220 230 240 250
HPNTLVKRHF QELYKADRSP SLSVAPQDRM KDPTFLGKLP SGFDLIPPAE
260 270 280 290 300
KCPSESLTQL NSYFSDPSAY ILEVSTALDL LAEHPQSPCV SDGICDAGFS
310 320 330 340 350
LVMTPDPEFL VSEAEVRKET ETKKDSEEML KAKKRVFPLS PASNLRVQPK
360 370 380 390 400
RKASMPHMVQ SKKVNLCRPF PKRTASRADN SSDSPTTLKL VKGQFPQKRK
410 420 430 440 450
RGAEVLTAQF VQKTKLDRKN QEAPISKDVP VPTNAKRARK QEKSPVKTVP
460 470 480 490 500
RAKPPVKKSP QKQRVNIVKG NENPRNRKQL QPVKGETASK LQSEISRGCQ
510 520 530 540 550
EDGISINSVQ PENTTAAHND LPENSIVNYD SQALNMLADL ALSSATSSTP
560 570 580 590 600
VSEARNLHCS SELPQNDVLL SKENSLRGTS DHEYHRGVKT QKGELLPNPS
610 620 630 640 650
SDRKSNSGSD LTVSQDEESL VPCSQAPAKA QSALTEEMLE SSDASQSSSV
660 670 680 690 700
SVEHSYALLL TEHSKKHLQE REILSPLFPR NGTKSPEAAT PVGKVMPFRH
710 720 730 740 750
QPGLLLQQKP PDDPVVKPKD RPPSARVKKS SCSRIVLSCD DSVKITFKCE
760 770 780 790 800
TEYAFSLDSK YTNNPLEKTV VRALHGPWNT DLPDNVEEVK LLLHMWVALF
810 820 830 840 850
YSNQNKIIRS SRKVVEHSNP AKYVSINSTL ESCELREIEE SLGLEKCSAD
860 870 880 890 900
SLLETNEISR AHAAEVSFRD PNCLLPFIKT PLTQGLELCV QNEQKKTFAR
910 920 930 940 950
ECDPDTQEDQ NFICSYNNEV TGEEAKQESL ETSNLVLSGI GSTQTNGPSV
960 970 980 990 1000
PSEEEIVQPL DSTRVASYSG TVTQATFTRT YDGPGSQPVI CQSSVYGTLE
1010 1020 1030 1040 1050
NKVDILDAAV QTKTGTLQDL IQHGSPINNE CHPSLERKDD NMGCAVINPE
1060 1070 1080 1090 1100
PITLTFEKNA HVPIQTEGVN TADERTTFKK ELIKQVSPAA SLRHPVSTSE
1110 1120 1130 1140 1150
NARTQGLRDI PSLVVAGQKG TKYLCASSVG GETLDKAVCS LQKETPLPVS
1160 1170 1180 1190 1200
LPSDKTMVME ALSLAKSSSH LSPSEEVRCT QDFLSQTQSL LGLSSEGLLE
1210 1220 1230 1240 1250
LTQVEVDSSS ASTTLGRQCS LNCISSGCHT SGDSLELRKN HKNGPNTENM
1260 1270 1280 1290 1300
NLEAFDSVFI KQTSLSVSRE VSLELSEEDS DIDLALTISP PTSPREEMPA
1310 1320 1330 1340 1350
GEIEQFEEAP FSNLELQDVA EEIGEPEEVA LTESREVSSA DNVSVYPSVS
1360 1370 1380 1390 1400
EEPVENKERK GDNLQPVTLI LSKENCTLEI AEEINVTSDF PFDSVIEEVS
1410 1420 1430 1440 1450
PASSPEPPVP VKETRPYQAV TPCILKLHGT QCEKSNQISQ CESEDLGITE
1460 1470 1480 1490 1500
KENVFVGPTH PVGQDNFTQV QQMQVSAEMP LILTDHPGRT GRPTLPGKVT
1510 1520 1530 1540 1550
EEIVSSEHDE GLSFSGKVQC YGRELNQPAS AAKCTGDFSP SPEKLVKSGN
1560 1570 1580 1590 1600
PLQPVSIENR NLDLKHLVLE SSEPPFGPRN VIENKSLSDT LVSTTAPSGI
1610 1620 1630 1640 1650
VNVSVKQQTS PKSSQNHLFP GDLKTDEGIY LQVKSLTAAS VDGAYSTQGC
1660 1670 1680 1690 1700
MCSVVPTLCS SSDNATLTHY VRPINAEPVF QAQEIPAGRM ASLLKNGEPE
1710 1720 1730 1740 1750
AELHKETTGP GTAGPQSNTT SSLKGERKAI HTLQDVSTCE TKELLNVGVS
1760 1770 1780 1790 1800
SLCAGPYQNT ADTKENLSKE PLASFVSESF DTSVCGIATE HVEIENSGEG
1810 1820 1830 1840 1850
LRAEAGSETL GRDGEVGVNS DMHYELSGDS DLDLLGDCRN PRLDLEDSYT
1860 1870 1880 1890 1900
LRGSYTRKKD VPTDGYESSL NFHNNNQEDW GCSSWVPGME TSLPPGHWTA
1910 1920 1930 1940 1950
AVKKEEKCVP PYVQIRDLHG ILRTYANFSI TKELKDTMRT SHGLRRHPSF
1960 1970 1980 1990 2000
SANCGLPSSW TSTWQVADDL TQNTLDLEYL RFAHKLKQTI KNGDSQHSAS
2010 2020 2030 2040 2050
SANVFPKESP TQISIGAFPS TKISEAPFLH PAPRSRSPLL VTVVESDPRP
2060 2070 2080 2090 2100
QGQPRRGYTA SSLDSSSSWR ERCSHNRDLR NSQRNHTVSF HLNKLKYNST
2110 2120 2130 2140 2150
VKESRNDISL ILNEYAEFNK VMKNSNQFIF QDKELNDVSG EATAQEMYLP
2160 2170 2180 2190 2200
FPGRSASYED IIIDVCTNLH VKLRSVVKEA CKSTFLFYLV ETEDKSFFVR
2210 2220 2230 2240 2250
TKNLLRKGGH TEIEPQHFCQ AFHRENDTLI IIIRNEDISS HLHQIPSLLK
2260 2270 2280 2290 2300
LKHFPSVIFA GVDSPGDVLD HTYQELFRAG GFVISDDKIL EAVTLVQLKE
2310 2320 2330 2340 2350
IIKILEKLNG NGRWKWLLHY RENKKLKEDE RVDSTAHKKN IMLKSFQSAN
2360 2370 2380 2390 2400
IIELLHYHQC DSRSSTKAEI LKCLLNLQIQ HIDARFAVLL TDKPTIPREV
2410 2420 2430
FENSGILVTD VNNFIENIEK IAAPFRSSYW
Length:2,430
Mass (Da):268,843
Last modified:December 7, 2004 - v1
Checksum:i8A6A94D318280DCE
GO
Isoform 2 (identifier: Q5VWN6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     333-1137: Missing.

Show »
Length:1,625
Mass (Da):180,380
Checksum:i633F6CEAFB1585AB
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KPH3J3KPH3_HUMAN
Protein FAM208B
FAM208B
246Annotation score:
A0A2R8YCW7A0A2R8YCW7_HUMAN
Protein FAM208B
FAM208B
117Annotation score:
A0A1D5RMU0A0A1D5RMU0_HUMAN
Protein FAM208B
FAM208B
8Annotation score:
A0A2R8YH03A0A2R8YH03_HUMAN
Protein FAM208B
FAM208B
2,645Annotation score:
A0A2R8YCL4A0A2R8YCL4_HUMAN
Protein FAM208B
FAM208B
71Annotation score:

Sequence cautioni

The sequence BAA91115 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB14336 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB14993 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC87251 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1885W → R in BAA91115 (PubMed:14702039).Curated1
Sequence conflicti2043V → A in BAA91115 (PubMed:14702039).Curated1
Sequence conflicti2065S → I in BAA91115 (PubMed:14702039).Curated1
Sequence conflicti2359Q → R in BAB14993 (PubMed:14702039).Curated1
Sequence conflicti2384A → T in BAB14993 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050848499C → G. Corresponds to variant dbSNP:rs2254067Ensembl.1
Natural variantiVAR_050849630A → D. Corresponds to variant dbSNP:rs4748636Ensembl.1
Natural variantiVAR_061601724S → Y. Corresponds to variant dbSNP:rs56856085Ensembl.1
Natural variantiVAR_061602807I → V. Corresponds to variant dbSNP:rs45575338Ensembl.1
Natural variantiVAR_0348381075R → P1 PublicationCorresponds to variant dbSNP:rs2797491Ensembl.1
Natural variantiVAR_0508501206V → M. Corresponds to variant dbSNP:rs3814196Ensembl.1
Natural variantiVAR_0508511578P → S. Corresponds to variant dbSNP:rs17143175Ensembl.1
Natural variantiVAR_0348391679V → A3 PublicationsCorresponds to variant dbSNP:rs2669142Ensembl.1
Natural variantiVAR_0508521782T → I. Corresponds to variant dbSNP:rs11593253Ensembl.1
Natural variantiVAR_0508532288K → R. Corresponds to variant dbSNP:rs2275774Ensembl.1
Natural variantiVAR_0348402404S → N3 PublicationsCorresponds to variant dbSNP:rs2797501Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_027733333 – 1137Missing in isoform 2. 1 PublicationAdd BLAST805

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL365356 Genomic DNA No translation available.
AL596094 Genomic DNA No translation available.
AB095927 mRNA Translation: BAC23103.1
AK000367 mRNA Translation: BAA91115.1 Different initiation.
AK022966 mRNA Translation: BAB14336.1 Different initiation.
AK024762 mRNA Translation: BAB14993.1 Different initiation.
AK027014 mRNA Translation: BAB15627.1
AK128051 mRNA Translation: BAC87251.1 Different initiation.
BC001759 mRNA Translation: AAH01759.2
BC110339 mRNA Translation: AAI10340.1
CCDSiCCDS41485.1 [Q5VWN6-1]
RefSeqiNP_001308712.1, NM_001321783.1
NP_001308713.1, NM_001321784.1
NP_001308714.1, NM_001321785.1
NP_060252.4, NM_017782.4
XP_005252532.1, XM_005252475.3 [Q5VWN6-1]
XP_005252537.1, XM_005252480.4 [Q5VWN6-1]
XP_005252538.1, XM_005252481.4 [Q5VWN6-1]
XP_005252539.1, XM_005252482.2 [Q5VWN6-1]
XP_011517827.1, XM_011519525.2 [Q5VWN6-1]
XP_016871852.1, XM_017016363.1 [Q5VWN6-1]
XP_016871854.1, XM_017016365.1 [Q5VWN6-1]
UniGeneiHs.610717
Hs.657238
Hs.659130
Hs.694576

Genome annotation databases

EnsembliENST00000328090; ENSP00000328426; ENSG00000108021 [Q5VWN6-1]
GeneIDi54906
KEGGihsa:54906
UCSCiuc001iij.3 human [Q5VWN6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL365356 Genomic DNA No translation available.
AL596094 Genomic DNA No translation available.
AB095927 mRNA Translation: BAC23103.1
AK000367 mRNA Translation: BAA91115.1 Different initiation.
AK022966 mRNA Translation: BAB14336.1 Different initiation.
AK024762 mRNA Translation: BAB14993.1 Different initiation.
AK027014 mRNA Translation: BAB15627.1
AK128051 mRNA Translation: BAC87251.1 Different initiation.
BC001759 mRNA Translation: AAH01759.2
BC110339 mRNA Translation: AAI10340.1
CCDSiCCDS41485.1 [Q5VWN6-1]
RefSeqiNP_001308712.1, NM_001321783.1
NP_001308713.1, NM_001321784.1
NP_001308714.1, NM_001321785.1
NP_060252.4, NM_017782.4
XP_005252532.1, XM_005252475.3 [Q5VWN6-1]
XP_005252537.1, XM_005252480.4 [Q5VWN6-1]
XP_005252538.1, XM_005252481.4 [Q5VWN6-1]
XP_005252539.1, XM_005252482.2 [Q5VWN6-1]
XP_011517827.1, XM_011519525.2 [Q5VWN6-1]
XP_016871852.1, XM_017016363.1 [Q5VWN6-1]
XP_016871854.1, XM_017016365.1 [Q5VWN6-1]
UniGeneiHs.610717
Hs.657238
Hs.659130
Hs.694576

3D structure databases

ProteinModelPortaliQ5VWN6
SMRiQ5VWN6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120252, 44 interactors
IntActiQ5VWN6, 55 interactors
MINTiQ5VWN6
STRINGi9606.ENSP00000328426

PTM databases

iPTMnetiQ5VWN6
PhosphoSitePlusiQ5VWN6

Polymorphism and mutation databases

BioMutaiFAM208B
DMDMi74747424

Proteomic databases

EPDiQ5VWN6
MaxQBiQ5VWN6
PaxDbiQ5VWN6
PeptideAtlasiQ5VWN6
PRIDEiQ5VWN6
ProteomicsDBi65545
65546 [Q5VWN6-2]

Protocols and materials databases

DNASUi54906
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000328090; ENSP00000328426; ENSG00000108021 [Q5VWN6-1]
GeneIDi54906
KEGGihsa:54906
UCSCiuc001iij.3 human [Q5VWN6-1]

Organism-specific databases

CTDi54906
EuPathDBiHostDB:ENSG00000108021.19
GeneCardsiFAM208B
H-InvDBiHIX0008613
HGNCiHGNC:23484 FAM208B
HPAiHPA038042
HPA038043
HPA061547
neXtProtiNX_Q5VWN6
OpenTargetsiENSG00000108021
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410II9C Eukaryota
ENOG410YF12 LUCA
GeneTreeiENSGT00530000063735
HOVERGENiHBG095571
InParanoidiQ5VWN6
OMAiDFKYVMK
OrthoDBiEOG091G00B8
PhylomeDBiQ5VWN6
TreeFamiTF337844

Miscellaneous databases

ChiTaRSiFAM208B human
GenomeRNAii54906
PROiPR:Q5VWN6

Gene expression databases

BgeeiENSG00000108021 Expressed in 229 organ(s), highest expression level in secondary oocyte
CleanExiHS_C10orf18
ExpressionAtlasiQ5VWN6 baseline and differential
GenevisibleiQ5VWN6 HS

Family and domain databases

InterProiView protein in InterPro
IPR022168 DUF3699
IPR022188 DUF3715
PfamiView protein in Pfam
PF12480 DUF3699, 1 hit
PF12509 DUF3715, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiF208B_HUMAN
AccessioniPrimary (citable) accession number: Q5VWN6
Secondary accession number(s): Q2YD91
, Q5VWN5, Q6ZRQ8, Q8IVG4, Q9BUZ7, Q9H5J9, Q9H7A4, Q9H996, Q9NXA1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: December 7, 2004
Last modified: November 7, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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