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Entry version 121 (13 Feb 2019)
Sequence version 1 (07 Dec 2004)
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Protein

Protein FAM208B

Gene

FAM208B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein FAM208B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FAM208B
Synonyms:C10orf18, KIAA2006
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000108021.19

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23484 FAM208B

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5VWN6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000108021

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FAM208B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74747424

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002995421 – 2430Protein FAM208BAdd BLAST2430

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei19PhosphoserineCombined sources1
Modified residuei219PhosphoserineCombined sources1
Modified residuei384PhosphoserineCombined sources1
Modified residuei685PhosphoserineCombined sources1
Modified residuei1025PhosphoserineCombined sources1
Modified residuei1087PhosphoserineCombined sources1
Modified residuei1172PhosphoserineCombined sources1
Modified residuei1541PhosphoserineCombined sources1
Modified residuei1848PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki2007Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei2009PhosphoserineCombined sources1
Modified residuei2037PhosphoserineCombined sources1
Modified residuei2062PhosphoserineBy similarity1
Modified residuei2066PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q5VWN6

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q5VWN6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q5VWN6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5VWN6

PeptideAtlas

More...
PeptideAtlasi
Q5VWN6

PRoteomics IDEntifications database

More...
PRIDEi
Q5VWN6

ProteomicsDB human proteome resource

More...
ProteomicsDBi
65545
65546 [Q5VWN6-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5VWN6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5VWN6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000108021 Expressed in 229 organ(s), highest expression level in secondary oocyte

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q5VWN6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5VWN6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA038042
HPA038043
HPA061547

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120252, 46 interactors

Protein interaction database and analysis system

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IntActi
Q5VWN6, 58 interactors

Molecular INTeraction database

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MINTi
Q5VWN6

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000328426

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q5VWN6

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q5VWN6

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FAM208 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410II9C Eukaryota
ENOG410YF12 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063735

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG095571

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5VWN6

Identification of Orthologs from Complete Genome Data

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OMAi
DFKYVMK

Database of Orthologous Groups

More...
OrthoDBi
21269at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5VWN6

TreeFam database of animal gene trees

More...
TreeFami
TF337844

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR022168 DUF3699
IPR022188 DUF3715

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12480 DUF3699, 1 hit
PF12509 DUF3715, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5VWN6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAPPAHKSIL ERSENVLMSP WKGKLIVQDR MLCDIALWST YGAMIPTQLP
60 70 80 90 100
QELDFKYVMK VSSLKKRLPE AAFRKQNYLE EKVCFQDLCF NLYEVELSNR
110 120 130 140 150
QGENIDKLTE CIKNKQLAII KCLEDRGFFI LLTSSALLSE PDFGGKQMGL
160 170 180 190 200
HGLHLFRSPL STGVKDLKVE DDISMKVIPI LSTLNCALLE TKKSLPEERI
210 220 230 240 250
HPNTLVKRHF QELYKADRSP SLSVAPQDRM KDPTFLGKLP SGFDLIPPAE
260 270 280 290 300
KCPSESLTQL NSYFSDPSAY ILEVSTALDL LAEHPQSPCV SDGICDAGFS
310 320 330 340 350
LVMTPDPEFL VSEAEVRKET ETKKDSEEML KAKKRVFPLS PASNLRVQPK
360 370 380 390 400
RKASMPHMVQ SKKVNLCRPF PKRTASRADN SSDSPTTLKL VKGQFPQKRK
410 420 430 440 450
RGAEVLTAQF VQKTKLDRKN QEAPISKDVP VPTNAKRARK QEKSPVKTVP
460 470 480 490 500
RAKPPVKKSP QKQRVNIVKG NENPRNRKQL QPVKGETASK LQSEISRGCQ
510 520 530 540 550
EDGISINSVQ PENTTAAHND LPENSIVNYD SQALNMLADL ALSSATSSTP
560 570 580 590 600
VSEARNLHCS SELPQNDVLL SKENSLRGTS DHEYHRGVKT QKGELLPNPS
610 620 630 640 650
SDRKSNSGSD LTVSQDEESL VPCSQAPAKA QSALTEEMLE SSDASQSSSV
660 670 680 690 700
SVEHSYALLL TEHSKKHLQE REILSPLFPR NGTKSPEAAT PVGKVMPFRH
710 720 730 740 750
QPGLLLQQKP PDDPVVKPKD RPPSARVKKS SCSRIVLSCD DSVKITFKCE
760 770 780 790 800
TEYAFSLDSK YTNNPLEKTV VRALHGPWNT DLPDNVEEVK LLLHMWVALF
810 820 830 840 850
YSNQNKIIRS SRKVVEHSNP AKYVSINSTL ESCELREIEE SLGLEKCSAD
860 870 880 890 900
SLLETNEISR AHAAEVSFRD PNCLLPFIKT PLTQGLELCV QNEQKKTFAR
910 920 930 940 950
ECDPDTQEDQ NFICSYNNEV TGEEAKQESL ETSNLVLSGI GSTQTNGPSV
960 970 980 990 1000
PSEEEIVQPL DSTRVASYSG TVTQATFTRT YDGPGSQPVI CQSSVYGTLE
1010 1020 1030 1040 1050
NKVDILDAAV QTKTGTLQDL IQHGSPINNE CHPSLERKDD NMGCAVINPE
1060 1070 1080 1090 1100
PITLTFEKNA HVPIQTEGVN TADERTTFKK ELIKQVSPAA SLRHPVSTSE
1110 1120 1130 1140 1150
NARTQGLRDI PSLVVAGQKG TKYLCASSVG GETLDKAVCS LQKETPLPVS
1160 1170 1180 1190 1200
LPSDKTMVME ALSLAKSSSH LSPSEEVRCT QDFLSQTQSL LGLSSEGLLE
1210 1220 1230 1240 1250
LTQVEVDSSS ASTTLGRQCS LNCISSGCHT SGDSLELRKN HKNGPNTENM
1260 1270 1280 1290 1300
NLEAFDSVFI KQTSLSVSRE VSLELSEEDS DIDLALTISP PTSPREEMPA
1310 1320 1330 1340 1350
GEIEQFEEAP FSNLELQDVA EEIGEPEEVA LTESREVSSA DNVSVYPSVS
1360 1370 1380 1390 1400
EEPVENKERK GDNLQPVTLI LSKENCTLEI AEEINVTSDF PFDSVIEEVS
1410 1420 1430 1440 1450
PASSPEPPVP VKETRPYQAV TPCILKLHGT QCEKSNQISQ CESEDLGITE
1460 1470 1480 1490 1500
KENVFVGPTH PVGQDNFTQV QQMQVSAEMP LILTDHPGRT GRPTLPGKVT
1510 1520 1530 1540 1550
EEIVSSEHDE GLSFSGKVQC YGRELNQPAS AAKCTGDFSP SPEKLVKSGN
1560 1570 1580 1590 1600
PLQPVSIENR NLDLKHLVLE SSEPPFGPRN VIENKSLSDT LVSTTAPSGI
1610 1620 1630 1640 1650
VNVSVKQQTS PKSSQNHLFP GDLKTDEGIY LQVKSLTAAS VDGAYSTQGC
1660 1670 1680 1690 1700
MCSVVPTLCS SSDNATLTHY VRPINAEPVF QAQEIPAGRM ASLLKNGEPE
1710 1720 1730 1740 1750
AELHKETTGP GTAGPQSNTT SSLKGERKAI HTLQDVSTCE TKELLNVGVS
1760 1770 1780 1790 1800
SLCAGPYQNT ADTKENLSKE PLASFVSESF DTSVCGIATE HVEIENSGEG
1810 1820 1830 1840 1850
LRAEAGSETL GRDGEVGVNS DMHYELSGDS DLDLLGDCRN PRLDLEDSYT
1860 1870 1880 1890 1900
LRGSYTRKKD VPTDGYESSL NFHNNNQEDW GCSSWVPGME TSLPPGHWTA
1910 1920 1930 1940 1950
AVKKEEKCVP PYVQIRDLHG ILRTYANFSI TKELKDTMRT SHGLRRHPSF
1960 1970 1980 1990 2000
SANCGLPSSW TSTWQVADDL TQNTLDLEYL RFAHKLKQTI KNGDSQHSAS
2010 2020 2030 2040 2050
SANVFPKESP TQISIGAFPS TKISEAPFLH PAPRSRSPLL VTVVESDPRP
2060 2070 2080 2090 2100
QGQPRRGYTA SSLDSSSSWR ERCSHNRDLR NSQRNHTVSF HLNKLKYNST
2110 2120 2130 2140 2150
VKESRNDISL ILNEYAEFNK VMKNSNQFIF QDKELNDVSG EATAQEMYLP
2160 2170 2180 2190 2200
FPGRSASYED IIIDVCTNLH VKLRSVVKEA CKSTFLFYLV ETEDKSFFVR
2210 2220 2230 2240 2250
TKNLLRKGGH TEIEPQHFCQ AFHRENDTLI IIIRNEDISS HLHQIPSLLK
2260 2270 2280 2290 2300
LKHFPSVIFA GVDSPGDVLD HTYQELFRAG GFVISDDKIL EAVTLVQLKE
2310 2320 2330 2340 2350
IIKILEKLNG NGRWKWLLHY RENKKLKEDE RVDSTAHKKN IMLKSFQSAN
2360 2370 2380 2390 2400
IIELLHYHQC DSRSSTKAEI LKCLLNLQIQ HIDARFAVLL TDKPTIPREV
2410 2420 2430
FENSGILVTD VNNFIENIEK IAAPFRSSYW
Length:2,430
Mass (Da):268,843
Last modified:December 7, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8A6A94D318280DCE
GO
Isoform 2 (identifier: Q5VWN6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     333-1137: Missing.

Show »
Length:1,625
Mass (Da):180,380
Checksum:i633F6CEAFB1585AB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KPH3J3KPH3_HUMAN
Transcription activation suppressor...
TASOR2
246Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YCW7A0A2R8YCW7_HUMAN
Transcription activation suppressor...
TASOR2
117Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YH03A0A2R8YH03_HUMAN
Transcription activation suppressor...
TASOR2
2,645Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1D5RMU0A0A1D5RMU0_HUMAN
Transcription activation suppressor...
TASOR2
8Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YCL4A0A2R8YCL4_HUMAN
Transcription activation suppressor...
TASOR2
71Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA91115 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB14336 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB14993 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC87251 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1885W → R in BAA91115 (PubMed:14702039).Curated1
Sequence conflicti2043V → A in BAA91115 (PubMed:14702039).Curated1
Sequence conflicti2065S → I in BAA91115 (PubMed:14702039).Curated1
Sequence conflicti2359Q → R in BAB14993 (PubMed:14702039).Curated1
Sequence conflicti2384A → T in BAB14993 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_050848499C → G. Corresponds to variant dbSNP:rs2254067Ensembl.1
Natural variantiVAR_050849630A → D. Corresponds to variant dbSNP:rs4748636Ensembl.1
Natural variantiVAR_061601724S → Y. Corresponds to variant dbSNP:rs56856085Ensembl.1
Natural variantiVAR_061602807I → V. Corresponds to variant dbSNP:rs45575338Ensembl.1
Natural variantiVAR_0348381075R → P1 PublicationCorresponds to variant dbSNP:rs2797491Ensembl.1
Natural variantiVAR_0508501206V → M. Corresponds to variant dbSNP:rs3814196Ensembl.1
Natural variantiVAR_0508511578P → S. Corresponds to variant dbSNP:rs17143175Ensembl.1
Natural variantiVAR_0348391679V → A3 PublicationsCorresponds to variant dbSNP:rs2669142Ensembl.1
Natural variantiVAR_0508521782T → I. Corresponds to variant dbSNP:rs11593253Ensembl.1
Natural variantiVAR_0508532288K → R. Corresponds to variant dbSNP:rs2275774Ensembl.1
Natural variantiVAR_0348402404S → N3 PublicationsCorresponds to variant dbSNP:rs2797501Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_027733333 – 1137Missing in isoform 2. 1 PublicationAdd BLAST805

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AL365356 Genomic DNA No translation available.
AL596094 Genomic DNA No translation available.
AB095927 mRNA Translation: BAC23103.1
AK000367 mRNA Translation: BAA91115.1 Different initiation.
AK022966 mRNA Translation: BAB14336.1 Different initiation.
AK024762 mRNA Translation: BAB14993.1 Different initiation.
AK027014 mRNA Translation: BAB15627.1
AK128051 mRNA Translation: BAC87251.1 Different initiation.
BC001759 mRNA Translation: AAH01759.2
BC110339 mRNA Translation: AAI10340.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS41485.1 [Q5VWN6-1]

NCBI Reference Sequences

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RefSeqi
NP_001308712.1, NM_001321783.1
NP_001308713.1, NM_001321784.1
NP_001308714.1, NM_001321785.1
NP_060252.4, NM_017782.4
XP_005252532.1, XM_005252475.3 [Q5VWN6-1]
XP_005252537.1, XM_005252480.4 [Q5VWN6-1]
XP_005252538.1, XM_005252481.4 [Q5VWN6-1]
XP_005252539.1, XM_005252482.2 [Q5VWN6-1]
XP_011517827.1, XM_011519525.2 [Q5VWN6-1]
XP_016871852.1, XM_017016363.1 [Q5VWN6-1]
XP_016871854.1, XM_017016365.1 [Q5VWN6-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.610717
Hs.657238
Hs.659130
Hs.694576

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000328090; ENSP00000328426; ENSG00000108021 [Q5VWN6-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
54906

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:54906

UCSC genome browser

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UCSCi
uc001iij.3 human [Q5VWN6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL365356 Genomic DNA No translation available.
AL596094 Genomic DNA No translation available.
AB095927 mRNA Translation: BAC23103.1
AK000367 mRNA Translation: BAA91115.1 Different initiation.
AK022966 mRNA Translation: BAB14336.1 Different initiation.
AK024762 mRNA Translation: BAB14993.1 Different initiation.
AK027014 mRNA Translation: BAB15627.1
AK128051 mRNA Translation: BAC87251.1 Different initiation.
BC001759 mRNA Translation: AAH01759.2
BC110339 mRNA Translation: AAI10340.1
CCDSiCCDS41485.1 [Q5VWN6-1]
RefSeqiNP_001308712.1, NM_001321783.1
NP_001308713.1, NM_001321784.1
NP_001308714.1, NM_001321785.1
NP_060252.4, NM_017782.4
XP_005252532.1, XM_005252475.3 [Q5VWN6-1]
XP_005252537.1, XM_005252480.4 [Q5VWN6-1]
XP_005252538.1, XM_005252481.4 [Q5VWN6-1]
XP_005252539.1, XM_005252482.2 [Q5VWN6-1]
XP_011517827.1, XM_011519525.2 [Q5VWN6-1]
XP_016871852.1, XM_017016363.1 [Q5VWN6-1]
XP_016871854.1, XM_017016365.1 [Q5VWN6-1]
UniGeneiHs.610717
Hs.657238
Hs.659130
Hs.694576

3D structure databases

ProteinModelPortaliQ5VWN6
SMRiQ5VWN6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120252, 46 interactors
IntActiQ5VWN6, 58 interactors
MINTiQ5VWN6
STRINGi9606.ENSP00000328426

PTM databases

iPTMnetiQ5VWN6
PhosphoSitePlusiQ5VWN6

Polymorphism and mutation databases

BioMutaiFAM208B
DMDMi74747424

Proteomic databases

EPDiQ5VWN6
jPOSTiQ5VWN6
MaxQBiQ5VWN6
PaxDbiQ5VWN6
PeptideAtlasiQ5VWN6
PRIDEiQ5VWN6
ProteomicsDBi65545
65546 [Q5VWN6-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
54906
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000328090; ENSP00000328426; ENSG00000108021 [Q5VWN6-1]
GeneIDi54906
KEGGihsa:54906
UCSCiuc001iij.3 human [Q5VWN6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
54906
EuPathDBiHostDB:ENSG00000108021.19

GeneCards: human genes, protein and diseases

More...
GeneCardsi
FAM208B

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0008613
HGNCiHGNC:23484 FAM208B
HPAiHPA038042
HPA038043
HPA061547
neXtProtiNX_Q5VWN6
OpenTargetsiENSG00000108021

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410II9C Eukaryota
ENOG410YF12 LUCA
GeneTreeiENSGT00530000063735
HOVERGENiHBG095571
InParanoidiQ5VWN6
OMAiDFKYVMK
OrthoDBi21269at2759
PhylomeDBiQ5VWN6
TreeFamiTF337844

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
FAM208B human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
54906

Protein Ontology

More...
PROi
PR:Q5VWN6

Gene expression databases

BgeeiENSG00000108021 Expressed in 229 organ(s), highest expression level in secondary oocyte
ExpressionAtlasiQ5VWN6 baseline and differential
GenevisibleiQ5VWN6 HS

Family and domain databases

InterProiView protein in InterPro
IPR022168 DUF3699
IPR022188 DUF3715
PfamiView protein in Pfam
PF12480 DUF3699, 1 hit
PF12509 DUF3715, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF208B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5VWN6
Secondary accession number(s): Q2YD91
, Q5VWN5, Q6ZRQ8, Q8IVG4, Q9BUZ7, Q9H5J9, Q9H7A4, Q9H996, Q9NXA1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: December 7, 2004
Last modified: February 13, 2019
This is version 121 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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