Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

PRAME family member 9/15

Gene

PRAMEF9

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
PRAME family member 9/15Curated
Gene namesi
Name:PRAMEF9Imported
AND
Name:PRAMEF15Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000204501.6
HGNCiHGNC:26764 PRAMEF15
HGNC:27996 PRAMEF9
neXtProtiNX_Q5VWM5

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000204501
PharmGKBiPA142671146

Polymorphism and mutation databases

BioMutaiPRAMEF9
DMDMi74756938

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001569831 – 478PRAME family member 9/15Add BLAST478

Proteomic databases

PaxDbiQ5VWM5
PRIDEiQ5VWM5
ProteomicsDBi65543

PTM databases

iPTMnetiQ5VWM5
PhosphoSitePlusiQ5VWM5

Expressioni

Gene expression databases

BgeeiENSG00000204501 Expressed in 4 organ(s), highest expression level in right lobe of liver
CleanExiHS_PRAMEF9
GenevisibleiQ5VWM5 HS

Interactioni

Protein-protein interaction databases

BioGridi575933, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ5VWM5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati99 – 126LRR 1; degenerateBy similarityAdd BLAST28
Repeati181 – 205LRR 2; degenerateBy similarityAdd BLAST25
Repeati206 – 232LRR 3; degenerateBy similarityAdd BLAST27
Repeati233 – 268LRR 4; degenerateBy similarityAdd BLAST36
Repeati269 – 294LRR 5By similarityAdd BLAST26
Repeati295 – 326LRR 6By similarityAdd BLAST32
Repeati327 – 347LRR 7By similarityAdd BLAST21
Repeati351 – 378LRR 8By similarityAdd BLAST28
Repeati379 – 403LRR 9By similarityAdd BLAST25

Sequence similaritiesi

Belongs to the PRAME family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410KDY5 Eukaryota
ENOG4111EBM LUCA
GeneTreeiENSGT00760000119028
HOGENOMiHOG000231112
HOVERGENiHBG006326
InParanoidiQ5VWM5
OMAiKEWAMDE
OrthoDBiEOG091G05PP
PhylomeDBiQ5VWM5
TreeFamiTF332708

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR032675 LRR_dom_sf
IPR026271 PRAME_family
PIRSFiPIRSF038286 PRAME, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q5VWM5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKMSIRTPPR LLELAGRSLL RDQALAMSTL EELPTELFPP LFMEAFSRRR
60 70 80 90 100
CEALKLMVQA WPFRRLPLRP LIKMPCLEAF QAVLDGLDAL LTQGVRPRRW
110 120 130 140 150
KLQVLDLQDV CENFWMVWSE AMAHGCFLNA KRNKKPVQDC PRMRGRQPLT
160 170 180 190 200
VFVELWLKNR TLDEYLTYLL LWVKQRKDLL HLCCKKLKIL GMPFRNIRSI
210 220 230 240 250
LKMVNLDCIQ EVEVNCKWVL PILTQFTPYL GHMRNLQKLV LSHMDVSRYV
260 270 280 290 300
SPEQKKEIVT QFTTQFLKLR CLQKLYMNSV SFLEGHLDQL LSCLKTSLKV
310 320 330 340 350
LTITNCVLLE SDLKHLSQCP SISQLKTLDL SGIRLTNYSL VPLQILLEKV
360 370 380 390 400
AATLEYLDLD DCGIIDSQVN AILPALSRCF ELNTFSFCGN PICMATLENL
410 420 430 440 450
LSHTIILKNL CVELYPAPRE SYGADGTLCW SRFAQIRAEL MNRVRDLRHP
460 470
KRILFCTDYC PDCGNRSFYD LEADQYCC
Length:478
Mass (Da):55,420
Last modified:December 7, 2004 - v1
Checksum:i01C7079F4D65BF10
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A096LNW4A0A096LNW4_HUMAN
PRAME family member 9/15
PRAMEF9
478Annotation score:
A0A1B0GU46A0A1B0GU46_HUMAN
PRAME family member 9/15
PRAMEF9
478Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL365443 Genomic DNA No translation available.
BX470067 Genomic DNA No translation available.
BC101343 mRNA Translation: AAI01344.1
BC137391 mRNA Translation: AAI37392.1
CCDSiCCDS44059.1
RefSeqiNP_001091846.1, NM_001098376.2
UniGeneiHs.551617
Hs.631873

Genome annotation databases

EnsembliENST00000376152; ENSP00000365322; ENSG00000204501
GeneIDi653619
KEGGihsa:653619
UCSCiuc001auw.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL365443 Genomic DNA No translation available.
BX470067 Genomic DNA No translation available.
BC101343 mRNA Translation: AAI01344.1
BC137391 mRNA Translation: AAI37392.1
CCDSiCCDS44059.1
RefSeqiNP_001091846.1, NM_001098376.2
UniGeneiHs.551617
Hs.631873

3D structure databases

ProteinModelPortaliQ5VWM5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi575933, 1 interactor

PTM databases

iPTMnetiQ5VWM5
PhosphoSitePlusiQ5VWM5

Polymorphism and mutation databases

BioMutaiPRAMEF9
DMDMi74756938

Proteomic databases

PaxDbiQ5VWM5
PRIDEiQ5VWM5
ProteomicsDBi65543

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376152; ENSP00000365322; ENSG00000204501
GeneIDi653619
KEGGihsa:653619
UCSCiuc001auw.2 human

Organism-specific databases

CTDi653619
EuPathDBiHostDB:ENSG00000204501.6
GeneCardsiPRAMEF15
PRAMEF9
HGNCiHGNC:26764 PRAMEF15
HGNC:27996 PRAMEF9
neXtProtiNX_Q5VWM5
OpenTargetsiENSG00000204501
PharmGKBiPA142671146
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KDY5 Eukaryota
ENOG4111EBM LUCA
GeneTreeiENSGT00760000119028
HOGENOMiHOG000231112
HOVERGENiHBG006326
InParanoidiQ5VWM5
OMAiKEWAMDE
OrthoDBiEOG091G05PP
PhylomeDBiQ5VWM5
TreeFamiTF332708

Miscellaneous databases

ChiTaRSiPRAMEF15 human
GenomeRNAii653619
PROiPR:Q5VWM5

Gene expression databases

BgeeiENSG00000204501 Expressed in 4 organ(s), highest expression level in right lobe of liver
CleanExiHS_PRAMEF9
GenevisibleiQ5VWM5 HS

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR032675 LRR_dom_sf
IPR026271 PRAME_family
PIRSFiPIRSF038286 PRAME, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPRAM9_HUMAN
AccessioniPrimary (citable) accession number: Q5VWM5
Secondary accession number(s): B2RPE1, Q08EQ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 7, 2004
Last modified: November 7, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again