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Protein

PRAME family member 8

Gene

PRAMEF8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
PRAME family member 8Imported
Gene namesi
Name:PRAMEF8Imported
Synonyms:PRAMEF24
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000182330.10
HGNCiHGNC:24074 PRAMEF8
neXtProtiNX_Q5VWM4

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000182330
PharmGKBiPA142671145

Polymorphism and mutation databases

BioMutaiPRAMEF8
DMDMi74756937

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001569821 – 474PRAME family member 8Add BLAST474

Proteomic databases

PaxDbiQ5VWM4
PeptideAtlasiQ5VWM4
PRIDEiQ5VWM4
ProteomicsDBi1530
65542

PTM databases

iPTMnetiQ5VWM4
PhosphoSitePlusiQ5VWM4

Expressioni

Gene expression databases

BgeeiENSG00000182330 Expressed in 4 organ(s), highest expression level in left testis
CleanExiHS_PRAMEF8

Organism-specific databases

HPAiHPA049887
HPA051704

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000349931

Structurei

3D structure databases

ProteinModelPortaliQ5VWM4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati97 – 122LRR 1; degenerateBy similarityAdd BLAST26
Repeati177 – 201LRR 2; degenerateBy similarityAdd BLAST25
Repeati202 – 228LRR 3; degenerateBy similarityAdd BLAST27
Repeati229 – 264LRR 4; degenerateBy similarityAdd BLAST36
Repeati265 – 290LRR 5By similarityAdd BLAST26
Repeati291 – 322LRR 6By similarityAdd BLAST32
Repeati323 – 341LRR 7By similarityAdd BLAST19
Repeati347 – 374LRR 8By similarityAdd BLAST28
Repeati375 – 399LRR 9By similarityAdd BLAST25

Sequence similaritiesi

Belongs to the PRAME family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410KFA8 Eukaryota
ENOG411141V LUCA
GeneTreeiENSGT00760000119028
HOGENOMiHOG000231112
HOVERGENiHBG006326
InParanoidiQ5VWM4
OMAiPRTICIS
OrthoDBiEOG091G05PP
TreeFamiTF332708

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR032675 LRR_dom_sf
IPR026271 PRAME_family
PIRSFiPIRSF038286 PRAME, 1 hit

Sequencei

Sequence statusi: Complete.

Q5VWM4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSIRAPPRLL ELARQRLLRD QALAISTMEE LPRELFPTLF MEAFSRRRCE
60 70 80 90 100
TLKTMVQAWP FTRLPLGSLM KSPHLESLKS VLEGVDVLLT QEVRPRQSKL
110 120 130 140 150
QVLDLRNVDE NFCDIFSGAT ASFPEALSQK QTADNCPGTG RQQPFMVFID
160 170 180 190 200
LCLKNRTLDE CLTHLLEWGK QRKGLLHVCC KELQVFGMPI HSIIEVLNMV
210 220 230 240 250
ELDCIQEVEV CCPWELSTLV KFAPYLGQMR NLRKLVLFNI RASACIPPDN
260 270 280 290 300
KGQFIARFTS QFLKLDYFQN LSMHSVSFLE GHLDQLLRCL QASLEMVVMT
310 320 330 340 350
DCLLSESDLK HLSWCPSIRQ LKELDLRGVT LTHFSPEPLT GLLEQVVATL
360 370 380 390 400
QTLDLEDCGI MDSQLSAILP VLSRCSQLST FSFCGNLISM AALENLLRHT
410 420 430 440 450
VGLSKLSLEL YPAPLESYDT QGALCWGRFA ELGAELMNTL RDLRQPKIIV
460 470
FCTVPCPRCG IRASYDLEPS HCLC
Length:474
Mass (Da):53,655
Last modified:April 1, 2015 - v2
Checksum:i73F5231BC6EB3B29
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC244216 Genomic DNA No translation available.
BC144565 mRNA Translation: AAI44566.1
CCDSiCCDS72709.1
RefSeqiNP_001012276.2, NM_001012276.3
XP_016856758.1, XM_017001269.1
UniGeneiHs.553832

Genome annotation databases

EnsembliENST00000357367; ENSP00000349931; ENSG00000182330
ENST00000611408; ENSP00000478860; ENSG00000278021
ENST00000614831; ENSP00000484204; ENSG00000182330
ENST00000616484; ENSP00000480509; ENSG00000278021
ENST00000621519; ENSP00000484753; ENSG00000182330
ENST00000631760; ENSP00000488367; ENSG00000282583
ENST00000632222; ENSP00000488892; ENSG00000282583
ENST00000632952; ENSP00000488817; ENSG00000282583
ENST00000636073; ENSP00000490581; ENSG00000283387
ENST00000637866; ENSP00000490715; ENSG00000283387
ENST00000637989; ENSP00000490790; ENSG00000283387
GeneIDi391002
KEGGihsa:391002
UCSCiuc031tpu.2 human
uc031tpv.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC244216 Genomic DNA No translation available.
BC144565 mRNA Translation: AAI44566.1
CCDSiCCDS72709.1
RefSeqiNP_001012276.2, NM_001012276.3
XP_016856758.1, XM_017001269.1
UniGeneiHs.553832

3D structure databases

ProteinModelPortaliQ5VWM4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000349931

PTM databases

iPTMnetiQ5VWM4
PhosphoSitePlusiQ5VWM4

Polymorphism and mutation databases

BioMutaiPRAMEF8
DMDMi74756937

Proteomic databases

PaxDbiQ5VWM4
PeptideAtlasiQ5VWM4
PRIDEiQ5VWM4
ProteomicsDBi1530
65542

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000357367; ENSP00000349931; ENSG00000182330
ENST00000611408; ENSP00000478860; ENSG00000278021
ENST00000614831; ENSP00000484204; ENSG00000182330
ENST00000616484; ENSP00000480509; ENSG00000278021
ENST00000621519; ENSP00000484753; ENSG00000182330
ENST00000631760; ENSP00000488367; ENSG00000282583
ENST00000632222; ENSP00000488892; ENSG00000282583
ENST00000632952; ENSP00000488817; ENSG00000282583
ENST00000636073; ENSP00000490581; ENSG00000283387
ENST00000637866; ENSP00000490715; ENSG00000283387
ENST00000637989; ENSP00000490790; ENSG00000283387
GeneIDi391002
KEGGihsa:391002
UCSCiuc031tpu.2 human
uc031tpv.2 human

Organism-specific databases

CTDi391002
EuPathDBiHostDB:ENSG00000182330.10
GeneCardsiPRAMEF8
HGNCiHGNC:24074 PRAMEF8
HPAiHPA049887
HPA051704
neXtProtiNX_Q5VWM4
OpenTargetsiENSG00000182330
PharmGKBiPA142671145
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KFA8 Eukaryota
ENOG411141V LUCA
GeneTreeiENSGT00760000119028
HOGENOMiHOG000231112
HOVERGENiHBG006326
InParanoidiQ5VWM4
OMAiPRTICIS
OrthoDBiEOG091G05PP
TreeFamiTF332708

Miscellaneous databases

GenomeRNAii391002
PROiPR:Q5VWM4

Gene expression databases

BgeeiENSG00000182330 Expressed in 4 organ(s), highest expression level in left testis
CleanExiHS_PRAMEF8

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR032675 LRR_dom_sf
IPR026271 PRAME_family
PIRSFiPIRSF038286 PRAME, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPRAM8_HUMAN
AccessioniPrimary (citable) accession number: Q5VWM4
Secondary accession number(s): A6NMC2, B7ZMI5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: April 1, 2015
Last modified: October 10, 2018
This is version 108 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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