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Protein

PRAME family member 18

Gene

PRAMEF18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
PRAME family member 18Imported
Gene namesi
Name:PRAMEF18Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:30693 PRAMEF18
neXtProtiNX_Q5VWM3

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000279804
PharmGKBiPA145148195

Polymorphism and mutation databases

BioMutaiPRAMEF18
DMDMi74747420

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002901631 – 479PRAME family member 18Add BLAST479

Proteomic databases

PeptideAtlasiQ5VWM3
PRIDEiQ5VWM3
ProteomicsDBi65541

PTM databases

iPTMnetiQ5VWM3
PhosphoSitePlusiQ5VWM3

Expressioni

Gene expression databases

CleanExiHS_PRAMEF18
ExpressionAtlasiQ5VWM3 baseline and differential

Organism-specific databases

HPAiHPA057423

Structurei

3D structure databases

ProteinModelPortaliQ5VWM3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati15 – 38LRR 1Sequence analysisAdd BLAST24
Repeati97 – 124LRR 1; degenerateBy similarityAdd BLAST28
Repeati179 – 203LRR 2; degenerateBy similarityAdd BLAST25
Repeati204 – 230LRR 3; degenerateBy similarityAdd BLAST27
Repeati231 – 265LRR 4; degenerateBy similarityAdd BLAST35
Repeati266 – 291LRR 5By similarityAdd BLAST26
Repeati292 – 323LRR 6By similarityAdd BLAST32
Repeati324 – 342LRR 7By similarityAdd BLAST19
Repeati348 – 375LRR 8By similarityAdd BLAST28
Repeati376 – 400LRR 9By similarityAdd BLAST25

Sequence similaritiesi

Belongs to the PRAME family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IUJ0 Eukaryota
ENOG4110PY0 LUCA
GeneTreeiENSGT00760000119028
HOGENOMiHOG000231112
HOVERGENiHBG006326
InParanoidiQ5VWM3
TreeFamiTF332708

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR032675 LRR_dom_sf
IPR026271 PRAME_family
PIRSFiPIRSF038286 PRAME, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q5VWM3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSFQAPRRLL ELAGQSLLRD QALAISVLDE LPRELFPPLF VEAFTSRRCE
60 70 80 90 100
VLKVMVQAWP FPCLPLGSLM KTPDLEILHY VVDGIDCLLA QKVRPRRWKL
110 120 130 140 150
QVLEMRDVDE NFWTIWSGAR LLSCSPEAMS KRQTVEDCPR TGEKQPLKVF
160 170 180 190 200
MDVCLKEKFM DEDLSFFSGW VQHRRGSVHL CCTKVVNYSM SILNFRNILE
210 220 230 240 250
TVYPDSIQVL EIWNMCWLCM IVEFSRYLSQ MRNLRKLFIS DGCRYLLSSD
260 270 280 290 300
SQEQLVAEFS SVLLRLENLQ MLYVRRVCFF RGHLDQLIRC LRSPLETLAL
310 320 330 340 350
TYGFLEEEDL KCLPRYPSLS QLKQLNLSHG ALRFIRLEPL RALLEKVAAT
360 370 380 390 400
LQTLFLVDCG IGYSKLRVIL PALSRCSNLT TFCFHGNDTS MDALKDLLRH
410 420 430 440 450
TGRLSNLSLE TYPAPRESLD NRGRVILELL TPLQAELMRI LREVREPKRI
460 470
FFGPVSCPCC GTSPTEQLES NFCLWGRPA
Length:479
Mass (Da):55,334
Last modified:January 20, 2016 - v2
Checksum:iB65477B0D5E3B8DC
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A096LP99A0A096LP99_HUMAN
PRAME family member 18
PRAMEF18
479Annotation score:
A0A0J9YWP7A0A0J9YWP7_HUMAN
PRAME family member 18
PRAMEF18
481Annotation score:
A0A140TA27A0A140TA27_HUMAN
PRAME family member 18
PRAMEF18
479Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC244216 Genomic DNA No translation available.
AL365443 Genomic DNA No translation available.
RefSeqiNP_001093320.2, NM_001099850.2

Genome annotation databases

EnsembliENST00000624297; ENSP00000485473; ENSG00000279804
ENST00000632307; ENSP00000488059; ENSG00000282212
GeneIDi391003
KEGGihsa:391003

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC244216 Genomic DNA No translation available.
AL365443 Genomic DNA No translation available.
RefSeqiNP_001093320.2, NM_001099850.2

3D structure databases

ProteinModelPortaliQ5VWM3
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ5VWM3
PhosphoSitePlusiQ5VWM3

Polymorphism and mutation databases

BioMutaiPRAMEF18
DMDMi74747420

Proteomic databases

PeptideAtlasiQ5VWM3
PRIDEiQ5VWM3
ProteomicsDBi65541

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000624297; ENSP00000485473; ENSG00000279804
ENST00000632307; ENSP00000488059; ENSG00000282212
GeneIDi391003
KEGGihsa:391003

Organism-specific databases

CTDi391003
GeneCardsiPRAMEF18
HGNCiHGNC:30693 PRAMEF18
HPAiHPA057423
neXtProtiNX_Q5VWM3
OpenTargetsiENSG00000279804
PharmGKBiPA145148195
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IUJ0 Eukaryota
ENOG4110PY0 LUCA
GeneTreeiENSGT00760000119028
HOGENOMiHOG000231112
HOVERGENiHBG006326
InParanoidiQ5VWM3
TreeFamiTF332708

Miscellaneous databases

PROiPR:Q5VWM3

Gene expression databases

CleanExiHS_PRAMEF18
ExpressionAtlasiQ5VWM3 baseline and differential

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR032675 LRR_dom_sf
IPR026271 PRAME_family
PIRSFiPIRSF038286 PRAME, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPRA18_HUMAN
AccessioniPrimary (citable) accession number: Q5VWM3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: January 20, 2016
Last modified: July 18, 2018
This is version 93 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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