UniProtKB - Q5VWK5 (IL23R_HUMAN)
Interleukin-23 receptor
IL23R
Functioni
GO - Molecular functioni
- cytokine binding Source: GO_Central
- cytokine receptor activity Source: GO_Central
GO - Biological processi
- cytokine-mediated signaling pathway Source: GO_Central
- defense response to Gram-negative bacterium Source: BHF-UCL
- inflammatory response Source: UniProtKB-KW
- interleukin-23-mediated signaling pathway Source: Reactome
- negative regulation of interleukin-10 production Source: BHF-UCL
- positive regulation of activated T cell proliferation Source: BHF-UCL
- positive regulation of activation of Janus kinase activity Source: BHF-UCL
- positive regulation of defense response to virus by host Source: BHF-UCL
- positive regulation of granulocyte macrophage colony-stimulating factor production Source: BHF-UCL
- positive regulation of interferon-gamma production Source: BHF-UCL
- positive regulation of interleukin-12 production Source: BHF-UCL
- positive regulation of interleukin-17 production Source: BHF-UCL
- positive regulation of memory T cell differentiation Source: BHF-UCL
- positive regulation of natural killer cell proliferation Source: BHF-UCL
- positive regulation of NK T cell activation Source: BHF-UCL
- positive regulation of osteoclast differentiation Source: BHF-UCL
- positive regulation of T cell mediated cytotoxicity Source: BHF-UCL
- positive regulation of T cell proliferation Source: BHF-UCL
- positive regulation of T-helper 17 cell lineage commitment Source: BHF-UCL
- positive regulation of T-helper 17 type immune response Source: BHF-UCL
- positive regulation of T-helper 1 type immune response Source: BHF-UCL
- positive regulation of tyrosine phosphorylation of STAT protein Source: BHF-UCL
- regulation of tyrosine phosphorylation of STAT protein Source: BHF-UCL
- response to interferon-gamma Source: BHF-UCL
- response to lipopolysaccharide Source: BHF-UCL
Keywordsi
Molecular function | Receptor |
Biological process | Immunity, Inflammatory response, Innate immunity |
Enzyme and pathway databases
PathwayCommonsi | Q5VWK5 |
Reactomei | R-HSA-6785807, Interleukin-4 and Interleukin-13 signaling R-HSA-9020933, Interleukin-23 signaling |
SignaLinki | Q5VWK5 |
SIGNORi | Q5VWK5 |
Names & Taxonomyi
Protein namesi | Recommended name: Interleukin-23 receptorShort name: IL-23 receptor Short name: IL-23R |
Gene namesi | Name:IL23R |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:19100, IL23R |
MIMi | 607562, gene |
neXtProti | NX_Q5VWK5 |
VEuPathDBi | HostDB:ENSG00000162594.14 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication
Plasma Membrane
- external side of plasma membrane Source: GO_Central
- interleukin-23 receptor complex Source: BHF-UCL
- plasma membrane Source: Reactome
Other locations
- receptor complex Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 24 – 355 | ExtracellularSequence analysisAdd BLAST | 332 | |
Transmembranei | 356 – 376 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 377 – 629 | CytoplasmicSequence analysisAdd BLAST | 253 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Involvement in diseasei
Inflammatory bowel disease 17 (IBD17)2 Publications
Organism-specific databases
DisGeNETi | 149233 |
MalaCardsi | IL23R |
MIMi | 612261, phenotype |
OpenTargetsi | ENSG00000162594 |
Orphaneti | 117, Behcet disease 206, NON RARE IN EUROPE: Crohn disease 771, NON RARE IN EUROPE: Ulcerative colitis |
PharmGKBi | PA134935109 |
Miscellaneous databases
Pharosi | Q5VWK5, Tbio |
Chemistry databases
ChEMBLi | CHEMBL4296013 |
Genetic variation databases
BioMutai | IL23R |
DMDMi | 311033431 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | Sequence analysisAdd BLAST | 23 | |
ChainiPRO_0000268662 | 24 – 629 | Interleukin-23 receptorAdd BLAST | 606 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 29 | N-linked (GlcNAc...) asparagine; partial1 Publication | 1 | |
Glycosylationi | 47 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 81 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 141 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 180 | N-linked (GlcNAc...) (high mannose) asparagine1 Publication | 1 | |
Glycosylationi | 232 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 262 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 273 | N-linked (GlcNAc...) asparagine; partial1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
MassIVEi | Q5VWK5 |
PaxDbi | Q5VWK5 |
PeptideAtlasi | Q5VWK5 |
PRIDEi | Q5VWK5 |
ProteomicsDBi | 65533 [Q5VWK5-1] 65534 [Q5VWK5-2] 65535 [Q5VWK5-3] 65536 [Q5VWK5-4] 65537 [Q5VWK5-5] 65538 [Q5VWK5-6] 65539 [Q5VWK5-7] |
PTM databases
GlyGeni | Q5VWK5, 8 sites |
iPTMneti | Q5VWK5 |
PhosphoSitePlusi | Q5VWK5 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000162594, Expressed in secondary oocyte and 47 other tissues |
ExpressionAtlasi | Q5VWK5, baseline and differential |
Genevisiblei | Q5VWK5, HS |
Organism-specific databases
HPAi | ENSG00000162594, Tissue enhanced (blood, lymphoid tissue) |
Interactioni
Subunit structurei
Heterodimer with IL12RB1. In presence of IL23, the heterodimer forms the IL23 receptor.
Interacts with JAK2 and in presence of IL23 with STAT3.
1 PublicationBinary interactionsi
Hide detailsQ5VWK5
With | #Exp. | IntAct |
---|---|---|
C1D [Q13901] | 3 | EBI-10248005,EBI-3844053 |
Jak2 [Q62120] from Mus musculus. | 2 | EBI-10248005,EBI-646604 |
GO - Molecular functioni
- cytokine binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 127199, 5 interactors |
ComplexPortali | CPX-383, Interleukin-23-receptor complex |
IntActi | Q5VWK5, 6 interactors |
STRINGi | 9606.ENSP00000321345 |
Chemistry databases
BindingDBi | Q5VWK5 |
Miscellaneous databases
RNActi | Q5VWK5, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q5VWK5 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 127 – 217 | Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST | 91 | |
Domaini | 219 – 318 | Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST | 100 |
Sequence similaritiesi
Keywords - Domaini
Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QUIH, Eukaryota |
GeneTreei | ENSGT00530000064198 |
HOGENOMi | CLU_029854_0_0_1 |
InParanoidi | Q5VWK5 |
OMAi | PNMENSN |
OrthoDBi | 144839at2759 |
PhylomeDBi | Q5VWK5 |
TreeFami | TF335930 |
Family and domain databases
Gene3Di | 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR003961, FN3_dom IPR036116, FN3_sf IPR013783, Ig-like_fold |
SUPFAMi | SSF49265, SSF49265, 2 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 2 hits |
s (7+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 7 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 7 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MNQVTIQWDA VIALYILFSW CHGGITNINC SGHIWVEPAT IFKMGMNISI
60 70 80 90 100
YCQAAIKNCQ PRKLHFYKNG IKERFQITRI NKTTARLWYK NFLEPHASMY
110 120 130 140 150
CTAECPKHFQ ETLICGKDIS SGYPPDIPDE VTCVIYEYSG NMTCTWNAGK
160 170 180 190 200
LTYIDTKYVV HVKSLETEEE QQYLTSSYIN ISTDSLQGGK KYLVWVQAAN
210 220 230 240 250
ALGMEESKQL QIHLDDIVIP SAAVISRAET INATVPKTII YWDSQTTIEK
260 270 280 290 300
VSCEMRYKAT TNQTWNVKEF DTNFTYVQQS EFYLEPNIKY VFQVRCQETG
310 320 330 340 350
KRYWQPWSSL FFHKTPETVP QVTSKAFQHD TWNSGLTVAS ISTGHLTSDN
360 370 380 390 400
RGDIGLLLGM IVFAVMLSIL SLIGIFNRSF RTGIKRRILL LIPKWLYEDI
410 420 430 440 450
PNMKNSNVVK MLQENSELMN NNSSEQVLYV DPMITEIKEI FIPEHKPTDY
460 470 480 490 500
KKENTGPLET RDYPQNSLFD NTTVVYIPDL NTGYKPQISN FLPEGSHLSN
510 520 530 540 550
NNEITSLTLK PPVDSLDSGN NPRLQKHPNF AFSVSSVNSL SNTIFLGELS
560 570 580 590 600
LILNQGECSS PDIQNSVEEE TTMLLENDSP SETIPEQTLL PDEFVSCLGI
610 620
VNEELPSINT YFPQNILESH FNRISLLEK
The sequence of this isoform differs from the canonical sequence as follows:
349-356: DNRGDIGL → GLKEGSYC
357-629: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
165-174: LETEEEQQYL → DTFCSRHFQG
175-629: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-365: Missing.
366-383: MLSILSLIGIFNRSFRTG → MEFWANSCFHLYRAPYFW
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A1B0GV19 | A0A1B0GV19_HUMAN | Interleukin-23 receptor | IL23R | 426 | Annotation score: | ||
A0A0D9SFJ7 | A0A0D9SFJ7_HUMAN | Interleukin-23 receptor | IL23R | 71 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 46 | M → T in AAY18346 (PubMed:16372191).Curated | 1 | |
Sequence conflicti | 133 | C → R in AAY18348 (PubMed:16372191).Curated | 1 | |
Sequence conflicti | 302 | R → G in AAY18348 (PubMed:16372191).Curated | 1 | |
Sequence conflicti | 475 | V → A in AAY18347 (PubMed:16372191).Curated | 1 | |
Sequence conflicti | 481 | N → D in AAY18347 (PubMed:16372191).Curated | 1 | |
Sequence conflicti | 581 | S → R in AAY18349 (PubMed:16372191).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_029752 | 3 | Q → H1 PublicationCorresponds to variant dbSNP:rs1884444Ensembl. | 1 | |
Natural variantiVAR_047955 | 175 | T → N. Corresponds to variant dbSNP:rs11465797Ensembl. | 1 | |
Natural variantiVAR_029753 | 310 | L → P5 PublicationsCorresponds to variant dbSNP:rs7530511Ensembl. | 1 | |
Natural variantiVAR_029754 | 381 | R → Q Associated with reduced disease susceptibility; has a protective effect against Crohn disease and psoriasis. 4 PublicationsCorresponds to variant dbSNP:rs11209026EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_021990 | 1 – 402 | Missing in isoform 7. 1 PublicationAdd BLAST | 402 | |
Alternative sequenceiVSP_021991 | 1 – 365 | Missing in isoform 5. 1 PublicationAdd BLAST | 365 | |
Alternative sequenceiVSP_021992 | 1 – 255 | Missing in isoform 6. 1 PublicationAdd BLAST | 255 | |
Alternative sequenceiVSP_021993 | 1 – 254 | Missing in isoform 2. 1 PublicationAdd BLAST | 254 | |
Alternative sequenceiVSP_021994 | 165 – 174 | LETEEEQQYL → DTFCSRHFQG in isoform 4. 1 Publication | 10 | |
Alternative sequenceiVSP_021995 | 175 – 629 | Missing in isoform 4. 1 PublicationAdd BLAST | 455 | |
Alternative sequenceiVSP_021996 | 256 – 266 | RYKATTNQTWN → MILRPYQPCGT in isoform 6. 1 PublicationAdd BLAST | 11 | |
Alternative sequenceiVSP_021997 | 349 – 356 | DNRGDIGL → GLKEGSYC in isoform 3. 1 Publication | 8 | |
Alternative sequenceiVSP_021998 | 357 – 629 | Missing in isoform 3. 1 PublicationAdd BLAST | 273 | |
Alternative sequenceiVSP_021999 | 366 – 383 | MLSIL…SFRTG → MEFWANSCFHLYRAPYFW in isoform 5. 1 PublicationAdd BLAST | 18 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF461422 mRNA Translation: AAM44229.1 AY937250 mRNA Translation: AAY18345.1 AY937251 mRNA Translation: AAY18346.1 AY937252 mRNA Translation: AAY18347.1 AY937253 mRNA Translation: AAY18348.1 AY937254 mRNA Translation: AAY18349.1 AY937255 mRNA Translation: AAY18350.1 AL109843 Genomic DNA No translation available. AL389925 Genomic DNA No translation available. BC016829 mRNA Translation: AAH16829.1 Different initiation. BC040720 mRNA Translation: AAH40720.1 |
CCDSi | CCDS637.1 [Q5VWK5-1] |
RefSeqi | NP_653302.2, NM_144701.2 [Q5VWK5-1] XP_005270573.1, XM_005270516.2 [Q5VWK5-2] XP_011539092.1, XM_011540790.2 [Q5VWK5-1] XP_011539093.1, XM_011540791.2 [Q5VWK5-1] |
Genome annotation databases
Ensembli | ENST00000347310; ENSP00000321345; ENSG00000162594 [Q5VWK5-1] ENST00000395227; ENSP00000378652; ENSG00000162594 [Q5VWK5-7] ENST00000425614; ENSP00000387640; ENSG00000162594 [Q5VWK5-6] |
GeneIDi | 149233 |
KEGGi | hsa:149233 |
UCSCi | uc001ddo.4, human [Q5VWK5-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF461422 mRNA Translation: AAM44229.1 AY937250 mRNA Translation: AAY18345.1 AY937251 mRNA Translation: AAY18346.1 AY937252 mRNA Translation: AAY18347.1 AY937253 mRNA Translation: AAY18348.1 AY937254 mRNA Translation: AAY18349.1 AY937255 mRNA Translation: AAY18350.1 AL109843 Genomic DNA No translation available. AL389925 Genomic DNA No translation available. BC016829 mRNA Translation: AAH16829.1 Different initiation. BC040720 mRNA Translation: AAH40720.1 |
CCDSi | CCDS637.1 [Q5VWK5-1] |
RefSeqi | NP_653302.2, NM_144701.2 [Q5VWK5-1] XP_005270573.1, XM_005270516.2 [Q5VWK5-2] XP_011539092.1, XM_011540790.2 [Q5VWK5-1] XP_011539093.1, XM_011540791.2 [Q5VWK5-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5MZV | X-ray | 2.80 | C | 1-317 | [»] | |
SMRi | Q5VWK5 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 127199, 5 interactors |
ComplexPortali | CPX-383, Interleukin-23-receptor complex |
IntActi | Q5VWK5, 6 interactors |
STRINGi | 9606.ENSP00000321345 |
Chemistry databases
BindingDBi | Q5VWK5 |
ChEMBLi | CHEMBL4296013 |
PTM databases
GlyGeni | Q5VWK5, 8 sites |
iPTMneti | Q5VWK5 |
PhosphoSitePlusi | Q5VWK5 |
Genetic variation databases
BioMutai | IL23R |
DMDMi | 311033431 |
Proteomic databases
MassIVEi | Q5VWK5 |
PaxDbi | Q5VWK5 |
PeptideAtlasi | Q5VWK5 |
PRIDEi | Q5VWK5 |
ProteomicsDBi | 65533 [Q5VWK5-1] 65534 [Q5VWK5-2] 65535 [Q5VWK5-3] 65536 [Q5VWK5-4] 65537 [Q5VWK5-5] 65538 [Q5VWK5-6] 65539 [Q5VWK5-7] |
Protocols and materials databases
ABCDi | Q5VWK5, 3 sequenced antibodies |
Antibodypediai | 33405, 511 antibodies |
DNASUi | 149233 |
Genome annotation databases
Ensembli | ENST00000347310; ENSP00000321345; ENSG00000162594 [Q5VWK5-1] ENST00000395227; ENSP00000378652; ENSG00000162594 [Q5VWK5-7] ENST00000425614; ENSP00000387640; ENSG00000162594 [Q5VWK5-6] |
GeneIDi | 149233 |
KEGGi | hsa:149233 |
UCSCi | uc001ddo.4, human [Q5VWK5-1] |
Organism-specific databases
CTDi | 149233 |
DisGeNETi | 149233 |
GeneCardsi | IL23R |
HGNCi | HGNC:19100, IL23R |
HPAi | ENSG00000162594, Tissue enhanced (blood, lymphoid tissue) |
MalaCardsi | IL23R |
MIMi | 607562, gene 612261, phenotype |
neXtProti | NX_Q5VWK5 |
OpenTargetsi | ENSG00000162594 |
Orphaneti | 117, Behcet disease 206, NON RARE IN EUROPE: Crohn disease 771, NON RARE IN EUROPE: Ulcerative colitis |
PharmGKBi | PA134935109 |
VEuPathDBi | HostDB:ENSG00000162594.14 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QUIH, Eukaryota |
GeneTreei | ENSGT00530000064198 |
HOGENOMi | CLU_029854_0_0_1 |
InParanoidi | Q5VWK5 |
OMAi | PNMENSN |
OrthoDBi | 144839at2759 |
PhylomeDBi | Q5VWK5 |
TreeFami | TF335930 |
Enzyme and pathway databases
PathwayCommonsi | Q5VWK5 |
Reactomei | R-HSA-6785807, Interleukin-4 and Interleukin-13 signaling R-HSA-9020933, Interleukin-23 signaling |
SignaLinki | Q5VWK5 |
SIGNORi | Q5VWK5 |
Miscellaneous databases
BioGRID-ORCSi | 149233, 10 hits in 988 CRISPR screens |
ChiTaRSi | IL23R, human |
GeneWikii | Interleukin-23_receptor |
GenomeRNAii | 149233 |
Pharosi | Q5VWK5, Tbio |
PROi | PR:Q5VWK5 |
RNActi | Q5VWK5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000162594, Expressed in secondary oocyte and 47 other tissues |
ExpressionAtlasi | Q5VWK5, baseline and differential |
Genevisiblei | Q5VWK5, HS |
Family and domain databases
Gene3Di | 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR003961, FN3_dom IPR036116, FN3_sf IPR013783, Ig-like_fold |
SUPFAMi | SSF49265, SSF49265, 2 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IL23R_HUMAN | |
Accessioni | Q5VWK5Primary (citable) accession number: Q5VWK5 Secondary accession number(s): C9JGX4 Q96AS1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 12, 2006 |
Last sequence update: | November 2, 2010 | |
Last modified: | April 7, 2021 | |
This is version 146 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families