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UniProtKB - Q5VWK5 (IL23R_HUMAN)

Protein

Interleukin-23 receptor

Gene

IL23R

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.1 Publication

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionReceptor
Biological processImmunity, Inflammatory response, Innate immunity

Enzyme and pathway databases

ReactomeiR-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-9020933 Interleukin-23 signaling
SignaLinkiQ5VWK5
SIGNORiQ5VWK5

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-23 receptor
Short name:
IL-23 receptor
Short name:
IL-23R
Gene namesi
Name:IL23R
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000162594.14
HGNCiHGNC:19100 IL23R
MIMi607562 gene
neXtProtiNX_Q5VWK5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 355ExtracellularSequence analysisAdd BLAST332
Transmembranei356 – 376HelicalSequence analysisAdd BLAST21
Topological domaini377 – 629CytoplasmicSequence analysisAdd BLAST253

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Inflammatory bowel disease 17 (IBD17)2 Publications
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints.
See also OMIM:612261

Organism-specific databases

DisGeNETi149233
MalaCardsiIL23R
MIMi612261 phenotype
OpenTargetsiENSG00000162594
Orphaneti117 Behcet disease
206 Crohn disease
771 Ulcerative colitis
PharmGKBiPA134935109

Polymorphism and mutation databases

BioMutaiIL23R
DMDMi311033431

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000026866224 – 629Interleukin-23 receptorAdd BLAST606

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi29N-linked (GlcNAc...) asparagine; partial1 Publication1
Glycosylationi47N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi81N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi141N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi180N-linked (GlcNAc...) (high mannose) asparagine1 Publication1
Glycosylationi232N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi262N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi273N-linked (GlcNAc...) asparagine; partial1 Publication1

Post-translational modificationi

Phosphorylated in response to IL23.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ5VWK5
PeptideAtlasiQ5VWK5
PRIDEiQ5VWK5
ProteomicsDBi65533
65534 [Q5VWK5-2]
65535 [Q5VWK5-3]
65536 [Q5VWK5-4]
65537 [Q5VWK5-5]
65538 [Q5VWK5-6]
65539 [Q5VWK5-7]

PTM databases

iPTMnetiQ5VWK5
PhosphoSitePlusiQ5VWK5
UniCarbKBiQ5VWK5

Expressioni

Tissue specificityi

Expressed by monocytes, Th1, Th0, NK and dendritic cells. Isoform 1 is specifically expressed in NK cells.2 Publications

Gene expression databases

BgeeiENSG00000162594 Expressed in 32 organ(s), highest expression level in secondary oocyte
ExpressionAtlasiQ5VWK5 baseline and differential
GenevisibleiQ5VWK5 HS

Organism-specific databases

HPAiHPA056427

Interactioni

Subunit structurei

Heterodimer with IL12RB1. In presence of IL23, the heterodimer forms the IL23 receptor. Interacts with JAK2 and in presence of IL23 with STAT3.1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi127199, 3 interactors
ComplexPortaliCPX-383 Interleukin-23-receptor complex
IntActiQ5VWK5, 6 interactors
STRINGi9606.ENSP00000321345

Structurei

Secondary structure

1629
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ5VWK5
SMRiQ5VWK5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini127 – 217Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST91
Domaini219 – 318Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST100

Sequence similaritiesi

Belongs to the type I cytokine receptor family. Type 2 subfamily.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHH9 Eukaryota
ENOG410YRR7 LUCA
GeneTreeiENSGT00530000064198
HOVERGENiHBG081787
InParanoidiQ5VWK5
KOiK05065
OMAiGNMTCTW
OrthoDBiEOG091G01O8
PhylomeDBiQ5VWK5
TreeFamiTF335930

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
SUPFAMiSSF49265 SSF49265, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 2 hits

Sequences (7+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 2 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: Q5VWK5-1) [UniParc]FASTAAdd to basket
Also known as: IL-23R1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNQVTIQWDA VIALYILFSW CHGGITNINC SGHIWVEPAT IFKMGMNISI 
        60         70         80         90        100
YCQAAIKNCQ PRKLHFYKNG IKERFQITRI NKTTARLWYK NFLEPHASMY 
       110        120        130        140        150
CTAECPKHFQ ETLICGKDIS SGYPPDIPDE VTCVIYEYSG NMTCTWNAGK 
       160        170        180        190        200
LTYIDTKYVV HVKSLETEEE QQYLTSSYIN ISTDSLQGGK KYLVWVQAAN 
       210        220        230        240        250
ALGMEESKQL QIHLDDIVIP SAAVISRAET INATVPKTII YWDSQTTIEK 
       260        270        280        290        300
VSCEMRYKAT TNQTWNVKEF DTNFTYVQQS EFYLEPNIKY VFQVRCQETG 
       310        320        330        340        350
KRYWQPWSSL FFHKTPETVP QVTSKAFQHD TWNSGLTVAS ISTGHLTSDN 
       360        370        380        390        400
RGDIGLLLGM IVFAVMLSIL SLIGIFNRSF RTGIKRRILL LIPKWLYEDI 
       410        420        430        440        450
PNMKNSNVVK MLQENSELMN NNSSEQVLYV DPMITEIKEI FIPEHKPTDY 
       460        470        480        490        500
KKENTGPLET RDYPQNSLFD NTTVVYIPDL NTGYKPQISN FLPEGSHLSN 
       510        520        530        540        550
NNEITSLTLK PPVDSLDSGN NPRLQKHPNF AFSVSSVNSL SNTIFLGELS 
       560        570        580        590        600
LILNQGECSS PDIQNSVEEE TTMLLENDSP SETIPEQTLL PDEFVSCLGI 
       610        620 
VNEELPSINT YFPQNILESH FNRISLLEK
Length:629
Mass (Da):71,722
Last modified:November 2, 2010 - v3
Checksum:iAC63C89E81AABF05
GO
Isoform 2 (identifier: Q5VWK5-2) [UniParc]FASTAAdd to basket
Also known as: IL-23R2-F2

The sequence of this isoform differs from the canonical sequence as follows:
     1-254: Missing.

Note: Produced by translation in an alternate frame of the cDNA encoding isoform 4. No experimental confirmation available.
Show »
Length:375
Mass (Da):42,822
Checksum:iF6436B1432AD56A9
GO
Isoform 3 (identifier: Q5VWK5-3) [UniParc]FASTAAdd to basket
Also known as: IL-23R3-F1

The sequence of this isoform differs from the canonical sequence as follows:
     349-356: DNRGDIGL → GLKEGSYC
     357-629: Missing.

Note: Produced by translation in an alternate frame of the cDNA encoding isoform 5. No experimental confirmation available.
Show »
Length:356
Mass (Da):40,859
Checksum:iD9A98F0E8F380490
GO
Isoform 4 (identifier: Q5VWK5-4) [UniParc]FASTAAdd to basket
Also known as: IL-23R2-F1

The sequence of this isoform differs from the canonical sequence as follows:
     165-174: LETEEEQQYL → DTFCSRHFQG
     175-629: Missing.

Note: Produced by translation in an alternate frame of the cDNA encoding isoform 2. No experimental confirmation available.
Show »
Length:174
Mass (Da):20,068
Checksum:i2F45099F46F673A5
GO
Isoform 5 (identifier: Q5VWK5-5) [UniParc]FASTAAdd to basket
Also known as: IL-23R3-F3

The sequence of this isoform differs from the canonical sequence as follows:
     1-365: Missing.
     366-383: MLSILSLIGIFNRSFRTG → MEFWANSCFHLYRAPYFW

Note: Produced by translation in an alternate frame of the cDNA encoding isoform 3. No experimental confirmation available.
Show »
Length:264
Mass (Da):30,278
Checksum:i1695194600E3DABF
GO
Isoform 6 (identifier: Q5VWK5-6) [UniParc]FASTAAdd to basket
Also known as: IL-23R6

The sequence of this isoform differs from the canonical sequence as follows:
     1-255: Missing.
     256-266: RYKATTNQTWN → MILRPYQPCGT

Note: No experimental confirmation available.
Show »
Length:374
Mass (Da):42,587
Checksum:iFCB35A2F849DA5F7
GO
Isoform 7 (identifier: Q5VWK5-7) [UniParc]FASTAAdd to basket
Also known as: IL-23R5

The sequence of this isoform differs from the canonical sequence as follows:
     1-402: Missing.

Note: No experimental confirmation available.
Show »
Length:227
Mass (Da):25,551
Checksum:i43A70A48046FA1F2
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1B0GV19A0A1B0GV19_HUMAN
Interleukin-23 receptor
IL23R
426Annotation score:
A0A0D9SFJ7A0A0D9SFJ7_HUMAN
Interleukin-23 receptor
IL23R
71Annotation score:

Sequence cautioni

The sequence AAH16829 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti46M → T in AAY18346 (PubMed:16372191).Curated1
Sequence conflicti133C → R in AAY18348 (PubMed:16372191).Curated1
Sequence conflicti302R → G in AAY18348 (PubMed:16372191).Curated1
Sequence conflicti475V → A in AAY18347 (PubMed:16372191).Curated1
Sequence conflicti481N → D in AAY18347 (PubMed:16372191).Curated1
Sequence conflicti581S → R in AAY18349 (PubMed:16372191).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0297523Q → H1 PublicationCorresponds to variant dbSNP:rs1884444Ensembl.1
Natural variantiVAR_047955175T → N. Corresponds to variant dbSNP:rs11465797Ensembl.1
Natural variantiVAR_029753310L → P5 PublicationsCorresponds to variant dbSNP:rs7530511Ensembl.1
Natural variantiVAR_029754381R → Q Polymorphism; associated with reduced disease susceptibility; has a protective effect against Crohn disease and psoriasis. 4 PublicationsCorresponds to variant dbSNP:rs11209026EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0219901 – 402Missing in isoform 7. 1 PublicationAdd BLAST402
Alternative sequenceiVSP_0219911 – 365Missing in isoform 5. 1 PublicationAdd BLAST365
Alternative sequenceiVSP_0219921 – 255Missing in isoform 6. 1 PublicationAdd BLAST255
Alternative sequenceiVSP_0219931 – 254Missing in isoform 2. 1 PublicationAdd BLAST254
Alternative sequenceiVSP_021994165 – 174LETEEEQQYL → DTFCSRHFQG in isoform 4. 1 Publication10
Alternative sequenceiVSP_021995175 – 629Missing in isoform 4. 1 PublicationAdd BLAST455
Alternative sequenceiVSP_021996256 – 266RYKATTNQTWN → MILRPYQPCGT in isoform 6. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_021997349 – 356DNRGDIGL → GLKEGSYC in isoform 3. 1 Publication8
Alternative sequenceiVSP_021998357 – 629Missing in isoform 3. 1 PublicationAdd BLAST273
Alternative sequenceiVSP_021999366 – 383MLSIL…SFRTG → MEFWANSCFHLYRAPYFW in isoform 5. 1 PublicationAdd BLAST18

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF461422 mRNA Translation: AAM44229.1
AY937250 mRNA Translation: AAY18345.1
AY937251 mRNA Translation: AAY18346.1
AY937252 mRNA Translation: AAY18347.1
AY937253 mRNA Translation: AAY18348.1
AY937254 mRNA Translation: AAY18349.1
AY937255 mRNA Translation: AAY18350.1
AL109843 Genomic DNA No translation available.
AL389925 Genomic DNA No translation available.
BC016829 mRNA Translation: AAH16829.1 Different initiation.
BC040720 mRNA Translation: AAH40720.1
CCDSiCCDS637.1 [Q5VWK5-1]
RefSeqiNP_653302.2, NM_144701.2 [Q5VWK5-1]
XP_005270573.1, XM_005270516.2 [Q5VWK5-2]
XP_011539092.1, XM_011540790.2 [Q5VWK5-1]
XP_011539093.1, XM_011540791.2 [Q5VWK5-1]
UniGeneiHs.677426

Genome annotation databases

EnsembliENST00000347310; ENSP00000321345; ENSG00000162594 [Q5VWK5-1]
ENST00000395227; ENSP00000378652; ENSG00000162594 [Q5VWK5-7]
ENST00000425614; ENSP00000387640; ENSG00000162594 [Q5VWK5-6]
GeneIDi149233
KEGGihsa:149233
UCSCiuc001ddo.4 human [Q5VWK5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiIL23R_HUMAN
AccessioniPrimary (citable) accession number: Q5VWK5
Secondary accession number(s): C9JGX4
, Q4VGP1, Q4VGP2, Q4VGP3, Q4VGP4, Q4VGP5, Q4VGP6, Q5VWK7, Q8IW84, Q8NFQ9, Q96AS1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: November 2, 2010
Last modified: September 12, 2018
This is version 132 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health

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