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Protein

Sorting nexin-30

Gene

SNX30

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in several stages of intracellular trafficking.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-30
Gene namesi
Name:SNX30
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000148158.16
HGNCiHGNC:23685 SNX30
neXtProtiNX_Q5VWJ9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi401548
OpenTargetsiENSG00000148158
PharmGKBiPA142670889

Polymorphism and mutation databases

BioMutaiSNX30
DMDMi74747407

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002845331 – 437Sorting nexin-30Add BLAST437

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei38PhosphothreonineBy similarity1
Modified residuei40PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ5VWJ9
MaxQBiQ5VWJ9
PaxDbiQ5VWJ9
PeptideAtlasiQ5VWJ9
PRIDEiQ5VWJ9
ProteomicsDBi65531

PTM databases

iPTMnetiQ5VWJ9
PhosphoSitePlusiQ5VWJ9

Expressioni

Gene expression databases

BgeeiENSG00000148158
CleanExiHS_SNX30
ExpressionAtlasiQ5VWJ9 baseline and differential
GenevisibleiQ5VWJ9 HS

Organism-specific databases

HPAiHPA019346

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SNX4O952192EBI-8099676,EBI-724909

Protein-protein interaction databases

BioGridi135142, 6 interactors
IntActiQ5VWJ9, 4 interactors
MINTiQ5VWJ9
STRINGi9606.ENSP00000363349

Structurei

3D structure databases

ProteinModelPortaliQ5VWJ9
SMRiQ5VWJ9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini89 – 210PXPROSITE-ProRule annotationAdd BLAST122

Sequence similaritiesi

Belongs to the sorting nexin family.Curated

Phylogenomic databases

eggNOGiKOG2273 Eukaryota
COG5391 LUCA
GeneTreeiENSGT00910000144107
HOGENOMiHOG000010283
HOVERGENiHBG009723
InParanoidiQ5VWJ9
KOiK17921
OMAiQRMEYVR
OrthoDBiEOG091G08JS
PhylomeDBiQ5VWJ9
TreeFamiTF328543

Family and domain databases

Gene3Di1.20.1270.60, 1 hit
3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR004148 BAR_dom
IPR001683 Phox
IPR036871 PX_dom_sf
IPR028649 SNX30
PANTHERiPTHR10555:SF123 PTHR10555:SF123, 1 hit
PfamiView protein in Pfam
PF03114 BAR, 1 hit
PF00787 PX, 1 hit
SMARTiView protein in SMART
SM00312 PX, 1 hit
SUPFAMiSSF103657 SSF103657, 1 hit
SSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50195 PX, 1 hit

Sequencei

Sequence statusi: Complete.

Q5VWJ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGGPPKALP STGPHSLRDM PHPLAGSSSE EAVGGDSTPS PDLLMARSFG
60 70 80 90 100
DKDLILPNGG TPAGTSSPAS SSSLLNRLQL DDDIDGETRD LFVIVDDPKK
110 120 130 140 150
HVCTMETYIT YRITTKSTRV EFDLPEYSVR RRYQDFDWLR SKLEESQPTH
160 170 180 190 200
LIPPLPEKFV VKGVVDRFSE EFVETRRKAL DKFLKRITDH PVLSFNEHFN
210 220 230 240 250
IFLTAKDLNA YKKQGIALLT RMGESVKHVT GGYKLRTRPL EFAAIGDYLD
260 270 280 290 300
TFALKLGTID RIAQRIIKEE IEYLVELREY GPVYSTWSAL EGELAEPLEG
310 320 330 340 350
VSACIGNCST ALEELTDDMT EDFLPVLREY ILYSDSMKSV LKKRDQVQAE
360 370 380 390 400
YEAKLEAVAL RKEDRPKVPA DVEKCQDRME CFNADLKADM ERWQNNKRQD
410 420 430
FRQLLMGMAD KNIQYYEKCL MAWESIIPLL QEKQEAK
Length:437
Mass (Da):49,677
Last modified:December 7, 2004 - v1
Checksum:i32496ED341C5E9A4
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03177183D → H. Corresponds to variant dbSNP:rs2796036Ensembl.1
Natural variantiVAR_052483125P → A. Corresponds to variant dbSNP:rs10117709Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL390067 Genomic DNA No translation available.
AL360235 Genomic DNA No translation available.
AL139041 Genomic DNA No translation available.
CCDSiCCDS43865.1
RefSeqiNP_001013012.1, NM_001012994.1
UniGeneiHs.522350

Genome annotation databases

EnsembliENST00000374232; ENSP00000363349; ENSG00000148158
GeneIDi401548
KEGGihsa:401548
UCSCiuc004bgj.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSNX30_HUMAN
AccessioniPrimary (citable) accession number: Q5VWJ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: December 7, 2004
Last modified: July 18, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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