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UniProtKB - Q5VWG9 (TAF3_HUMAN)

Entry version 162 (25 May 2022)
Sequence version 1 (07 Dec 2004)
Previous versions | rss
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Protein

Transcription initiation factor TFIID subunit 3

Gene

TAF3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473).

TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473).

The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473).

The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C (PubMed:33795473).

TAF3 forms the TFIID-A module together with TAF5 and TBP (PubMed:33795473).

Required in complex with TBPL2 for the differentiation of myoblasts into myocytes (PubMed:11438666).

The TAF3-TBPL2 complex replaces TFIID at specific promoters at an early stage in the differentiation process (PubMed:11438666).

2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi868Zinc 1Combined sources1
Metal bindingi871Zinc 1Combined sources1
Metal bindingi883Zinc 2Combined sources1
Metal bindingi886Zinc 2Combined sources1
Metal bindingi891Zinc 1; via pros nitrogenCombined sources1
Metal bindingi894Zinc 1Combined sources1
Metal bindingi909Zinc 2Combined sources1
Metal bindingi912Zinc 2Combined sources1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri865 – 915PHD-typePROSITE-ProRule annotationAdd BLAST51

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q5VWG9

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-167161, HIV Transcription Initiation
R-HSA-167162, RNA Polymerase II HIV Promoter Escape
R-HSA-167172, Transcription of the HIV genome
R-HSA-674695, RNA Polymerase II Pre-transcription Events
R-HSA-6804756, Regulation of TP53 Activity through Phosphorylation
R-HSA-73776, RNA Polymerase II Promoter Escape
R-HSA-73779, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-HSA-75953, RNA Polymerase II Transcription Initiation
R-HSA-76042, RNA Polymerase II Transcription Initiation And Promoter Clearance

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q5VWG9

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q5VWG9

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcription initiation factor TFIID subunit 3
Alternative name(s):
140 kDa TATA box-binding protein-associated factor
TBP-associated factor 3
Transcription initiation factor TFIID 140 kDa subunit
Short name:
TAF(II)140
Short name:
TAF140
Short name:
TAFII-140
Short name:
TAFII140
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TAF3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:17303, TAF3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		606576, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q5VWG9

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000165632

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi23W → R: Loss of interaction with TAF10. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		83860

Open Targets

More...OpenTargetsi		ENSG00000165632

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA38222

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q5VWG9, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4523329

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TAF3

Domain mapping of disease mutations (DMDM)

More...DMDMi		74747393

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002455281 – 929Transcription initiation factor TFIID subunit 3Add BLAST929

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei183PhosphoserineCombined sources1
Modified residuei199PhosphoserineCombined sources1
Modified residuei229PhosphoserineCombined sources1
Modified residuei243PhosphoserineCombined sources1
Modified residuei266N6-acetyllysineCombined sources1
Modified residuei291PhosphoserineCombined sources1
Modified residuei297PhosphoserineCombined sources1
Modified residuei301PhosphoserineCombined sources1
Modified residuei501PhosphothreonineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki581Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei667PhosphoserineCombined sources1
Cross-linki746Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei755PhosphoserineCombined sources1
Modified residuei776N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q5VWG9

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q5VWG9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q5VWG9

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q5VWG9

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q5VWG9

PeptideAtlas

More...PeptideAtlasi		Q5VWG9

PRoteomics IDEntifications database

More...PRIDEi		Q5VWG9

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		65526

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q5VWG9

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q5VWG9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q5VWG9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000165632, Expressed in tendon of biceps brachii and 223 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q5VWG9, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000165632, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the TFIID basal transcription factor complex, composed of TATA-box-binding protein TBP, and a number of TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473).

Interacts with TAF10 via the histone fold (PubMed:11438666).

Interacts with TAF13, TBP, SAP130 and GCN5L2 (PubMed:11438666).

Interacts with TBPL2 (PubMed:11438666).

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		123775, 62 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-915, General transcription factor complex TFIID
CPX-930, General transcription factor complex TFIID, TAF4B variant

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q5VWG9

Database of interacting proteins

More...DIPi		DIP-38920N

Protein interaction database and analysis system

More...IntActi		Q5VWG9, 22 interactors

Molecular INTeraction database

More...MINTi		Q5VWG9

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000340271

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q5VWG9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1929
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q5VWG9

Biological Magnetic Resonance Data Bank

More...BMRBi		Q5VWG9

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q5VWG9

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni131 – 152DisorderedSequence analysisAdd BLAST22
Regioni176 – 197DisorderedSequence analysisAdd BLAST22
Regioni221 – 358DisorderedSequence analysisAdd BLAST138
Regioni405 – 578DisorderedSequence analysisAdd BLAST174
Regioni603 – 658DisorderedSequence analysisAdd BLAST56
Regioni692 – 748DisorderedSequence analysisAdd BLAST57
Regioni778 – 807DisorderedSequence analysisAdd BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi176 – 194Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi260 – 297Polar residuesSequence analysisAdd BLAST38
Compositional biasi317 – 358Polar residuesSequence analysisAdd BLAST42
Compositional biasi414 – 467Polar residuesSequence analysisAdd BLAST54
Compositional biasi488 – 502Pro residuesSequence analysisAdd BLAST15
Compositional biasi505 – 526Basic and acidic residuesSequence analysisAdd BLAST22
Compositional biasi534 – 578Basic and acidic residuesSequence analysisAdd BLAST45
Compositional biasi603 – 648Basic and acidic residuesSequence analysisAdd BLAST46
Compositional biasi710 – 748Basic and acidic residuesSequence analysisAdd BLAST39
Compositional biasi785 – 807Pro residuesSequence analysisAdd BLAST23

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PHD-type zinc finger mediates binding to histone H3 methyllysine at position 4 (H3K4me3).By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TAF3 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri865 – 915PHD-typePROSITE-ProRule annotationAdd BLAST51

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1973, Eukaryota
KOG2389, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00710000106806

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_014486_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q5VWG9

Identification of Orthologs from Complete Genome Data

More...OMAi		FPQPGAR

Database of Orthologous Groups

More...OrthoDBi		826756at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q5VWG9

TreeFam database of animal gene trees

More...TreeFami		TF316513

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.20.10, 1 hit
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR006565, BTP
IPR009072, Histone-fold
IPR019786, Zinc_finger_PHD-type_CS
IPR011011, Znf_FYVE_PHD
IPR001965, Znf_PHD
IPR019787, Znf_PHD-finger
IPR013083, Znf_RING/FYVE/PHD

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07524, Bromo_TP, 1 hit
PF00628, PHD, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00576, BTP, 1 hit
SM00249, PHD, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57903, SSF57903, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01359, ZF_PHD_1, 1 hit
PS50016, ZF_PHD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q5VWG9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCESYSRSLL RVSVAQICQA LGWDSVQLSA CHLLTDVLQR YLQQLGRGCH 
        60         70         80         90        100
RYSELYGRTD PILDDVGEAF QLMGVSLHEL EDYIHNIEPV TFPHQIPSFP 
       110        120        130        140        150
VSKNNVLQFP QPGSKDAEER KEYIPDYLPP IVSSQEEEEE EQVPTDGGTS 
       160        170        180        190        200
AEAMQVPLEE DDELEEEEII NDENFLGKRP LDSPEAEELP AMKRPRLLST 
       210        220        230        240        250
KGDTLDVVLL EAREPLSSIN TQKIPPMLSP VHVQDSTDLA PPSPEPPMLA 
       260        270        280        290        300
PVAKSQMPTA KPLETKSFTP KTKTKTSSPG QKTKSPKTAQ SPAMVGSPIR 
       310        320        330        340        350
SPKTVSKEKK SPGRSKSPKS PKSPKVTTHI PQTPVRPETP NRTPSATLSE 
       360        370        380        390        400
KISKETIQVK QIQTPPDAGK LNSENQPKKA VVADKTIEAS IDAVIARACA 
       410        420        430        440        450
EREPDPFEFS SGSESEGDIF TSPKRISGPE CTTPKASTSA NNFTKSGSTP 
       460        470        480        490        500
LPLSGGTSSS DNSWTMDASI DEVVRKAKLG TPSNMPPNFP YISSPSVSPP 
       510        520        530        540        550
TPEPLHKVYE EKTKLPSSVE VKKKLKKELK TKMKKKEKQR DREREKDKNK 
       560        570        580        590        600
DKSKEKDKVK EKEKDKETGR ETKYPWKEFL KEEEADPYKF KIKEFEDVDP 
       610        620        630        640        650
KVKLKDGLVR KEKEKHKDKK KDREKGKKDK DKREKEKVKD KGREDKMKAP 
       660        670        680        690        700
APPLVLPPKE LALPLFSPAT ASRVPAMLPS LLPVLPEKLF EEKEKVKEKE 
       710        720        730        740        750
KKKDKKEKKK KKEKEKEKKE KEREKEKRER EKREKEKEKH KHEKIKVEPV 
       760        770        780        790        800
ALAPSPVIPR LTLRVGAGQD KIVISKVVPA PEAKPAPSQN RPKTPPPAPA 
       810        820        830        840        850
PAPGPMLVSP APVPLPLLAQ AAAGPALLPS PGPAASGASA KAPVRSVVTE 
       860        870        880        890        900
TVSTYVIRDE WGNQIWICPG CNKPDDGSPM IGCDDCDDWY HWPCVGIMTA 
       910        920 
PPEEMQWFCP KCANKKKDKK HKKRKHRAH
Length:929
Mass (Da):103,582
Last modified:December 7, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC951754B5B532E72
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A8I5KR98A0A8I5KR98_HUMAN
Transcription initiation factor TFI...
TAF3
928Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A8I5QJF0A0A8I5QJF0_HUMAN
Transcription initiation factor TFI...
TAF3
146Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH45106 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH62352 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH73884 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti23 – 25WDS → TRP in CAB56032 (PubMed:17974005).Curated3
Sequence conflicti533M → K in AAH73884 (PubMed:15489334).Curated1
Sequence conflicti537 – 539EKQ → KKK in AAH17320 (PubMed:15489334).Curated3
Sequence conflicti696V → P in AAH62352 (PubMed:15489334).Curated1
Sequence conflicti700E → K in CAB56032 (PubMed:17974005).Curated1
Sequence conflicti707E → K in AAH62352 (PubMed:15489334).Curated1
Sequence conflicti713E → K in AAH62352 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_052254349S → T. Corresponds to variant dbSNP:rs17366712Ensembl.1
Natural variantiVAR_052255442N → S1 PublicationCorresponds to variant dbSNP:rs4747647Ensembl.1
Natural variantiVAR_052256696V → A1 PublicationCorresponds to variant dbSNP:rs1244229Ensembl.1
Natural variantiVAR_052257696V → L. Corresponds to variant dbSNP:rs10795583Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AJ292190 mRNA Translation: CAC34475.1
AL390294 Genomic DNA No translation available.
AL353754 Genomic DNA No translation available.
AL159172 Genomic DNA No translation available.
BC017320 mRNA Translation: AAH17320.1
BC045106 mRNA Translation: AAH45106.1 Sequence problems.
BC073884 mRNA Translation: AAH73884.1 Different initiation.
BC062352 mRNA Translation: AAH62352.1 Different initiation.
AL117661 mRNA Translation: CAB56032.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS41487.1

Protein sequence database of the Protein Information Resource

More...PIRi		T17342

NCBI Reference Sequences

More...RefSeqi		NP_114129.1, NM_031923.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000344293.6; ENSP00000340271.5; ENSG00000165632.9

Database of genes from NCBI RefSeq genomes

More...GeneIDi		83860

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:83860

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000344293.6; ENSP00000340271.5; NM_031923.4; NP_114129.1

UCSC genome browser

More...UCSCi		uc010qbd.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ292190 mRNA Translation: CAC34475.1
AL390294 Genomic DNA No translation available.
AL353754 Genomic DNA No translation available.
AL159172 Genomic DNA No translation available.
BC017320 mRNA Translation: AAH17320.1
BC045106 mRNA Translation: AAH45106.1 Sequence problems.
BC073884 mRNA Translation: AAH73884.1 Different initiation.
BC062352 mRNA Translation: AAH62352.1 Different initiation.
AL117661 mRNA Translation: CAB56032.1
CCDSiCCDS41487.1
PIRiT17342
RefSeqiNP_114129.1, NM_031923.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5C13X-ray2.10A/C/E/G855-915[»]
5WXGX-ray1.70A853-915[»]
5WXHX-ray1.30A/C853-915[»]
5XMYX-ray1.70A/C853-915[»]
6MZDelectron microscopy9.80C1-929[»]
6MZLelectron microscopy23.00C1-929[»]
7EDXelectron microscopy4.50c1-929[»]
7EG7electron microscopy6.20c1-929[»]
7EG8electron microscopy7.40c1-929[»]
7EG9electron microscopy3.70c1-929[»]
7EGAelectron microscopy4.10c1-929[»]
7EGBelectron microscopy3.30c1-929[»]
7EGCelectron microscopy3.90c1-929[»]
7EGDelectron microscopy6.75c1-929[»]
7EGEelectron microscopy9.00c1-929[»]
7EGFelectron microscopy3.16c1-929[»]
7EGIelectron microscopy9.82c1-929[»]
7EGJelectron microscopy8.64c1-929[»]
7ENAelectron microscopy4.07Dc1-929[»]
7ENCelectron microscopy4.13Dc1-929[»]
AlphaFoldDBiQ5VWG9
BMRBiQ5VWG9
SMRiQ5VWG9
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi123775, 62 interactors
ComplexPortaliCPX-915, General transcription factor complex TFIID
CPX-930, General transcription factor complex TFIID, TAF4B variant
CORUMiQ5VWG9
DIPiDIP-38920N
IntActiQ5VWG9, 22 interactors
MINTiQ5VWG9
STRINGi9606.ENSP00000340271

Chemistry databases

ChEMBLiCHEMBL4523329

PTM databases

iPTMnetiQ5VWG9
MetOSiteiQ5VWG9
PhosphoSitePlusiQ5VWG9

Genetic variation databases

BioMutaiTAF3
DMDMi74747393

Proteomic databases

EPDiQ5VWG9
jPOSTiQ5VWG9
MassIVEiQ5VWG9
MaxQBiQ5VWG9
PaxDbiQ5VWG9
PeptideAtlasiQ5VWG9
PRIDEiQ5VWG9
ProteomicsDBi65526

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		24519, 137 antibodies from 26 providers

The DNASU plasmid repository

More...DNASUi		83860

Genome annotation databases

EnsembliENST00000344293.6; ENSP00000340271.5; ENSG00000165632.9
GeneIDi83860
KEGGihsa:83860
MANE-SelectiENST00000344293.6; ENSP00000340271.5; NM_031923.4; NP_114129.1
UCSCiuc010qbd.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		83860
DisGeNETi83860

GeneCards: human genes, protein and diseases

More...GeneCardsi		TAF3
HGNCiHGNC:17303, TAF3
HPAiENSG00000165632, Low tissue specificity
MIMi606576, gene
neXtProtiNX_Q5VWG9
OpenTargetsiENSG00000165632
PharmGKBiPA38222
VEuPathDBiHostDB:ENSG00000165632

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1973, Eukaryota
KOG2389, Eukaryota
GeneTreeiENSGT00710000106806
HOGENOMiCLU_014486_0_0_1
InParanoidiQ5VWG9
OMAiFPQPGAR
OrthoDBi826756at2759
PhylomeDBiQ5VWG9
TreeFamiTF316513

Enzyme and pathway databases

PathwayCommonsiQ5VWG9
ReactomeiR-HSA-167161, HIV Transcription Initiation
R-HSA-167162, RNA Polymerase II HIV Promoter Escape
R-HSA-167172, Transcription of the HIV genome
R-HSA-674695, RNA Polymerase II Pre-transcription Events
R-HSA-6804756, Regulation of TP53 Activity through Phosphorylation
R-HSA-73776, RNA Polymerase II Promoter Escape
R-HSA-73779, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-HSA-75953, RNA Polymerase II Transcription Initiation
R-HSA-76042, RNA Polymerase II Transcription Initiation And Promoter Clearance
SignaLinkiQ5VWG9
SIGNORiQ5VWG9

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		83860, 186 hits in 1098 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TAF3, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		TAF3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		83860
PharosiQ5VWG9, Tbio

Protein Ontology

More...PROi		PR:Q5VWG9
RNActiQ5VWG9, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000165632, Expressed in tendon of biceps brachii and 223 other tissues
GenevisibleiQ5VWG9, HS

Family and domain databases

Gene3Di1.10.20.10, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR006565, BTP
IPR009072, Histone-fold
IPR019786, Zinc_finger_PHD-type_CS
IPR011011, Znf_FYVE_PHD
IPR001965, Znf_PHD
IPR019787, Znf_PHD-finger
IPR013083, Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF07524, Bromo_TP, 1 hit
PF00628, PHD, 1 hit
SMARTiView protein in SMART
SM00576, BTP, 1 hit
SM00249, PHD, 1 hit
SUPFAMiSSF57903, SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS01359, ZF_PHD_1, 1 hit
PS50016, ZF_PHD_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTAF3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5VWG9
Secondary accession number(s): Q05DA0
, Q6GMS5, Q6P6B5, Q86VY6, Q9BQS9, Q9UFI8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: December 7, 2004
Last modified: May 25, 2022
This is version 162 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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