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UniProtKB - Q5VW38 (GP107_HUMAN)

Entry version 140 (29 Sep 2021)
Sequence version 1 (07 Dec 2004)
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Protein

Protein GPR107

Gene

GPR107

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Has been proposed to act as a receptor for neuronostatin, a peptide derived from the somatostatin/SST precursor (PubMed:22933024).

Involved in blood sugar regulation through the induction of glucagon in response to low glucose (By similarity).

By similarity1 Publication

(Microbial infection) Required for intoxication by Pseudomonas aeruginosa exotoxin A and Campylobacter jejuni CDT. May contribute to the retrograde transport of bacterial toxins, including cholera toxin, from the trans-Golgi network to the endoplasmic reticulum.

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q5VW38

Protein family/group databases

Transport Classification Database

More...TCDBi		9.A.14.22.2, the g-protein-coupled receptor (gpcr) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein GPR107
Alternative name(s):
Lung seven transmembrane receptor 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GPR107
Synonyms:KIAA1624, LUSTR1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:17830, GPR107

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		618490, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q5VW38

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000148358

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini40 – 263ExtracellularSequence analysisAdd BLAST224
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei264 – 284Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini285 – 293CytoplasmicSequence analysis9
Transmembranei294 – 314Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini315 – 337ExtracellularSequence analysisAdd BLAST23
Transmembranei338 – 358Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini359 – 368CytoplasmicSequence analysis10
Transmembranei369 – 389Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini390 – 402ExtracellularSequence analysisAdd BLAST13
Transmembranei403 – 423Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini424 – 498CytoplasmicSequence analysisAdd BLAST75
Transmembranei499 – 519Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini520 – 524ExtracellularSequence analysis5
Transmembranei525 – 544Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini545 – 600CytoplasmicSequence analysisAdd BLAST56

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi182R → A: Loss of furin cleavage. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		57720

Open Targets

More...OpenTargetsi		ENSG00000148358

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA28854

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q5VW38, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		GPR107

Domain mapping of disease mutations (DMDM)

More...DMDMi		68565572

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 39Sequence analysisAdd BLAST39
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002134040 – 600Protein GPR107Add BLAST561

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi70N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi109 ↔ 2281 Publication
Glycosylationi169N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi211N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Cleaved by FURIN to yield two fragments of 17 and 35 kDa that remain associated via a disulfide bond.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q5VW38

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q5VW38

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q5VW38

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q5VW38

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q5VW38

PeptideAtlas

More...PeptideAtlasi		Q5VW38

PRoteomics IDEntifications database

More...PRIDEi		Q5VW38

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		65517 [Q5VW38-1]
65518 [Q5VW38-2]
65519 [Q5VW38-3]

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		1660, 2 N-Linked glycans (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q5VW38, 3 sites, 1 N-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q5VW38

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q5VW38

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000148358, Expressed in corpus callosum and 255 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q5VW38, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q5VW38, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000148358, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		121743, 19 interactors

Protein interaction database and analysis system

More...IntActi		Q5VW38, 8 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000361483

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q5VW38, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni157 – 185DisorderedSequence analysisAdd BLAST29

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi157 – 178Polar residuesSequence analysisAdd BLAST22

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the LU7TM family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2569, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160451

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_020277_4_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q5VW38

Identification of Orthologs from Complete Genome Data

More...OMAi		AEPQGEW

Database of Orthologous Groups

More...OrthoDBi		1427067at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q5VW38

TreeFam database of animal gene trees

More...TreeFami		TF314804

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR009637, GPR107/GPR108-like

The PANTHER Classification System

More...PANTHERi		PTHR21229, PTHR21229, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF06814, Lung_7-TM_R, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5VW38-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAALAPVGSP ASRGPRLAAG LRLLPMLGLL QLLAEPGLGR VHHLALKDDV 
        60         70         80         90        100
RHKVHLNTFG FFKDGYMVVN VSSLSLNEPE DKDVTIGFSL DRTKNDGFSS 
       110        120        130        140        150
YLDEDVNYCI LKKQSVSVTL LILDISRSEV RVKSPPEAGT QLPKIIFSRD 
       160        170        180        190        200
EKVLGQSQEP NVNPASAGNQ TQKTQDGGKS KRSTVDSKAM GEKSFSVHNN 
       210        220        230        240        250
GGAVSFQFFF NISTDDQEGL YSLYFHKCLG KELPSDKFTF SLDIEITEKN 
       260        270        280        290        300
PDSYLSAGEI PLPKLYISMA FFFFLSGTIW IHILRKRRND VFKIHWLMAA 
       310        320        330        340        350
LPFTKSLSLV FHAIDYHYIS SQGFPIEGWA VVYYITHLLK GALLFITIAL 
       360        370        380        390        400
IGTGWAFIKH ILSDKDKKIF MIVIPLQVLA NVAYIIIEST EEGTTEYGLW 
       410        420        430        440        450
KDSLFLVDLL CCGAILFPVV WSIRHLQEAS ATDGKGDSMG PLQQRANLRA 
       460        470        480        490        500
GSRIESHHFA QADLELLASS CPPASVSQRA GITAAINLAK LKLFRHYYVL 
       510        520        530        540        550
IVCYIYFTRI IAFLLKLAVP FQWKWLYQLL DETATLVFFV LTGYKFRPAS 
       560        570        580        590        600
DNPYLQLSQE EEDLEMESVV TTSGVMESMK KVKKVTNGSV EPQGEWEGAV
Length:600
Mass (Da):66,990
Last modified:December 7, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i679D414C0EB9F205
GO
Isoform 2 (identifier: Q5VW38-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     436-483: Missing.

Show »
Length:552
Mass (Da):61,976
Checksum:iC5BD664C167B2230
GO
Isoform 3 (identifier: Q5VW38-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     298-300: MAA → GFH
     301-600: Missing.

Show »
Length:300
Mass (Da):33,384
Checksum:i27ED28675ABF911B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G5E994G5E994_HUMAN
G protein-coupled receptor 107, iso...
GPR107 hCG_1810895
571Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
U3KQD2U3KQD2_HUMAN
Protein GPR107
GPR107
128Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti250N → D in BAB15408 (PubMed:14702039).Curated1
Sequence conflicti457H → R in BAB13450 (PubMed:10997877).Curated1
Sequence conflicti461Q → R in BAB13450 (PubMed:10997877).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_030863189A → P. Corresponds to variant dbSNP:rs640343Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_014434298 – 300MAA → GFH in isoform 3. 1 Publication3
Alternative sequenceiVSP_014435301 – 600Missing in isoform 3. 1 PublicationAdd BLAST300
Alternative sequenceiVSP_014436436 – 483Missing in isoform 2. 3 PublicationsAdd BLAST48

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF376725 mRNA Translation: AAK57695.1
AK026244 mRNA Translation: BAB15408.1
AL136141 Genomic DNA No translation available.
AL360004 Genomic DNA No translation available.
AL392105 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87924.1
BC110518 mRNA Translation: AAI10519.1
AB046844 mRNA Translation: BAB13450.1
AL834359 mRNA Translation: CAI46205.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS35162.1 [Q5VW38-2]
CCDS48041.1 [Q5VW38-1]

NCBI Reference Sequences

More...RefSeqi		NP_001130029.1, NM_001136557.1 [Q5VW38-1]
NP_001130030.1, NM_001136558.1
NP_066011.2, NM_020960.4 [Q5VW38-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000347136; ENSP00000336988; ENSG00000148358 [Q5VW38-2]
ENST00000372406; ENSP00000361483; ENSG00000148358 [Q5VW38-1]
ENST00000610997; ENSP00000483750; ENSG00000148358 [Q5VW38-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		57720

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:57720

UCSC genome browser

More...UCSCi		uc004bzd.3, human [Q5VW38-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF376725 mRNA Translation: AAK57695.1
AK026244 mRNA Translation: BAB15408.1
AL136141 Genomic DNA No translation available.
AL360004 Genomic DNA No translation available.
AL392105 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87924.1
BC110518 mRNA Translation: AAI10519.1
AB046844 mRNA Translation: BAB13450.1
AL834359 mRNA Translation: CAI46205.1
CCDSiCCDS35162.1 [Q5VW38-2]
CCDS48041.1 [Q5VW38-1]
RefSeqiNP_001130029.1, NM_001136557.1 [Q5VW38-1]
NP_001130030.1, NM_001136558.1
NP_066011.2, NM_020960.4 [Q5VW38-2]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi121743, 19 interactors
IntActiQ5VW38, 8 interactors
STRINGi9606.ENSP00000361483

Protein family/group databases

TCDBi9.A.14.22.2, the g-protein-coupled receptor (gpcr) family

PTM databases

GlyConnecti1660, 2 N-Linked glycans (1 site)
GlyGeniQ5VW38, 3 sites, 1 N-linked glycan (1 site)
iPTMnetiQ5VW38
PhosphoSitePlusiQ5VW38

Genetic variation databases

BioMutaiGPR107
DMDMi68565572

Proteomic databases

EPDiQ5VW38
jPOSTiQ5VW38
MassIVEiQ5VW38
MaxQBiQ5VW38
PaxDbiQ5VW38
PeptideAtlasiQ5VW38
PRIDEiQ5VW38
ProteomicsDBi65517 [Q5VW38-1]
65518 [Q5VW38-2]
65519 [Q5VW38-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		31467, 150 antibodies

The DNASU plasmid repository

More...DNASUi		57720

Genome annotation databases

EnsembliENST00000347136; ENSP00000336988; ENSG00000148358 [Q5VW38-2]
ENST00000372406; ENSP00000361483; ENSG00000148358 [Q5VW38-1]
ENST00000610997; ENSP00000483750; ENSG00000148358 [Q5VW38-1]
GeneIDi57720
KEGGihsa:57720
UCSCiuc004bzd.3, human [Q5VW38-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		57720
DisGeNETi57720

GeneCards: human genes, protein and diseases

More...GeneCardsi		GPR107
HGNCiHGNC:17830, GPR107
HPAiENSG00000148358, Low tissue specificity
MIMi618490, gene
neXtProtiNX_Q5VW38
OpenTargetsiENSG00000148358
PharmGKBiPA28854
VEuPathDBiHostDB:ENSG00000148358

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2569, Eukaryota
GeneTreeiENSGT00940000160451
HOGENOMiCLU_020277_4_1_1
InParanoidiQ5VW38
OMAiAEPQGEW
OrthoDBi1427067at2759
PhylomeDBiQ5VW38
TreeFamiTF314804

Enzyme and pathway databases

PathwayCommonsiQ5VW38

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		57720, 12 hits in 1020 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		GPR107, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		GPR107

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		57720
PharosiQ5VW38, Tbio

Protein Ontology

More...PROi		PR:Q5VW38
RNActiQ5VW38, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000148358, Expressed in corpus callosum and 255 other tissues
ExpressionAtlasiQ5VW38, baseline and differential
GenevisibleiQ5VW38, HS

Family and domain databases

InterProiView protein in InterPro
IPR009637, GPR107/GPR108-like
PANTHERiPTHR21229, PTHR21229, 1 hit
PfamiView protein in Pfam
PF06814, Lung_7-TM_R, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGP107_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5VW38
Secondary accession number(s): A6NJ53
, Q2TB81, Q5JPA3, Q5VW39, Q96T26, Q9H658, Q9HCE8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: December 7, 2004
Last modified: September 29, 2021
This is version 140 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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