UniProtKB - Q5VW38 (GP107_HUMAN)
Protein
Protein GPR107
Gene
GPR107
Organism
Homo sapiens (Human)
Status
Functioni
Has been proposed to act as a receptor for neuronostatin, a peptide derived from the somatostatin/SST precursor (PubMed:22933024). Involved in blood sugar regulation through the induction of glucagon in response to low glucose (By similarity).By similarity1 Publication
(Microbial infection) Required for intoxication by Pseudomonas aeruginosa exotoxin A and Campylobacter jejuni CDT. May contribute to the retrograde transport of bacterial toxins, including cholera toxin, from the trans-Golgi network to the endoplasmic reticulum.1 Publication
GO - Molecular functioni
- clathrin heavy chain binding Source: GO_Central
GO - Biological processi
- clathrin-dependent endocytosis Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | Q5VW38 |
Protein family/group databases
TCDBi | 9.A.14.22.2, the g-protein-coupled receptor (gpcr) family |
Names & Taxonomyi
Protein namesi | Recommended name: Protein GPR107Alternative name(s): Lung seven transmembrane receptor 1 |
Gene namesi | Name:GPR107 Synonyms:KIAA1624, LUSTR1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000148358.19 |
HGNCi | HGNC:17830, GPR107 |
MIMi | 618490, gene |
neXtProti | NX_Q5VW38 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein Curated
Golgi apparatus
- trans-Golgi network membrane 1 Publication
Endosome
- early endosome Source: Ensembl
Golgi apparatus
- Golgi apparatus Source: HPA
Nucleus
- nucleoplasm Source: HPA
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- clathrin-coated vesicle Source: GO_Central
- integral component of membrane Source: UniProtKB-KW
- membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 40 – 263 | ExtracellularSequence analysisAdd BLAST | 224 | |
Transmembranei | 264 – 284 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 285 – 293 | CytoplasmicSequence analysis | 9 | |
Transmembranei | 294 – 314 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 315 – 337 | ExtracellularSequence analysisAdd BLAST | 23 | |
Transmembranei | 338 – 358 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 359 – 368 | CytoplasmicSequence analysis | 10 | |
Transmembranei | 369 – 389 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 390 – 402 | ExtracellularSequence analysisAdd BLAST | 13 | |
Transmembranei | 403 – 423 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 424 – 498 | CytoplasmicSequence analysisAdd BLAST | 75 | |
Transmembranei | 499 – 519 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 520 – 524 | ExtracellularSequence analysis | 5 | |
Transmembranei | 525 – 544 | Helical; Name=7Sequence analysisAdd BLAST | 20 | |
Topological domaini | 545 – 600 | CytoplasmicSequence analysisAdd BLAST | 56 |
Keywords - Cellular componenti
Cell membrane, Golgi apparatus, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 182 | R → A: Loss of furin cleavage. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 57720 |
OpenTargetsi | ENSG00000148358 |
PharmGKBi | PA28854 |
Miscellaneous databases
Pharosi | Q5VW38, Tdark |
Polymorphism and mutation databases
BioMutai | GPR107 |
DMDMi | 68565572 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 39 | Sequence analysisAdd BLAST | 39 | |
ChainiPRO_0000021340 | 40 – 600 | Protein GPR107Add BLAST | 561 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 70 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 109 ↔ 228 | 1 Publication | ||
Glycosylationi | 169 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 211 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
Cleaved by FURIN to yield two fragments of 17 and 35 kDa that remain associated via a disulfide bond.1 Publication
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
EPDi | Q5VW38 |
jPOSTi | Q5VW38 |
MassIVEi | Q5VW38 |
MaxQBi | Q5VW38 |
PaxDbi | Q5VW38 |
PeptideAtlasi | Q5VW38 |
PRIDEi | Q5VW38 |
ProteomicsDBi | 65517 [Q5VW38-1] 65518 [Q5VW38-2] 65519 [Q5VW38-3] |
PTM databases
GlyConnecti | 1660, 2 N-Linked glycans (1 site) |
GlyGeni | Q5VW38, 3 sites |
iPTMneti | Q5VW38 |
PhosphoSitePlusi | Q5VW38 |
Expressioni
Gene expression databases
Bgeei | ENSG00000148358, Expressed in corpus callosum and 254 other tissues |
ExpressionAtlasi | Q5VW38, baseline and differential |
Genevisiblei | Q5VW38, HS |
Organism-specific databases
HPAi | ENSG00000148358, Low tissue specificity |
Interactioni
GO - Molecular functioni
- clathrin heavy chain binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 121743, 14 interactors |
IntActi | Q5VW38, 8 interactors |
STRINGi | 9606.ENSP00000361483 |
Miscellaneous databases
RNActi | Q5VW38, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the LU7TM family.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2569, Eukaryota |
GeneTreei | ENSGT00940000160451 |
HOGENOMi | CLU_020277_4_1_1 |
InParanoidi | Q5VW38 |
OMAi | VMEGMKK |
OrthoDBi | 1427067at2759 |
PhylomeDBi | Q5VW38 |
TreeFami | TF314804 |
Family and domain databases
InterProi | View protein in InterPro IPR009637, GPR107/GPR108-like |
PANTHERi | PTHR21229, PTHR21229, 1 hit |
Pfami | View protein in Pfam PF06814, Lung_7-TM_R, 2 hits |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q5VW38-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAALAPVGSP ASRGPRLAAG LRLLPMLGLL QLLAEPGLGR VHHLALKDDV
60 70 80 90 100
RHKVHLNTFG FFKDGYMVVN VSSLSLNEPE DKDVTIGFSL DRTKNDGFSS
110 120 130 140 150
YLDEDVNYCI LKKQSVSVTL LILDISRSEV RVKSPPEAGT QLPKIIFSRD
160 170 180 190 200
EKVLGQSQEP NVNPASAGNQ TQKTQDGGKS KRSTVDSKAM GEKSFSVHNN
210 220 230 240 250
GGAVSFQFFF NISTDDQEGL YSLYFHKCLG KELPSDKFTF SLDIEITEKN
260 270 280 290 300
PDSYLSAGEI PLPKLYISMA FFFFLSGTIW IHILRKRRND VFKIHWLMAA
310 320 330 340 350
LPFTKSLSLV FHAIDYHYIS SQGFPIEGWA VVYYITHLLK GALLFITIAL
360 370 380 390 400
IGTGWAFIKH ILSDKDKKIF MIVIPLQVLA NVAYIIIEST EEGTTEYGLW
410 420 430 440 450
KDSLFLVDLL CCGAILFPVV WSIRHLQEAS ATDGKGDSMG PLQQRANLRA
460 470 480 490 500
GSRIESHHFA QADLELLASS CPPASVSQRA GITAAINLAK LKLFRHYYVL
510 520 530 540 550
IVCYIYFTRI IAFLLKLAVP FQWKWLYQLL DETATLVFFV LTGYKFRPAS
560 570 580 590 600
DNPYLQLSQE EEDLEMESVV TTSGVMESMK KVKKVTNGSV EPQGEWEGAV
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketG5E994 | G5E994_HUMAN | G protein-coupled receptor 107, iso... | GPR107 hCG_1810895 | 571 | Annotation score: | ||
U3KQD2 | U3KQD2_HUMAN | Protein GPR107 | GPR107 | 128 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 250 | N → D in BAB15408 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 457 | H → R in BAB13450 (PubMed:10997877).Curated | 1 | |
Sequence conflicti | 461 | Q → R in BAB13450 (PubMed:10997877).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_030863 | 189 | A → P. Corresponds to variant dbSNP:rs640343Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_014434 | 298 – 300 | MAA → GFH in isoform 3. 1 Publication | 3 | |
Alternative sequenceiVSP_014435 | 301 – 600 | Missing in isoform 3. 1 PublicationAdd BLAST | 300 | |
Alternative sequenceiVSP_014436 | 436 – 483 | Missing in isoform 2. 3 PublicationsAdd BLAST | 48 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF376725 mRNA Translation: AAK57695.1 AK026244 mRNA Translation: BAB15408.1 AL136141 Genomic DNA No translation available. AL360004 Genomic DNA No translation available. AL392105 Genomic DNA No translation available. CH471090 Genomic DNA Translation: EAW87924.1 BC110518 mRNA Translation: AAI10519.1 AB046844 mRNA Translation: BAB13450.1 AL834359 mRNA Translation: CAI46205.1 |
CCDSi | CCDS35162.1 [Q5VW38-2] CCDS48041.1 [Q5VW38-1] |
RefSeqi | NP_001130029.1, NM_001136557.1 [Q5VW38-1] NP_001130030.1, NM_001136558.1 NP_066011.2, NM_020960.4 [Q5VW38-2] |
Genome annotation databases
Ensembli | ENST00000347136; ENSP00000336988; ENSG00000148358 [Q5VW38-2] ENST00000372406; ENSP00000361483; ENSG00000148358 [Q5VW38-1] ENST00000610997; ENSP00000483750; ENSG00000148358 [Q5VW38-1] |
GeneIDi | 57720 |
KEGGi | hsa:57720 |
UCSCi | uc004bzd.3, human [Q5VW38-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF376725 mRNA Translation: AAK57695.1 AK026244 mRNA Translation: BAB15408.1 AL136141 Genomic DNA No translation available. AL360004 Genomic DNA No translation available. AL392105 Genomic DNA No translation available. CH471090 Genomic DNA Translation: EAW87924.1 BC110518 mRNA Translation: AAI10519.1 AB046844 mRNA Translation: BAB13450.1 AL834359 mRNA Translation: CAI46205.1 |
CCDSi | CCDS35162.1 [Q5VW38-2] CCDS48041.1 [Q5VW38-1] |
RefSeqi | NP_001130029.1, NM_001136557.1 [Q5VW38-1] NP_001130030.1, NM_001136558.1 NP_066011.2, NM_020960.4 [Q5VW38-2] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 121743, 14 interactors |
IntActi | Q5VW38, 8 interactors |
STRINGi | 9606.ENSP00000361483 |
Protein family/group databases
TCDBi | 9.A.14.22.2, the g-protein-coupled receptor (gpcr) family |
PTM databases
GlyConnecti | 1660, 2 N-Linked glycans (1 site) |
GlyGeni | Q5VW38, 3 sites |
iPTMneti | Q5VW38 |
PhosphoSitePlusi | Q5VW38 |
Polymorphism and mutation databases
BioMutai | GPR107 |
DMDMi | 68565572 |
Proteomic databases
EPDi | Q5VW38 |
jPOSTi | Q5VW38 |
MassIVEi | Q5VW38 |
MaxQBi | Q5VW38 |
PaxDbi | Q5VW38 |
PeptideAtlasi | Q5VW38 |
PRIDEi | Q5VW38 |
ProteomicsDBi | 65517 [Q5VW38-1] 65518 [Q5VW38-2] 65519 [Q5VW38-3] |
Protocols and materials databases
Antibodypediai | 31467, 140 antibodies |
Genome annotation databases
Ensembli | ENST00000347136; ENSP00000336988; ENSG00000148358 [Q5VW38-2] ENST00000372406; ENSP00000361483; ENSG00000148358 [Q5VW38-1] ENST00000610997; ENSP00000483750; ENSG00000148358 [Q5VW38-1] |
GeneIDi | 57720 |
KEGGi | hsa:57720 |
UCSCi | uc004bzd.3, human [Q5VW38-1] |
Organism-specific databases
CTDi | 57720 |
DisGeNETi | 57720 |
EuPathDBi | HostDB:ENSG00000148358.19 |
GeneCardsi | GPR107 |
HGNCi | HGNC:17830, GPR107 |
HPAi | ENSG00000148358, Low tissue specificity |
MIMi | 618490, gene |
neXtProti | NX_Q5VW38 |
OpenTargetsi | ENSG00000148358 |
PharmGKBi | PA28854 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2569, Eukaryota |
GeneTreei | ENSGT00940000160451 |
HOGENOMi | CLU_020277_4_1_1 |
InParanoidi | Q5VW38 |
OMAi | VMEGMKK |
OrthoDBi | 1427067at2759 |
PhylomeDBi | Q5VW38 |
TreeFami | TF314804 |
Enzyme and pathway databases
PathwayCommonsi | Q5VW38 |
Miscellaneous databases
BioGRID-ORCSi | 57720, 9 hits in 846 CRISPR screens |
ChiTaRSi | GPR107, human |
GeneWikii | GPR107 |
GenomeRNAii | 57720 |
Pharosi | Q5VW38, Tdark |
PROi | PR:Q5VW38 |
RNActi | Q5VW38, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000148358, Expressed in corpus callosum and 254 other tissues |
ExpressionAtlasi | Q5VW38, baseline and differential |
Genevisiblei | Q5VW38, HS |
Family and domain databases
InterProi | View protein in InterPro IPR009637, GPR107/GPR108-like |
PANTHERi | PTHR21229, PTHR21229, 1 hit |
Pfami | View protein in Pfam PF06814, Lung_7-TM_R, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GP107_HUMAN | |
Accessioni | Q5VW38Primary (citable) accession number: Q5VW38 Secondary accession number(s): A6NJ53 Q9HCE8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 5, 2005 |
Last sequence update: | December 7, 2004 | |
Last modified: | December 2, 2020 | |
This is version 136 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations