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Protein

Protein GPR107

Gene

GPR107

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in Golgi-to-ER retrograde transport. Functions as a host factor required for infection by Pseudomonas aeruginosa exotoxin A and Campylobacter jejuni CDT toxins.1 Publication

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Protein GPR107
Alternative name(s):
Lung seven transmembrane receptor 1
Gene namesi
Name:GPR107
Synonyms:KIAA1624, LUSTR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000148358.19
HGNCiHGNC:17830 GPR107
neXtProtiNX_Q5VW38

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini40 – 263LumenalSequence analysisAdd BLAST224
Transmembranei264 – 284Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini285 – 293CytoplasmicSequence analysis9
Transmembranei294 – 314Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini315 – 337LumenalSequence analysisAdd BLAST23
Transmembranei338 – 358Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini359 – 368CytoplasmicSequence analysis10
Transmembranei369 – 389Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini390 – 402LumenalSequence analysisAdd BLAST13
Transmembranei403 – 423Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini424 – 498CytoplasmicSequence analysisAdd BLAST75
Transmembranei499 – 519Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini520 – 524LumenalSequence analysis5
Transmembranei525 – 544Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini545 – 600CytoplasmicSequence analysisAdd BLAST56

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi182R → A: Abolishes proteolytic cleavage. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000148358
PharmGKBiPA28854

Polymorphism and mutation databases

BioMutaiGPR107
DMDMi68565572

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 39Sequence analysisAdd BLAST39
ChainiPRO_000002134040 – 600Protein GPR107Add BLAST561

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi70N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi109 ↔ 2281 Publication
Glycosylationi169N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi211N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Cleaved by a furin endopeptidase to yield two fragments of 17 and 35 kDa that remain associated via a disulfide bond.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ5VW38
MaxQBiQ5VW38
PaxDbiQ5VW38
PeptideAtlasiQ5VW38
PRIDEiQ5VW38
ProteomicsDBi65517
65518 [Q5VW38-2]
65519 [Q5VW38-3]

PTM databases

GlyConnecti1660
iPTMnetiQ5VW38
PhosphoSitePlusiQ5VW38

Expressioni

Gene expression databases

BgeeiENSG00000148358 Expressed in 244 organ(s), highest expression level in corpus callosum
CleanExiHS_GPR107
ExpressionAtlasiQ5VW38 baseline and differential
GenevisibleiQ5VW38 HS

Organism-specific databases

HPAiHPA031704

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi121743, 10 interactors
IntActiQ5VW38, 2 interactors

Structurei

3D structure databases

ProteinModelPortaliQ5VW38
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LU7TM family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2569 Eukaryota
ENOG410XQAQ LUCA
GeneTreeiENSGT00390000008649
HOVERGENiHBG056147
InParanoidiQ5VW38
OMAiLYFHKCS
OrthoDBiEOG091G05OJ
PhylomeDBiQ5VW38
TreeFamiTF314804

Family and domain databases

InterProiView protein in InterPro
IPR009637 GPR107-like
PANTHERiPTHR21229 PTHR21229, 1 hit
PfamiView protein in Pfam
PF06814 Lung_7-TM_R, 2 hits

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5VW38-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAALAPVGSP ASRGPRLAAG LRLLPMLGLL QLLAEPGLGR VHHLALKDDV
60 70 80 90 100
RHKVHLNTFG FFKDGYMVVN VSSLSLNEPE DKDVTIGFSL DRTKNDGFSS
110 120 130 140 150
YLDEDVNYCI LKKQSVSVTL LILDISRSEV RVKSPPEAGT QLPKIIFSRD
160 170 180 190 200
EKVLGQSQEP NVNPASAGNQ TQKTQDGGKS KRSTVDSKAM GEKSFSVHNN
210 220 230 240 250
GGAVSFQFFF NISTDDQEGL YSLYFHKCLG KELPSDKFTF SLDIEITEKN
260 270 280 290 300
PDSYLSAGEI PLPKLYISMA FFFFLSGTIW IHILRKRRND VFKIHWLMAA
310 320 330 340 350
LPFTKSLSLV FHAIDYHYIS SQGFPIEGWA VVYYITHLLK GALLFITIAL
360 370 380 390 400
IGTGWAFIKH ILSDKDKKIF MIVIPLQVLA NVAYIIIEST EEGTTEYGLW
410 420 430 440 450
KDSLFLVDLL CCGAILFPVV WSIRHLQEAS ATDGKGDSMG PLQQRANLRA
460 470 480 490 500
GSRIESHHFA QADLELLASS CPPASVSQRA GITAAINLAK LKLFRHYYVL
510 520 530 540 550
IVCYIYFTRI IAFLLKLAVP FQWKWLYQLL DETATLVFFV LTGYKFRPAS
560 570 580 590 600
DNPYLQLSQE EEDLEMESVV TTSGVMESMK KVKKVTNGSV EPQGEWEGAV
Length:600
Mass (Da):66,990
Last modified:December 7, 2004 - v1
Checksum:i679D414C0EB9F205
GO
Isoform 2 (identifier: Q5VW38-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     436-483: Missing.

Show »
Length:552
Mass (Da):61,976
Checksum:iC5BD664C167B2230
GO
Isoform 3 (identifier: Q5VW38-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     298-300: MAA → GFH
     301-600: Missing.

Note: No experimental confirmation available.
Show »
Length:300
Mass (Da):33,384
Checksum:i27ED28675ABF911B
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G5E994G5E994_HUMAN
G protein-coupled receptor 107, iso...
GPR107 hCG_1810895
571Annotation score:
U3KQD2U3KQD2_HUMAN
Protein GPR107
GPR107
128Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti250N → D in BAB15408 (PubMed:14702039).Curated1
Sequence conflicti457H → R in BAB13450 (PubMed:10997877).Curated1
Sequence conflicti461Q → R in BAB13450 (PubMed:10997877).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_030863189A → P. Corresponds to variant dbSNP:rs640343Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_014434298 – 300MAA → GFH in isoform 3. 1 Publication3
Alternative sequenceiVSP_014435301 – 600Missing in isoform 3. 1 PublicationAdd BLAST300
Alternative sequenceiVSP_014436436 – 483Missing in isoform 2. 3 PublicationsAdd BLAST48

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF376725 mRNA Translation: AAK57695.1
AK026244 mRNA Translation: BAB15408.1
AL136141 Genomic DNA No translation available.
AL360004 Genomic DNA No translation available.
AL392105 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87924.1
BC110518 mRNA Translation: AAI10519.1
AB046844 mRNA Translation: BAB13450.1
AL834359 mRNA Translation: CAI46205.1 Sequence problems.
CCDSiCCDS35162.1 [Q5VW38-2]
CCDS48041.1 [Q5VW38-1]
RefSeqiNP_001130029.1, NM_001136557.1 [Q5VW38-1]
NP_001130030.1, NM_001136558.1
NP_066011.2, NM_020960.4 [Q5VW38-2]
UniGeneiHs.512461

Genome annotation databases

EnsembliENST00000347136; ENSP00000336988; ENSG00000148358 [Q5VW38-2]
ENST00000372406; ENSP00000361483; ENSG00000148358 [Q5VW38-1]
ENST00000610997; ENSP00000483750; ENSG00000148358 [Q5VW38-1]
GeneIDi57720
KEGGihsa:57720
UCSCiuc004bzd.3 human [Q5VW38-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF376725 mRNA Translation: AAK57695.1
AK026244 mRNA Translation: BAB15408.1
AL136141 Genomic DNA No translation available.
AL360004 Genomic DNA No translation available.
AL392105 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87924.1
BC110518 mRNA Translation: AAI10519.1
AB046844 mRNA Translation: BAB13450.1
AL834359 mRNA Translation: CAI46205.1 Sequence problems.
CCDSiCCDS35162.1 [Q5VW38-2]
CCDS48041.1 [Q5VW38-1]
RefSeqiNP_001130029.1, NM_001136557.1 [Q5VW38-1]
NP_001130030.1, NM_001136558.1
NP_066011.2, NM_020960.4 [Q5VW38-2]
UniGeneiHs.512461

3D structure databases

ProteinModelPortaliQ5VW38
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121743, 10 interactors
IntActiQ5VW38, 2 interactors

PTM databases

GlyConnecti1660
iPTMnetiQ5VW38
PhosphoSitePlusiQ5VW38

Polymorphism and mutation databases

BioMutaiGPR107
DMDMi68565572

Proteomic databases

EPDiQ5VW38
MaxQBiQ5VW38
PaxDbiQ5VW38
PeptideAtlasiQ5VW38
PRIDEiQ5VW38
ProteomicsDBi65517
65518 [Q5VW38-2]
65519 [Q5VW38-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000347136; ENSP00000336988; ENSG00000148358 [Q5VW38-2]
ENST00000372406; ENSP00000361483; ENSG00000148358 [Q5VW38-1]
ENST00000610997; ENSP00000483750; ENSG00000148358 [Q5VW38-1]
GeneIDi57720
KEGGihsa:57720
UCSCiuc004bzd.3 human [Q5VW38-1]

Organism-specific databases

CTDi57720
EuPathDBiHostDB:ENSG00000148358.19
GeneCardsiGPR107
HGNCiHGNC:17830 GPR107
HPAiHPA031704
neXtProtiNX_Q5VW38
OpenTargetsiENSG00000148358
PharmGKBiPA28854
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2569 Eukaryota
ENOG410XQAQ LUCA
GeneTreeiENSGT00390000008649
HOVERGENiHBG056147
InParanoidiQ5VW38
OMAiLYFHKCS
OrthoDBiEOG091G05OJ
PhylomeDBiQ5VW38
TreeFamiTF314804

Miscellaneous databases

ChiTaRSiGPR107 human
GeneWikiiGPR107
GenomeRNAii57720
PROiPR:Q5VW38

Gene expression databases

BgeeiENSG00000148358 Expressed in 244 organ(s), highest expression level in corpus callosum
CleanExiHS_GPR107
ExpressionAtlasiQ5VW38 baseline and differential
GenevisibleiQ5VW38 HS

Family and domain databases

InterProiView protein in InterPro
IPR009637 GPR107-like
PANTHERiPTHR21229 PTHR21229, 1 hit
PfamiView protein in Pfam
PF06814 Lung_7-TM_R, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiGP107_HUMAN
AccessioniPrimary (citable) accession number: Q5VW38
Secondary accession number(s): A6NJ53
, Q2TB81, Q5JPA3, Q5VW39, Q96T26, Q9H658, Q9HCE8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: December 7, 2004
Last modified: November 7, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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