UniProtKB - Q5VW38 (GP107_HUMAN)

BLAST

>sp|Q5VW38|GP107_HUMAN Protein GPR107 OS=Homo sapiens OX=9606 GN=GPR107 PE=1 SV=1
MAALAPVGSPASRGPRLAAGLRLLPMLGLLQLLAEPGLGRVHHLALKDDVRHKVHLNTFG
FFKDGYMVVNVSSLSLNEPEDKDVTIGFSLDRTKNDGFSSYLDEDVNYCILKKQSVSVTL
LILDISRSEVRVKSPPEAGTQLPKIIFSRDEKVLGQSQEPNVNPASAGNQTQKTQDGGKS
KRSTVDSKAMGEKSFSVHNNGGAVSFQFFFNISTDDQEGLYSLYFHKCLGKELPSDKFTF
SLDIEITEKNPDSYLSAGEIPLPKLYISMAFFFFLSGTIWIHILRKRRNDVFKIHWLMAA
LPFTKSLSLVFHAIDYHYISSQGFPIEGWAVVYYITHLLKGALLFITIALIGTGWAFIKH
ILSDKDKKIFMIVIPLQVLANVAYIIIESTEEGTTEYGLWKDSLFLVDLLCCGAILFPVV
WSIRHLQEASATDGKGDSMGPLQQRANLRAGSRIESHHFAQADLELLASSCPPASVSQRA
GITAAINLAKLKLFRHYYVLIVCYIYFTRIIAFLLKLAVPFQWKWLYQLLDETATLVFFV
LTGYKFRPASDNPYLQLSQEEEDLEMESVVTTSGVMESMKKVKKVTNGSVEPQGEWEGAV

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History
Entry version 120 (07 Nov 2018)
Sequence version 1 (07 Dec 2004)
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Protein

Protein GPR107

Gene

GPR107

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Involved in Golgi-to-ER retrograde transport. Functions as a host factor required for infection by Pseudomonas aeruginosa exotoxin A and Campylobacter jejuni CDT toxins.1 Publication

GO - Molecular functionⁱ

clathrin heavy chain binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

clathrin-dependent endocytosis Source: Ensembl

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein GPR107 Alternative name(s): Lung seven transmembrane receptor 1
Gene namesⁱ	Name:GPR107 Synonyms:KIAA1624, LUSTR1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 9

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000148358.19
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:17830 GPR107
neXtProtⁱ	NX_Q5VW38

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	40 – 263	LumenalSequence analysisAdd BLAST	224
Transmembraneⁱ	264 – 284	Helical; Name=1Sequence analysisAdd BLAST	21
Topological domainⁱ	285 – 293	CytoplasmicSequence analysis	9
Transmembraneⁱ	294 – 314	Helical; Name=2Sequence analysisAdd BLAST	21
Topological domainⁱ	315 – 337	LumenalSequence analysisAdd BLAST	23
Transmembraneⁱ	338 – 358	Helical; Name=3Sequence analysisAdd BLAST	21
Topological domainⁱ	359 – 368	CytoplasmicSequence analysis	10
Transmembraneⁱ	369 – 389	Helical; Name=4Sequence analysisAdd BLAST	21
Topological domainⁱ	390 – 402	LumenalSequence analysisAdd BLAST	13
Transmembraneⁱ	403 – 423	Helical; Name=5Sequence analysisAdd BLAST	21
Topological domainⁱ	424 – 498	CytoplasmicSequence analysisAdd BLAST	75
Transmembraneⁱ	499 – 519	Helical; Name=6Sequence analysisAdd BLAST	21
Topological domainⁱ	520 – 524	LumenalSequence analysis	5
Transmembraneⁱ	525 – 544	Helical; Name=7Sequence analysisAdd BLAST	20
Topological domainⁱ	545 – 600	CytoplasmicSequence analysisAdd BLAST	56

Keywords - Cellular componentⁱ

Golgi apparatus, Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	182	R → A: Abolishes proteolytic cleavage. 1 Publication		1

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000148358
PharmGKBⁱ	PA28854

Polymorphism and mutation databases

BioMutaⁱ	GPR107
DMDMⁱ	68565572

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 39	Sequence analysisAdd BLAST		39
ChainⁱPRO_0000021340	40 – 600	Protein GPR107Add BLAST		561

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	70	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	109 ↔ 228	1 Publication
Glycosylationⁱ	169	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	211	N-linked (GlcNAc...) asparagineSequence analysis	1

Post-translational modificationⁱ

Cleaved by a furin endopeptidase to yield two fragments of 17 and 35 kDa that remain associated via a disulfide bond.1 Publication

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

EPDⁱ	Q5VW38
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q5VW38
PaxDbⁱ	Q5VW38
PeptideAtlas More...PeptideAtlasⁱ	Q5VW38
PRIDEⁱ	Q5VW38
ProteomicsDBⁱ	65517 65518 [Q5VW38-2] 65519 [Q5VW38-3]

PTM databases

GlyConnectⁱ	1660
iPTMnetⁱ	Q5VW38
PhosphoSitePlusⁱ	Q5VW38

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000148358 Expressed in 244 organ(s), highest expression level in corpus callosum
CleanExⁱ	HS_GPR107
ExpressionAtlasⁱ	Q5VW38 baseline and differential
Genevisibleⁱ	Q5VW38 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA031704

HPAⁱ

HPA031704

Interactionⁱ

GO - Molecular functionⁱ

clathrin heavy chain binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	121743, 10 interactors
IntActⁱ	Q5VW38, 2 interactors

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q5VW38
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the LU7TM family.Curated

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG2569 Eukaryota ENOG410XQAQ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000008649
HOVERGENⁱ	HBG056147
InParanoidⁱ	Q5VW38
OMAⁱ	LYFHKCS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05OJ
PhylomeDBⁱ	Q5VW38
TreeFamⁱ	TF314804

Family and domain databases

InterProⁱ	View protein in InterPro IPR009637 GPR107-like
PANTHERⁱ	PTHR21229 PTHR21229, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF06814 Lung_7-TM_R, 2 hits

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q5VW38-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAALAPVGSP ASRGPRLAAG LRLLPMLGLL QLLAEPGLGR VHHLALKDDV 
        60         70         80         90        100
RHKVHLNTFG FFKDGYMVVN VSSLSLNEPE DKDVTIGFSL DRTKNDGFSS 
       110        120        130        140        150
YLDEDVNYCI LKKQSVSVTL LILDISRSEV RVKSPPEAGT QLPKIIFSRD 
       160        170        180        190        200
EKVLGQSQEP NVNPASAGNQ TQKTQDGGKS KRSTVDSKAM GEKSFSVHNN 
       210        220        230        240        250
GGAVSFQFFF NISTDDQEGL YSLYFHKCLG KELPSDKFTF SLDIEITEKN 
       260        270        280        290        300
PDSYLSAGEI PLPKLYISMA FFFFLSGTIW IHILRKRRND VFKIHWLMAA 
       310        320        330        340        350
LPFTKSLSLV FHAIDYHYIS SQGFPIEGWA VVYYITHLLK GALLFITIAL 
       360        370        380        390        400
IGTGWAFIKH ILSDKDKKIF MIVIPLQVLA NVAYIIIEST EEGTTEYGLW 
       410        420        430        440        450
KDSLFLVDLL CCGAILFPVV WSIRHLQEAS ATDGKGDSMG PLQQRANLRA 
       460        470        480        490        500
GSRIESHHFA QADLELLASS CPPASVSQRA GITAAINLAK LKLFRHYYVL 
       510        520        530        540        550
IVCYIYFTRI IAFLLKLAVP FQWKWLYQLL DETATLVFFV LTGYKFRPAS 
       560        570        580        590        600
DNPYLQLSQE EEDLEMESVV TTSGVMESMK KVKKVTNGSV EPQGEWEGAV

Length:600

Mass (Da):66,990

Last modified:December 7, 2004 - v1

Checksum:ⁱ679D414C0EB9F205

Isoform 2 (identifier: Q5VW38-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
436-483: Missing.

« Hide

        10         20         30         40         50
MAALAPVGSP ASRGPRLAAG LRLLPMLGLL QLLAEPGLGR VHHLALKDDV 
        60         70         80         90        100
RHKVHLNTFG FFKDGYMVVN VSSLSLNEPE DKDVTIGFSL DRTKNDGFSS 
       110        120        130        140        150
YLDEDVNYCI LKKQSVSVTL LILDISRSEV RVKSPPEAGT QLPKIIFSRD 
       160        170        180        190        200
EKVLGQSQEP NVNPASAGNQ TQKTQDGGKS KRSTVDSKAM GEKSFSVHNN 
       210        220        230        240        250
GGAVSFQFFF NISTDDQEGL YSLYFHKCLG KELPSDKFTF SLDIEITEKN 
       260        270        280        290        300
PDSYLSAGEI PLPKLYISMA FFFFLSGTIW IHILRKRRND VFKIHWLMAA 
       310        320        330        340        350
LPFTKSLSLV FHAIDYHYIS SQGFPIEGWA VVYYITHLLK GALLFITIAL 
       360        370        380        390        400
IGTGWAFIKH ILSDKDKKIF MIVIPLQVLA NVAYIIIEST EEGTTEYGLW 
       410        420        430        440        450
KDSLFLVDLL CCGAILFPVV WSIRHLQEAS ATDGKAAINL AKLKLFRHYY 
       460        470        480        490        500
VLIVCYIYFT RIIAFLLKLA VPFQWKWLYQ LLDETATLVF FVLTGYKFRP 
       510        520        530        540        550
ASDNPYLQLS QEEEDLEMES VVTTSGVMES MKKVKKVTNG SVEPQGEWEG 

AV

Show »

Length:552

Mass (Da):61,976

Checksum:ⁱC5BD664C167B2230

Isoform 3 (identifier: Q5VW38-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
298-300: MAA → GFH
301-600: Missing.

« Hide

        10         20         30         40         50
MAALAPVGSP ASRGPRLAAG LRLLPMLGLL QLLAEPGLGR VHHLALKDDV 
        60         70         80         90        100
RHKVHLNTFG FFKDGYMVVN VSSLSLNEPE DKDVTIGFSL DRTKNDGFSS 
       110        120        130        140        150
YLDEDVNYCI LKKQSVSVTL LILDISRSEV RVKSPPEAGT QLPKIIFSRD 
       160        170        180        190        200
EKVLGQSQEP NVNPASAGNQ TQKTQDGGKS KRSTVDSKAM GEKSFSVHNN 
       210        220        230        240        250
GGAVSFQFFF NISTDDQEGL YSLYFHKCLG KELPSDKFTF SLDIEITEKN 
       260        270        280        290        300
PDSYLSAGEI PLPKLYISMA FFFFLSGTIW IHILRKRRND VFKIHWLGFH

Note: No experimental confirmation available.

Show »

Length:300

Mass (Da):33,384

Checksum:ⁱ27ED28675ABF911B

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

G5E994	G5E994_HUMAN	G protein-coupled receptor 107, iso... G protein-coupled receptor 107, isoform CRA_c (Protein GPR107)	GPR107 hCG_1810895	571	Annotation score:
U3KQD2	U3KQD2_HUMAN	Protein GPR107 Protein GPR107	GPR107	128	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	250	N → D in BAB15408 (PubMed:14702039).Curated	1
Sequence conflictⁱ	457	H → R in BAB13450 (PubMed:10997877).Curated	1
Sequence conflictⁱ	461	Q → R in BAB13450 (PubMed:10997877).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_030863	189	A → P. Corresponds to variant dbSNP:rs640343Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_014434	298 – 300	MAA → GFH in isoform 3. 1 Publication	3
Alternative sequenceⁱVSP_014435	301 – 600	Missing in isoform 3. 1 PublicationAdd BLAST	300
Alternative sequenceⁱVSP_014436	436 – 483	Missing in isoform 2. 3 PublicationsAdd BLAST	48

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF376725 mRNA Translation: AAK57695.1 AK026244 mRNA Translation: BAB15408.1 AL136141 Genomic DNA No translation available. AL360004 Genomic DNA No translation available. AL392105 Genomic DNA No translation available. CH471090 Genomic DNA Translation: EAW87924.1 BC110518 mRNA Translation: AAI10519.1 AB046844 mRNA Translation: BAB13450.1 AL834359 mRNA Translation: CAI46205.1 Sequence problems.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS35162.1 [Q5VW38-2] CCDS48041.1 [Q5VW38-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001130029.1, NM_001136557.1 [Q5VW38-1] NP_001130030.1, NM_001136558.1 NP_066011.2, NM_020960.4 [Q5VW38-2]
UniGeneⁱ	Hs.512461

Genome annotation databases

Ensemblⁱ	ENST00000347136; ENSP00000336988; ENSG00000148358 [Q5VW38-2] ENST00000372406; ENSP00000361483; ENSG00000148358 [Q5VW38-1] ENST00000610997; ENSP00000483750; ENSG00000148358 [Q5VW38-1]
GeneIDⁱ	57720
KEGGⁱ	hsa:57720
UCSC genome browser More...UCSCⁱ	uc004bzd.3 human [Q5VW38-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q5VW38	GPR107 protein (Fragment)		HUMAN		379	UniRef100_Q5VW38

Protein	Similar proteins		Species	Score	Length	Source
Q5VW38	GPR107 protein (Fragment)		HUMAN		379	UniRef90_Q5VW38
G protein-coupled receptor 107		PANTR		600
GPR107 isoform 4		PONAB		600
Uncharacterized protein		PANPA		600
G protein-coupled receptor 107		GORGO		600
+12
Q5VW38-2	Uncharacterized protein		MUSPF		560	UniRef90_Q5VW38-2
G protein-coupled receptor 107, isoform CRA_c (Fragment)		NEOVI		264
protein GPR107 isoform X3		ODORO		557
protein GPR107 isoform X2		Enhydra lutris kenyoni		555
Uncharacterized protein		FELCA		555
+53

Protein	Similar proteins		Species	Score	Length	Source
Q5VW38	GPR107 protein (Fragment)		HUMAN		379	UniRef50_Q5VW38
G protein-coupled receptor 107		PANTR		600
GPR107 isoform 3		PONAB		600
Uncharacterized protein		MACNE		600
Uncharacterized protein		MACFA		600
+202
Q5VW38-2	Protein GPR107		MOUSE		551	UniRef50_Q5VW38-2
Uncharacterized protein		MUSPF		560
G protein-coupled receptor 107, isoform CRA_c (Fragment)		NEOVI		264
protein GPR107 isoform X3		ODORO		557
Uncharacterized protein		FELCA		555
+236

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF376725 mRNA Translation: AAK57695.1 AK026244 mRNA Translation: BAB15408.1 AL136141 Genomic DNA No translation available. AL360004 Genomic DNA No translation available. AL392105 Genomic DNA No translation available. CH471090 Genomic DNA Translation: EAW87924.1 BC110518 mRNA Translation: AAI10519.1 AB046844 mRNA Translation: BAB13450.1 AL834359 mRNA Translation: CAI46205.1 Sequence problems.
CCDSⁱ	CCDS35162.1 [Q5VW38-2] CCDS48041.1 [Q5VW38-1]
RefSeqⁱ	NP_001130029.1, NM_001136557.1 [Q5VW38-1] NP_001130030.1, NM_001136558.1 NP_066011.2, NM_020960.4 [Q5VW38-2]
UniGeneⁱ	Hs.512461

3D structure databases

ProteinModelPortalⁱ	Q5VW38
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	121743, 10 interactors
IntActⁱ	Q5VW38, 2 interactors

PTM databases

GlyConnectⁱ	1660
iPTMnetⁱ	Q5VW38
PhosphoSitePlusⁱ	Q5VW38

Polymorphism and mutation databases

BioMutaⁱ	GPR107
DMDMⁱ	68565572

Proteomic databases

EPDⁱ	Q5VW38
MaxQBⁱ	Q5VW38
PaxDbⁱ	Q5VW38
PeptideAtlasⁱ	Q5VW38
PRIDEⁱ	Q5VW38
ProteomicsDBⁱ	65517 65518 [Q5VW38-2] 65519 [Q5VW38-3]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000347136; ENSP00000336988; ENSG00000148358 [Q5VW38-2] ENST00000372406; ENSP00000361483; ENSG00000148358 [Q5VW38-1] ENST00000610997; ENSP00000483750; ENSG00000148358 [Q5VW38-1]
GeneIDⁱ	57720
KEGGⁱ	hsa:57720
UCSCⁱ	uc004bzd.3 human [Q5VW38-1]

Organism-specific databases

CTDⁱ	57720
EuPathDBⁱ	HostDB:ENSG00000148358.19
GeneCardsⁱ	GPR107
HGNCⁱ	HGNC:17830 GPR107
HPAⁱ	HPA031704
neXtProtⁱ	NX_Q5VW38
OpenTargetsⁱ	ENSG00000148358
PharmGKBⁱ	PA28854
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2569 Eukaryota ENOG410XQAQ LUCA
GeneTreeⁱ	ENSGT00390000008649
HOVERGENⁱ	HBG056147
InParanoidⁱ	Q5VW38
OMAⁱ	LYFHKCS
OrthoDBⁱ	EOG091G05OJ
PhylomeDBⁱ	Q5VW38
TreeFamⁱ	TF314804

Miscellaneous databases

ChiTaRSⁱ	GPR107 human
GeneWikiⁱ	GPR107
GenomeRNAiⁱ	57720
Protein Ontology More...PROⁱ	PR:Q5VW38

Gene expression databases

Bgeeⁱ	ENSG00000148358 Expressed in 244 organ(s), highest expression level in corpus callosum
CleanExⁱ	HS_GPR107
ExpressionAtlasⁱ	Q5VW38 baseline and differential
Genevisibleⁱ	Q5VW38 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR009637 GPR107-like
PANTHERⁱ	PTHR21229 PTHR21229, 1 hit
Pfamⁱ	View protein in Pfam PF06814 Lung_7-TM_R, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GP107_HUMAN
Accessionⁱ	Q5VW38Primary (citable) accession number: Q5VW38 Secondary accession number(s): A6NJ53 Q9HCE8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 5, 2005
	Last sequence update:	December 7, 2004
	Last modified:	November 7, 2018
	This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM

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UniProtKB - Q5VW38 (GP107_HUMAN)

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Protein GPR107

GPR107

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Golgi apparatus

Endosome

Golgi apparatus

Nucleus

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ