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Entry version 127 (12 Aug 2020)
Sequence version 1 (07 Dec 2004)
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Protein

Focadhesin

Gene

FOCAD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Potential tumor suppressor in gliomas.By similarity1 Publication

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q5VW36

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Focadhesin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FOCAD
Synonyms:KIAA1797
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000188352.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23377, FOCAD

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
614606, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5VW36

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei404 – 424HelicalSequence analysisAdd BLAST21
Transmembranei441 – 461HelicalSequence analysisAdd BLAST21
Transmembranei1036 – 1056HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
54914

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134934777

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q5VW36, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FOCAD

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74747342

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003144571 – 1801FocadhesinAdd BLAST1801

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei819N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5VW36

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5VW36

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q5VW36

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q5VW36

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5VW36

PeptideAtlas

More...
PeptideAtlasi
Q5VW36

PRoteomics IDEntifications database

More...
PRIDEi
Q5VW36

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
65516

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5VW36

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5VW36

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous. High expression in brain followed by testis, muscle, pancreas, heart, ovary, small intestine, placenta, prostate, thymus, kidney, colon, liver, lung, spleen and leukocytes. Expression is reduced in most glioblastomas and all glioblastoma cell lines.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000188352, Expressed in choroid plexus epithelium and 226 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5VW36, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5VW36, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000188352, Tissue enriched (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with VCL.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
120256, 14 interactors

Protein interaction database and analysis system

More...
IntActi
Q5VW36, 7 interactors

Molecular INTeraction database

More...
MINTi
Q5VW36

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000369599

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q5VW36, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QQKG, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002970_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5VW36

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5VW36

TreeFam database of animal gene trees

More...
TreeFami
TF323261

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024, ARM-type_fold
IPR022542, DUF3730
IPR021392, Focadhesin

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12530, DUF3730, 1 hit
PF11229, Focadhesin, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q5VW36-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDDIRKRFE FPNSLIQSQA VGHLIAAVLK ENGFSEKIHQ STNQTPALNL
60 70 80 90 100
LWEKCCSDNV VVRTACCEGL VALVAQDHAE FSYVLNGILN LIPSTRNTHG
110 120 130 140 150
LIKAIMHLLQ MQALKEGQGG EKNIQSIYTI RNHPHPLITV LEHRPDCWPV
160 170 180 190 200
FLQQLTAFFQ QCPERLEVSC IQIMAPFLWY LYCEPSQLQE YAKLRLALLK
210 220 230 240 250
VLLQPQVLCD KDQPSILEQQ ILQLCCDIVP CLQVKDLIQT TEAMMFIEEV
260 270 280 290 300
CLSLLRHPVF WKIQLTQMSL QLLCVSEVSL KITGECSSSI HLLEHSVELL
310 320 330 340 350
KEDFPVELVI IGIALLLLQT PASQQKPILN LALKLLSVTE DQKIPKSSLL
360 370 380 390 400
LVMPILQILS STALEDCISV DEEGPSRQQL ALNLLEMIQQ ECYRDDHQKL
410 420 430 440 450
SYKLVCPVTS MYGTIFTAWR ILEVMTDSSA ASDWLASVES LLPITAVIPA
460 470 480 490 500
PAFLLLAHLL VEDKGQNLHQ ILKVTTELAQ ADSSQVPNLI PVLMFKLGRP
510 520 530 540 550
LEPILYNDIL YTLPKLGVHK VCIGQILRII QLLGTTPRLR AVTLRLLTSL
560 570 580 590 600
WEKQDRVYPE LQRFMAVSDV PSLSVGKEVQ WEKLIAKAAS IRDICKQRPY
610 620 630 640 650
QHGADMLAAI SQVLNECTKP DQATPAALVL QGLHALCQAE VVCIRSTWNA
660 670 680 690 700
LSPKLSCDTR PLILKTLSEL FSLVPSLTVN TTEYENFKVQ VLSFLWTHTQ
710 720 730 740 750
NKDPIVANAA YRSLANFTAG EHTILHLPEK IRPEIPIPEE LDDDEDVEDV
760 770 780 790 800
DLSVPGSCYL KLLSLTPPLV LPALEEFFTS LVKQEMVNMP RGIYHSALKG
810 820 830 840 850
GARSDQGKTV AGIPNFILKM YETNKQPGLK PGLAGGMLFC YDVSMYQSKD
860 870 880 890 900
GKPLNRLMAS RGRSFKQTSL ALVHEVHIQL SEWHRAIFLP QAWLAYMNRA
910 920 930 940 950
YHAILQGRLG ELELQLKHGK EEPEEVQYKK STAWLWVRDM LTDEITKAAA
960 970 980 990 1000
KESPVVKGNA LLALSSLAVV VSRHEASLSS DSDGLLEVQP NFLSMKEWVS
1010 1020 1030 1040 1050
MVLDTLLVIV DSHYQPRGQL LSWFYYKSYS GENTASAIAR SAAATALSLL
1060 1070 1080 1090 1100
VPVFIISCKE KVEEILNMLT ARLPGKPSAD ESQAVQIHMG LALGMFLSRL
1110 1120 1130 1140 1150
CEEKLSDISG QEMNLLLMKS LDALENCCFD TSLEYNTGCI LGVGLVLSLM
1160 1170 1180 1190 1200
SHSSQMQSRV HVAALLRKLS AHVDDSGSQS RTFQEVLAYT LSCVCTSAFS
1210 1220 1230 1240 1250
AGIIEATEAE DVMNKLRLLV ENSQQTSGFA LALGNIVHGL SVCGHGKAED
1260 1270 1280 1290 1300
LGSKLLPAWI RIVLTEGTPT MLCLAALHGM VALVGSEGDV MQLKSEAIQT
1310 1320 1330 1340 1350
SHFQGRLNEV IRTLTQVISV SGVIGLQSNA VWLLGHLHLS TLSSSQSRAS
1360 1370 1380 1390 1400
VPTDYSYLPE SSFIGAAIGF FITGGKKGPE SVPPSLLKVV MKPIATVGES
1410 1420 1430 1440 1450
YQYPPVNWAA LLSPLMRLNF GEEIQQLCLE IMVTQAQSSQ NAAALLGLWV
1460 1470 1480 1490 1500
TPPLIHSLSL NTKRYLLISA PLWIKHISDE QILGFVENLM VAVFKAASPL
1510 1520 1530 1540 1550
GSPELCPSAL HGLSQAMKLP SPAHHLWSLL SEATGKIFDL LPNKIRRKDL
1560 1570 1580 1590 1600
ELYISIAKCL LEMTDDDANR IAQVTKSNIE KAAFVKLYLV SQGRFPLVNL
1610 1620 1630 1640 1650
TDMLSVAVQH REKEVLAWMI LHSLYQARIV SHANTGVLKR MEWLLELMGY
1660 1670 1680 1690 1700
IRNVAYQSTS FHNTALDKAL DFFLLIFATA VVAWADHTAP LLLGLSASWL
1710 1720 1730 1740 1750
PWHQENGPAG PVPSFLGRSP MHRVTLQEVL TLLPNSMALL LQKEPWKEQT
1760 1770 1780 1790 1800
QKFIDWLFSI MESPKEALSA QSRDLLKATL LSLRVLPEFK KKAVWTRAYG

W
Length:1,801
Mass (Da):200,072
Last modified:December 7, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD9E96037C621FB80
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
S4R400S4R400_HUMAN
Focadhesin
FOCAD
1,237Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R3N8S4R3N8_HUMAN
Focadhesin
FOCAD
180Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R3S9S4R3S9_HUMAN
Focadhesin
FOCAD
99Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R450S4R450_HUMAN
Focadhesin
FOCAD
128Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R437S4R437_HUMAN
Focadhesin
FOCAD
46Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA91129 differs from that shown. Reason: Frameshift.Curated
The sequence BAA91129 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAD18787 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti481A → V in AAN17740 (Ref. 1) Curated1
Sequence conflicti481A → V in BAB71203 (PubMed:14702039).Curated1
Sequence conflicti1430E → D in AAH01246 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_037877166L → S. Corresponds to variant dbSNP:rs10511687EnsemblClinVar.1
Natural variantiVAR_037878234V → I. Corresponds to variant dbSNP:rs10441706Ensembl.1
Natural variantiVAR_037879523I → V. Corresponds to variant dbSNP:rs17832431Ensembl.1
Natural variantiVAR_037880718T → S4 PublicationsCorresponds to variant dbSNP:rs7875872Ensembl.1
Natural variantiVAR_049528721E → K. Corresponds to variant dbSNP:rs10964742Ensembl.1
Natural variantiVAR_0612511373T → A1 PublicationCorresponds to variant dbSNP:rs3206852Ensembl.1
Natural variantiVAR_0378811373T → P. Corresponds to variant dbSNP:rs3206852Ensembl.1
Natural variantiVAR_0612521373T → S. Corresponds to variant dbSNP:rs3206852Ensembl.1
Natural variantiVAR_0378821668K → E4 PublicationsCorresponds to variant dbSNP:rs4977881EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY139834 mRNA Translation: AAN17740.1
AL392163 Genomic DNA No translation available.
AL445624 Genomic DNA No translation available.
AL662879 Genomic DNA No translation available.
AK000382 mRNA Translation: BAA91129.1 Frameshift.
AK056522 mRNA Translation: BAB71203.1
AK172818 mRNA Translation: BAD18787.1 Different initiation.
AB058700 mRNA Translation: BAB47426.1
CH471071 Genomic DNA Translation: EAW58627.1
CH471071 Genomic DNA Translation: EAW58628.1
CH471071 Genomic DNA Translation: EAW58629.1
BC001246 mRNA Translation: AAH01246.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34993.1

NCBI Reference Sequences

More...
RefSeqi
NP_060264.4, NM_017794.4
XP_005251551.2, XM_005251494.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000338382; ENSP00000344307; ENSG00000188352
ENST00000380249; ENSP00000369599; ENSG00000188352

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
54914

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:54914

UCSC genome browser

More...
UCSCi
uc003zog.2, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY139834 mRNA Translation: AAN17740.1
AL392163 Genomic DNA No translation available.
AL445624 Genomic DNA No translation available.
AL662879 Genomic DNA No translation available.
AK000382 mRNA Translation: BAA91129.1 Frameshift.
AK056522 mRNA Translation: BAB71203.1
AK172818 mRNA Translation: BAD18787.1 Different initiation.
AB058700 mRNA Translation: BAB47426.1
CH471071 Genomic DNA Translation: EAW58627.1
CH471071 Genomic DNA Translation: EAW58628.1
CH471071 Genomic DNA Translation: EAW58629.1
BC001246 mRNA Translation: AAH01246.2
CCDSiCCDS34993.1
RefSeqiNP_060264.4, NM_017794.4
XP_005251551.2, XM_005251494.3

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi120256, 14 interactors
IntActiQ5VW36, 7 interactors
MINTiQ5VW36
STRINGi9606.ENSP00000369599

PTM databases

iPTMnetiQ5VW36
PhosphoSitePlusiQ5VW36

Polymorphism and mutation databases

BioMutaiFOCAD
DMDMi74747342

Proteomic databases

EPDiQ5VW36
jPOSTiQ5VW36
MassIVEiQ5VW36
MaxQBiQ5VW36
PaxDbiQ5VW36
PeptideAtlasiQ5VW36
PRIDEiQ5VW36
ProteomicsDBi65516

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
66171, 10 antibodies

Genome annotation databases

EnsembliENST00000338382; ENSP00000344307; ENSG00000188352
ENST00000380249; ENSP00000369599; ENSG00000188352
GeneIDi54914
KEGGihsa:54914
UCSCiuc003zog.2, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
54914
DisGeNETi54914
EuPathDBiHostDB:ENSG00000188352.12

GeneCards: human genes, protein and diseases

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GeneCardsi
FOCAD
HGNCiHGNC:23377, FOCAD
HPAiENSG00000188352, Tissue enriched (brain)
MIMi614606, gene
neXtProtiNX_Q5VW36
PharmGKBiPA134934777

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502QQKG, Eukaryota
HOGENOMiCLU_002970_0_0_1
InParanoidiQ5VW36
PhylomeDBiQ5VW36
TreeFamiTF323261

Enzyme and pathway databases

PathwayCommonsiQ5VW36

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
54914, 10 hits in 873 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
FOCAD, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
KIAA1797

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
54914
PharosiQ5VW36, Tdark

Protein Ontology

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PROi
PR:Q5VW36
RNActiQ5VW36, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000188352, Expressed in choroid plexus epithelium and 226 other tissues
ExpressionAtlasiQ5VW36, baseline and differential
GenevisibleiQ5VW36, HS

Family and domain databases

InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR022542, DUF3730
IPR021392, Focadhesin
PfamiView protein in Pfam
PF12530, DUF3730, 1 hit
PF11229, Focadhesin, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFOCAD_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5VW36
Secondary accession number(s): D3DRJ9
, Q6ZME1, Q8IZG0, Q96JM8, Q96MS9, Q9BVF3, Q9NX87
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 7, 2004
Last modified: August 12, 2020
This is version 127 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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