Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 6

Gene

AGAP6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Putative GTPase-activating protein.Curated

Miscellaneous

Encoded by one of the numerous copies of centaurin gamma-like genes clustered in the q11 region of chromosome 10.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri456 – 479C4-typePROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

Keywordsi

Molecular functionGTPase activation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 6
Short name:
AGAP-6
Alternative name(s):
Centaurin-gamma-like family member 3
Gene namesi
Name:AGAP6
Synonyms:CTGLF3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000204149.9
HGNCiHGNC:23466 AGAP6
neXtProtiNX_Q5VW22

Pathology & Biotechi

Polymorphism and mutation databases

BioMutaiAGAP6
DMDMi74756919

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002846741 – 663Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 6Add BLAST663

Proteomic databases

PeptideAtlasiQ5VW22
PRIDEiQ5VW22
ProteomicsDBi65507
65508 [Q5VW22-2]

PTM databases

iPTMnetiQ5VW22
PhosphoSitePlusiQ5VW22

Expressioni

Gene expression databases

BgeeiENSG00000204149
ExpressionAtlasiQ5VW22 baseline and differential
GenevisibleiQ5VW22 HS

Organism-specific databases

HPAiHPA042490

Structurei

3D structure databases

ProteinModelPortaliQ5VW22
SMRiQ5VW22
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini259 – 420PHPROSITE-ProRule annotationAdd BLAST162
Domaini441 – 561Arf-GAPPROSITE-ProRule annotationAdd BLAST121
Repeati600 – 629ANK 1Add BLAST30
Repeati633 – 662ANK 2Add BLAST30

Sequence similaritiesi

Belongs to the centaurin gamma-like family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri456 – 479C4-typePROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

ANK repeat, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG0705 Eukaryota
COG5347 LUCA
GeneTreeiENSGT00760000118874
HOGENOMiHOG000007233
HOVERGENiHBG054045
InParanoidiQ5VW22
OrthoDBiEOG091G123A
PhylomeDBiQ5VW22
TreeFamiTF317762

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
3.30.40.160, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR037278 ARFGAP/RecO
IPR001164 ArfGAP_dom
IPR038508 ArfGAP_dom_sf
IPR001849 PH_domain
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF01412 ArfGap, 1 hit
PRINTSiPR00405 REVINTRACTNG
SMARTiView protein in SMART
SM00248 ANK, 2 hits
SM00105 ArfGap, 1 hit
SM00233 PH, 1 hit
SUPFAMiSSF48403 SSF48403, 1 hit
SSF57863 SSF57863, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 1 hit
PS50115 ARFGAP, 1 hit
PS50003 PH_DOMAIN, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5VW22-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGNILTCRVH PSVSLEFDQQ QGSVCPSESE TYEAGARDRM AGAPMAAAVQ
60 70 80 90 100
PAEVTVEVGE DLHMHHVRDR EMPEALEFNP SANPEASTIF QRNSQTDVVE
110 120 130 140 150
IRRSNCTNHV SAVRFSQQYS LCSTIFLDDS TAIQHYLTMT IISVTLEIPH
160 170 180 190 200
HITQRDADRT LSIPDEQLHS FAVSTVHIMK KRNGGGSLNN YSSSIPSTPS
210 220 230 240 250
TSQEDPQFSV PPTANTPTPV CKRSMRWSNL FTSEKGSDPD KERKAPENHA
260 270 280 290 300
DTIGSGRAIP IKQGMLLKRS GKWLKTWKKK YVTLCSNGML TYYSSLGDYM
310 320 330 340 350
KNIHKKEIDL QTSTIKVPGK WPSLATSACT PISSSKSNGL SKDMDTGLGD
360 370 380 390 400
SICFSPSISS TTSPKLNPPP SPHANKKKHL KKKSTNNFMI VSATGQTWHF
410 420 430 440 450
EATTYEERDA WVQAIQSQIL ASLQSCESSK SKSQLTSQSE AMALQSIQNM
460 470 480 490 500
RGNAHCVDCE TQNPKWASLN LGVLMCIECS GIHRSLGPHL SRVRSLELDD
510 520 530 540 550
WPVELRKVMS SIVNDLANSI WEGSSQGQTK PSEKSTREEK ERWIRSKYEE
560 570 580 590 600
KLFLAPLPCT ELSLGQQLLR ATADEDLQTA ILLLAHGSCE EVNETCGEGD
610 620 630 640 650
GCTALHLACR KGNVVLAQLL IWYGVDVMAR DAHGNTALTY ARQASSQECI
660
NVLLQYGCPD ECV
Note: Prediction based on family homologs sequence.
Length:663
Mass (Da):73,127
Last modified:December 7, 2004 - v1
Checksum:iD37B8B139F967113
GO
Isoform 2 (identifier: Q5VW22-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     73-73: P → PEALEFNLSANPESSTIFQRNSQT

Show »
Length:686
Mass (Da):75,692
Checksum:i8EC96B32C51A8552
GO

Sequence cautioni

The sequence BC131545 differs from that shown. Reason: Frameshift at several positions.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti37R → G in BC131545 (PubMed:15489334).Curated1
Sequence conflicti70R → Q in BC131545 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04081573P → PEALEFNLSANPESSTIFQR NSQT in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL442003 Genomic DNA No translation available.
BC131545 mRNA No translation available.
CCDSiCCDS44397.1 [Q5VW22-2]
RefSeqiNP_001071133.2, NM_001077665.2 [Q5VW22-2]
XP_016871759.1, XM_017016270.1 [Q5VW22-1]
UniGeneiHs.536158

Genome annotation databases

EnsembliENST00000374056; ENSP00000363168; ENSG00000204149 [Q5VW22-1]
ENST00000412531; ENSP00000400972; ENSG00000204149 [Q5VW22-2]
GeneIDi414189
KEGGihsa:414189
UCSCiuc001jix.5 human [Q5VW22-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiAGAP6_HUMAN
AccessioniPrimary (citable) accession number: Q5VW22
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: December 7, 2004
Last modified: June 20, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health