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Entry version 131 (12 Aug 2020)
Sequence version 2 (04 Dec 2007)
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Protein

GTPase-activating Rap/Ran-GAP domain-like protein 3

Gene

GARNL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

It is uncertain whether Met-1 or Met-19 is the initiator.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q5VVW2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
GTPase-activating Rap/Ran-GAP domain-like protein 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GARNL3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000136895.18

Human Gene Nomenclature Database

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HGNCi
HGNC:25425, GARNL3

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5VVW2

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
84253

Open Targets

More...
OpenTargetsi
ENSG00000136895

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134861523

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q5VVW2, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GARNL3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
162416278

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003122151 – 1013GTPase-activating Rap/Ran-GAP domain-like protein 3Add BLAST1013

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei45PhosphoserineBy similarity1
Modified residuei426PhosphoserineBy similarity1
Modified residuei432PhosphoserineBy similarity1
Modified residuei827PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q5VVW2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q5VVW2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5VVW2

PeptideAtlas

More...
PeptideAtlasi
Q5VVW2

PRoteomics IDEntifications database

More...
PRIDEi
Q5VVW2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
6539
65495 [Q5VVW2-1]
65496 [Q5VVW2-2]
65497 [Q5VVW2-3]
65498 [Q5VVW2-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5VVW2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5VVW2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000136895, Expressed in right hemisphere of cerebellum and 185 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5VVW2, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5VVW2, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000136895, Tissue enhanced (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
123980, 3 interactors

Protein interaction database and analysis system

More...
IntActi
Q5VVW2, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000362485

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q5VVW2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5VVW2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini191 – 407Rap-GAPPROSITE-ProRule annotationAdd BLAST217
Domaini489 – 800CNHPROSITE-ProRule annotationAdd BLAST312

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GARNL3 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3686, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159362

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_008685_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5VVW2

Identification of Orthologs from Complete Genome Data

More...
OMAi
FPYVLAF

Database of Orthologous Groups

More...
OrthoDBi
845465at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5VVW2

TreeFam database of animal gene trees

More...
TreeFami
TF318626

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.11210, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001180, CNH_dom
IPR035974, Rap/Ran-GAP_sf
IPR000331, Rap_GAP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00780, CNH, 1 hit
PF02145, Rap_GAP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00036, CNH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF111347, SSF111347, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50219, CNH, 1 hit
PS50085, RAPGAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5VVW2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVVDFCRRFV ARSLCIILMK HFCSSSVSED LGCRRGDFSR KHYGSVELLI
60 70 80 90 100
SSDADGAIQR AGRFRVENGS SDENATALPG TWRRTDVHLE NPEYHTRWYF
110 120 130 140 150
KYFLGQVHQN YIGNDAEKSP FFLSVTLSDQ NNQRVPQYRA ILWRKTGTQK
160 170 180 190 200
ICLPYSPTKT LSVKSILSAM NLDKFEKGPR EIFHPEIQKD LLVLEEQEGS
210 220 230 240 250
VNFKFGVLFA KDGQLTDDEM FSNEIGSEPF QKFLNLLGDT ITLKGWTGYR
260 270 280 290 300
GGLDTKNDTT GIHSVYTVYQ GHEIMFHVST MLPYSKENKQ QVERKRHIGN
310 320 330 340 350
DIVTIVFQEG EESSPAFKPS MIRSHFTHIF ALVRYNQQND NYRLKIFSEE
360 370 380 390 400
SVPLFGPPLP TPPVFTDHQE FRDFLLVKLI NGEKATLETP TFAQKRRRTL
410 420 430 440 450
DMLIRSLHQD LMPDLHKNML NRRSFSDVLP ESPKSARKKE EARQAEFVRI
460 470 480 490 500
GQALKLKSIV RGDAPSSLAA SGICKKEPWE PQCFCSNFPH EAVCADPWGQ
510 520 530 540 550
ALLVSTDAGV LLVDDDLPSV PVFDRTLPVK QMHVLETLDL LVLRADKGKD
560 570 580 590 600
ARLFVFRLSA LQKGLEGKQA GKSRSDCREN KLEKTKGCHL YAINTHHSRE
610 620 630 640 650
LRIVVAIRNK LLLITRKHNK PSGVTSTSLL SPLSESPVEE FQYIREICLS
660 670 680 690 700
DSPMVMTLVD GPAEESDNLI CVAYRHQFDV VNESTGEAFR LHHVEANRVN
710 720 730 740 750
FVAAIDVYED GEAGLLLCYN YSCIYKKVCP FNGGSFLVQP SASDFQFCWN
760 770 780 790 800
QAPYAIVCAF PYLLAFTTDS MEIRLVVNGN LVHTAVVPQL QLVASRSDIY
810 820 830 840 850
FTATAAVNEV SSGGSSKGAS ARNSPQTPPG RDTPVFPSSL GEGEIQSKNL
860 870 880 890 900
YKIPLRNLVG RSIERPLKSP LVSKVITPPT PISVGLAAIP VTHSLSLSRM
910 920 930 940 950
EIKEIASRTR RELLGLSDEG GPKSEGAPKA KSKPRKRLEE SQGGPKPGAV
960 970 980 990 1000
RSSSSDRIPS GSLESASTSE ANPEGHSASS DQDPVADREG SPVSGSSPFQ
1010
LTAFSDEDII DLK
Length:1,013
Mass (Da):112,852
Last modified:December 4, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1DF777ECF38DC561
GO
Isoform 2 (identifier: Q5VVW2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     797-820: SDIYFTATAAVNEVSSGGSSKGAS → VKFNQKICTRFHLETSWAEASNDL
     821-1013: Missing.

Show »
Length:820
Mass (Da):93,047
Checksum:iE5065CE61A0127D0
GO
Isoform 3 (identifier: Q5VVW2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     170-210: Missing.
     453-465: ALKLKSIVRGDAP → VGFLLKPFLRDM
     466-1013: Missing.

Show »
Length:423
Mass (Da):48,776
Checksum:i3465A220A94F2564
GO
Isoform 4 (identifier: Q5VVW2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-770: Missing.

Show »
Length:243
Mass (Da):25,483
Checksum:i3A9E00377A606011
GO
Isoform 5 (identifier: Q5VVW2-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: MVVDFCRRFVARSLCIILMKHFCS → MK

Show »
Length:991
Mass (Da):110,254
Checksum:i63C30C9ED9DF3C87
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5JS19Q5JS19_HUMAN
GTPase-activating Rap/Ran-GAP domai...
GARNL3
267Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J8L5C9J8L5_HUMAN
GTPase-activating Rap/Ran-GAP domai...
GARNL3
167Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4DFW0A0A0C4DFW0_HUMAN
GTPase-activating Rap/Ran-GAP domai...
GARNL3
802Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JFS0C9JFS0_HUMAN
GTPase-activating Rap/Ran-GAP domai...
GARNL3
110Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R3P7S4R3P7_HUMAN
GTPase-activating Rap/Ran-GAP domai...
GARNL3
81Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J9U0C9J9U0_HUMAN
GTPase-activating Rap/Ran-GAP domai...
GARNL3
139Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WB68F8WB68_HUMAN
GTPase-activating Rap/Ran-GAP domai...
GARNL3
88Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F2Z2Q8F2Z2Q8_HUMAN
GTPase-activating Rap/Ran-GAP domai...
GARNL3
48Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH34983 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAB66508 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_037456108H → R1 PublicationCorresponds to variant dbSNP:rs11550746Ensembl.1
Natural variantiVAR_037457752A → S. Corresponds to variant dbSNP:rs34608132Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0297451 – 770Missing in isoform 4. 1 PublicationAdd BLAST770
Alternative sequenceiVSP_0548751 – 24MVVDF…KHFCS → MK in isoform 5. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_029740170 – 210Missing in isoform 3. 1 PublicationAdd BLAST41
Alternative sequenceiVSP_029741453 – 465ALKLK…RGDAP → VGFLLKPFLRDM in isoform 3. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_029742466 – 1013Missing in isoform 3. 1 PublicationAdd BLAST548
Alternative sequenceiVSP_029743797 – 820SDIYF…SKGAS → VKFNQKICTRFHLETSWAEA SNDL in isoform 2. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_029744821 – 1013Missing in isoform 2. 1 PublicationAdd BLAST193

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK095679 mRNA Translation: BAC04605.1
AK293732 mRNA Translation: BAG57158.1
AK296246 mRNA Translation: BAH12292.1
AL834149 mRNA Translation: CAD38860.1
AL445222 Genomic DNA No translation available.
AL450263 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87656.1
BC034983 mRNA Translation: AAH34983.1 Different initiation.
AL136573 mRNA Translation: CAB66508.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6869.2 [Q5VVW2-1]
CCDS69663.1 [Q5VVW2-5]

NCBI Reference Sequences

More...
RefSeqi
NP_001273708.1, NM_001286779.1 [Q5VVW2-5]
NP_115669.3, NM_032293.4 [Q5VVW2-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000373387; ENSP00000362485; ENSG00000136895 [Q5VVW2-1]
ENST00000435213; ENSP00000396205; ENSG00000136895 [Q5VVW2-5]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
84253

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:84253

UCSC genome browser

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UCSCi
uc011mad.3, human [Q5VVW2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095679 mRNA Translation: BAC04605.1
AK293732 mRNA Translation: BAG57158.1
AK296246 mRNA Translation: BAH12292.1
AL834149 mRNA Translation: CAD38860.1
AL445222 Genomic DNA No translation available.
AL450263 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87656.1
BC034983 mRNA Translation: AAH34983.1 Different initiation.
AL136573 mRNA Translation: CAB66508.1 Different initiation.
CCDSiCCDS6869.2 [Q5VVW2-1]
CCDS69663.1 [Q5VVW2-5]
RefSeqiNP_001273708.1, NM_001286779.1 [Q5VVW2-5]
NP_115669.3, NM_032293.4 [Q5VVW2-1]

3D structure databases

SMRiQ5VVW2
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi123980, 3 interactors
IntActiQ5VVW2, 1 interactor
STRINGi9606.ENSP00000362485

PTM databases

iPTMnetiQ5VVW2
PhosphoSitePlusiQ5VVW2

Polymorphism and mutation databases

BioMutaiGARNL3
DMDMi162416278

Proteomic databases

MassIVEiQ5VVW2
MaxQBiQ5VVW2
PaxDbiQ5VVW2
PeptideAtlasiQ5VVW2
PRIDEiQ5VVW2
ProteomicsDBi6539
65495 [Q5VVW2-1]
65496 [Q5VVW2-2]
65497 [Q5VVW2-3]
65498 [Q5VVW2-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
16601, 44 antibodies

Genome annotation databases

EnsembliENST00000373387; ENSP00000362485; ENSG00000136895 [Q5VVW2-1]
ENST00000435213; ENSP00000396205; ENSG00000136895 [Q5VVW2-5]
GeneIDi84253
KEGGihsa:84253
UCSCiuc011mad.3, human [Q5VVW2-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
84253
DisGeNETi84253
EuPathDBiHostDB:ENSG00000136895.18

GeneCards: human genes, protein and diseases

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GeneCardsi
GARNL3
HGNCiHGNC:25425, GARNL3
HPAiENSG00000136895, Tissue enhanced (brain)
neXtProtiNX_Q5VVW2
OpenTargetsiENSG00000136895
PharmGKBiPA134861523

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3686, Eukaryota
GeneTreeiENSGT00940000159362
HOGENOMiCLU_008685_1_0_1
InParanoidiQ5VVW2
OMAiFPYVLAF
OrthoDBi845465at2759
PhylomeDBiQ5VVW2
TreeFamiTF318626

Enzyme and pathway databases

PathwayCommonsiQ5VVW2

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
84253, 4 hits in 874 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
GARNL3, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
84253
PharosiQ5VVW2, Tdark

Protein Ontology

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PROi
PR:Q5VVW2
RNActiQ5VVW2, protein

Gene expression databases

BgeeiENSG00000136895, Expressed in right hemisphere of cerebellum and 185 other tissues
ExpressionAtlasiQ5VVW2, baseline and differential
GenevisibleiQ5VVW2, HS

Family and domain databases

Gene3Di3.40.50.11210, 1 hit
InterProiView protein in InterPro
IPR001180, CNH_dom
IPR035974, Rap/Ran-GAP_sf
IPR000331, Rap_GAP_dom
PfamiView protein in Pfam
PF00780, CNH, 1 hit
PF02145, Rap_GAP, 1 hit
SMARTiView protein in SMART
SM00036, CNH, 1 hit
SUPFAMiSSF111347, SSF111347, 1 hit
PROSITEiView protein in PROSITE
PS50219, CNH, 1 hit
PS50085, RAPGAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGARL3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5VVW2
Secondary accession number(s): B4DEP7
, B7Z3Q6, Q8IYU1, Q8N951, Q8ND89, Q9BQH6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 4, 2007
Last modified: August 12, 2020
This is version 131 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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