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Entry version 101 (17 Jun 2020)
Sequence version 1 (07 Dec 2004)
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Protein

Spermatogenesis-associated protein 31A6

Gene

SPATA31A6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in spermatogenesis.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDifferentiation, Spermatogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Spermatogenesis-associated protein 31A6
Alternative name(s):
Protein FAM75A6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SPATA31A6
Synonyms:FAM75A6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000185775.9

Human Gene Nomenclature Database

More...
HGNCi
HGNC:32006 SPATA31A6

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5VVP1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei23 – 43HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000185775

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA164719932

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q5VVP1 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SPATA31A6

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74747270

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002976681 – 1343Spermatogenesis-associated protein 31A6Add BLAST1343

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q5VVP1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5VVP1

PeptideAtlas

More...
PeptideAtlasi
Q5VVP1

PRoteomics IDEntifications database

More...
PRIDEi
Q5VVP1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
65478

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5VVP1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5VVP1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000185775 Expressed in right testis and 5 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5VVP1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000185775 Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q5VVP1 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi68 – 75Poly-Arg8
Compositional biasi120 – 228Pro-richAdd BLAST109
Compositional biasi1329 – 1336His-rich8

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SPATA31 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IF6X Eukaryota
ENOG4111EH8 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183043

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_005668_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5VVP1

Identification of Orthologs from Complete Genome Data

More...
OMAi
ARSHMEN

Database of Orthologous Groups

More...
OrthoDBi
1095565at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5VVP1

TreeFam database of animal gene trees

More...
TreeFami
TF338531

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027970 DUF4599
IPR039509 SPATA31/FAM205

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15371 DUF4599, 1 hit
PF14650 FAM75, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5VVP1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MENLPFPLKL LSASSLNAPS STPWVLDIFL TLVFALGFFF LLLPYLSYFH
60 70 80 90 100
CDDPPSPSPG KRKCPVGRRR RPRGRMKNHS LRAGRECPRG LEETSDLLSQ
110 120 130 140 150
LQSLLGPHLD KGDFGQLSGP DPPGEVGERA PDGASQSSHE PMEDAAPILS
160 170 180 190 200
PLASPDPQAK HPQDLASTPS PGPMTTSVSS LSASQPPEPS LPLEHPSPEP
210 220 230 240 250
PALFPHPPHT PDPLACSPPP PKGFTAPPLR DSTLITPSHC DSVALPLGTV
260 270 280 290 300
PQSLSPHEDL VASVPAISGL GGSNSHVSAS SRWQETARTS CAFNSSVQQD
310 320 330 340 350
PLSRHPPETC QMEAGSLFLL SSDGQNVVGI QVTETAKVNI WEEKENVGSF
360 370 380 390 400
TNQMTPEKHL NSLGNLAKSL DAEQDTTNPK PFWNMGENSK QLPGPQKCSD
410 420 430 440 450
PRLLQESFWK NYSQLFWGLP SLHSESLVAN AWVTDRSYTL QSPPFLFNEM
460 470 480 490 500
SNVCPIQRET TMSPLLFQAQ PLSHRQPFIS STPQFLPTPM AQAEAQAHLQ
510 520 530 540 550
SSFPVLSPAF PSLIKNTGVA CPASQNKVQA LSLPETQHPE WPLLRKQLEG
560 570 580 590 600
RLALPSRVQK SQDVFSVSTP NLPQESLTSI LPENFPVSPE LRRQLEQHIK
610 620 630 640 650
KWIIQHWGNL GRIQESLDLM QLRDESPGTS QAKGKPSPWQ SSTSTGESSK
660 670 680 690 700
EAQKVKFQLE RDLCPHLGQI LGETPQNLSR DMKSFPRKVL GVTSEESERN
710 720 730 740 750
LRKPLRSDSG SDLLRCTERT HIENILKAHM GRNLGQTNEG LIPVRVRRSW
760 770 780 790 800
LAVNQALPVS NTHVKTSNLA APKSGKACVN TAQVLSFLEP CTQQGLGAHI
810 820 830 840 850
VRFWAKHRWG LPLRVLKPIQ CFKLEKVSSL SLTQLAGPSS ATCESGAGSE
860 870 880 890 900
VEVDMFLRKP PMASLRKQVL TKASDHMPES LLASSPAWKQ FQRAPRGIPS
910 920 930 940 950
WNDHGPLKPP PAGQEGRWPS KPLTYSLTGS TQQSRSLGAQ SSKAGETREA
960 970 980 990 1000
VPQCRVPLET CMLANLQATS EDVHGFEAPG TSKSSLHPRV SVSQDPRKLC
1010 1020 1030 1040 1050
LMEEVVSEFE PGMATKSETQ PQVCAAVVLL PDGQASVVPH ASENLVSQVP
1060 1070 1080 1090 1100
QGHLQSMPTG NMRASQELHD LMAARRSKLV QEEPRNPNCQ GSCKSQRPMF
1110 1120 1130 1140 1150
PPIHKSEKSR KPNLEKHEER LEGLRTPQLT PVRKTEDTHQ DEGVQLLPSK
1160 1170 1180 1190 1200
KQPPSVSHFG ENIKQFFQWI FSKKKSKPAP VTAESQKTVK NRSCVYSSSA
1210 1220 1230 1240 1250
EAQGLMTAVG QMLDKKMSLC HAHHASKVNQ HKQKFQAPVC GFPCNHRHLF
1260 1270 1280 1290 1300
YSEHGRILSY AASSQQATLK SQGCPNRDRQ IRNQQPLKSV RCNNEQWGLR
1310 1320 1330 1340
HPQILHPKKA VSPVSPPQHW PKTSGASSHH HHCPRHCLLW EGI
Length:1,343
Mass (Da):147,818
Last modified:December 7, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC7859D919C26D347
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL445584 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS75837.1

NCBI Reference Sequences

More...
RefSeqi
NP_001138668.1, NM_001145196.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000332857; ENSP00000329825; ENSG00000185775

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
389730

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:389730

UCSC genome browser

More...
UCSCi
uc033csq.2 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL445584 Genomic DNA No translation available.
CCDSiCCDS75837.1
RefSeqiNP_001138668.1, NM_001145196.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

PTM databases

iPTMnetiQ5VVP1
PhosphoSitePlusiQ5VVP1

Polymorphism and mutation databases

BioMutaiSPATA31A6
DMDMi74747270

Proteomic databases

MassIVEiQ5VVP1
PaxDbiQ5VVP1
PeptideAtlasiQ5VVP1
PRIDEiQ5VVP1
ProteomicsDBi65478

Genome annotation databases

EnsembliENST00000332857; ENSP00000329825; ENSG00000185775
GeneIDi389730
KEGGihsa:389730
UCSCiuc033csq.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
389730
EuPathDBiHostDB:ENSG00000185775.9

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SPATA31A6
HGNCiHGNC:32006 SPATA31A6
HPAiENSG00000185775 Tissue enriched (testis)
neXtProtiNX_Q5VVP1
OpenTargetsiENSG00000185775
PharmGKBiPA164719932

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IF6X Eukaryota
ENOG4111EH8 LUCA
GeneTreeiENSGT00950000183043
HOGENOMiCLU_005668_2_0_1
InParanoidiQ5VVP1
OMAiARSHMEN
OrthoDBi1095565at2759
PhylomeDBiQ5VVP1
TreeFamiTF338531

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
389730 298 hits in 781 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
389730
PharosiQ5VVP1 Tdark

Protein Ontology

More...
PROi
PR:Q5VVP1
RNActiQ5VVP1 protein

Gene expression databases

BgeeiENSG00000185775 Expressed in right testis and 5 other tissues
GenevisibleiQ5VVP1 HS

Family and domain databases

InterProiView protein in InterPro
IPR027970 DUF4599
IPR039509 SPATA31/FAM205
PfamiView protein in Pfam
PF15371 DUF4599, 1 hit
PF14650 FAM75, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS31A6_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5VVP1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: December 7, 2004
Last modified: June 17, 2020
This is version 101 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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