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Entry version 146 (18 Sep 2019)
Sequence version 1 (07 Dec 2004)
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Protein

Peroxisome proliferator-activated receptor gamma coactivator-related protein 1

Gene

PPRC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a coactivator during transcriptional activation of nuclear genes related to mitochondrial biogenesis and cell growth. Involved in the transcription coactivation of CREB and NRF1 target genes.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, RNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Peroxisome proliferator-activated receptor gamma coactivator-related protein 1
Alternative name(s):
PGC-1-related coactivator
Short name:
PRC
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PPRC1
Synonyms:KIAA0595
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30025 PPRC1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617462 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5VV67

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
23082

Open Targets

More...
OpenTargetsi
ENSG00000148840

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134886297

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PPRC1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74756889

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002966661 – 1664Peroxisome proliferator-activated receptor gamma coactivator-related protein 1Add BLAST1664

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei237PhosphoserineCombined sources1
Modified residuei536PhosphoserineCombined sources1
Modified residuei548PhosphoserineCombined sources1
Modified residuei1076PhosphoserineCombined sources1
Modified residuei1411PhosphoserineCombined sources1
Modified residuei1413PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5VV67

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5VV67

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q5VV67

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q5VV67

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5VV67

PeptideAtlas

More...
PeptideAtlasi
Q5VV67

PRoteomics IDEntifications database

More...
PRIDEi
Q5VV67

ProteomicsDB human proteome resource

More...
ProteomicsDBi
65451 [Q5VV67-1]
65452 [Q5VV67-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5VV67

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5VV67

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Strongly expressed in heart and skeletal muscle, moderately in lung, placenta, intestine, liver, kidney, spleen, thymus, colon and brain. Also expressed in several oncocytic thyroid tumors.2 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by serum (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000148840 Expressed in 208 organ(s), highest expression level in left lobe of thyroid gland

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5VV67 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5VV67 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA038511
HPA057571

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CREB1 and NRF1.

2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116713, 10 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
Q5VV67

Protein interaction database and analysis system

More...
IntActi
Q5VV67, 9 interactors

Molecular INTeraction database

More...
MINTi
Q5VV67

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000278070

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1543 – 1619RRMPROSITE-ProRule annotationAdd BLAST77

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni433 – 467Necessary for interaction with CREB1 and NRF1 and for transcriptional coactivation1 PublicationAdd BLAST35
Regioni1379 – 1450Necessary for interaction with CREB1 and NRF11 PublicationAdd BLAST72

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi772 – 1137Pro-richAdd BLAST366
Compositional biasi1400 – 1543Arg-richAdd BLAST144
Compositional biasi1411 – 1523Ser-richAdd BLAST113

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IK9Y Eukaryota
ENOG4111HH9 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183137

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5VV67

KEGG Orthology (KO)

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KOi
K17963

Identification of Orthologs from Complete Genome Data

More...
OMAi
PYTHYAP

Database of Orthologous Groups

More...
OrthoDBi
94418at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5VV67

TreeFam database of animal gene trees

More...
TreeFami
TF343068

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12624 RRM_PRC, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.330, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR034605 PGC-1
IPR034597 PRC
IPR034834 PRC_RRM
IPR035979 RBD_domain_sf
IPR000504 RRM_dom

The PANTHER Classification System

More...
PANTHERi
PTHR15528 PTHR15528, 1 hit
PTHR15528:SF5 PTHR15528:SF5, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00076 RRM_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00360 RRM, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54928 SSF54928, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50102 RRM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5VV67-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAARRGRRDG VAPPPSGGPG PDPGGGARGS GWGSRSQAPY GTLGAVSGGE
60 70 80 90 100
QVLLHEEAGD SGFVSLSRLG PSLRDKDLEM EELMLQDETL LGTMQSYMDA
110 120 130 140 150
SLISLIEDFG SLGESRLSLE DQNEVSLLTA LTEILDNADS ENLSPFDSIP
160 170 180 190 200
DSELLVSPRE GSSLHKLLTL SRTPPERDLI TPVDPLGPST GSSRGSGVEM
210 220 230 240 250
SLPDPSWDFS PPSFLETSSP KLPSWRPPRS RPRWGQSPPP QQRSDGEEEE
260 270 280 290 300
EVASFSGQIL AGELDNCVSS IPDFPMHLAC PEEEDKATAA EMAVPAAGDE
310 320 330 340 350
SISSLSELVR AMHPYCLPNL THLASLEDEL QEQPDDLTLP EGCVVLEIVG
360 370 380 390 400
QAATAGDDLE IPVVVRQVSP GPRPVLLDDS LETSSALQLL MPTLESETEA
410 420 430 440 450
AVPKVTLCSE KEGLSLNSEE KLDSACLLKP REVVEPVVPK EPQNPPANAA
460 470 480 490 500
PGSQRARKGR KKKSKEQPAA CVEGYARRLR SSSRGQSTVG TEVTSQVDNL
510 520 530 540 550
QKQPQEELQK ESGPLQGKGK PRAWARAWAA ALENSSPKNL ERSAGQSSPA
560 570 580 590 600
KEGPLDLYPK LADTIQTNPI PTHLSLVDSA QASPMPVDSV EADPTAVGPV
610 620 630 640 650
LAGPVPVDPG LVDLASTSSE LVEPLPAEPV LINPVLADSA AVDPAVVPIS
660 670 680 690 700
DNLPPVDAVP SGPAPVDLAL VDPVPNDLTP VDPVLVKSRP TDPRRGAVSS
710 720 730 740 750
ALGGSAPQLL VESESLDPPK TIIPEVKEVV DSLKIESGTS ATTHEARPRP
760 770 780 790 800
LSLSEYRRRR QQRQAETEER SPQPPTGKWP SLPETPTGLA DIPCLVIPPA
810 820 830 840 850
PAKKTALQRS PETPLEICLV PVGPSPASPS PEPPVSKPVA SSPTEQVPSQ
860 870 880 890 900
EMPLLARPSP PVQSVSPAVP TPPSMSAALP FPAGGLGMPP SLPPPPLQPP
910 920 930 940 950
SLPLSMGPVL PDPFTHYAPL PSWPCYPHVS PSGYPCLPPP PTVPLVSGTP
960 970 980 990 1000
GAYAVPPTCS VPWAPPPAPV SPYSSTCTYG PLGWGPGPQH APFWSTVPPP
1010 1020 1030 1040 1050
PLPPASIGRA VPQPKMESRG TPAGPPENVL PLSMAPPLSL GLPGHGAPQT
1060 1070 1080 1090 1100
EPTKVEVKPV PASPHPKHKV SALVQSPQMK ALACVSAEGV TVEEPASERL
1110 1120 1130 1140 1150
KPETQETRPR EKPPLPATKA VPTPRQSTVP KLPAVHPARL RKLSFLPTPR
1160 1170 1180 1190 1200
TQGSEDVVQA FISEIGIEAS DLSSLLEQFE KSEAKKECPP PAPADSLAVG
1210 1220 1230 1240 1250
NSGGVDIPQE KRPLDRLQAP ELANVAGLTP PATPPHQLWK PLAAVSLLAK
1260 1270 1280 1290 1300
AKSPKSTAQE GTLKPEGVTE AKHPAAVRLQ EGVHGPSRVH VGSGDHDYCV
1310 1320 1330 1340 1350
RSRTPPKKMP ALVIPEVGSR WNVKRHQDIT IKPVLSLGPA APPPPCIAAS
1360 1370 1380 1390 1400
REPLDHRTSS EQADPSAPCL APSSLLSPEA SPCRNDMNTR TPPEPSAKQR
1410 1420 1430 1440 1450
SMRCYRKACR SASPSSQGWQ GRRGRNSRSV SSGSNRTSEA SSSSSSSSSS
1460 1470 1480 1490 1500
SRSRSRSLSP PHKRWRRSSC SSSGRSRRCS SSSSSSSSSS SSSSSSSSSR
1510 1520 1530 1540 1550
SRSRSPSPRR RSDRRRRYSS YRSHDHYQRQ RVLQKERAIE ERRVVFIGKI
1560 1570 1580 1590 1600
PGRMTRSELK QRFSVFGEIE ECTIHFRVQG DNYGFVTYRY AEEAFAAIES
1610 1620 1630 1640 1650
GHKLRQADEQ PFDLCFGGRR QFCKRSYSDL DSNREDFDPA PVKSKFDSLD
1660
FDTLLKQAQK NLRR
Length:1,664
Mass (Da):177,544
Last modified:December 7, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i01D4138F80C620E8
GO
Isoform 2 (identifier: Q5VV67-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-120: Missing.
     121-147: DQNEVSLLTALTEILDNADSENLSPFD → MRHCWGPCRATWMPPLSPSLRILGALE
     1518-1519: Missing.

Show »
Length:1,542
Mass (Da):164,965
Checksum:i9B120057AA1A0CA4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EVG6E7EVG6_HUMAN
Peroxisome proliferator-activated r...
PPRC1
1,400Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X6R7H2X6R7H2_HUMAN
Peroxisome proliferator-activated r...
PPRC1
631Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH02561 differs from that shown. Reason: Frameshift at position 1643.Curated
The sequence BAA25521 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti33G → R in AAK11573 (PubMed:11340167).Curated1
Sequence conflicti69L → Q in AAK11573 (PubMed:11340167).Curated1
Sequence conflicti122Q → H in AAK11573 (PubMed:11340167).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_034633536S → G. Corresponds to variant dbSNP:rs17114388Ensembl.1
Natural variantiVAR_034634834P → R1 PublicationCorresponds to variant dbSNP:rs17855877Ensembl.1
Natural variantiVAR_0746281288R → Q1 PublicationCorresponds to variant dbSNP:rs118161359Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0272291 – 120Missing in isoform 2. 1 PublicationAdd BLAST120
Alternative sequenceiVSP_027230121 – 147DQNEV…LSPFD → MRHCWGPCRATWMPPLSPSL RILGALE in isoform 2. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_0272311518 – 1519Missing in isoform 2. 1 Publication2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF325193 mRNA Translation: AAK11573.1
AB011167 mRNA Translation: BAA25521.2 Different initiation.
AL500527 Genomic DNA No translation available.
BC002561 mRNA Translation: AAH02561.2 Frameshift.
BC063806 mRNA Translation: AAH63806.1
BC063829 mRNA Translation: AAH63829.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS7529.1 [Q5VV67-1]

Protein sequence database of the Protein Information Resource

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PIRi
T00273

NCBI Reference Sequences

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RefSeqi
NP_001275656.1, NM_001288727.1
NP_001275657.1, NM_001288728.1 [Q5VV67-2]
NP_055877.3, NM_015062.4 [Q5VV67-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000278070; ENSP00000278070; ENSG00000148840 [Q5VV67-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
23082

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:23082

UCSC genome browser

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UCSCi
uc001kum.5 human [Q5VV67-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF325193 mRNA Translation: AAK11573.1
AB011167 mRNA Translation: BAA25521.2 Different initiation.
AL500527 Genomic DNA No translation available.
BC002561 mRNA Translation: AAH02561.2 Frameshift.
BC063806 mRNA Translation: AAH63806.1
BC063829 mRNA Translation: AAH63829.1
CCDSiCCDS7529.1 [Q5VV67-1]
PIRiT00273
RefSeqiNP_001275656.1, NM_001288727.1
NP_001275657.1, NM_001288728.1 [Q5VV67-2]
NP_055877.3, NM_015062.4 [Q5VV67-1]

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi116713, 10 interactors
ELMiQ5VV67
IntActiQ5VV67, 9 interactors
MINTiQ5VV67
STRINGi9606.ENSP00000278070

PTM databases

iPTMnetiQ5VV67
PhosphoSitePlusiQ5VV67

Polymorphism and mutation databases

BioMutaiPPRC1
DMDMi74756889

Proteomic databases

EPDiQ5VV67
jPOSTiQ5VV67
MassIVEiQ5VV67
MaxQBiQ5VV67
PaxDbiQ5VV67
PeptideAtlasiQ5VV67
PRIDEiQ5VV67
ProteomicsDBi65451 [Q5VV67-1]
65452 [Q5VV67-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000278070; ENSP00000278070; ENSG00000148840 [Q5VV67-1]
GeneIDi23082
KEGGihsa:23082
UCSCiuc001kum.5 human [Q5VV67-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23082
DisGeNETi23082

GeneCards: human genes, protein and diseases

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GeneCardsi
PPRC1
HGNCiHGNC:30025 PPRC1
HPAiHPA038511
HPA057571
MIMi617462 gene
neXtProtiNX_Q5VV67
OpenTargetsiENSG00000148840
PharmGKBiPA134886297

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IK9Y Eukaryota
ENOG4111HH9 LUCA
GeneTreeiENSGT00950000183137
InParanoidiQ5VV67
KOiK17963
OMAiPYTHYAP
OrthoDBi94418at2759
PhylomeDBiQ5VV67
TreeFamiTF343068

Enzyme and pathway databases

ReactomeiR-HSA-2151201 Transcriptional activation of mitochondrial biogenesis

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PPRC1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
PPRC1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
23082

Pharos

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Pharosi
Q5VV67

Protein Ontology

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PROi
PR:Q5VV67

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000148840 Expressed in 208 organ(s), highest expression level in left lobe of thyroid gland
ExpressionAtlasiQ5VV67 baseline and differential
GenevisibleiQ5VV67 HS

Family and domain databases

CDDicd12624 RRM_PRC, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR034605 PGC-1
IPR034597 PRC
IPR034834 PRC_RRM
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PANTHERiPTHR15528 PTHR15528, 1 hit
PTHR15528:SF5 PTHR15528:SF5, 1 hit
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPPRC1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5VV67
Secondary accession number(s): Q5VV66
, Q6P3U5, Q6P3W1, Q76N31, Q9BUJ3, Q9BZE5, Q9Y4E0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: December 7, 2004
Last modified: September 18, 2019
This is version 146 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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