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Entry version 145 (05 Jun 2019)
Sequence version 2 (20 Feb 2007)
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Protein

Attractin-like protein 1

Gene

ATRNL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in melanocortin signaling pathways that regulate energy homeostasis.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandLectin

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Attractin-like protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ATRNL1
Synonyms:KIAA0534
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29063 ATRNL1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
612869 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5VV63

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini53 – 1230ExtracellularSequence analysisAdd BLAST1178
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1231 – 1251HelicalSequence analysisAdd BLAST21
Topological domaini1252 – 1379CytoplasmicSequence analysisAdd BLAST128

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
26033

Open Targets

More...
OpenTargetsi
ENSG00000107518

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134961599

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ATRNL1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
189081675

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 52Sequence analysisAdd BLAST52
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000033465053 – 1379Attractin-like protein 1Add BLAST1327

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi63 ↔ 79By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi76N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi81 ↔ 90By similarity
Disulfide bondi93 ↔ 119By similarity
Glycosylationi174N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi198N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi211 ↔ 221By similarity
Disulfide bondi215 ↔ 233By similarity
Disulfide bondi235 ↔ 244By similarity
Glycosylationi380N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi763N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi776 ↔ 872By similarity
Glycosylationi778N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi898N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1014 ↔ 1022By similarity
Disulfide bondi1016 ↔ 1028By similarity
Disulfide bondi1031 ↔ 1040By similarity
Disulfide bondi1043 ↔ 1057By similarity
Disulfide bondi1060 ↔ 1069By similarity
Disulfide bondi1062 ↔ 1076By similarity
Disulfide bondi1078 ↔ 1088By similarity
Disulfide bondi1091 ↔ 1106By similarity
Glycosylationi1157N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5VV63

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5VV63

PeptideAtlas

More...
PeptideAtlasi
Q5VV63

PRoteomics IDEntifications database

More...
PRIDEi
Q5VV63

ProteomicsDB human proteome resource

More...
ProteomicsDBi
65449
65450 [Q5VV63-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5VV63

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5VV63

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000107518 Expressed in 148 organ(s), highest expression level in kidney

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5VV63 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5VV63 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA038070

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MC4R.By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
117499, 3 interactors

Protein interaction database and analysis system

More...
IntActi
Q5VV63, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000347152

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini53 – 91EGF-like 1PROSITE-ProRule annotationAdd BLAST39
Domaini93 – 209CUBPROSITE-ProRule annotationAdd BLAST117
Domaini207 – 245EGF-like 2PROSITE-ProRule annotationAdd BLAST39
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati316 – 365Kelch 1Add BLAST50
Repeati367 – 415Kelch 2Add BLAST49
Repeati427 – 475Kelch 3Add BLAST49
Repeati480 – 531Kelch 4Add BLAST52
Repeati533 – 591Kelch 5Add BLAST59
Repeati592 – 638Kelch 6Add BLAST47
Domaini614 – 657PSI 1Add BLAST44
Domaini666 – 709PSI 2Add BLAST44
Domaini715 – 760PSI 3Add BLAST46
Domaini755 – 873C-type lectinPROSITE-ProRule annotationAdd BLAST119
Domaini889 – 939PSI 4Add BLAST51
Domaini942 – 1012PSI 5Add BLAST71
Domaini1014 – 1059Laminin EGF-like 1PROSITE-ProRule annotationAdd BLAST46
Domaini1060 – 1108Laminin EGF-like 2PROSITE-ProRule annotationAdd BLAST49

Keywords - Domaini

EGF-like domain, Kelch repeat, Laminin EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1388 Eukaryota
ENOG410XRW4 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155790

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5VV63

Identification of Orthologs from Complete Genome Data

More...
OMAi
WNVGTLS

Database of Orthologous Groups

More...
OrthoDBi
49565at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5VV63

TreeFam database of animal gene trees

More...
TreeFami
TF321873

Family and domain databases

Conserved Domains Database

More...
CDDi
cd03597 CLECT_attractin_like, 1 hit
cd00041 CUB, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.120.10.80, 2 hits
2.60.120.290, 1 hit
3.10.100.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR034011 Attractin-like_CTLD
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
IPR000859 CUB_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR013111 EGF_extracell
IPR015915 Kelch-typ_b-propeller
IPR002049 Laminin_EGF
IPR002165 Plexin_repeat
IPR016201 PSI
IPR035914 Sperma_CUB_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00431 CUB, 1 hit
PF07974 EGF_2, 1 hit
PF00059 Lectin_C, 1 hit
PF01437 PSI, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00034 CLECT, 1 hit
SM00042 CUB, 1 hit
SM00181 EGF, 3 hits
SM00180 EGF_Lam, 2 hits
SM00423 PSI, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF117281 SSF117281, 2 hits
SSF49854 SSF49854, 1 hit
SSF56436 SSF56436, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50041 C_TYPE_LECTIN_2, 1 hit
PS01180 CUB, 1 hit
PS00022 EGF_1, 3 hits
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 2 hits
PS01248 EGF_LAM_1, 1 hit
PS50027 EGF_LAM_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5VV63-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
METGGRARTG TPQPAAPGVW RARPAGGGGG GASSWLLDGN SWLLCYGFLY
60 70 80 90 100
LALYAQVSQS KPCERTGSCF SGRCVNSTCL CDPGWVGDQC QHCQGRFKLT
110 120 130 140 150
EPSGYLTDGP INYKYKTKCT WLIEGYPNAV LRLRFNHFAT ECSWDHMYVY
160 170 180 190 200
DGDSIYAPLI AVLSGLIVPE IRGNETVPEV VTTSGYALLH FFSDAAYNLT
210 220 230 240 250
GFNIFYSINS CPNNCSGHGK CTTSVSVPSQ VYCECDKYWK GEACDIPYCK
260 270 280 290 300
ANCGSPDHGY CDLTGEKLCV CNDSWQGPDC SLNVPSTESY WILPNVKPFS
310 320 330 340 350
PSVGRASHKA VLHGKFMWVI GGYTFNYSSF QMVLNYNLES SIWNVGTPSR
360 370 380 390 400
GPLQRYGHSL ALYQENIFMY GGRIETNDGN VTDELWVFNI HSQSWSTKTP
410 420 430 440 450
TVLGHGQQYA VEGHSAHIME LDSRDVVMII IFGYSAIYGY TSSIQEYHIS
460 470 480 490 500
SNTWLVPETK GAIVQGGYGH TSVYDEITKS IYVHGGYKAL PGNKYGLVDD
510 520 530 540 550
LYKYEVNTKT WTILKESGFA RYLHSAVLIN GAMLIFGGNT HNDTSLSNGA
560 570 580 590 600
KCFSADFLAY DIACDEWKIL PKPNLHRDVN RFGHSAVVIN GSMYIFGGFS
610 620 630 640 650
SVLLNDILVY KPPNCKAFRD EELCKNAGPG IKCVWNKNHC ESWESGNTNN
660 670 680 690 700
ILRAKCPPKT AASDDRCYRY ADCASCTANT NGCQWCDDKK CISANSNCSM
710 720 730 740 750
SVKNYTKCHV RNEQICNKLT SCKSCSLNLN CQWDQRQQEC QALPAHLCGE
760 770 780 790 800
GWSHIGDACL RVNSSRENYD NAKLYCYNLS GNLASLTTSK EVEFVLDEIQ
810 820 830 840 850
KYTQQKVSPW VGLRKINISY WGWEDMSPFT NTTLQWLPGE PNDSGFCAYL
860 870 880 890 900
ERAAVAGLKA NPCTSMANGL VCEKPVVSPN QNARPCKKPC SLRTSCSNCT
910 920 930 940 950
SNGMECMWCS STKRCVDSNA YIISFPYGQC LEWQTATCSP QNCSGLRTCG
960 970 980 990 1000
QCLEQPGCGW CNDPSNTGRG HCIEGSSRGP MKLIGMHHSE MVLDTNLCPK
1010 1020 1030 1040 1050
EKNYEWSFIQ CPACQCNGHS TCINNNVCEQ CKNLTTGKQC QDCMPGYYGD
1060 1070 1080 1090 1100
PTNGGQCTAC TCSGHANICH LHTGKCFCTT KGIKGDQCQL CDSENRYVGN
1110 1120 1130 1140 1150
PLRGTCYYSL LIDYQFTFSL LQEDDRHHTA INFIANPEQS NKNLDISINA
1160 1170 1180 1190 1200
SNNFNLNITW SVGSTAGTIS GEETSIVSKN NIKEYRDSFS YEKFNFRSNP
1210 1220 1230 1240 1250
NITFYVYVSN FSWPIKIQIA FSQHNTIMDL VQFFVTFFSC FLSLLLVAAV
1260 1270 1280 1290 1300
VWKIKQTCWA SRRREQLLRE RQQMASRPFA SVDVALEVGA EQTEFLRGPL
1310 1320 1330 1340 1350
EGAPKPIAIE PCAGNRAAVL TVFLCLPRGS SGAPPPGQSG LAIASALIDI
1360 1370
SQQKASDSKD KTSGVRNRKH LSTRQGTCV
Length:1,379
Mass (Da):152,639
Last modified:February 20, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i67904F946FAF6028
GO
Isoform 2 (identifier: Q5VV63-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     450-467: SSNTWLVPETKGAIVQGG → CELLKNCNFFIDWECFSL
     468-1379: Missing.

Note: No experimental confirmation available.
Show »
Length:467
Mass (Da):51,867
Checksum:iC66273EDFFEC1E01
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3B3ISV6A0A3B3ISV6_HUMAN
Attractin-like protein 1
ATRNL1
1,316Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
R4GMZ1R4GMZ1_HUMAN
Attractin-like protein 1
ATRNL1
398Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PL90E9PL90_HUMAN
Attractin-like protein 1
ATRNL1
252Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YDQ9H0YDQ9_HUMAN
Attractin-like protein 1
ATRNL1
216Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X0X7A0A087X0X7_HUMAN
Attractin-like protein 1
ATRNL1
36Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC86914 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_043446989S → N2 PublicationsCorresponds to variant dbSNP:rs1953758Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_033718450 – 467SSNTW…IVQGG → CELLKNCNFFIDWECFSL in isoform 2. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_033719468 – 1379Missing in isoform 2. 1 PublicationAdd BLAST912

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AY442317 mRNA Translation: AAR14297.1
AC022542 Genomic DNA No translation available.
AC091667 Genomic DNA No translation available.
AL355530 Genomic DNA No translation available.
AL356100 Genomic DNA No translation available.
AL357059 Genomic DNA No translation available.
AL392087 Genomic DNA No translation available.
AL512304 Genomic DNA No translation available.
BC047716 mRNA Translation: AAH47716.1
BC139916 mRNA Translation: AAI39917.1
BC139923 mRNA Translation: AAI39924.1
AK127277 mRNA Translation: BAC86914.1 Different initiation.
AB011106 mRNA Translation: BAA25460.2

The Consensus CDS (CCDS) project

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CCDSi
CCDS73204.1 [Q5VV63-2]
CCDS7592.1 [Q5VV63-1]

Protein sequence database of the Protein Information Resource

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PIRi
T00266

NCBI Reference Sequences

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RefSeqi
NP_001263211.1, NM_001276282.3 [Q5VV63-2]
NP_997186.1, NM_207303.4 [Q5VV63-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000355044; ENSP00000347152; ENSG00000107518 [Q5VV63-1]
ENST00000609571; ENSP00000476902; ENSG00000107518 [Q5VV63-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
26033

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:26033

UCSC genome browser

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UCSCi
uc001lcg.4 human [Q5VV63-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY442317 mRNA Translation: AAR14297.1
AC022542 Genomic DNA No translation available.
AC091667 Genomic DNA No translation available.
AL355530 Genomic DNA No translation available.
AL356100 Genomic DNA No translation available.
AL357059 Genomic DNA No translation available.
AL392087 Genomic DNA No translation available.
AL512304 Genomic DNA No translation available.
BC047716 mRNA Translation: AAH47716.1
BC139916 mRNA Translation: AAI39917.1
BC139923 mRNA Translation: AAI39924.1
AK127277 mRNA Translation: BAC86914.1 Different initiation.
AB011106 mRNA Translation: BAA25460.2
CCDSiCCDS73204.1 [Q5VV63-2]
CCDS7592.1 [Q5VV63-1]
PIRiT00266
RefSeqiNP_001263211.1, NM_001276282.3 [Q5VV63-2]
NP_997186.1, NM_207303.4 [Q5VV63-1]

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi117499, 3 interactors
IntActiQ5VV63, 2 interactors
STRINGi9606.ENSP00000347152

PTM databases

iPTMnetiQ5VV63
PhosphoSitePlusiQ5VV63

Polymorphism and mutation databases

BioMutaiATRNL1
DMDMi189081675

Proteomic databases

EPDiQ5VV63
PaxDbiQ5VV63
PeptideAtlasiQ5VV63
PRIDEiQ5VV63
ProteomicsDBi65449
65450 [Q5VV63-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
26033
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355044; ENSP00000347152; ENSG00000107518 [Q5VV63-1]
ENST00000609571; ENSP00000476902; ENSG00000107518 [Q5VV63-2]
GeneIDi26033
KEGGihsa:26033
UCSCiuc001lcg.4 human [Q5VV63-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
26033
DisGeNETi26033

GeneCards: human genes, protein and diseases

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GeneCardsi
ATRNL1

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0021959
HGNCiHGNC:29063 ATRNL1
HPAiHPA038070
MIMi612869 gene
neXtProtiNX_Q5VV63
OpenTargetsiENSG00000107518
PharmGKBiPA134961599

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1388 Eukaryota
ENOG410XRW4 LUCA
GeneTreeiENSGT00940000155790
InParanoidiQ5VV63
OMAiWNVGTLS
OrthoDBi49565at2759
PhylomeDBiQ5VV63
TreeFamiTF321873

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ATRNL1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
26033

Protein Ontology

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PROi
PR:Q5VV63

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000107518 Expressed in 148 organ(s), highest expression level in kidney
ExpressionAtlasiQ5VV63 baseline and differential
GenevisibleiQ5VV63 HS

Family and domain databases

CDDicd03597 CLECT_attractin_like, 1 hit
cd00041 CUB, 1 hit
Gene3Di2.120.10.80, 2 hits
2.60.120.290, 1 hit
3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR034011 Attractin-like_CTLD
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
IPR000859 CUB_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR013111 EGF_extracell
IPR015915 Kelch-typ_b-propeller
IPR002049 Laminin_EGF
IPR002165 Plexin_repeat
IPR016201 PSI
IPR035914 Sperma_CUB_dom_sf
PfamiView protein in Pfam
PF00431 CUB, 1 hit
PF07974 EGF_2, 1 hit
PF00059 Lectin_C, 1 hit
PF01437 PSI, 2 hits
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SM00042 CUB, 1 hit
SM00181 EGF, 3 hits
SM00180 EGF_Lam, 2 hits
SM00423 PSI, 5 hits
SUPFAMiSSF117281 SSF117281, 2 hits
SSF49854 SSF49854, 1 hit
SSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS50041 C_TYPE_LECTIN_2, 1 hit
PS01180 CUB, 1 hit
PS00022 EGF_1, 3 hits
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 2 hits
PS01248 EGF_LAM_1, 1 hit
PS50027 EGF_LAM_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiATRN1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5VV63
Secondary accession number(s): O60283
, Q5JSE8, Q5T5Y9, Q6T256, Q6ZSN4, Q86WX2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 20, 2007
Last modified: June 5, 2019
This is version 145 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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